메뉴 건너뛰기




Volumn 98, Issue 20, 2014, Pages 8617-8628

Tanshinones extend chronological lifespan in budding yeast Saccharomyces cerevisiae

Author keywords

Amino acid; Chronological lifespan; Conserved longevity mechanism; Cryptotanshinone; Nutrient sensing pathway; Tor1 Sch9 Gcn2 Sod2

Indexed keywords

AMINO ACIDS; CELL PROLIFERATION; NUTRIENTS; PROTEINS;

EID: 84920258760     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-014-5890-5     Document Type: Article
Times cited : (21)

References (54)
  • 1
    • 67651162109 scopus 로고    scopus 로고
    • Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae
    • PID: 19302372, COI: 1:CAS:528:DC%2BD1MXhtVSjtbnI
    • Alvers AL, Fishwick LK, Wood MS, Hu D, Chung HS, Dunn WA Jr, Aris JP (2009) Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae. Aging Cell 8:353–369
    • (2009) Aging Cell , vol.8 , pp. 353-369
    • Alvers, A.L.1    Fishwick, L.K.2    Wood, M.S.3    Hu, D.4    Chung, H.S.5    Dunn, W.A.6    Aris, J.P.7
  • 2
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: the in vivo evidence
    • PID: 16732220, COI: 1:CAS:528:DC%2BD28XlsV2jur8%3D
    • Baur JA, Sinclair DA (2006) Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 5:493–506
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 3
    • 44349186331 scopus 로고    scopus 로고
    • Influence of genotype and nutrition on survival and metabolism of starving yeast
    • PID: 18456835, COI: 1:CAS:528:DC%2BD1cXmt1Gitr4%3D
    • Boer VM, Amini S, Botstein D (2008) Influence of genotype and nutrition on survival and metabolism of starving yeast. Proc Natl Acad Sci U S A 105:6930–6935
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 6930-6935
    • Boer, V.M.1    Amini, S.2    Botstein, D.3
  • 4
    • 84866773226 scopus 로고    scopus 로고
    • Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan
    • PID: 22894934, COI: 1:CAS:528:DC%2BC3sXovVGjtg%3D%3D
    • Burstein MT, Kyryakov P, Beach A, Richard VR, Koupaki O, Gomez-Perez A, Leonov A, Levy S, Noohi F, Titorenko VI (2012) Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan. Cell Cycle 11:3443–3462
    • (2012) Cell Cycle , vol.11 , pp. 3443-3462
    • Burstein, M.T.1    Kyryakov, P.2    Beach, A.3    Richard, V.R.4    Koupaki, O.5    Gomez-Perez, A.6    Leonov, A.7    Levy, S.8    Noohi, F.9    Titorenko, V.I.10
  • 5
    • 77955452597 scopus 로고    scopus 로고
    • Cryptotanshinone inhibits cancer cell proliferation by suppressing mammalian target of rapamycin-mediated cyclin D1 expression and Rb phosphorylation
    • COI: 1:CAS:528:DC%2BC3cXht1GrtL3M
    • Chen W, Luo Y, Liu L, Zhou H, Xu BS, Han XZ, Shen T, Liu ZJ, Lu Y, Huang SL (2010) Cryptotanshinone inhibits cancer cell proliferation by suppressing mammalian target of rapamycin-mediated cyclin D1 expression and Rb phosphorylation. Cancer Prev Res 3:1015–1025
    • (2010) Cancer Prev Res , vol.3 , pp. 1015-1025
    • Chen, W.1    Luo, Y.2    Liu, L.3    Zhou, H.4    Xu, B.S.5    Han, X.Z.6    Shen, T.7    Liu, Z.J.8    Lu, Y.9    Huang, S.L.10
  • 6
    • 84866177086 scopus 로고    scopus 로고
    • Cryptotanshinone activates p38/JNK and inhibits Erk1/2 leading to caspase-independent cell death in tumor cells
    • COI: 1:CAS:528:DC%2BC38Xptl2iu78%3D
    • Chen W, Liu L, Luo Y, Odaka Y, Awate S, Zhou H, Shen T, Zheng S, Lu Y, Huang S (2012) Cryptotanshinone activates p38/JNK and inhibits Erk1/2 leading to caspase-independent cell death in tumor cells. Cancer Prev Res 5:778–787
    • (2012) Cancer Prev Res , vol.5 , pp. 778-787
    • Chen, W.1    Liu, L.2    Luo, Y.3    Odaka, Y.4    Awate, S.5    Zhou, H.6    Shen, T.7    Zheng, S.8    Lu, Y.9    Huang, S.10
  • 7
    • 34347337539 scopus 로고    scopus 로고
    • Cryptotanshinone inhibits chemotactic migration in macrophages through negative regulation of the PI3K signaling pathway
    • PID: 17471173, COI: 1:CAS:528:DC%2BD2sXntFemtr0%3D
    • Don MJ, Liao JF, Lin LY, Chiou WF (2007) Cryptotanshinone inhibits chemotactic migration in macrophages through negative regulation of the PI3K signaling pathway. Br J Pharmacol 151:638–646
    • (2007) Br J Pharmacol , vol.151 , pp. 638-646
    • Don, M.J.1    Liao, J.F.2    Lin, L.Y.3    Chiou, W.F.4
  • 9
    • 0035853552 scopus 로고    scopus 로고
    • Regulation of longevity and stress resistance by Sch9 in yeast
    • PID: 11292860, COI: 1:CAS:528:DC%2BD3MXivVygsrk%3D
    • Fabrizio P, Pozza F, Pletcher SD, Gendron CM, Longo VD (2001) Regulation of longevity and stress resistance by Sch9 in yeast. Science 292:288–290
    • (2001) Science , vol.292 , pp. 288-290
    • Fabrizio, P.1    Pozza, F.2    Pletcher, S.D.3    Gendron, C.M.4    Longo, V.D.5
  • 11
    • 0034626735 scopus 로고    scopus 로고
    • Oxidants, oxidative stress and the biology of ageing
    • PID: 11089981, COI: 1:CAS:528:DC%2BD3cXotFGltb0%3D
    • Finkel T, Holbrook NJ (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408:239–247
    • (2000) Nature , vol.408 , pp. 239-247
    • Finkel, T.1    Holbrook, N.J.2
  • 12
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span-from yeast to humans
    • PID: 20395504, COI: 1:CAS:528:DC%2BC3cXks1Snsro%3D
    • Fontana L, Partridge L, Longo VD (2010) Extending healthy life span-from yeast to humans. Science 328:321–326
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 14
    • 34347385392 scopus 로고    scopus 로고
    • Low auxotrophy-complementing amino acid concentrations reduce yeast chronological life span
    • PID: 17544056, COI: 1:CAS:528:DC%2BD2sXnsFWmt7Y%3D
    • Gomes P, Sampaio-Marques B, Ludovico P, Rodrigues F, Leao C (2007) Low auxotrophy-complementing amino acid concentrations reduce yeast chronological life span. Mech Ageing Dev 128:383–391
    • (2007) Mech Ageing Dev , vol.128 , pp. 383-391
    • Gomes, P.1    Sampaio-Marques, B.2    Ludovico, P.3    Rodrigues, F.4    Leao, C.5
  • 15
    • 77049308856 scopus 로고
    • Aging: a theory based on free radical and radiation chemistry
    • PID: 13332224, COI: 1:STN:280:DyaG28%2FosVygsw%3D%3D
    • Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 11:298–300
    • (1956) J Gerontol , vol.11 , pp. 298-300
    • Harman, D.1
  • 17
    • 27144510561 scopus 로고    scopus 로고
    • Translational regulation of GCN4 and the general amino acid control of yeast
    • PID: 16153175, COI: 1:CAS:528:DC%2BD2MXht1ShsL7N
    • Hinnebusch AG (2005) Translational regulation of GCN4 and the general amino acid control of yeast. Annu Rev Microbiol 59:407–450
    • (2005) Annu Rev Microbiol , vol.59 , pp. 407-450
    • Hinnebusch, A.G.1
  • 18
    • 0036463655 scopus 로고    scopus 로고
    • Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress
    • PID: 12455968, COI: 1:CAS:528:DC%2BD38XitVSls78%3D
    • Hinnebusch AG, Natarajan K (2002) Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress. Eukaryot Cell 1:22–32
    • (2002) Eukaryot Cell , vol.1 , pp. 22-32
    • Hinnebusch, A.G.1    Natarajan, K.2
  • 19
    • 43049095216 scopus 로고    scopus 로고
    • Xenohormesis: sensing the chemical cues of other species
    • PID: 18455976, COI: 1:CAS:528:DC%2BD1cXmt1SmtLs%3D
    • Howitz KT, Sinclair D (2008) Xenohormesis: sensing the chemical cues of other species. Cell 133:387–391
    • (2008) Cell , vol.133 , pp. 387-391
    • Howitz, K.T.1    Sinclair, D.2
  • 21
    • 69249240179 scopus 로고    scopus 로고
    • Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis
    • PID: 19684113, COI: 1:CAS:528:DC%2BD1MXhtVegurbI
    • Huber A, Bodenmiller B, Uotila A, Stahl M, Wanka S, Gerrits B, Aebersold R, Loewith R (2009) Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis. Gene Dev 23:1929–1943
    • (2009) Gene Dev , vol.23 , pp. 1929-1943
    • Huber, A.1    Bodenmiller, B.2    Uotila, A.3    Stahl, M.4    Wanka, S.5    Gerrits, B.6    Aebersold, R.7    Loewith, R.8
  • 22
    • 84872527628 scopus 로고    scopus 로고
    • mTOR is a key modulator of ageing and age-related disease
    • PID: 23325216, COI: 1:CAS:528:DC%2BC3sXptlyntg%3D%3D
    • Johnson SC, Rabinovitch PS, Kaeberlein M (2013) mTOR is a key modulator of ageing and age-related disease. Nature 493:338–345
    • (2013) Nature , vol.493 , pp. 338-345
    • Johnson, S.C.1    Rabinovitch, P.S.2    Kaeberlein, M.3
  • 23
    • 77950214581 scopus 로고    scopus 로고
    • Lessons on longevity from budding yeast
    • PID: 20336133, COI: 1:CAS:528:DC%2BC3cXjvVGltLY%3D
    • Kaeberlein M (2010) Lessons on longevity from budding yeast. Nature 464:513–519
    • (2010) Nature , vol.464 , pp. 513-519
    • Kaeberlein, M.1
  • 26
    • 13244266921 scopus 로고    scopus 로고
    • Lead- and drug-like compounds: the rule-of-five revolution
    • PID: 24981612, COI: 1:CAS:528:DC%2BD2MXhtlSqsrg%3D
    • Lipinski CA (2004) Lead- and drug-like compounds: the rule-of-five revolution. Drug Discov Today Technol 1:337–341
    • (2004) Drug Discov Today Technol , vol.1 , pp. 337-341
    • Lipinski, C.A.1
  • 27
    • 84863524526 scopus 로고    scopus 로고
    • Replicative and chronological aging in Saccharomyces cerevisiae
    • PID: 22768836, COI: 1:CAS:528:DC%2BC38XpvFGhu7c%3D
    • Longo VD, Shadel GS, Kaeberlein M, Kennedy B (2012) Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab 16:18–31
    • (2012) Cell Metab , vol.16 , pp. 18-31
    • Longo, V.D.1    Shadel, G.S.2    Kaeberlein, M.3    Kennedy, B.4
  • 28
    • 77955717406 scopus 로고    scopus 로고
    • Cryptotanshinione upregulates α-secretase by activation PI3K pathway in cortical neurons
    • PID: 20595051, COI: 1:CAS:528:DC%2BC3cXptlWmu7k%3D
    • Mei Z, Situ B, Tan X, Zheng S, Zhang F, Yan P, Liu P (2010) Cryptotanshinione upregulates α-secretase by activation PI3K pathway in cortical neurons. Brain Res 1348:165–173
    • (2010) Brain Res , vol.1348 , pp. 165-173
    • Mei, Z.1    Situ, B.2    Tan, X.3    Zheng, S.4    Zhang, F.5    Yan, P.6    Liu, P.7
  • 30
    • 80054856662 scopus 로고    scopus 로고
    • Mitochondria, reactive oxygen species, and chronological aging: a message from yeast
    • PID: 21884780, COI: 1:CAS:528:DC%2BC3MXhtlOksbvK
    • Pan Y (2011) Mitochondria, reactive oxygen species, and chronological aging: a message from yeast. Exp Gerontol 46:847–852
    • (2011) Exp Gerontol , vol.46 , pp. 847-852
    • Pan, Y.1
  • 31
    • 79958068191 scopus 로고    scopus 로고
    • Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling
    • PID: 21641548, COI: 1:CAS:528:DC%2BC3MXntFSltbo%3D
    • Pan Y, Schroeder EA, Ocampo A, Barrientos A, Shadel GS (2011) Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. Cell Metab 13:668–678
    • (2011) Cell Metab , vol.13 , pp. 668-678
    • Pan, Y.1    Schroeder, E.A.2    Ocampo, A.3    Barrientos, A.4    Shadel, G.S.5
  • 32
    • 84862286997 scopus 로고    scopus 로고
    • Cryptotanshinone induces ER stress-mediated apoptosis in HepG2 and MCF7 cells
    • PID: 22113823, COI: 1:CAS:528:DC%2BC38XisFaqt78%3D
    • Park IJ, Kim MJ, Park OJ, Choe W, Kang I, Kim SS, Ha J (2012a) Cryptotanshinone induces ER stress-mediated apoptosis in HepG2 and MCF7 cells. Apoptosis 17:248–257
    • (2012) Apoptosis , vol.17 , pp. 248-257
    • Park, I.J.1    Kim, M.J.2    Park, O.J.3    Choe, W.4    Kang, I.5    Kim, S.S.6    Ha, J.7
  • 34
    • 30944458446 scopus 로고    scopus 로고
    • Extension of chronological life span in yeast by decreased TOR pathway signaling
    • PID: 16418483, COI: 1:CAS:528:DC%2BD28XptlKjtA%3D%3D
    • Powers RW 3rd, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S (2006) Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev 20:174–184
    • (2006) Genes Dev , vol.20 , pp. 174-184
    • Powers, R.W.1    Kaeberlein, M.2    Caldwell, S.D.3    Kennedy, B.K.4    Fields, S.5
  • 35
    • 77952548782 scopus 로고    scopus 로고
    • How increased oxidative stress promotes longevity and metabolic health: the concept of mitochondrial hormesis (mitohormesis)
    • PID: 20350594, COI: 1:CAS:528:DC%2BC3cXlsV2kurc%3D
    • Ristow M, Zarse K (2010) How increased oxidative stress promotes longevity and metabolic health: the concept of mitochondrial hormesis (mitohormesis). Exp Gerontol 45:410–418
    • (2010) Exp Gerontol , vol.45 , pp. 410-418
    • Ristow, M.1    Zarse, K.2
  • 36
    • 84855182851 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
    • PID: 22186033, COI: 1:CAS:528:DC%2BC38Xjs1Cqtb0%3D
    • Salminen A, Kaarniranta K (2012) AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Res Rev 11:230–241
    • (2012) Ageing Res Rev , vol.11 , pp. 230-241
    • Salminen, A.1    Kaarniranta, K.2
  • 37
    • 0025978949 scopus 로고
    • Getting started with yeast
    • PID: 2005794, COI: 1:CAS:528:DyaK3MXit1GhsbY%3D
    • Sherman F (1991) Getting started with yeast. Methods Enzymol 194:3–21
    • (1991) Methods Enzymol , vol.194 , pp. 3-21
    • Sherman, F.1
  • 38
    • 77952755857 scopus 로고    scopus 로고
    • Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast
    • PID: 20233714, COI: 1:CAS:528:DC%2BC3cXmtlygt70%3D
    • Staschke KA, Dey S, Zaborske JM, Palam LR, McClintick JN, Pan T, Edenberg HJ, Wek RC (2010) Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast. J Biol Chem 285:16893–16911
    • (2010) J Biol Chem , vol.285 , pp. 16893-16911
    • Staschke, K.A.1    Dey, S.2    Zaborske, J.M.3    Palam, L.R.4    McClintick, J.N.5    Pan, T.6    Edenberg, H.J.7    Wek, R.C.8
  • 41
    • 55849153499 scopus 로고    scopus 로고
    • Replicative aging in yeast: the means to the end
    • PID: 18616424, COI: 1:CAS:528:DC%2BD1cXhtlOgtbnJ
    • Steinkraus KA, Kaeberlein M, Kennedy BK (2008) Replicative aging in yeast: the means to the end. Annu Rev Cell Dev Biol 24:29–54
    • (2008) Annu Rev Cell Dev Biol , vol.24 , pp. 29-54
    • Steinkraus, K.A.1    Kaeberlein, M.2    Kennedy, B.K.3
  • 42
    • 34249667555 scopus 로고    scopus 로고
    • Effects of deleting mitochondrial antioxidant genes on life span
    • PID: 17460215, COI: 1:CAS:528:DC%2BD2sXlslOitbo%3D
    • Unlu ES, Koc A (2007) Effects of deleting mitochondrial antioxidant genes on life span. Ann N Y Acad Sci 1100:505–509
    • (2007) Ann N Y Acad Sci , vol.1100 , pp. 505-509
    • Unlu, E.S.1    Koc, A.2
  • 45
    • 38949137849 scopus 로고    scopus 로고
    • Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9
    • PID: 18225956
    • Wei M, Fabrizio P, Hu J, Ge H, Cheng C, Li L, Longo VD (2008) Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. PLoS Genet 4:e13
    • (2008) PLoS Genet , vol.4 , pp. e13
    • Wei, M.1    Fabrizio, P.2    Hu, J.3    Ge, H.4    Cheng, C.5    Li, L.6    Longo, V.D.7
  • 46
    • 67149130284 scopus 로고    scopus 로고
    • Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension
    • PID: 19424415
    • Wei M, Fabrizio P, Madia F, Hu J, Ge H, Li LM, Longo VD (2009) Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension. PLoS Genet 5:e1000467
    • (2009) PLoS Genet , vol.5 , pp. e1000467
    • Wei, M.1    Fabrizio, P.2    Madia, F.3    Hu, J.4    Ge, H.5    Li, L.M.6    Longo, V.D.7
  • 47
    • 0020044308 scopus 로고
    • Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence
    • PID: 7063854, COI: 1:STN:280:DyaL387lt1OlsA%3D%3D
    • Weindruch R, Walford RL (1982) Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science 215:1415–1418
    • (1982) Science , vol.215 , pp. 1415-1418
    • Weindruch, R.1    Walford, R.L.2
  • 48
    • 0037131560 scopus 로고    scopus 로고
    • Nutrient-regulated protein kinases in budding yeast
    • PID: 12408859, COI: 1:CAS:528:DC%2BD38Xotlaiu7k%3D
    • Wilson WA, Roach PJ (2002) Nutrient-regulated protein kinases in budding yeast. Cell 111:155–158
    • (2002) Cell , vol.111 , pp. 155-158
    • Wilson, W.A.1    Roach, P.J.2
  • 49
    • 80054848214 scopus 로고    scopus 로고
    • A high throughput screening assay for determination of chronological lifespan of yeast
    • PID: 21871551, COI: 1:CAS:528:DC%2BC3MXhtlOksbjI
    • Wu Z, Song L, Liu SQ, Huang D (2011) A high throughput screening assay for determination of chronological lifespan of yeast. Exp Gerontol 46:915–922
    • (2011) Exp Gerontol , vol.46 , pp. 915-922
    • Wu, Z.1    Song, L.2    Liu, S.Q.3    Huang, D.4
  • 50
    • 84877856132 scopus 로고    scopus 로고
    • Dietary restriction depends on nutrient composition to extend chronological lifespan in budding yeast Saccharomyces cerevisiae
    • PID: 23691220, COI: 1:CAS:528:DC%2BC3sXoslamsrk%3D
    • Wu Z, Liu SQ, Huang D (2013) Dietary restriction depends on nutrient composition to extend chronological lifespan in budding yeast Saccharomyces cerevisiae. PLoS ONE 8:e64448
    • (2013) PLoS ONE , vol.8 , pp. e64448
    • Wu, Z.1    Liu, S.Q.2    Huang, D.3
  • 51
    • 84055199781 scopus 로고    scopus 로고
    • Modernization one step at a time
    • PID: 22190089, COI: 1:CAS:528:DC%2BC3MXhs1GjsL3J
    • Xu ZG (2011) Modernization one step at a time. Nature 480:S90–S92
    • (2011) Nature , vol.480 , pp. S90-S92
    • Xu, Z.G.1
  • 52
    • 0022381249 scopus 로고
    • Nutritional influences on aging of Fischer 344 rats: I. Physical, metabolic, and longevity characteristics
    • PID: 4056321, COI: 1:STN:280:DyaL28%2FjsFWqtA%3D%3D
    • Yu BP, Masoro EJ, McMahan CA (1985) Nutritional influences on aging of Fischer 344 rats: I. Physical, metabolic, and longevity characteristics. J Gerontol 40:657–670
    • (1985) J Gerontol , vol.40 , pp. 657-670
    • Yu, B.P.1    Masoro, E.J.2    McMahan, C.A.3
  • 53
    • 34249035885 scopus 로고    scopus 로고
    • Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer’s disease, across the blood-brain barrier
    • PID: 17504224, COI: 1:CAS:528:DC%2BD2sXmsFehu7s%3D
    • Yu XY, Lin SG, Chen X, Zhou ZW, Liang J, Duan W, Chowbay B, Wen JY, Chan E, Cao J, Li CG, Zhou SF (2007) Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer’s disease, across the blood-brain barrier. Curr Drug Metab 8:365–377
    • (2007) Curr Drug Metab , vol.8 , pp. 365-377
    • Yu, X.Y.1    Lin, S.G.2    Chen, X.3    Zhou, Z.W.4    Liang, J.5    Duan, W.6    Chowbay, B.7    Wen, J.Y.8    Chan, E.9    Cao, J.10    Li, C.G.11    Zhou, S.F.12
  • 54
    • 27844511101 scopus 로고    scopus 로고
    • Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use
    • PID: 16291709, COI: 1:CAS:528:DC%2BD2MXhtlSjtrzL
    • Zhou L, Zuo Z, Chow MS (2005) Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J Clin Pharmacol 45:1345–1359
    • (2005) J Clin Pharmacol , vol.45 , pp. 1345-1359
    • Zhou, L.1    Zuo, Z.2    Chow, M.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.