Role of carnitine palmitoyltransferase I in the control of ketogenesis in primary cultures of rat astrocytes

Journal of Neurochemistry

Volumn 71, Issue 4, 1998, Pages 1597-1606

  Blázquez, Cristina ^a   Sánchez, Cristina ^a   Velasco, Guillermo ^a   Guzmán, Manuel ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Acetyl CoA carboxylase; Astrocytes; Carnitine palmitoyltransferase I; Fatty acids; Ketone bodies; Malonyl CoA

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CARNITINE PALMITOYLTRANSFERASE; FORSKOLIN; GLYCIDOL; KETONE BODY; MALONYL COENZYME A; PALMITIC ACID;

ANIMAL CELL; ARTICLE; ASTROCYTE; CONTROLLED STUDY; ENZYME ACTIVITY; IMMUNOBLOTTING; KETOGENESIS; METABOLIC REGULATION; NERVE CELL CULTURE; NEWBORN; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALIA;

EID: 0031714313     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.71041597.x     Document Type: Article

References (50)

1. Arduini A., Denisova N., Virmani A., Avrova N., Federici G., and Arrigoni-Martelli E. (1994) Evidence for the involvement of carnitine-dependent long-chain acyltransferases in neuronal triglyceride and phospholipid fatty acid turnover. J. Neurochem. 62, 1530-1538.
2. Auestad N., Korsak R. A., Morrow J. W., and Edmond J. (1991) Fatty acid oxidation and ketogenesis by astrocytes in primary culture. J. Neurochem. 56, 1376-1386.
3. Bergmeyer H. U. (1985) Methods of Enzymatic Analysis. Verlag Chemie, Weinheim.
4. Bianchi A., Evans J. L., Iverson A. J., Nordlund A. C., Watts T. D., and Witters L. A. (1990) Identification of an isozymic form of acetyl-CoA carboxylase. J. Biol. Chem. 265, 1502-1509.
5. Bijleveld C. and Geelen M. J. H. (1987) Measurement of acetyl-CoA carboxylase activity in isolated hepatocytes. Biochim. Biophys. Acta 918, 274-283.
6. Bittar P. G., Charnay Y., Pellerin L., Bouras C., and Magistretti P. J. (1996) Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain. J. Cereb. Blood Flow Metab. 16, 1079-1089.
7. Bixel M. G. and Hamprecht B. (1995) Generation of ketone bodies from leucine by cultured astroglial cells. J. Neurochem. 65, 2450-2461.
8. Brown N. F., Hill J. K., Esser V., Kirkland J. L., Corkey B. E., Foster D. W., and McGarry J. D. (1997) Mouse white adipocytes and 3T3 cells display an anomalous pattern of carnitine palmitoyl-transferase (CPT) I isoform expression during differentiation. Inter-tissue and inter-species expression of CPT I and CPT II enzymes. Biochem. J. 327, 225-231.
9. Casals N., Roca N., Guerrero M., Gil-Gómez G., Ayté J., Ciudad C., and Hegardt F. G. (1992) Regulation of the expression of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene. Its role in the control of ketogenesis. Biochem. J. 283, 261-264.
10. Cullingford T. E., Dolphin C. T., Bhakoo K. K., Peuchen S., Canevari L., and Clark J. B. (1998) Molecular cloning of rat mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase and detection of the corresponding mRNA and of those encoding the remaining enzymes comprising the ketogenic 3-hydroxy-3-methylglutaryl-CoA cycle in central nervous system of suckling rats. Biochem. J. 329, 373-381.
11. Dringen R., Wiesinger H., and Hamprecht B. (1993) Uptake of L-lactate by cultured rat brain neurons. Neurosci. Lett. 163, 5-7.
12. Dringen R., Peters H., Wiesinger H., and Hamprecht B. (1995) Lactate transport in cultured glial cells. Dev. Neurosci. 17, 63-69.
13. Drynan L., Quant P.A., and Zammit V. A. (1996) Flux control exerted by mitochondrial outer membrane carnitine palmitoyl-transferase over β-oxidation, ketogenesis and tricarboxylic acid cycle activity in hepatocytes isolated from rats in different metabolic states. Biochem. J. 317, 791-795.
14. Eaton S., Bartlett K., and Pourfarzam M. (1996) Mammalian mitochondrial β-oxidation. Biochem. J. 320, 345-357.
15. Edmond J. (1992) Energy metabolism in developing brain cells. Can. J. Physiol. Pharmacol. 70(Suppl.), S118-S129.
16. Edmond J., Robbins R. A., Bergstrom J. D., Cole R. A., and de Vellis J. (1987) Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture. J. Neurosci. Res. 18, 551-561.
17. Galve-Roperh I., Haro A., and Diaz-Laviada I. (1997) Induction of nerve growth factor synthesis by sphingomyelinase and ceramide in primary astrocyte cultures. Mol. Brain Res. 52, 90-97.
18. Guzmán M. and Geelen M. J. H. (1988) Short-term regulation of carnitine palmitoyltransferase activity in isolated rat hepatocytes. Biochem. Biophys. Res. Commun. 151, 781-787.
19. Guzmán M. and Geelen M. J. H. (1992) Activity of carnitine palmitoyltransferase in mitochondrial outer membranes and peroxisomes in digitonin-permeabilized hepatocytes. Selective modulation of mitochondrial enzyme activity by okadaic acid. Biochem. J. 287, 487-492.
20. Guzmán M. and Geelen M. J. H. (1993) Regulation of fatty acid oxidation in mammalian liver. Biochim. Biophys. Acta 1167, 227-241.
21. Guzmán M., Kolodziej M. P., Caldwell A., Costorphine C. G., and Zammit V. A. (1994) Evidence against direct involvement of phosphorylation in the activation of carnitine palmitoyltransferase by okadaic acid in rat hepatocytes. Biochem. J. 300, 693-699.
22. Guzmán M., Bijleveld C., and Geelen M. J. H. (1995) Flexibility of zonation of fatty acid oxidation in rat liver. Biochem. J. 311, 853-860.
23. Ha J., Lee J. K., Kim K. S., Witters L. A., and Kim K. H. (1996) Cloning of human acetyl-CoA carboxylase-β and its unique features. Proc. Natl. Acad. Sci. USA 93, 11466-11470.
24. Izumi Y., Benz A. M., Katsuki H., and Zorumski C. F. (1997) Endogenous monocarboxylates sustain hyppocampal synaptic function and morphological integrity during energy deprivation. J. Neurosci. 17, 9448-9457.
25. Lopaschuk G. D., Belke D. D., Gamble J., Itoi T., and Schönekess B. O. (1994) Regulation of fatty acid oxidation in the mammalian heart in health and disease. Biochim. Biophys. Acta 1213, 263-276.
26. Lopes-Cardozo M. and Klein W. (1982) Ketone-body utilization by homogenates of adult rat brain. Neurochem. Res. 7, 687-703.
27. Lopes-Cardozo M., Larson O. M., and Schousboe A. (1986) Acetoacetate and glucose as lipid precursors and energy substrates in primary cultures of astrocytes and neurons from mouse cerebral cortex. J. Neurochem. 46, 773-778.
28. Magistretti P. J. and Pellerin L. (1996) Cellular bases of brain energy metabolism and their relevance to functional brain imaging. Cereb. Cortex 6, 50-61.
29. 2 are involved. Biochem. J. 316, 805-811.
30. McGarry J. D. and Brown N. F. (1997) The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur. J. Biochem. 244, 1-14.
31. McGarry J. D. and-Foster D. W. (1980) Regulation of hepatic fatty acid oxidation and ketone body production. Annu. Rev. Biochem. 49, 395-420.
32. O'Malley E. K., Black I. B., and Dreyfus C. F. (1993) Local support cells promote survival of substantia nigra dopaminergic neurons in culture. Exp. Neurol. 112, 40-48.
33. Pégorier J. P., Duée P. H., Herbin C., Laulan, P. Y., Bladé C., Peret J., and Girard J. (1988) Fatty acid metabolism in hepatocytes isolated from rats adapted to high-fat diets containing long-or medium-chain triacylglycerols. Biochem. J. 249, 801-806.
34. Pellerin L., Stolz M., Sorg O., Martin J. C., Deschepper C. F., and Magistretti P. J. (1997) Regulation of energy metabolism by neurotransmitters in astrocytes in primary culture and in an immortalized cell line. Glia 21, 74-83.
35. Porter J. T. and McCarthy K. D. (1997) Astrocyte neurotransmitter receptors in situ and in vivo. Prog. Neurobiol. 51, 439-455.
36. 9-Tetrahydrocannabinol stimulates glucose utilization in C6 glioma cells. Brain Res. 767, 64-71.
37. Serra D., Asins G., and Hegardt F. G. (1993) Ketogenic mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene expression in intestine and liver of suckling rats. Arch. Biochem. Biophys. 301, 445-448.
38. Sonnewald U., Westergaard N., and Schousboe A. (1997) Glutamate transport and metabolism in astrocytes. Glia 21, 56-63.
39. Spurway T., Sherrat H. S. A., Pogson C. I., and Agius L. (1997) The flux control coefficient of carnitine palmitoyltransferase I on palmitate β-oxidation in rat hepatocyte cultures. Biochem. J. 323, 119-122.
40. Staub F., Winkler A., Peters J., Goerke U., Kempski O., and Baethmann A. (1995) Clearance and metabolism of arachidonic acid by C6 glioma cells and astrocytes. Neurochem. Res. 20, 1449-1456.
41. Tildon J. T., McKenna M. C., Stevenson J., and Couto R. (1993) Transport of L-lactate by cultured rat brain astrocytes. Neurochem. Res. 18, 177-184.
42. Tsacopoulos M., Poitry-Yamate C. L., Poitry S., Porrottet P., and Veuthey A. L. (1997) The nutritive function of glia is regulated by signals released by neurons. Glia 21, 84-91.
43. Vanucci S. J., Maher F., and Simpson I. A. (1997) Glucose transporter proteins in brain: delivery of glucose to neurons and glia. Glia 21, 2-21.
44. Velasco G., Sánchez C., Geelen M. J. H., and Guzmán M. (1996) Are cytoskeletal components involved in the control of hepatic carnitine palmitoyltransferase I activity? Biochem. Biophys. Res. Commun. 224, 754-759.
45. Velasco G., Geelen M. J. H., and Guzmán M. (1997a) Control of hepatic fatty acid oxidation by 5′-AMP-activated protein kinase involves a malonyl-CoA-dependent and a malonyl-CoA-independent mechanism. Arch. Biochem. Biophys. 337, 169-175.
46. 2+/calmodulin-dependent protein kinase II in the activation of carnitine palmitoyltransferase I by okadaic acid in rat hepatocytes. Biochem. J. 321, 211-216.
47. Wiesinger H., Hamprecht B., and Dringen R. (1997) Metabolic pathways for glucose in astrocytes. Glia 21, 22-34.
48. Witters L. A., Gao G., Kemp B. E., and Quistorff B. (1994) Hepatic 5́-AMP-activated protein kinase: zonal distribution and relationship to acetyl-CoA carboxylase activity in varying nutritional states. Arch. Biochem. Biophys. 308, 413-419.
49. Winz R., Hess D., Aebersold R., and Brownsey R. W. (1994) Unique structural features and differential phosphorylation of the 280-kDa component (isozyme) of rat liver acetyl-CoA carboxylase. J. Biol. Chem. 269, 14438-14445.
50. Zammit V. A. (1994) Regulation of ketone body metabolism. A cellular perspective. Diabetes Rev. 2, 132-155.