Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice

Toxicology and Applied Pharmacology

Volumn 282, Issue 2, 2015, Pages 195-206

  Hagiya, Yoshifumi ^a   Kamata, Shotaro ^a   Mitsuoka, Saya ^a   Okada, Norihiko ^a   Yoshida, Saori ^a   Yamamoto, Junya ^a   Ohkubo, Rika ^a   Abiko, Yumi ^b   Yamada, Hidenori ^c   Akahoshi, Noriyuki ^d   Kasahara, Tadashi ^a   Kumagai, Yoshito ^b   Ishii, Isao ^a  

^a KEIO UNIVERSITY   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c Jobu Hospital for Respiratory Disease   (Japan)

^d AKITA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

2D DIGE; Cystathionine synthase; Cystathionine lyase; Glutamate cysteine ligase; MALDI TOF MS; Oncosis

Indexed keywords

ALANINE AMINOTRANSFERASE; CYSTATHIONINE BETA SYNTHASE; CYSTATHIONINE GAMMA LYASE; CYSTEINE; GLUTAMIC ACID; GLUTATHIONE; HETERODIMER; LIVER PROTEIN; MALONALDEHYDE; PARACETAMOL; PROTEOME; ANALGESIC AGENT; SULFATE;

ACETAMINOPHEN INDUCED HEPATOTOXICITY; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DESULFURIZATION; ENZYME ACTIVITY; FEMALE; GENE ACTIVITY; HEMIZYGOSITY; KNOCKOUT MOUSE; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TRANSSULFURATION ENZYME; TWO DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS; WESTERN BLOTTING; ANIMAL; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; GENETICS; METABOLISM; MUTATION; PATHOLOGY; PHYSIOLOGY; ZYGOTE;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; CYSTATHIONINE BETA-SYNTHASE; CYSTATHIONINE GAMMA-LYASE; DRUG-INDUCED LIVER INJURY; FEMALE; GLUTATHIONE; MICE; MICE, KNOCKOUT; MUTATION; SULFATES; ZYGOTE;

EID: 84919935008     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.11.015     Document Type: Article

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