Cochlioquinones and Epi-cochlioquinones: Antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum

Journal of Antibiotics

Volumn 57, Issue 1, 2004, Pages 59-63

  Yoganathan, K ^a   Yang, Lay Kien ^a   Rossant, Christine ^a,b   Huang, Yicun ^a   Ng, Siewbee ^a   Butler, Mark S ^a   Buss, Antony D ^a  

^a MerLion Pharmaceuticals Pte Ltd   (Singapore)

^b Upstate Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; COCHLIOQUINONE DERIVATIVE; EPICOCHLIOQUINONE DERIVATIVE; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING ASSAY; BIPOLARIS BRIZAE; CHO CELL; CONTROLLED STUDY; CULTURE MEDIUM; DRUG STRUCTURE; FERMENTATION; FREEZE DRYING; FUNGUS; FUNGUS CULTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RECEPTOR BINDING; STACHYBOTRYS CHARTARUM; STRUCTURE ANALYSIS;

BIPOLARIS BRIZAE; STACHYBOTRYS CHARTARUM;

EID: 1142311557     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.57.59     Document Type: Article

References (12)

1. Kedzierska, K.; S. M. Crowe, S. Turville & A. L. Cunningham: The influence of cytokines, chemokines and their receptors on HIV-1 replication in monocytes and macropharges. Rev. Med. Virology 13: 39-56, 2003
2. Locati, M. & P. M. Murphy: Chemokines and chemokine receptors: biology and clinical relevance in inflammation and AIDS. Ann. Rev. Med. 50: 425-440, 1999
3. Lehner, T.: The role of CCR5 chemokine ligands and antibodies to CCR5 coreceptors in preventing HIV infection. Trends in Immunology 23: 347-351, 2002
4. Kazmierski, W. M.; L. Boone, W. Lawrence, C. Watson & T. Kenakin: CCR5 chemokine receptors: gatekeepers of HIV-1 infection. Current Drug Targets: Infectious Disorders 2: 265-278, 2002
5. De Clercq, E.: New anti-HIV agents and targets, Med. Res. Rev. 22: 531-565, 2002
6. Yoganathan, K.; C. Rossant, S. Ng, Y. Huang, M. S. Butler & A. D. Buss: 10-Methoxydihydrofuscin, fuscinarin and fuscin, novel antagonists of the human CCR5 receptor from Oidiodendron griseum. J. Nat. Prod. 66: 1116-1117, 2003
7. Cao, S.; C. Rossant, S. Ng, A. D. Buss & M. S. Butler: Phenolic derivatives from Wigandia urens active against the chemokine receptor CCR5. Phytochemistry 64: 987-990, 2003
8. Lim, C.-H.; H. Miyagawa, M. Akamatsu, Y. Nakagawa & T. Ueno: Structures and biological activities of phytoxins produced by the plant pathogenic fungus Bipalaris cynodontis cynA. J. Pesticide Sci. 23: 281-288, 1998
9. Miyagawa, H.; S. Nagai, T. Tsurushima, M. Sato, T. Ueno & H. Fukami: Phytotoxins produced by the plant pathogenic fungus Bipolaris bicolor El-1. Biosci. Biotech. Biochem. 58: 1143-1145, 1994
10. Lim, C.-H.; H. Ueno, H. Miyoshi, H. Miyagawa, H. Iwamura & T. Ueno: Phytoxic compounds cochlioquinones are inhibitors of mitochondrial NADH-ubiquinone reductase. J. Pesticide Sci. 21: 213-215, 1996
11. Fujioka, T.; K. Yao, K. Hamano, T. Hosoya, T. Kagasaki, Y. Furukawa, H. Haruyama, S. Sato, T. Koga & Y. Tsujita: Epi-cochlioquinone A, a novel acyl-CoA: Cholesterol acyltranferase inhibitor produced by Stachybotrys bisbyi. J. Antibiotics 49: 409-413, 1996
12. Cook, N. D.: Drug Discovery Today 1: 287-295, 1996