The past, present and future of secondary metabolite research in the Dothideomycetes

Molecular Plant Pathology

Volumn 16, Issue 1, 2015, Pages 92-107

  Muria Gonzalez, Mariano Jordi ^a   Chooi, Yit Heng ^a   Breen, Susan ^a   Solomon, Peter S ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

Dothideomycetes; Plant pathogens; Secondary metabolites

Indexed keywords

ALTERNARIA; COCHLIOBOLUS; DOTHIDEOMYCETES; FUNGI; MYCOSPHAERELLA; PYRENOPHORA;

ASCOMYCETES; METABOLISM; RESEARCH; SECONDARY METABOLISM; TRENDS;

ASCOMYCOTA; RESEARCH; SECONDARY METABOLISM;

EID: 84919844120     PISSN: 14646722     EISSN: 13643703     Source Type: Journal    
DOI: 10.1111/mpp.12162     Document Type: Review

References (191)

1. Akimitsu, K., Tsuge, T., Kodama, M., Yamamoto, M. and Otani, H. (2013) Alternaria host-selective toxins: determinant factors of plant disease. J. Gen. Plant Pathol. 80, 1-14.
2. Aly, A., Debbab, A. and Proksch, P. (2011) Fifty years of drug discovery from fungi. Fungal Divers. 50, 3-19.
3. Araujo, A.R., Monfardini, J.D., Chapla, V.M., Lopes, M.N., Silva, D.H.S., Cavalheiro, A.J. and da S Bolzani, V. (2012) Dihydroisocoumarins produced by Botryosphaeria parva an endophytic fungus from Eugenia jambolana. Planta Med. 78, PI87.
4. Arnold, A.E. (2007) Understanding the diversity of foliar endophytic fungi: progress, challenges, and frontiers. Fungal Biol. Rev. 21, 51-66.
5. Au, T.K., Chick, W.S.H. and Leung, P.C. (2000) The biology of ophiobolins. Life Sci. 67, 733-742.
6. Bach, E., Christensen, S., Dalgaard, L., Larsen, P.O., Olsen, C.E. and Smedegård-Petersen, V. (1979) Structures, properties and relationship to the aspergillomarasmines of toxins produced by Pyrenophora teres. Physiol. Plant Pathol. 14, 41-46.
7. Bader, J., Mast-Gerlach, E., Popović, M.K., Bajpai, R. and Stahl, U. (2010) Relevance of microbial coculture fermentations in biotechnology. J. Appl. Microbiol. 109, 371-387.
8. Barnes, I., Crous, P.W., Wingfield, B.D. and Wingfield, M.J. (2004) Multigene phylogenies reveal that red band needle blight of Pinus is caused by two distinct species of Dothistroma, D.septosporum and D.pini. Stud. Mycol. 50, 551-565.
9. Bayram, Ö., Krappmann, S., Ni, M., Bok, J.W., Helmstaedt, K., Valerius, O., Braus-Stromeyer, S., Kwon, N.-J., Keller, N.P., Yu, J.-H. and Braus, G.H. (2008) VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. Science, 320, 1504-1506.
10. Bennett, J.W. and Klich, M. (2003) Mycotoxins. Clin. Microbiol. Rev. 16, 497-516.
11. Bergmann, S., Schumann, J., Scherlach, K., Lange, C., Brakhage, A.A. and Hertweck, C. (2007) Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Nat. Chem. Biol. 3, 213-217.
12. Bode, H.B., Bethe, B., Höfs, R. and Zeeck, A. (2002) Big effects from small changes: possible ways to explore nature's chemical diversity. ChemBioChem, 3, 619-627.
13. Bok, J.W. and Keller, N.P. (2004) LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryot. Cell, 3, 527-535.
14. Bok, J.W., Chiang, Y.-M., Szewczyk, E., Reyes-Dominguez, Y., Davidson, A.D., Sanchez, J.F., Lo, H.-C., Watanabe, K., Strauss, J., Oakley, B.R., Wang, C.C.C. and Keller, N.P. (2009) Chromatin-level regulation of biosynthetic gene clusters. Nat. Chem. Biol. 5, 462-464.
15. Bouras, N. and Strelkov, S.E. (2008) The anthraquinone catenarin is phytotoxic and produced in leaves and kernels of wheat infected by Pyrenophora tritici-repentis. Physiol. Mol. Plant Pathol. 72, 87-95.
16. Bradshaw, R.E., Slot, J.C., Moore, G.G., Chettri, P., de Wit, P.J.G.M., Ehrlich, K.C., Ganley, A.R.D., Olson, M.A., Rokas, A., Carbone, I. and Cox, M.P. (2013) Fragmentation of an aflatoxin-like gene cluster in a forest pathogen. New Phytol. 198, 525-535.
17. Brakhage, A.A. and Schroeckh, V. (2011) Fungal secondary metabolites-strategies to activate silent gene clusters. Fungal Genet. Biol. 48, 15-22.
18. Briggs, D.E. (1966) Gibberellin-like activity of helminthosporol and helminthosporic acid. Nature, 210, 418-419.
19. Bury, M., Novo-Uzal, E., Andolfi, A., Cimini, S., Wauthoz, N., Heffeter, P., Lallemand, B., Avolio, F., Delporte, C., Cimmino, A., Dubois, J., Van Antwerpen, P., Zonno, M.C., Vurro, M., Poumay, Y., Berger, W., Evidente, A., De Gara, L., Kiss, R. and Locato, V. (2013) Ophiobolin A, a sesterterpenoid fungal phytotoxin, displays higher invitro growth-inhibitory effects in mammalian than in plant cells and displays invivo antitumor activity. Int. J. Oncol. 43, 575-585.
20. Campos, F.F., Rosa, L.H., Cota, B.B., Caligiorne, R.B., Teles Rabello, A.L., Alves, T.M.A., Rosa, C.A. and Zani, C.L. (2008) Leishmanicidal metabolites from Cochliobolus sp., an endophytic fungus isolated from Piptadenia adiantoides (Fabaceae). Plos Negl. Trop. Dis. 2, e348.
21. Capasso, R., Evidente, A., Randazzo, G., Ritieni, A., Bottalico, A., Vurro, M. and Logrieco, A. (1987) Isolation of cytochalasins A and B from Ascochyta heteromorpha. J. Nat. Prod. 50, 989-990.
22. Capasso, R., Evidente, A., Ritieni, A., Randazzo, G., Vurro, M. and Bottalico, A. (1988) Ascochalasin, a new cytochalasin from Ascochyta heteromorpha. J. Nat. Prod. 51, 567-571.
23. Capasso, R., Evidente, A. and Vurro, M. (1991) Cytochalasins from Phoma exigua var. heteromorpha. Phytochemistry, 30, 3945-3950.
24. Carruthers, J.R., Cerrini, S., Fedeli, W., Casinovi, C.G., Galeffi, C., Vaccaro, A.M.T. and Scala, A. (1971) Structures of cochlioquinones A and B, new metabolites of Cochliobolus miyabeanus: chemical and X-ray crystallographic determination. J. Chem. Soc. D, 3, 164-166.
25. Chiang, Y.-M., Szewczyk, E., Davidson, A.D., Keller, N., Oakley, B.R. and Wang, C.C.C. (2009) A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans. J. Am. Chem. Soc. 131, 2965-2970.
26. Chiang, Y.-M., Oakley, C.E., Ahuja, M., Entwistle, R., Schultz, A., Chang, S.-L., Sung, C.T., Wang, C.C.C. and Oakley, B.R. (2013) An efficient system for heterologous expression of secondary metabolite genes in Aspergillus nidulans. J. Am. Chem. Soc. 135, 7720-7731.
27. Chiba, R., Minami, A., Gomi, K. and Oikawa, H. (2013) Identification of ophiobolin F synthase by a genome mining approach: a sesterterpene synthase from Aspergillus clavatus. Org. Lett. 15, 594-597.
28. Chujo, T. and Scott, B. (2014) Histone H3K9 and H3K27 methylation regulates fungal alkaloid biosynthesis in a fungal endophyte-plant symbiosis. Mol. Microbiol. 92, 413-434.
29. Ciuffetti, L.M., Manning, V.A., Pandelova, I., Betts, M.F. and Martinez, J.P. (2010) Host-selective toxins, Ptr ToxA and Ptr ToxB, as necrotrophic effectors in the Pyrenophora tritici-repentis-wheat interaction. New Phytol. 187, 911-919.
30. Collemare, J. and Lebrun, M.-H. (2011) Fungal secondary metabolites: ancient toxins and novel effectors in plant-microbe interactions. In: Effectors in Plant-Microbe Interactions (Martin, F. and Kamoun, S., eds.), pp. 377-400. Oxford, UK: Wiley-Blackwell.
31. Collemare, J., Griffiths, S., Iida, Y., Karimi Jashni, M., Battaglia, E., Cox, R.J. and de Wit, P.J.G.M. (2014) Secondary metabolism and biotrophic lifestyle in the tomato pathogen Cladosporium fulvum. PLoS ONE, 9, e85877.
32. Condon, B.J., Leng, Y., Wu, D., Bushley, K.E., Ohm, R.A., Otillar, R., Martin, J., Schackwitz, W., Grimwood, J., MohdZainudin, N., Xue, C., Wang, R., Manning, V.A., Dhillon, B., Tu, Z.J., Steffenson, B.J., Salamov, A., Sun, H., Lowry, S., LaButti, K., Han, J., Copeland, A., Lindquist, E., Barry, K., Schmutz, J., Baker, S.E., Ciuffetti, L.M., Grigoriev, I.V., Zhong, S. and Turgeon, B. (2013) Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens. Plos Genet. 9, e1003233.
33. Connolly, L.R., Smith, K.M. and Freitag, M. (2013) The Fusarium graminearum histone H3 K27 methyltransferase KMT6 regulates development and expression of secondary metabolite gene clusters. Plos Genet. 9, e1003916.
34. Coombe, B., Mander, L., Paleg, L. and Turner, J. (1974) Gibberellin-like activity of helminthosporic acid analogues. Funct. Plant Biol. 1, 473-481.
35. Coval, S.J., Hradil, C.M., Lu, H.S.M., Clardy, J., Satouri, S. and Strobel, G.A. (1990) Pyrenoline-A and -B, two new phytotoxins from Pyrenophora teres. Tetrahedron Lett. 31, 2117-2120.
36. Crous, P.W. (2009) Taxonomy and phylogeny of the genus Mycosphaerella and its anamorphs. Fungal Divers. 38, 1-24.
37. Cutler, H.G., Crumley, F.G., Cox, R.H., Springer, J.P., Arrendale, R.F., Cole, R.J. and Cole, P.D. (1984) Ophiobolins G and H: new fungal metabolites from a novel source, Aspergillus ustus. J. Agric. Food Chem. 32, 778-782.
38. Daub, M. and Chung, K.-R. (2009) Photoactivated perylenequinone toxins in plant pathogenesis. In: Plant Relationships (Deising, H., ed.), pp. 201-219. Berlin, Heidelberg: Springer.
39. Daub, M.E. and Ehrenshaft, M. (2000) The photoactivated Cercospora toxin cercosporin: contributions to plant disease and fundamental biology. Annu. Rev. Phytopathol. 38, 461-490.
40. Dawson, M.J., Farthing, J.E., Marshall, P.S., Middleton, R.F., O'Neill, M.J., Shuttleworth, A., Stylli, C., Tait, R.M., Taylor, P.M., Wildman, H.G., Buss, A.D., Langley, D. and Hayes, M.V. (1992) The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity. J. Antibiot. 45, 639-647.
41. Dean, R., Van Kan, J.A.L., Pretorius, Z.A., Hammond-Kosack, K.E., Di Pietro, A., Spanu, P.D., Rudd, J.J., Dickman, M., Kahmann, R., Ellis, J. and Foster, G.D. (2012) The top 10 fungal pathogens in molecular plant pathology. Mol. Plant Pathol. 13, 414-430.
42. Devys, M., Bousquet, J.F., Kollmann, A. and Barbier, M. (1980) Dihydroisocoumarines et acide mycophenolique du milieu de culture du champignon phytopathogene Septoria nodorum. Phytochemistry, 19, 2221-2222.
43. Devys, M., Barbier, M., Kollmann, A. and Bousquet, J.F. (1982) Septorine and N-methoxy septorine, substituted pyrazines from the fungus Septoria nodorum Berk. Tetrahedron Lett. 23, 5409-5412.
44. Devys, M., Ferezou, J.-P., Topgi, R.S., Barbier, M., Bousquet, J.-F. and Kollmann, A. (1984) Structure and biosynthesis of phomenoic acid, an antifungal compound isolated from Phoma lingam Tode. J. Chem. Soc., Perkin Trans. 1, 2133-2137.
45. Devys, M., Barbier, M., Bousquet, J.F. and Kollmann, A. (1994) Isolation of the (-)-(3R)-5-hydroxymellein from the fungus Septoria nodorum. Phytochemistry, 35, 825-826.
46. Djoukeng, J., Polli, S., Larignon, P. and Abou-Mansour, E. (2009) Identification of phytotoxins from Botryosphaeria obtusa, a pathogen of black dead arm disease of grapevine. Eur. J. Plant Pathol. 124, 303-308.
47. Elliott, C.E., Callahan, D.L., Schwenk, D., Nett, M., Hoffmeister, D. and Howlett, B.J. (2013) A gene cluster responsible for biosynthesis of phomenoic acid in the plant pathogenic fungus, Leptosphaeria maculans. Fungal Genet. Biol. 53, 50-58.
48. Ellwood, S., Liu, Z., Syme, R., Lai, Z., Hane, J., Keiper, F., Moffat, C., Oliver, R. and Friesen, T. (2010) A first genome assembly of the barley fungal pathogen Pyrenophora teres f. teres. Genome Biol. 11, R109.
49. Evidente, A., Lanzetta, R., Capasso, R., Vurro, M. and Bottalico, A. (1992) Cytochalasins U and V, two new cytochalasans, from Phoma exigua var. heteromorpha. Tetrahedron, 48, 6317-6324.
50. Evidente, A., Capasso, R., Abouzeid, M.A., Lanzetta, R., Vurro, M. and Bottalico, A. (1993a) Three new toxic pinolidoxins from Ascochyta pinodes. J. Nat. Prod. 56, 1937-1943.
51. Evidente, A., Capasso, R., Vurro, M. and Bottalico, A. (1993b) Ascosalitoxin, a phytotoxic trisubstituted salicylic aldehyde from Ascochyta pisi. Phytochemistry, 34, 995-998.
52. Evidente, A., Capasso, R., Vurro, M. and Bottalico, A. (1996) Cytochalasin W, a new 24-oxa[14]cytochalasan from Phoma exigua var. heteromorpha. Nat. Toxins, 4, 53-57.
53. Evidente, A., Cimmino, A., Berestetskiy, A., Andolfi, A. and Motta, A. (2008) Stagonolides G-I and modiolide A, nonenolides produced by Stagonospora cirsii, a potential mycoherbicide for Cirsium arvense. J. Nat. Prod. 71, 1897-1901.
54. Ferezou, J.-P., Quesneau-Thierry, A., Servy, C., Zissmann, E. and Barbier, M. (1980) Sirodesmin PL biosynthesis in Phoma lingam tode. J. Chem. Soc., Perkin Trans. 1, 1739-1746.
55. Friesen, T.L., Stukenbrock, E.H., Liu, Z., Meinhardt, S., Ling, H., Faris, J.D., Rasmussen, J.B., Solomon, P.S., McDonald, B.A. and Oliver, R.P. (2006) Emergence of a new disease as a result of interspecific virulence gene transfer. Nat. Genet. 38, 953-956.
56. Friis, P., Olsen, C.E. and Moller, B.L. (1991) Toxin production in Pyrenophora teres, the ascomycete causing the net-spot blotch disease of barley (Hordeum vulgare L.). J. Biol. Chem. 266, 13329-13335.
57. Fukushima, Y., Sakagami, Y. and Marumo, S. (1993) β-Glucan biosynthesis inhibitors isolated from fungi as hyphal malformation inducer. Bioorg. Med. Chem. Lett. 3, 1219-1222.
58. Gardiner, D.M., Cozijnsen, A.J., Wilson, L.M., Pedras, M.S.C. and Howlett, B.J. (2004) The sirodesmin biosynthetic gene cluster of the plant pathogenic fungus Leptosphaeria maculans. Mol. Microbiol. 53, 1307-1318.
59. Gilbert, B.M. and Wolpert, T.J. (2013) Characterization of the LOV1-mediated, victorin-induced, cell-death response with virus-induced gene silencing. Mol. Plant-Microbe Interact. 26, 903-917.
60. Glauser, G., Gindro, K., Fringeli, J., De Joffrey, J.-P., Rudaz, S. and Wolfender, J.-L. (2009) Differential analysis of mycoalexins in confrontation zones of grapevine fungal pathogens by ultrahigh pressure liquid chromatography/time-of-flight mass spectrometry and capillary nuclear magnetic resonance. J. Agric. Food Chem. 57, 1127-1134.
61. Goudet, C., Milat, M.-L., Sentenac, H. and Thibaud, J.-B. (2000) Beticolins, nonpeptidic, polycyclic molecules produced by the phytopathogenic fungus Cercospora beticola, as a new family of ion channel-forming toxins. Mol. Plant-Microbe Interact. 13, 203-209.
62. Halabalaki, M., Vougogiannopoulou, K., Mikros, E. and Skaltsounis, A.L. (2014) Recent advances and new strategies in the NMR-based identification of natural products. Curr. Opin. Biotechnol. 25, 1-7.
63. Hallock, Y.F., Lu, H.S.M., Clardy, J., Strobel, G.A., Sugawara, F., Samsoedin, R. and Yoshida, S. (1993) Triticones, spirocyclic lactams from the fungal plant pathogen Drechslera tritici-repentis. J. Nat. Prod. 56, 747-754.
64. Hamid, K. and Strange, R.N. (2000) Phytotoxicity of solanapyrones A and B produced by the chickpea pathogen Ascochyta rabiei (Pass.) Labr. and the apparent metabolism of solanapyrone A by chickpea tissues. Physiol. Mol. Plant Pathol. 56, 235-244.
65. Hane, J.K., Lowe, R.G.T., Solomon, P.S., Tan, K.-C., Schoch, C.L., Spatafora, J.W., Crous, P.W., Kodira, C., Birren, B.W., Galagan, J.E., Torriani, S.F.F., McDonald, B.A. and Oliver, R.P. (2007) Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum. Plant Cell, 19, 3347-3368.
66. Hanson, J.R. (2008) The Chemistry of Fungi. Cambridge: The Royal Society of Chemistry.
67. Hardham, A.R., Jones, D.A. and Takemoto, D. (2007) Cytoskeleton and cell wall function in penetration resistance. Curr. Opin. Plant Biol. 10, 342-348.
68. Härri, E., Loeffler, W., Sigg, H.P., Stähelin, H. and Tamm, C. (1963) Über die Isolierung neuer stoffwechselprodukte aus Penicillium brefeldianum DODGE. Helv. Chim. Acta, 46, 1235-1243.
69. Hazuda, D., Blau, C.U., Felock, P., Hastings, J., Pramanik, B., Wolfe, A., Bushman, F., Farnet, C., Goetz, M., Williams, M., Silverman, K., Lingham, R. and Singh, S. (1999) Isolation and characterization of novel human immunodeficiency virus integrase inhibitors from fungal metabolites. Antivir. Chem. Chemother. 10, 63-70.
70. Heckman, D.S., Geiser, D.M., Eidell, B.R., Stauffer, R.L., Kardos, N.L. and Hedges, S.B. (2001) Molecular evidence for the early colonization of land by fungi and plants. Science, 293, 1129-1133.
71. Heiser, I., Heß, M., Schmidtke, K.-U., Vogler, U., Miethbauer, S. and Liebermann, B. (2004) Fatty acid peroxidation by rubellin B, C and D, phytotoxins produced by Ramularia collo-cygni (Sutton et Waller). Physiol. Mol. Plant Pathol. 64, 135-143.
72. Hogenhout, S.A., Van der Hoorn, R.A.L., Terauchi, R. and Kamoun, S. (2009) Emerging concepts in effector biology of plant-associated organisms. Mol. Plant-Microbe Interact. 22, 115-122.
73. Hopwood, D.A. (2013) Imaging mass spectrometry reveals highly specific interactions between actinomycetes to activate specialized metabolic gene clusters. MBio, 4, e00612-13.
74. Horbach, R., Navarro-Quesada, A.R., Knogge, W. and Deising, H.B. (2011) When and how to kill a plant cell: infection strategies of plant pathogenic fungi. J. Plant Physiol. 168, 51-62.
75. Howlett, B.J., Idnurm, A. and Pedras, M.S.C. (2001) Leptosphaeria maculans, the causal agent of blackleg disease of brassicas. Fungal Genet. Biol. 33, 1-14.
76. Humphreys, C.P., Franks, P.J., Rees, M., Bidartondo, M.I., Leake, J.R. and Beerling, D.J. (2010) Mutualistic mycorrhiza-like symbiosis in the most ancient group of land plants. Nat. Commun. 1, 103.
77. Inderbitzin, P., Asvarak, T. and Turgeon, B.G. (2010) Six new genes required for production of T-toxin, a polyketide determinant of high virulence of Cochliobolus heterostrophus to maize. Mol. Plant-Microbe Interact. 23, 458-472.
78. Ipcho, S.V.S., Hane, J.K., Antoni, E.A., Ahren, D.A.G., Henrissat, B., Friesen, T.L., Solomon, P.S. and Oliver, R.P. (2012) Transcriptome analysis of Stagonospora nodorum: gene models, effectors, metabolism and pantothenate dispensability. Mol. Plant Pathol. 13, 531-545.
79. Itai, A., Nozoe, S., Tsuda, K., Okuda, S., Iitaka, Y. and Nakayama, Y. (1967) The structure of cephalonic acid, a pentaprenyl terpenoid. Tetrahedron Lett. 8, 4111-4112.
80. 2+-binding, chlorinated anthraquinone-xanthone conjugates. J. Am. Chem. Soc. 114, 5967-5971.
81. Kachlicki, P. and Wakuliński, W. (2002) Analysis of anthraquinone pigments of Pyrenophora tritici-repentis. Acta Agrobot. 53, 97-105.
82. Kato, J., Shiotani, Y., Tamura, S. and Sakurai, A. (1964) A new plant growth-promoting substance: helminthosporol. Naturwissenschaften, 51, 341.
83. Kaur, S. (1995) Phytotoxicity of solanapyrones produced by the fungus Ascochyta rabiei and their possible role in blight of chickpea (Cicer arietinum). Plant Sci. 109, 23-29.
84. Keller, N.P., Turner, G. and Bennett, J.W. (2005) Fungal secondary metabolism: from biochemistry to genomics. Nat. Rev. Microbiol. 3, 937-947.
85. Kenfield, D., Strobel, S., Sugawara, F., Berglund, D. and Strobel, G. (1988) Triticone A: a novel bioactive lactam with potential as a molecular probe. Biochem. Biophys. Res. Commun. 157, 174-182.
86. Kersten, R.D., Meehan, M.J. and Dorrestein, P.C. (2010) Applications of modern mass spectrometry techniques in natural products chemistry. In: Comprehensive Natural Products II (Lew, M. and Hung-Wen, L., eds), pp. 389-456. Oxford: Elsevier.
87. Khaldi, N., Seifuddin, F.T., Turner, G., Haft, D., Nierman, W.C., Wolfe, K.H. and Fedorova, N.D. (2010) SMURF: genomic mapping of fungal secondary metabolite clusters. Fungal Genet. Biol. 47, 736-741.
88. Kirk, P.M., Ainsworth, G.G.C. and Bisby, G.R. (2008) Dictionary of the Fungi. UK: CAB International.
89. Kobayashi, Y., Kobayashi, I., Funaki, Y., Fujimoto, S., Takemoto, T. and Kunoh, H. (1997a) Dynamic reorganization of microfilaments and microtubules is necessary for the expression of non-host resistance in barley coleoptile cells. Plant J. 11, 525-537.
90. Kobayashi, Y., Yamada, M., Kobayashi, I. and Kunoh, H. (1997b) Actin microfilaments are required for the expression of nonhost resistance in higher plants. Plant Cell Physiol. 38, 725-733.
91. Kruys, Å., Eriksson, O.E. and Wedin, M. (2006) Phylogenetic relationships of coprophilous Pleosporales (Dothideomycetes, Ascomycota), and the classification of some bitunicate taxa of unknown position. Mycol. Res. 110, 527-536.
92. Kuyama, S. and Tamura, T. (1957) Cercosporin. A pigment of Cercosporina kikuchii Matsumoto et Tomoyasu. I. Cultivation of fungus, isolation and purification of pigment. J. Am. Chem. Soc. 79, 5725-5726.
93. Latif, Z., Strange, R.N., Bilton, J. and Riazuddin, S. (1993) Production of the phytotoxins, solanapyrones A and C and cytochalasin D among nine isolates of Ascochyta rabiei. Plant Pathol. 42, 172-180.
94. Leung, P.C., Taylor, W.A., Wang, J.H. and Tipton, C.L. (1984) Ophiobolin A. A natural product inhibitor of calmodulin. J. Biol. Chem. 259, 2742-2747.
95. Leung, P.C., Taylor, W.A., Wang, J.H. and Tipton, C.L. (1985) Role of calmodulin inhibition in the mode of action of ophiobolin A. Plant Physiol. 77, 303-308.
96. Li, G., Wang, H., Zhu, R., Sun, L., Wang, L., Li, M., Li, Y., Liu, Y., Zhao, Z. and Lou, H. (2012) Phaeosphaerins A-F, cytotoxic perylenequinones from an endolichenic fungus, Phaeosphaeria sp. J. Nat. Prod. 75, 142-147.
97. Li, P., Zhang, Z., Hu, X. and Zhang, Q. (2013) Advanced hyphenated chromatographic-mass spectrometry in mycotoxin determination: current status and prospects. Mass Spectrom. Rev. 32, 420-452.
98. Lim, C.-H., Ueno, H., Miyoshi, H., Miyagawa, H., Iwamura, H. and Ueno, T. (1996) Phytotoxic compounds cochlioquinones are inhibitors of mitochondrial NADH-ubiquinone reductase. J. Pestic. Sci. 21, 213-215.
99. Lim, C.-H., Miyagawa, H., Akamatsu, M., Nakagawa, Y. and Ueno, T. (1998) Structures and biological activities of phytotoxins produced by the plant pathogenic fungus Bipolaris cynodontis cynA. J. Pestic. Sci. 23, 281-288.
100. Lim, F.Y., Sanchez, J.F., Wang, C.C.C. and Keller, N.P. (2012) Toward awakening cryptic secondary metabolite gene clusters in filamentous fungi. In: Methods Enzymol (David, A.H., ed.), pp. 303-324. USA: Academic Press.
101. Lorang, J.M., Sweat, T.A. and Wolpert, T.J. (2007) Plant disease susceptibility conferred by a 'resistance' gene. Proc. Natl. Acad. Sci. USA, 104, 14861-14866.
102. Lou, J., Fu, L., Peng, Y. and Zhou, L. (2013) Metabolites from Alternaria fungi and their bioactivities. Molecules, 18, 5891-5935.
103. Ma, S.M., Li, J.W.-H., Choi, J.W., Zhou, H., Lee, K.K.M., Moorthie, V.A., Xie, X., Kealey, J.T., Da Silva, N.A., Vederas, J.C. and Tang, Y. (2009) Complete reconstitution of a highly reducing iterative polyketide synthase. Science, 326, 589-592.
104. Machida, T., Higashi, K. and Ogawara, H. (1995) Cochlioquinone A, an inhibitor of diacylglycerol kinase. J. Antibiot. 48, 1076-1080.
105. Manning, V.A., Pandelova, I., Dhillon, B., Wilhelm, L.J., Goodwin, S.B., Berlin, A.M., Figueroa, M., Freitag, M., Hane, J.K., Henrissat, B., Holman, W.H., Kodira, C.D., Martin, J., Oliver, R.P., Robbertse, B., Schackwitz, W., Schwartz, D.C., Spatafora, J.W., Turgeon, B.G., Yandava, C., Young, S., Zhou, S., Zeng, Q., Grigoriev, I.V., Ma, L.-J. and Ciuffetti, L.M. (2013) Comparative genomics of a plant-pathogenic fungus, Pyrenophora tritici-repentis, reveals transduplication and the impact of repeat elements on pathogenicity and population divergence. G3 (Bethesda), 3, 41-63.
106. McGary, K.L., Slot, J.C. and Rokas, A. (2013) Physical linkage of metabolic genes in fungi is an adaptation against the accumulation of toxic intermediate compounds. Proc. Natl. Acad. Sci. USA, 110, 11481-11486.
107. Medema, M.H., Blin, K., Cimermancic, P., de Jager, V., Zakrzewski, P., Fischbach, M.A., Weber, T., Takano, E. and Breitling, R. (2011) antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences. Nucleic Acids Res. 39, W339-W346.
108. Miethbauer, S., Haase, S., Schmidtke, K.-U., Günther, W., Heiser, I. and Liebermann, B. (2006) Biosynthesis of photodynamically active rubellins and structure elucidation of new anthraquinone derivatives produced by Ramularia collo-cygni. Phytochemistry, 67, 1206-1213.
109. Miethbauer, S., Gaube, F., Möllmann, U., Dahse, H.-M., Schmidtke, M., Gareis, M., Pickhardt, M. and Liebermann, B. (2009) Antimicrobial, antiproliferative, cytotoxic, and Tau inhibitory activity of rubellins and caeruleoramularin produced by the phytopathogenic fungus Ramularia collo-cygni. Planta Med. 75, 1523-1525.
110. Milat, M.L., Prange, T., Ducrot, P.H., Tabet, J.C., Einhorn, J., Blein, J.P. and Lallemand, J.Y. (1992) Structures of the beticolins, the yellow toxins produced by Cercospora beticola. J. Am. Chem. Soc. 114, 1478-1479.
111. Miyagawa, H., Nagai, S., Tsurushima, T., Sato, M., Ueno, T. and Fukami, H. (1994) Phytotoxins produced by the plant pathogenic fungus Bipolaris bicolor El-1. Biosci. Biotechnol. Biochem. 58, 1143-1145.
112. Möbius, N. and Hertweck, C. (2009) Fungal phytotoxins as mediators of virulence. Curr. Opin. Plant Biol. 12, 390-398.
113. Mullbacher, A., Waring, P., Tiwari-Palni, U. and Eichner, R.D. (1986) Structural relationship of epipolythiodioxopiperazines and their immunomodulating activity. Mol. Immunol. 23, 231-235.
114. Nakanishi, K. (1999) A brief history of natural products chemistry. In: Comprehensive Natural Products Chemistry (Otto, M.-C., Sir Derek, B. and NakanishiA2, K., eds), pp. 1-31. Oxford: Pergamon.
115. Nelsen, M.P., Lücking, R., Mbatchou, J.S., Andrew, C.J., Spielmann, A.A. and Lumbsch, H.T. (2011) New insights into relationships of lichen-forming Dothideomycetes. Fungal Divers. 51, 155-162.
116. Niessen, W.M.A. (2006) Liquid Chromatography-Mass Spectrometry. USA: Taylor & Francis.
117. Nukina, M., Hattori, H. and Marumo, S. (1975) cis-Sativenediol, a plant growth promotor, produced by fungi. J. Am. Chem. Soc. 97, 2542-2543.
118. Nukina, M., Ikeda, M. and Sassa, T. (1980a) Two new pyrenolides, fungal morphogenic substances produced by Pyrenophora teres (Diedicke) Drechsler. Agric. Biol. Chem. 44, 2761-2762.
119. Nukina, M., Sassa, T. and Ikeda, M. (1980b) A new fungal morphogenic substance, pyrenolide A from Pyrenophora teres. Tetrahedron Lett. 21, 301-302.
120. Nützmann, H.-W., Reyes-Dominguez, Y., Scherlach, K., Schroeckh, V., Horn, F., Gacek, A., Schümann, J., Hertweck, C., Strauss, J. and Brakhage, A.A. (2011) Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. Proc. Natl. Acad. Sci. USA, 108, 14282-14287.
121. Nützmann, H.-W., Schroeckh, V. and Brakhage, A.A. (2012) Regulatory cross talk and microbial induction of fungal secondary metabolite gene clusters. In: Methods Enzymol (David, A.H., ed.), pp. 325-341. USA: Academic Press.
122. O'Brien, J. and Wright, G.D. (2011) An ecological perspective of microbial secondary metabolism. Curr. Opin. Biotechnol. 22, 552-558.
123. Ohm, R.A., Feau, N., Henrissat, B., Schoch, C.L., Horwitz, B.A., Barry, K.W., Condon, B.J., Copeland, A.C., Dhillon, B., Glaser, F., Hesse, C.N., Kosti, I., LaButti, K., Lindquist, E.A., Lucas, S., Salamov, A.A., Bradshaw, R.E., Ciuffetti, L., Hamelin, R.C., Kema, G.H.J., Lawrence, C., Scott, J.A., Spatafora, J.W., Turgeon, B.G., de Wit, P.J.G.M., Zhong, S., Goodwin, S.B. and Grigoriev, I.V. (2012) Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi. Plos Pathog. 8, e1003037.
124. Oliver, R.P. and Solomon, P.S. (2010) New developments in pathogenicity and virulence of necrotrophs. Curr. Opin. Plant Biol. 13, 415-419.
125. Panaccione, D.G. (1993) The fungal genus Cochliobolus and toxin-mediated plant disease. Trends Microbiol. 1, 14-20.
126. Pedras, M.S.C. and Yu, Y. (2009) Phytotoxins, elicitors and other secondary metabolites from phytopathogenic 'blackleg' fungi: structure, phytotoxicity and biosynthesis. Nat. Prod. Commun. 4, 1291-1304.
127. Pedras, M.S.C., Morales, V.M. and Taylor, J.L. (1993) Phomaligols and phomaligadiones: new metabolites from the blackleg fungus. Tetrahedron, 49, 8317-8322.
128. Pongcharoen, W., Rukachaisirikul, V., Phongpaichit, S. and Sakayaroj, J. (2007) A new dihydrobenzofuran derivative from the endophytic fungus Botryosphaeria mamane PSU-M76. Chem. Pharm. Bull. 55, 1404-1405.
129. Quaedvlieg, W., Kema, G.H.J., Groenewald, J.Z., Verkley, G.J.M., Seifbarghi, S., Razavi, M., Gohari, A.M., Mehrabi, R. and Crous, P.W. (2011) Zymoseptoria gen. nov.: a new genus to accommodate Septoria-like species occurring on graminicolous hosts. Persoonia, 26, 57-69.
130. Rai, M., Deshmukh, P., Gade, A., Ingle, A., Kövics, G.J. and Irinyi, L. (2009) Phoma Saccardo: distribution, secondary metabolite production and biotechnological applications. Crit. Rev. Microbiol. 35, 182-196.
131. Raistrick, H., Stickings, C.E. and Thomas, R. (1953) Studies in the biochemistry of micro-organisms. 90. Alternariol and alternariol monomethyl ether, metabolic products of Alternaria tenuis. Biochem. J. 55, 421-433.
132. Reverberi, M., Ricelli, A., Zjalic, S., Fabbri, A. and Fanelli, C. (2010) Natural functions of mycotoxins and control of their biosynthesis in fungi. Appl. Microbiol. Biotechnol. 87, 899-911.
133. Riaz, A., Nicklin, J., Haque, I., Rauf, C.A., Qadir, G. and Naz, F. (2013) Toxicity induced by solanapyrone A in chickpea shoots and its metabolism through glutathione/glutathione-S-transferase system. Pak. J. Bot. 45, 135-139.
134. Ruibal, C., Gueidan, C., Selbmann, L., Gorbushina, A.A., Crous, P.W., Groenewald, J.Z., Muggia, L., Grube, M., Isola, D., Schoch, C.L., Staley, J.T., Lutzoni, F. and de Hoog, G.S. (2009) Phylogeny of rock-inhabiting fungi related to Dothideomycetes. Stud. Mycol. 64, 123-133.
135. Saha, D., Fetzner, R., Burkhardt, B., Podlech, J., Metzler, M., Dang, H., Lawrence, C. and Fischer, R. (2012) Identification of a polyketide synthase required for alternariol (AOH) and alternariol-9-methyl ether (AME) formation in Alternaria alternata. PLoS ONE, 7, e40564.
136. Sarker, S. and Nahar, L. (2012) Hyphenated techniques and their applications in natural products analysis. In: Natural Products Isolation (Sarker, S. D. and Nahar, L., eds.), pp. 301-340. USA: Humana Press.
137. Sarpeleh, A., Wallwork, H., Catcheside, D.E.A., Tate, M.E. and Able, A.J. (2007) Proteinaceous metabolites from Pyrenophora teres contribute to symptom development of barley net blotch. Phytopathology, 97, 907-915.
138. Sassa, T., Suzuki, K. and Haruki, E. (1989) Isolation and identification of gibberellins A4 and A9 from a fungus Phaeosphaeria sp. Agric. Biol. Chem. 53, 303-304.
139. Scharf, D.H., Heinekamp, T. and Brakhage, A.A. (2014) Human and plant fungal pathogens: the role of secondary metabolites. Plos Pathog. 10, e1003859.
140. Scherlach, K. and Hertweck, C. (2009) Triggering cryptic natural product biosynthesis in microorganisms. Org. Biomol. Chem. 7, 1753-1760.
141. Schoch, C.L., Crous, P.W., Groenewald, J.Z., Boehm, E.W.A., Burgess, T.I., de Gruyter, J., de Hoog, G.S., Dixon, L.J., Grube, M., Gueidan, C., Harada, Y., Hatakeyama, S., Hirayama, K., Hosoya, T., Huhndorf, S.M., Hyde, K.D., Jones, E.B.G., Kohlmeyer, J., Kruys, Å., Li, Y.M., Lücking, R., Lumbsch, H.T., Marvanová, L., Mbatchou, J.S., McVay, A.H., Miller, A.N., Mugambi, G.K., Muggia, L., Nelsen, M.P., Nelson, P., Owensby, C.A., Phillips, A.J.L., Phongpaichit, S., Pointing, S.B., Pujade-Renaud, V., Raja, H.A., Plata, E.R., Robbertse, B., Ruibal, C., Sakayaroj, J., Sano, T., Selbmann, L., Shearer, C.A., Shirouzu, T., Slippers, B., Suetrong, S., Tanaka, K., Volkmann-Kohlmeyer, B., Wingfield, M.J., Wood, A.R., Woudenberg, J.H.C., Yonezawa, H., Zhang, Y. and Spatafora, J.W. (2009) A class-wide phylogenetic assessment of Dothideomycetes. Stud. Mycol. 64, 1-15.
142. Schümann, J. and Hertweck, C. (2006) Advances in cloning, functional analysis and heterologous expression of fungal polyketide synthase genes. J. Biotechnol. 124, 690-703.
143. Schwelm, A., Barron, N.J., Baker, J., Dick, M., Long, P.G., Zhang, S. and Bradshaw, R.E. (2009) Dothistromin toxin is not required for dothistroma needle blight in Pinus radiata. Plant Pathol. 58, 293-304.
144. Seger, C., Sturm, S. and Stuppner, H. (2013) Mass spectrometry and NMR spectroscopy: modern high-end detectors for high resolution separation techniques-state of the art in natural product HPLC-MS, HPLC-NMR, and CE-MS hyphenations. Nat. Prod. Rep. 30, 970-987.
145. Shain, L. and Franich, R.A. (1981) Induction of Dothistroma blight symptoms with dothistromin. Physiol. Plant Pathol. 19, 49-55.
146. Shearer, C.A., Raja, H.A., Miller, A.N., Nelson, P., Tanaka, K., Hirayama, K., Marvanová, L., Hyde, K. D. and Zhang, Y. (2009) The molecular phylogeny of freshwater Dothideomycetes. Stud. Mycol. 64, 145-153.
147. Shoemaker, R.A. and Babcock, C.E. (1989) Phaeosphaeria. Can. J. Bot. 67, 1500-1599.
148. Shoemaker, R.A. and Brun, H. (2001) The teleomorph of the weakly aggressive segregate of Leptosphaeria maculans. Can. J. Bot. 79, 412-419.
149. Shwab, E.K., Bok, J.W., Tribus, M., Galehr, J., Graessle, S. and Keller, N.P. (2007) Histone deacetylase activity regulates chemical diversity in Aspergillus. Eukaryot. Cell, 6, 1656-1664.
150. Singh, S.B., Ball, R.G., Zink, D.L., Monaghan, R.L., Polishook, J.D., Sanchez, M., Pelaez, F., Silverman, K.C. and Lingham, R.B. (1997) Fusidienol A: a novel Ras farnesyl-protein transferase inhibitor from Phoma sp. J. Org. Chem. 62, 7485-7488.
151. Slippers, B. and Wingfield, M.J. (2007) Botryosphaeriaceae as endophytes and latent pathogens of woody plants: diversity, ecology and impact. Fungal Biol. Rev. 21, 90-106.
152. So, P.-K., Hu, B. and Yao, Z. (2013) Mass spectrometry: towards invivo analysis of biological systems. Mol. BioSyst. 9, 915-929.
153. Soledade, M., Pedras, C., Morales, V.M. and Taylor, J.L. (1994) Phomapyrones: three metabolites from the blackleg fungus. Phytochemistry, 36, 1315-1318.
154. Solomon, P. (2011) Assessing the mycotoxigenic threat of necrotrophic pathogens of wheat. Mycotoxin Res. 27, 231-237.
155. Stadler, M. and Keller, N.P. (2008) Paradigm shifts in fungal secondary metabolite research. Mycol. Res. 112, 127-130.
156. Stergiopoulos, I., Collemare, J., Mehrabi, R. and De Wit, P.J.G.M. (2013) Phytotoxic secondary metabolites and peptides produced by plant pathogenic Dothideomycete fungi. FEMS Microbiol. Rev. 37, 67-93.
157. Strobel, G., Kenfield, D. and Sugawara, F. (1988) The incredible fungal genus-Drechslera-and its phytotoxic ophiobolins. Phytoparasitica, 16, 145-152.
158. Sturm, S. and Seger, C. (2012) Liquid chromatography-nuclear magnetic resonance coupling as alternative to liquid chromatography-mass spectrometry hyphenations: curious option or powerful and complementary routine tool? J. Chromatogr. A, 1259, 50-61.
159. Suetrong, S., Schoch, C.L., Spatafora, J.W., Kohlmeyer, J., Volkmann-Kohlmeyer, B., Sakayaroj, J., Phongpaichit, S., Tanaka, K., Hirayama, K. and Jones, E.B.G. (2009) Molecular systematics of the marine Dothideomycetes. Stud. Mycol. 64, 155-173.
160. Sugawara, F., Takahashi, N., Strobel, G.A., Strobel, S.A., Lu, H.S.M. and Clardy, J. (1988) Triticones A and B, novel phytotoxins from the plant pathogenic fungus Drechslera tritici-repentis. J. Am. Chem. Soc. 110, 4086-4087.
161. Takahashi, J., Teles, A., Almeida Pinto Bracarense, A. and Gomes, D. (2013) Classical and epigenetic approaches to metabolite diversification in filamentous fungi. Phytochem. Rev. 12, 773-789.
162. Tamura, S., Sakurai, A., Kainuma, K. and Takai, M. (1963) Isolation of helminthosporol as a natural plant growth regulator and its chemical structure. Agric. Biol. Chem. 27, 738-739.
163. Tan, K.C., Trengove, R.D., Maker, G.L., Oliver, R.P. and Solomon, P.S. (2009) Metabolite profiling identifies the mycotoxin alternariol in the pathogen Stagonospora nodorum. Metabolomics, 5, 330-335.
164. Thomas, R. (1961) Studies in the biosynthesis of fungal metabolites. 2. The biosynthesis of alternariol and its relation to other fungal phenols. Biochem. J. 78, 748-758.
165. Thomma, B.P., VAN Esse, H.P., Crous, P.W. and DE Wit, P.J. (2005) Cladosporium fulvum (syn. Passalora fulva), a highly specialized plant pathogen as a model for functional studies on plant pathogenic Mycosphaerellaceae. Mol. Plant Pathol. 6, 379-393.
166. Thomma, B.P.H.J. (2003) Alternaria spp.: from general saprophyte to specific parasite. Mol. Plant Pathol. 4, 225-236.
167. Traxler, M.F., Watrous, J.D., Alexandrov, T., Dorrestein, P.C. and Kolter, R. (2013) Interspecies interactions stimulate diversification of the Streptomyces coelicolor secreted metabolome. MBio, 4, e00459-13.
168. Tsuda, K., Nozoe, S., Morisaki, M., Hirai, K., Itai, A., Okuda, S., Canonica, L., Fiecchi, A., Kienle, M.G. and Scala, A. (1967) Nomenclature of ophiobolins. Tetrahedron Lett. 8, 3369-3370.
169. Tsuge, T., Harimoto, Y., Akimitsu, K., Ohtani, K., Kodama, M., Akagi, Y., Egusa, M., Yamamoto, M. and Otani, H. (2013) Host-selective toxins produced by the plant pathogenic fungus Alternaria alternata. FEMS Microbiol. Rev. 37, 44-66.
170. Tsunematsu, Y., Ishiuchi, K., Hotta, K. and Watanabe, K. (2013) Yeast-based genome mining, production and mechanistic studies of the biosynthesis of fungal polyketide and peptide natural products. Nat. Prod. Rep. 30, 1139-1149.
171. Upchurch, R.G., Walker, D.C., Rollins, J.A., Ehrenshaft, M. and Daub, M.E. (1991) Mutants of Cercospora kikuchii altered in cercosporin synthesis and pathogenicity. Appl. Environ. Microbiol. 57, 2940-2945.
172. Venkatasubbaiah, P. and Chilton, W.S. (1990) Phytotoxins of Botryosphaeria obtusa. J. Nat. Prod. 53, 1628-1630.
173. Venkatasubbaiah, P., Sutton, T.B. and Chilton, W.S. (1991) Effect of phytotoxins produced by Botryosphaeria obtusa, the cause of black rot of apple fruit and frogeye leaf spot. Phytopathology, 81, 243-247.
174. Vurro, M., Zonno, M.C., Evidente, A., Capasso, R. and Bottaiico, A. (1992) Isolation of cytochalasins A and B from Ascochyta lathyri. Mycotoxin Res. 8, 17-20.
175. Walters, D.R., Havis, N.D. and Oxley, S.J.P. (2008) Ramularia collo-cygni: the biology of an emerging pathogen of barley. FEMS Microbiol. Lett. 279, 1-7.
176. Walton, J.D. (2006) HC-toxin. Phytochemistry, 67, 1406-1413.
177. Watrous, J.D. and Dorrestein, P.C. (2011) Imaging mass spectrometry in microbiology. Nat. Rev. Microbiol. 9, 683-694.
178. Weber, R.W.S., Stenger, E., Meffert, A. and Hahn, M. (2004) Brefeldin A production by Phoma medicaginis in dead pre-colonized plant tissue: a strategy for habitat conquest? Mycol. Res. 108, 662-671.
179. Weiergang, I., Lyngs Jorgensen, H.J., Moller, I.M., Friis, P. and Smedegaard-petersen, V. (2002) Correlation between sensitivity of barley to Pyrenophora teres toxins and susceptibility to the fungus. Physiol. Mol. Plant Pathol. 60, 121-129.
180. Wiemann, P. and Keller, N.P. (2014) Strategies for mining fungal natural products. J. Ind. Microbiol. Biotechnol. 41, 301-313.
181. Williams, D.H., Stone, M.J., Hauck, P.R. and Rahman, S.K. (1989) Why are secondary metabolites (natural products) biosynthesized? J. Nat. Prod. 52, 1189-1208.
182. Williams, R.B., Henrikson, J.C., Hoover, A.R., Lee, A.E. and Cichewicz, R.H. (2008) Epigenetic remodeling of the fungal secondary metabolome. Org. Biomol. Chem. 6, 1895-1897.
183. de Wit, P.J.G.M., van der Burgt, A., Ökmen, B., Stergiopoulos, I., Abd-Elsalam, K.A., Aerts, A.L., Bahkali, A.H., Beenen, H.G., Chettri, P., Cox, M., Datema, E., de Vries, R., Dhillon, B., Ganley, A.R., Griffiths, S.A., Guo, Y., Hamelin, R.C., Henrissat, B., Kabir, M.S., Jashni, M.K., Kema, G., Klaubauf, S., Lapidus, A., Levasseur, A., Lindquist, E., Mehrabi, R., Ohm, R.A., Owen, T.J., Salamov, A., Schwelm, A., Schijlen, E., Sun, H., van den Burg, H.A., van Ham, R.C.H.J., Zhang, S., Goodwin, S.B., Grigoriev, I.V., Collemare, J. and Bradshaw, R. (2012) The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry. Plos Genet. 8, e1003088.
184. Wolfender, J.-L. (2009) HPLC in natural product analysis: the detection issue. Planta Med. 75, 719-734.
185. Wolpert, T.J., Dunkle, L.D. and Ciuffetti, L.M. (2002) Host-selective toxins and avirulence determinants: what's in a name? Annu. Rev. Phytopathol. 40, 251-285.
186. Xiao, J., Zhang, Q., Gao, Y.-Q., Tang, J.-J., Zhang, A.-L. and Gao, J.-M. (2014) Secondary metabolites from the endophytic Botryosphaeria dothidea of Melia azedarach and their antifungal, antibacterial, antioxidant, and cytotoxic activities. J. Agric. Food Chem. 62, 3584-3590.
187. Yang, X.-L., Awakawa, T., Wakimoto, T. and Abe, I. (2013) Induced biosyntheses of a novel butyrophenone and two aromatic polyketides in the plant pathogen Stagonospora nodorum. Nat. Prod. Bioprospect. 3, 141-144.
188. Yin, W. and Keller, N. (2011) Transcriptional regulatory elements in fungal secondary metabolism. Microbiology, 49, 329-339.
189. Yoganathan, K., Yang, L.-K., Rossant, C., Huang, Y., Ng, S., Butler, M.S. and Buss, A.D. (2004) Cochlioquinones and Epi-cochlioquinones. Antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum. J. Antibiot. 57, 59-63.
190. Zabala, A.O., Xu, W., Chooi, Y.-H. and Tang, Y. (2012) Characterization of a silent azaphilone gene cluster from Aspergillus niger ATCC 1015 reveals a hydroxylation-mediated pyran-ring formation. Chem. Biol. 19, 1049-1059.
191. Zhang, S., Schwelm, A., Jin, H., Collins, L.J. and Bradshaw, R.E. (2007) A fragmented aflatoxin-like gene cluster in the forest pathogen Dothistroma septosporum. Fungal Genet. Biol. 44, 1342-1354.