Glutathione is essential for early embryogenesis - Analysis of a glutathione synthetase knockout mouse

Biochemical and Biophysical Research Communications

Volumn 412, Issue 1, 2011, Pages 121-126

  Winkler, Andreas ^a   Njålsson, Runa ^a   Carlsson, Katarina ^a   Elgadi, Abdelaziz ^a   Rozell, Björn ^a   Abraham, Linu ^b   Ercal, Nuran ^b   Shi, Zheng Zheng ^c   Lieberman, Michael W ^c   Larsson, Agne ^a   Norgren, Svante ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b MISSOURI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (United States)

^c HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

Author keywords

Glutamylcysteine; Glutathione; Glutathione synthetase; Glutathione synthetase deficiency; Transgenic mice

Indexed keywords

GLUTATHIONE SYNTHASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME ANALYSIS; FEMALE; GLUTATHIONE METABOLISM; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; DISEASE MODELS, ANIMAL; EMBRYONIC DEVELOPMENT; GLUTATHIONE; GLUTATHIONE SYNTHASE; MICE; MICE, KNOCKOUT; OXIDATIVE STRESS;

MAMMALIA; MUS; MUS MUSCULUS;

EID: 80051781561     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.07.056     Document Type: Article

References (28)

1. A. Larsson, E. Ristoff, M. Anderson, Glutathione synthetase deficiency and other disorders of the gamma-glutamyl cycle. in: C.R. Scriver, A.L. Beaudet, W.S. Sly, D. Valle, (Eds.) The Metabolic and Molecular Bases of Inherited Disease, McGraw-Hill, New York, 2005. Online: http://genetics.accessmedicine.com.
2. Meister A. Transport and metabolism of glutathione and gamma-glutamyl amino acids. Biochem. Soc. Trans. 1983, 11:793-794.
3. Meister A., Anderson M.E. Glutathione. Annu. Rev. Biochem. 1983, 52:711-760.
4. Meister A. Glutathione metabolism and its selective modification. J. Biol. Chem. 1988, 263:17205-17208.
5. Townsend D.M., Tew K.D., Tapiero H. The importance of glutathione in human disease. Biomed. Pharmacother. 2003, 57:145-155.
6. Webb G.C., Vaska V.L., Gali R.R., Ford J.H., Board P.G. The gene encoding human glutathione synthetase (GSS) maps to the long arm of chromosome 20 at band 11.2. Genomics 1995, 30:617-619.
7. Shi Z.Z., Carter B.Z., Habib G.M., He X., Sazer S., Lebovitz R.M., Lieberman M.W. A single mouse glutathione synthetase gene encodes six mRNAs with different 5′ ends. Arch. Biochem. Biophys. 1996, 331:215-224.
8. http://smd.stanford.edu/cgi-bin/source/sourceResult.
9. http://www.informatics.jax.org/.
10. Dahl N., Pigg M., Ristoff E., Gali R., Carlsson B., Mannervik B., Larsson A., Board P. Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction. Hum. Mol. Genet. 1997, 6:1147-1152.
11. Njalsson R., Carlsson K., Olin B., Carlsson B., Whitbread L., Polekhina G., Parker M.W., Norgren S., Mannervik B., Board P.G., Larsson A. Kinetic properties of missense mutations in patients with glutathione synthetase deficiency. Biochem. J. 2000, 349:275-279.
12. Njalsson R., Ristoff E., Carlsson K., Winkler A., Larsson A., Norgren S. Genotype, enzyme activity, glutathione level, and clinical phenotype in patients with glutathione synthetase deficiency. Hum. Genet. 2005, 17:17.
13. Shi Z.Z., Habib G.M., Rhead W.J., Gahl W.A., He X., Sazer S., Lieberman M.W. Mutations in the glutathione synthetase gene cause 5-oxoprolinuria. Nat. Genet. 1996, 14:361-365.
14. Ristoff E., Mayatepek E., Larsson A. Long-term clinical outcome in patients with glutathione synthetase deficiency. J. Pediatr. 2001, 139:79-84.
15. Njalsson R., Carlsson K., Winkler A., Larsson A., Norgren S. Diagnostics in patients with glutathione synthetase deficiency but without mutations in the exons of the GSS gene. Hum. Mutat. 2003, 22:497.
16. Grant C.M., MacIver F.H., Dawes I.W. Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide gamma-glutamylcysteine. Mol. Biol. Cell 1997, 8:1699-1707.
17. Ristoff E., Hebert C., Njalsson R., Norgren S., Rooyackers O., Larsson A. Glutathione synthetase deficiency: is gamma-glutamylcysteine accumulation a way to cope with oxidative stress in cells with insufficient levels of glutathione?. J. Inherit. Metab. Dis. 2002, 25:577-584.
18. Winters R.A., Zukowski J., Ercal N., Matthews R.H., Spitz D.R. Analysis of glutathione, glutathione disulfide, cysteine, homocysteine, and other biological thiols by high-performance liquid chromatography following derivatization by n-(1-pyrenyl)maleimide. Anal. Biochem. 1995, 227:14-21.
19. Whitbread L., Gali R.R., Board P.G. The structure of the human glutathione synthetase gene. Chem. Biol. Interact. 1998, 111-112:35-40.
20. Hinchman C.A., Ballatori N. Glutathione-degrading capacities of liver and kidney in different species. Biochem. Pharmacol. 1990, 40:1131-1135.
21. Hazelton G.A., Lang C.A. Glutathione contents of tissues in the aging mouse. Biochem. J. 1980, 188:25-30.
22. Lash L.H. Role of glutathione transport processes in kidney function. Toxicol. Appl. Pharmacol. 2005, 204:329-342.
23. Dalton T.P., Dieter M.Z., Yang Y., Shertzer H.G., Nebert D.W. Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous. Biochem. Biophys. Res. Commun. 2000, 279:324-329.
24. Shi Z.Z., Osei-Frimpong J., Kala G., Kala S.V., Barrios R.J., Habib G.M., Lukin D.J., Danney C.M., Matzuk M.M., Lieberman M.W. Glutathione synthesis is essential for mouse development but not for cell growth in culture. Proc. Natl. Acad. Sci. USA 2000, 97:5101-5106.
25. Gardiner C.S., Reed D.J. Status of glutathione during oxidant-induced oxidative stress in the preimplantation mouse embryo. Biol. Reprod. 1994, 51:1307-1314.
26. Luberda Z. The role of glutathione in mammalian gametes. Reprod. Biol. 2005, 5:5-17.
27. Gardiner C.S., Reed D.J. Synthesis of glutathione in the preimplantation mouse embryo. Arch. Biochem. Biophys. 1995, 318:30-36.
28. Dumollard R., Ward Z., Carroll J., Duchen M.R. Regulation of redox metabolism in the mouse oocyte and embryo. Development 2007, 134:455-465.