Ophiobolin A, a sesterterpenoid fungal phytotoxin, displays higher in vitro growth-inhibitory effects in mammalian than in plant cells and displays in vivo antitumor activity

International Journal of Oncology

Volumn 43, Issue 2, 2013, Pages 575-585

  Bury, Marina ^a   Novo Uzal, Esther ^b   Andolfi, Anna ^c   Cimini, Sara ^b   Wauthoz, Nathalie ^a   Heffeter, Petra ^d   Lallemand, Benjamin ^a   Avolio, Fabiana ^c   Delporte, Cédric ^a   Cimmino, Alessio ^c   Dubois, Jacques ^a   Van Antwerpen, Pierre ^a   Zonno, Maria Chiara ^e   Vurro, Maurizio ^e   Poumay, Yves ^f   Berger, Walter ^d   Evidente, Antonio ^c   De Gara, Laura ^b   Kiss, Robert ^a   Locato, Vittoria ^b  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d MEDICAL UNIVERSITY OF VIENNA   (Austria)

^e INSTITUTE OF SCIENCES OF FOOD PRODUCTION   (Italy)

^f UNIVERSITY OF NAMUR   (Belgium)

Author keywords

Cytotoxicity; In vivo antitumor activity; Mammalian cells; Ophiobolin A; Plant cells

Indexed keywords

ANTINEOPLASTIC AGENT; OPHIOBOLIN A; TERPENOID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SCREENING; IN VITRO STUDY; IN VIVO STUDY; KERATINOCYTE; MAMMAL CELL; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PLANT CELL; PRIORITY JOURNAL; TOBACCO;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; HYDROGEN PEROXIDE; KERATINOCYTES; MICE; NEOPLASMS; PLANT CELLS; SESTERTERPENES; TOBACCO;

EID: 84879631544     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.1979     Document Type: Article

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