Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 301, Issue 1, 2011, Pages

  Kuhajda, Francis P ^a   Aja, Susan ^a   Tu, Yajun ^a   Han, Wan Fang ^a   Medghalchi, Susan M ^a   El Meskini, Rajaa ^a   Landree, Leslie E ^a   Peterson, Jonathan M ^a   Daniels, Khadija ^a   Wong, Kody ^a   Wydysh, Edward A ^a   Townsend, Craig A ^a   Ronnett, Gabriele V ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acylglyceride synthesis; Fatty acid oxidation; Hepatic steatosis; Hypothalamus

Indexed keywords

AGOUTI RELATED PEPTIDE; CHOLESTEROL; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; ENZYME INHIBITOR; FSG 67; GLUCOSE; GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE; NEUROPEPTIDE; NEUROPEPTIDE Y; OREXIGENIC HYPOTHALAMIC NEUROPEPTIDE; PROOPIOMELANOCORTIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; BODY MASS; BROWN ADIPOSE TISSUE; CALORIC INTAKE; CALORIMETRY; CELL SIZE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENERGY EXPENDITURE; ENZYME INHIBITION; FATTY ACID OXIDATION; FATTY LIVER; FOOD INTAKE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HUMAN; HUMAN CELL; HYPOPHAGIA; IC 50; INSULIN SENSITIVITY; LIPID DIET; LIPID STORAGE; LIVER MITOCHONDRION; LUNG GAS EXCHANGE; MALE; METABOLISM; MOUSE; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE DRUG DOSE; TASTE AVERSION; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION; WHITE ADIPOSE TISSUE;

ADIPOSITY; AGOUTI-RELATED PROTEIN; ANIMALS; DIETARY FATS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; ENZYME INHIBITORS; FATTY LIVER; GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE; INSULIN RESISTANCE; MICE; MICE, INBRED STRAINS; MITOCHONDRIA, LIVER; NEUROPEPTIDE Y; OBESITY; OXYGEN CONSUMPTION; THINNESS; TRIGLYCERIDES;

EID: 79959978817     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00147.2011     Document Type: Article

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