Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity

Chirality

Volumn 25, Issue 5, 2013, Pages 281-287

  Makowski, Kamil ^a   Mera, Paula ^a   Paredes, David ^a   Herrero, Laura ^a   Ariza, Xavier ^a   Asins, Guillermina ^a   Hegardt, Fausto G ^a   García, Jordi ^a   Serra, Dolors ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

cancer, stereoselectivity; CPT1 (carnitine palmitoyltransferase 1); FAS (fatty acid synthase); obesity

Indexed keywords

ANOREXIGENIC AGENT; ANTINEOPLASTIC AGENT; C75; CARNITINE PALMITOYLTRANSFERASE; FATTY ACID SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CYTOTOXICITY; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

4-BUTYROLACTONE; ANIMALS; ANTINEOPLASTIC AGENTS; APPETITE DEPRESSANTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM;

EID: 84876907631     PISSN: 08990042     EISSN: 1520636X     Source Type: Journal    
DOI: 10.1002/chir.22139     Document Type: Article

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