메뉴 건너뛰기




Volumn 517, Issue , 2012, Pages 303-324

Toward awakening cryptic secondary metabolite gene clusters in filamentous fungi

Author keywords

Cryptic; Double joint PCR; Filamentous fungi; Secondary metabolite; Semipurification; Transformation

Indexed keywords

SILICA GEL;

EID: 84867626750     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/B978-0-12-404634-4.00015-2     Document Type: Chapter
Times cited : (97)

References (45)
  • 1
    • 84857041431 scopus 로고    scopus 로고
    • Identification and characterization of Penicillium citrinum VeA and LaeA as global regulators for ML-236B production
    • S. Baba, H. Kinoshita, and T. Nihira Identification and characterization of Penicillium citrinum VeA and LaeA as global regulators for ML-236B production Current Genetics 58 2011 1 11
    • (2011) Current Genetics , vol.58 , pp. 1-11
    • Baba, S.1    Kinoshita, H.2    Nihira, T.3
  • 2
    • 73949113518 scopus 로고    scopus 로고
    • Aspergillus fumigatus inhibits angiogenesis through the production of gliotoxin and other secondary metabolites
    • R. Ben-Ami, R. Lewis, K. Leventakos, and D. Kontoyiannis Aspergillus fumigatus inhibits angiogenesis through the production of gliotoxin and other secondary metabolites Blood 114 2009 5393 5399
    • (2009) Blood , vol.114 , pp. 5393-5399
    • Ben-Ami, R.1    Lewis, R.2    Leventakos, K.3    Kontoyiannis, D.4
  • 3
    • 78650356368 scopus 로고    scopus 로고
    • Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster
    • S. Bergmann, A.N. Funk, K. Scherlach, V. Schroeckh, E. Shelest, and U. Horn Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster Applied and Environmental Microbiology 76 2010 8143 8149
    • (2010) Applied and Environmental Microbiology , vol.76 , pp. 8143-8149
    • Bergmann, S.1    Funk, A.N.2    Scherlach, K.3    Schroeckh, V.4    Shelest, E.5    Horn, U.6
  • 7
    • 4143090400 scopus 로고    scopus 로고
    • LaeA, a regulator of secondary metabolism in Aspergillus spp
    • DOI 10.1128/EC.3.2.527-535.2004
    • J. Bok, and N. Keller LaeA, a regulator of secondary metabolism in Aspergillus spp Eukaryotic Cell 3 2004 527 535 (Pubitemid 38497990)
    • (2004) Eukaryotic Cell , vol.3 , Issue.2 , pp. 527-535
    • Bok, J.W.1    Keller, N.P.2
  • 9
    • 78650198931 scopus 로고    scopus 로고
    • Fungal secondary metabolites. Strategies to activate silent gene clusters
    • A.A. Brakhage, and V. Schroeckh Fungal secondary metabolites. Strategies to activate silent gene clusters Fungal Genetics and Biology 48 2011 15 22
    • (2011) Fungal Genetics and Biology , vol.48 , pp. 15-22
    • Brakhage, A.A.1    Schroeckh, V.2
  • 10
    • 70349959824 scopus 로고    scopus 로고
    • A proteomics approach to discovering natural products and their biosynthetic pathways
    • S. Bumpus, B. Evans, P. Thomas, I. Ntai, and N. Kelleher A proteomics approach to discovering natural products and their biosynthetic pathways Nature Biotechnology 27 2009 951 956
    • (2009) Nature Biotechnology , vol.27 , pp. 951-956
    • Bumpus, S.1    Evans, B.2    Thomas, P.3    Ntai, I.4    Kelleher, N.5
  • 11
    • 79851515868 scopus 로고    scopus 로고
    • Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms
    • Y.-M. Chiang, S.-L. Chang, B.R. Oakley, and C.C.C. Wang Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms Current Opinion in Chemical Biology 15 2011 137 143
    • (2011) Current Opinion in Chemical Biology , vol.15 , pp. 137-143
    • Chiang, Y.-M.1    Chang, S.-L.2    Oakley, B.R.3    Wang, C.C.C.4
  • 12
    • 73949102298 scopus 로고    scopus 로고
    • Epigenome manipulation as a pathway to new natural product scaffolds and their congeners
    • R. Cichewicz Epigenome manipulation as a pathway to new natural product scaffolds and their congeners Natural Product Reports 27 2010 11 22
    • (2010) Natural Product Reports , vol.27 , pp. 11-22
    • Cichewicz, R.1
  • 15
    • 0030756319 scopus 로고    scopus 로고
    • Overexpression of aflR leads to upregulation of pathway gene transcription and increased aflatoxin production in Aspergillus flavus
    • J.E. Flaherty, and G.A. Payne Overexpression of aflR leads to upregulation of pathway gene transcription and increased aflatoxin production in Aspergillus flavus Applied and Environmental Microbiology 63 1997 3995 4000 (Pubitemid 27411360)
    • (1997) Applied and Environmental Microbiology , vol.63 , Issue.10 , pp. 3995-4000
    • Flaherty, J.E.1    Payne, G.A.2
  • 16
    • 67650308266 scopus 로고    scopus 로고
    • Hidden biosynthetic treasures brought to light
    • C. Hertweck Hidden biosynthetic treasures brought to light Nature Chemical Biology 5 2009 450 452
    • (2009) Nature Chemical Biology , vol.5 , pp. 450-452
    • Hertweck, C.1
  • 17
    • 53049091681 scopus 로고    scopus 로고
    • Requirement of LaeA for secondary metabolism and sclerotial production in Aspergillus flavus
    • S. Kale, L. Milde, M. Trapp, J. Frisvad, N. Keller, and J. Bok Requirement of LaeA for secondary metabolism and sclerotial production in Aspergillus flavus Fungal Genetics and Biology 45 2008 1422 1429
    • (2008) Fungal Genetics and Biology , vol.45 , pp. 1422-1429
    • Kale, S.1    Milde, L.2    Trapp, M.3    Frisvad, J.4    Keller, N.5    Bok, J.6
  • 18
    • 0031079973 scopus 로고    scopus 로고
    • Metabolic pathway gene clusters in filamentous fungi
    • DOI 10.1006/fgbi.1997.0970
    • N. Keller, and T. Hohn Metabolic pathway gene clusters in filamentous fungi Fungal Genetics and Biology 21 1997 17 29 (Pubitemid 27226551)
    • (1997) Fungal Genetics and Biology , vol.21 , Issue.1 , pp. 17-29
    • Keller, N.P.1    Hohn, T.M.2
  • 20
    • 68549090550 scopus 로고    scopus 로고
    • HdaA, a class 2 histone deacetylase of Aspergillus fumigatus, affects germination and secondary metabolite production
    • I. Lee, J. Oh, E. Shwab, T. Dagenais, D. Andes, and N. Keller HdaA, a class 2 histone deacetylase of Aspergillus fumigatus, affects germination and secondary metabolite production Fungal Genetics and Biology 46 2009 782 790
    • (2009) Fungal Genetics and Biology , vol.46 , pp. 782-790
    • Lee, I.1    Oh, J.2    Shwab, E.3    Dagenais, T.4    Andes, D.5    Keller, N.6
  • 21
    • 67651120253 scopus 로고    scopus 로고
    • Effect of competition on the production and activity of secondary metabolites in Aspergillus species
    • L. Losada, O. Ajayi, J.C. Frisvad, J.J. Yu, and W.C. Nierman Effect of competition on the production and activity of secondary metabolites in Aspergillus species Medical Mycology 47 2009 S88 S96
    • (2009) Medical Mycology , vol.47
    • Losada, L.1    Ajayi, O.2    Frisvad, J.C.3    Yu, J.J.4    Nierman, W.C.5
  • 22
    • 79959920872 scopus 로고    scopus 로고
    • AntiSMASH: Rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
    • M.H. Medema, K. Blin, P. Cimermancic, V. de Jager, P. Zakrzewski, and M.A. Fischbach antiSMASH: Rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences Nucleic Acids Research 39 2011 W339 W346
    • (2011) Nucleic Acids Research , vol.39
    • Medema, M.H.1    Blin, K.2    Cimermancic, P.3    De Jager, V.4    Zakrzewski, P.5    Fischbach, M.A.6
  • 24
    • 57349146942 scopus 로고    scopus 로고
    • H3K9 methylation regulates growth and development in Aspergillus fumigatus
    • J. Palmer, R. Perrin, T. Dagenais, and N. Keller H3K9 methylation regulates growth and development in Aspergillus fumigatus Eukaryotic Cell 7 2008 2052 2060
    • (2008) Eukaryotic Cell , vol.7 , pp. 2052-2060
    • Palmer, J.1    Perrin, R.2    Dagenais, T.3    Keller, N.4
  • 25
    • 77955428831 scopus 로고    scopus 로고
    • Secondary metabolism in fungi, does location matter?
    • J.M. Palmer, and N.P. Keller Secondary metabolism in fungi, does location matter? Current Opinion in Microbiology 13 2010 431 436
    • (2010) Current Opinion in Microbiology , vol.13 , pp. 431-436
    • Palmer, J.M.1    Keller, N.P.2
  • 26
    • 34247626534 scopus 로고    scopus 로고
    • Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA
    • R. Perrin, N. Fedorova, J. Bok, R. Cramer, J. Wortman, and H. Kim Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA PLoS Pathogens 3 2007 50
    • (2007) PLoS Pathogens , vol.3 , pp. 50
    • Perrin, R.1    Fedorova, N.2    Bok, J.3    Cramer, R.4    Wortman, J.5    Kim, H.6
  • 27
    • 77952890057 scopus 로고    scopus 로고
    • Heterochromatic marks are associated with the repression of secondary metabolism clusters in Aspergillus nidulans
    • Y. Reyes-Dominguez, J. Bok, H. Berger, E. Shwab, A. Basheer, and A. Gallmetzer Heterochromatic marks are associated with the repression of secondary metabolism clusters in Aspergillus nidulans Molecular Microbiology 76 2010 1376 1786
    • (2010) Molecular Microbiology , vol.76 , pp. 1376-1786
    • Reyes-Dominguez, Y.1    Bok, J.2    Berger, H.3    Shwab, E.4    Basheer, A.5    Gallmetzer, A.6
  • 29
    • 84857922403 scopus 로고    scopus 로고
    • Heterologous expression system in Aspergillus oryzae for fungal biosynthetic gene clusters of secondary metabolites
    • K. Sakai, H. Kinoshita, and T. Nihira Heterologous expression system in Aspergillus oryzae for fungal biosynthetic gene clusters of secondary metabolites Applied Microbiology and Biotechnology 93 2012 2011 2022
    • (2012) Applied Microbiology and Biotechnology , vol.93 , pp. 2011-2022
    • Sakai, K.1    Kinoshita, H.2    Nihira, T.3
  • 30
    • 77953139150 scopus 로고    scopus 로고
    • Identification of csypyrone B1 as the novel product of Aspergillus oryzae type III polyketide synthase CsyB
    • Y. Seshime, P.R. Juvvadi, K. Kitamoto, Y. Ebizuka, and I. Fujii Identification of csypyrone B1 as the novel product of Aspergillus oryzae type III polyketide synthase CsyB Bioorganic & Medicinal Chemistry 18 2010 4542 4546
    • (2010) Bioorganic & Medicinal Chemistry , vol.18 , pp. 4542-4546
    • Seshime, Y.1    Juvvadi, P.R.2    Kitamoto, K.3    Ebizuka, Y.4    Fujii, I.5
  • 31
    • 34748829074 scopus 로고    scopus 로고
    • Historie deacetylase activity regulates chemical diversity in Aspergillus
    • DOI 10.1128/EC.00186-07
    • E. Shwab, J. Bok, M. Tribus, J. Galehr, S. Graessle, and N. Keller Histone deacetylase activity regulates chemical diversity in Aspergillus Eukaryotic Cell 6 2007 1656 1664 (Pubitemid 47483608)
    • (2007) Eukaryotic Cell , vol.6 , Issue.9 , pp. 1656-1664
    • Shwab, E.K.1    Jin, W.B.2    Tribus, M.3    Galehr, J.4    Graessle, S.5    Keller, N.P.6
  • 32
    • 15244354736 scopus 로고    scopus 로고
    • Aspergillus fumigatus suppresses the human cellular immune response via gliotoxin-mediated apoptosis of monocytes
    • DOI 10.1182/blood-2004-09-3421
    • M. Stanzani, E. Orciuolo, R. Lewis, D. Kontoyiannis, S. Martins, and L. St John Aspergillus fumigatus suppresses the human cellular immune response via gliotoxin-mediated apoptosis of monocytes Blood 105 2005 2258 2265 (Pubitemid 40387017)
    • (2005) Blood , vol.105 , Issue.6 , pp. 2258-2265
    • Stanzani, M.1    Orciuolo, E.2    Lewis, R.3    Kontoyiannis, D.P.4    Martins, S.L.R.5    St. John, L.S.6    Komanduri, K.V.7
  • 33
    • 78650200243 scopus 로고    scopus 로고
    • Regulation of secondary metabolism by chromatin structure and epigenetic codes
    • J. Strauss, and Y. Reyes-Dominguez Regulation of secondary metabolism by chromatin structure and epigenetic codes Fungal Genetics and Biology 48 2011 62 69
    • (2011) Fungal Genetics and Biology , vol.48 , pp. 62-69
    • Strauss, J.1    Reyes-Dominguez, Y.2
  • 35
    • 58149343558 scopus 로고    scopus 로고
    • Transcriptional profiling identifies a role for BrlA in the response to nitrogen depletion and for StuA in the regulation of secondary metabolite clusters in Aspergillus fumigatus
    • K. Twumasi-Boateng, Y. Yu, D. Chen, F.N. Gravelat, W.C. Nierman, and D.C. Sheppard Transcriptional profiling identifies a role for BrlA in the response to nitrogen depletion and for StuA in the regulation of secondary metabolite clusters in Aspergillus fumigatus Eukaryotic Cell 8 2009 104 115
    • (2009) Eukaryotic Cell , vol.8 , pp. 104-115
    • Twumasi-Boateng, K.1    Yu, Y.2    Chen, D.3    Gravelat, F.N.4    Nierman, W.C.5    Sheppard, D.C.6
  • 36
    • 0033762670 scopus 로고    scopus 로고
    • Horizontal gene transfer and the evolution of secondary metabolite gene clusters in fungi: An hypothesis
    • J.D. Walton Horizontal gene transfer and the evolution of secondary metabolite gene clusters in fungi: An hypothesis Fungal Genetics and Biology 30 2000 167 171
    • (2000) Fungal Genetics and Biology , vol.30 , pp. 167-171
    • Walton, J.D.1
  • 37
    • 77953005706 scopus 로고    scopus 로고
    • Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an atlantic-forest-soil-derived Penicillium citreonigrum
    • X. Wang, J.G. Sena Filho, A.R. Hoover, J.B. King, T.K. Ellis, and D.R. Powell Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an atlantic-forest-soil-derived Penicillium citreonigrum Journal of Natural Products 73 2011 942 948
    • (2011) Journal of Natural Products , vol.73 , pp. 942-948
    • Wang, X.1    Sena Filho, J.G.2    Hoover, A.R.3    King, J.B.4    Ellis, T.K.5    Powell, D.R.6
  • 38
    • 77955379554 scopus 로고    scopus 로고
    • FfVel1 and FfLae1, components of a velvet-like complex in Fusarium fujikuroi, affect differentiation, secondary metabolism and virulence
    • P. Wiemann, D.W. Brown, K. Kleigrewe, J.W. Bok, N.P. Keller, and H.-U. Humpf FfVel1 and FfLae1, components of a velvet-like complex in Fusarium fujikuroi, affect differentiation, secondary metabolism and virulence Molecular Microbiology 77 2010 972 994
    • (2010) Molecular Microbiology , vol.77 , pp. 972-994
    • Wiemann, P.1    Brown, D.W.2    Kleigrewe, K.3    Bok, J.W.4    Keller, N.P.5    Humpf, H.-U.6
  • 40
    • 77957947578 scopus 로고    scopus 로고
    • Molecular cloning and characterization of the global regulator LaeA in Penicillium citrinum
    • W. Xing, C. Deng, and C.-H. Hu Molecular cloning and characterization of the global regulator LaeA in Penicillium citrinum Biotechnology letters 32 2010 1733 1737
    • (2010) Biotechnology Letters , vol.32 , pp. 1733-1737
    • Xing, W.1    Deng, C.2    Hu, C.-H.3
  • 41
    • 6344277118 scopus 로고    scopus 로고
    • Rapid production of gene replacement constructs and generation of a green fluorescent protein-tagged centromeric marker in Aspergillus nidulans
    • DOI 10.1128/EC.3.5.1359-1362.2004
    • L. Yang, L. Ukil, A. Osmani, F. Nahm, J. Davies, and C.P. De Souza Rapid production of gene replacement constructs and generation of a green fluorescent protein-tagged centromeric marker in Aspergillus nidulans Eukaryotic Cell 3 2004 1359 1362 (Pubitemid 39385242)
    • (2004) Eukaryotic Cell , vol.3 , Issue.5 , pp. 1359-1362
    • Yang, L.1    Ukil, L.2    Osmani, A.3    Nahm, F.4    Davies, J.5    De Souza, C.P.C.6    Dou, X.7    Perez-Balaguer, A.8    Osmani, S.A.9
  • 43
    • 84862804476 scopus 로고    scopus 로고
    • An Aspergillus nidulans bZIP response pathway hardwired for defensive secondary metabolism operates through aflR
    • W. Yin, S. Amaike, D.J. Wohlbach, A.P. Gasch, Y.-M. Chiang, and C.C. Wang An Aspergillus nidulans bZIP response pathway hardwired for defensive secondary metabolism operates through aflR Molecular Microbiology 83 2012 1024 1034
    • (2012) Molecular Microbiology , vol.83 , pp. 1024-1034
    • Yin, W.1    Amaike, S.2    Wohlbach, D.J.3    Gasch, A.P.4    Chiang, Y.-M.5    Wang, C.C.6
  • 44
    • 79959769183 scopus 로고    scopus 로고
    • Transcriptional regulatory elements in fungal secondary metabolism
    • W. Yin, and N.P. Keller Transcriptional regulatory elements in fungal secondary metabolism Journal of Microbiology 49 2011 329 339
    • (2011) Journal of Microbiology , vol.49 , pp. 329-339
    • Yin, W.1    Keller, N.P.2
  • 45
    • 4644220750 scopus 로고    scopus 로고
    • Double-joint PCR: A PCR-based molecular tool for gene manipulations in filamentous fungi
    • DOI 10.1016/j.fgb.2004.08.001, PII S1087184504001185
    • J.H. Yu, Z. Hamari, K.H. Han, J.A. Seo, Y. Reyes-Dominguez, and C. Scazzocchio Double-joint PCR: A PCR-based molecular tool for gene manipulations in filamentous fungi Fungal Genetics and Biology 41 2004 973 981 (Pubitemid 39304095)
    • (2004) Fungal Genetics and Biology , vol.41 , Issue.11 , pp. 973-981
    • Yu, J.-H.1    Hamari, Z.2    Han, K.-H.3    Seo, J.-A.4    Reyes-Dominguez, Y.5    Scazzocchio, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.