Increasing fatty acid oxidation remodels the hypothalamic neurometabolome to mitigate stress and inflammation

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  McFadden, Joseph W ^a,c   Aja, Susan ^a   Li, Qun ^a   Bandaru, Veera V R ^a   Kim, Eun Kyoung ^b   Haughey, Norman J ^a   Kuhajda, Francis P ^a   Ronnett, Gabriele V ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Daegu Gyeongbuk Institute of Science and Technology   (South Korea)

^c WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLGLYCEROL; ADENOSINE TRIPHOSPHATE; ANOREXIGENIC AGENT; C 75; CARNITINE PALMITOYLTRANSFERASE I; CERAMIDE DERIVATIVE; CHOLESTEROL ESTER; FSG 67; GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PALMITIC ACID; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; 2-(NONYLSULFONAMIDO)BENZOIC ACID; 4-METHYLENE-2-OCTYL-5-OXOFURAN-3-CARBOXYLIC ACID; ANTHRANILIC ACID DERIVATIVE; CERAMIDE; GAMMA BUTYROLACTONE; PALMITIC ACID DERIVATIVE; SULFONAMIDE;

ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME INACTIVATION; FATTY ACID OXIDATION; GENETIC TRANSCRIPTION; HYPOTHALAMUS; IN VITRO STUDY; LIPIDOMICS; LIPOLYSIS; LIPOTOXICITY; METABOLIC FLUX ANALYSIS; METABOLIC STRESS; METABOLOME; METABOLOMICS; NERVOUS SYSTEM INFLAMMATION; OXIDATIVE STRESS; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL LINE; CHEMISTRY; CYTOLOGY; HAMSTER; HUMAN; INFLAMMATION; METABOLISM; MOUSE; NERVE CELL; OXIDATION REDUCTION REACTION; PHYSIOLOGICAL STRESS;

4-BUTYROLACTONE; ADENOSINE TRIPHOSPHATE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APPETITE DEPRESSANTS; CELL LINE; CELLS, CULTURED; CERAMIDES; CHOLESTEROL ESTERS; CRICETINAE; GLYCERIDES; GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE; HUMANS; HYPOTHALAMUS; INFLAMMATION; METABOLOME; MICE; NEURONS; ORTHO-AMINOBENZOATES; OXIDATION-REDUCTION; PALMITATES; REACTIVE OXYGEN SPECIES; STRESS, PHYSIOLOGICAL; SULFONAMIDES;

EID: 84919934511     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0115642     Document Type: Article

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