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Volumn 19, Issue 12, 2014, Pages 20864-20879

Relevance of the anti-inflammatory properties of curcumin in neurodegenerative diseases and depression

Author keywords

Curcumin; Depression; Inflammation; Neuroprotection; Parkinson's disease

Indexed keywords

ANTIDEPRESSANT AGENT; ANTIINFLAMMATORY AGENT; CURCUMIN; NEUROPROTECTIVE AGENT;

EID: 84919774867     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules191220864     Document Type: Review
Times cited : (65)

References (139)
  • 1
    • 84903272081 scopus 로고    scopus 로고
    • The effect of the water on the curcumin tautomerism: A quantitative approach
    • Manolova, Y.; Deneva, V.; Antonov, L. The effect of the water on the curcumin tautomerism: A quantitative approach. Spectrochim. Acta A 2014, 132, 815-820.
    • (2014) Spectrochim. Acta A , vol.132 , pp. 815-820
    • Manolova, Y.1    Deneva, V.2    Antonov, L.3
  • 2
    • 0017075410 scopus 로고
    • Antioxidant activity of curcumin and related compounds
    • Sharma, O.P. Antioxidant activity of curcumin and related compounds. Biochem. Pharmacol. 1976, 25, 1811-1812.
    • (1976) Biochem. Pharmacol. , vol.25 , pp. 1811-1812
    • Sharma, O.P.1
  • 5
  • 7
    • 80052735248 scopus 로고    scopus 로고
    • Hepatoprotective effect of curcumin onlindane-induced oxidative stress in male Wistar rats
    • Singh, R.; Sharma, P. Hepatoprotective effect of curcumin onlindane-induced oxidative stress in male Wistar rats. Toxicol. Int. 2011, 18, 124-129.
    • (2011) Toxicol. Int. , vol.18 , pp. 124-129
    • Singh, R.1    Sharma, P.2
  • 9
    • 70350334260 scopus 로고    scopus 로고
    • Study on the antibiotic activity of microcapsule curcumin against foodborne pathogens
    • Wang, Y.; Lu, Z.; Wu, H.; Lv, F. Study on the antibiotic activity of microcapsule curcumin against foodborne pathogens. Int. J. Food Microbiol. 2009, 136, 71-74.
    • (2009) Int. J. Food Microbiol. , vol.136 , pp. 71-74
    • Wang, Y.1    Lu, Z.2    Wu, H.3    Lv, F.4
  • 10
    • 34548058841 scopus 로고    scopus 로고
    • Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism
    • Sandur, S.K.; Pandey, M.K.; Sung, B.; Ahn, K.S.; Murakami, A.; Sethi, G.; Limtrakul, P.; Badmaev, V.; Aggarwal, B.B. Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis 2007, 28, 1765-1773.
    • (2007) Carcinogenesis , vol.28 , pp. 1765-1773
    • Sandur, S.K.1    Pandey, M.K.2    Sung, B.3    Ahn, K.S.4    Murakami, A.5    Sethi, G.6    Limtrakul, P.7    Badmaev, V.8    Aggarwal, B.B.9
  • 11
    • 55949117806 scopus 로고    scopus 로고
    • Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases
    • Aggarwal, B.B.; Harikumar, K.B. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int. J. Biochem. Cell Biol. 2009, 41, 40-59.
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , pp. 40-59
    • Aggarwal, B.B.1    Harikumar, K.B.2
  • 12
    • 67650973761 scopus 로고    scopus 로고
    • Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: A review of preclinical and clinical research
    • Jurenka, J.S. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: A review of preclinical and clinical research. Altern. Med. Rev. 2009, 14, 141-153.
    • (2009) Altern. Med. Rev. , vol.14 , pp. 141-153
    • Jurenka, J.S.1
  • 13
    • 84878621998 scopus 로고    scopus 로고
    • Ameliorating effects of curcumin on 6-OHDA-induced dopaminergic denervation, glial response, and SOD1 reduction in the striatum of hemiparkinsonian mice
    • Tripanichkul, W.; Jaroensuppaperch, E.O. Ameliorating effects of curcumin on 6-OHDA-induced dopaminergic denervation, glial response, and SOD1 reduction in the striatum of hemiparkinsonian mice. Eur. Rev. Med. Pharmacol. Sci. 2013, 10, 1360-1368.
    • (2013) Eur. Rev. Med. Pharmacol. Sci. , vol.10 , pp. 1360-1368
    • Tripanichkul, W.1    Jaroensuppaperch, E.O.2
  • 14
    • 26444486974 scopus 로고    scopus 로고
    • Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats
    • Xu, Y.; Ku, B.S.; Yao, H.Y.; Lin, Y.H.; Ma, X.; Zhang, Y.H.; Li, X.J. Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats. Pharmacol. Biochem. Behav. 2005, 82, 200-206.
    • (2005) Pharmacol. Biochem. Behav. , vol.82 , pp. 200-206
    • Xu, Y.1    Ku, B.S.2    Yao, H.Y.3    Lin, Y.H.4    Ma, X.5    Zhang, Y.H.6    Li, X.J.7
  • 15
    • 56549103334 scopus 로고    scopus 로고
    • Antidepressant activity of curcumin: Involvement of serotonin and dopamine system
    • Kulkarni, S.K.; Bhutani, M.K.; Bishnoi, M. Antidepressant activity of curcumin: Involvement of serotonin and dopamine system. Psychopharmacology 2008, 201, 435-442.
    • (2008) Psychopharmacology , vol.201 , pp. 435-442
    • Kulkarni, S.K.1    Bhutani, M.K.2    Bishnoi, M.3
  • 16
    • 58549120562 scopus 로고    scopus 로고
    • Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes
    • Bhutani, M.K.; Bishnoi, M.; Kulkarni, S.K. Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes. Pharmacol. Biochem. Behav. 2009, 92, 39-43.
    • (2009) Pharmacol. Biochem. Behav. , vol.92 , pp. 39-43
    • Bhutani, M.K.1    Bishnoi, M.2    Kulkarni, S.K.3
  • 17
    • 62849090443 scopus 로고    scopus 로고
    • Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats
    • Li, Y.C.; Wang, F.M.; Pan, Y.; Qiang, L.Q.; Cheng, G.; Zhang, W.Y.; Kong, L.D. Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats. Prog. Neuropsychopharmacol. Biol. Psychiatry 2009, 33, 435-449.
    • (2009) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.33 , pp. 435-449
    • Li, Y.C.1    Wang, F.M.2    Pan, Y.3    Qiang, L.Q.4    Cheng, G.5    Zhang, W.Y.6    Kong, L.D.7
  • 18
    • 80054871119 scopus 로고    scopus 로고
    • Curcumin ameliorates reserpine-induced pain depression dyad: Behavioural, neurochemical and molecular evidences
    • Arora, V.; Kuhad, A.; Tiwari, V.; Chopra, K. Curcumin ameliorates reserpine-induced pain depression dyad: Behavioural, neurochemical and molecular evidences. Psychoneuroendocrinology 2011, 36, 1570-1581.
    • (2011) Psychoneuroendocrinology , vol.36 , pp. 1570-1581
    • Arora, V.1    Kuhad, A.2    Tiwari, V.3    Chopra, K.4
  • 19
    • 84869237281 scopus 로고    scopus 로고
    • Antidepressant-like effects of curcumin in WKY rat model of depression is associated with an increase in hippocampal BDNF
    • Hurley, L.L.; Akinfiresoye, L.; Nwulia, E.; Kamiya, A.; Kulkarni, A.A.; Tizabi, Y. Antidepressant-like effects of curcumin in WKY rat model of depression is associated with an increase in hippocampal BDNF. Behav. Brain Res. 2013, 239, 27-30.
    • (2013) Behav. Brain Res. , vol.239 , pp. 27-30
    • Hurley, L.L.1    Akinfiresoye, L.2    Nwulia, E.3    Kamiya, A.4    Kulkarni, A.A.5    Tizabi, Y.6
  • 24
    • 0031914408 scopus 로고    scopus 로고
    • Low numbers and no loss of melanized nigral neurons with increasing age in normal human brains from India
    • Muthane, U.;Yasha, T.C.; Shankar, S.K. Low numbers and no loss of melanized nigral neurons with increasing age in normal human brains from India. Ann. Neurol. 1998, 43, 283-287.
    • (1998) Ann. Neurol. , vol.43 , pp. 283-287
    • Muthane, U.1    Yasha, T.C.2    Shankar, S.K.3
  • 25
    • 60349100004 scopus 로고    scopus 로고
    • Absence of age-related changes in nigral dopaminergic neurons of Asian Indians: Relevance to lower incidence of Parkinson's disease
    • Alladi, P.A.; Mahadevan, A.; Yasha, T.C.; Raju, T.R.; Shankar, S.K.; Muthane, U. Absence of age-related changes in nigral dopaminergic neurons of Asian Indians: Relevance to lower incidence of Parkinson's disease. Neuroscience 2009, 159, 236-245.
    • (2009) Neuroscience , vol.159 , pp. 236-245
    • Alladi, P.A.1    Mahadevan, A.2    Yasha, T.C.3    Raju, T.R.4    Shankar, S.K.5    Muthane, U.6
  • 27
    • 34447327253 scopus 로고    scopus 로고
    • Prevalence of mental disorders based on general population surveys
    • Baumeister, H.; Harter, M. Prevalence of mental disorders based on general population surveys. Soc. Psychiatry Psychiatr. Epidemiol. 2007, 42, 537-546.
    • (2007) Soc. Psychiatry Psychiatr. Epidemiol. , vol.42 , pp. 537-546
    • Baumeister, H.1    Harter, M.2
  • 28
    • 0038486204 scopus 로고    scopus 로고
    • Research issues in the study of difficult-to-treat depression
    • Rush, A.J.; Thase, M.E.; Dube, S. Research issues in the study of difficult-to-treat depression. Biol. Psychiatry 2003, 53, 743-753.
    • (2003) Biol. Psychiatry , vol.53 , pp. 743-753
    • Rush, A.J.1    Thase, M.E.2    Dube, S.3
  • 29
    • 33751338530 scopus 로고    scopus 로고
    • Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: A STAR D report
    • Rush, A.j.; Trivedi, M.H.; Wisniewski, S.R.; Nierenberg, A.A.; Stewart, J.W.; Warden, D. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: A STAR D report. Am. J. Psychiatry 2006, 163, 1905-191.
    • (2006) Am. J. Psychiatry , vol.163 , pp. 1905-2191
    • Rush, A.J.1    Trivedi, M.H.2    Wisniewski, S.R.3    Nierenberg, A.A.4    Stewart, J.W.5    Warden, D.6
  • 30
  • 31
    • 0035295487 scopus 로고    scopus 로고
    • Impairments of neuroplasticity and cellular resilience in severe mood disorders: Implications for the development of novel therapeutics
    • Manji, H.K.; Duman, R.S. Impairments of neuroplasticity and cellular resilience in severe mood disorders: Implications for the development of novel therapeutics. Psychopharmacol. Bull. 2001, 35, 5-49.
    • (2001) Psychopharmacol. Bull. , vol.35 , pp. 5-49
    • Manji, H.K.1    Duman, R.S.2
  • 32
    • 0036113348 scopus 로고    scopus 로고
    • Stress and depression: Possible links to neuron death in the hippocampus
    • Lee, A.L.; Ogle, W.O.; Sapolsky, R.M. Stress and depression: Possible links to neuron death in the hippocampus. Bipolar Disord. 2002, 4, 117-128.
    • (2002) Bipolar Disord. , vol.4 , pp. 117-128
    • Lee, A.L.1    Ogle, W.O.2    Sapolsky, R.M.3
  • 33
    • 0036264409 scopus 로고    scopus 로고
    • Chronic, treatment-resistant depression and right fronto-striatal atrophy
    • Shah, P.J.; Glabus, M.F.; Goodwin, G.M.; Ebmeier, K.P. Chronic, treatment-resistant depression and right fronto-striatal atrophy. Br. J. Psychiatry 2002, 180, 434-440.
    • (2002) Br. J. Psychiatry , vol.180 , pp. 434-440
    • Shah, P.J.1    Glabus, M.F.2    Goodwin, G.M.3    Ebmeier, K.P.4
  • 34
    • 77951880669 scopus 로고    scopus 로고
    • Glial pathology in an animal model of depression: Reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole
    • Banasr, M.; Chowdhury, G.M.; Terwilliger, R.; Newton, S.S.; Duman, R.S.; Behar, K.L. Glial pathology in an animal model of depression: Reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole. Mol. Psychiatry 2010, 15, 501-511.
    • (2010) Mol. Psychiatry , vol.15 , pp. 501-511
    • Banasr, M.1    Chowdhury, G.M.2    Terwilliger, R.3    Newton, S.S.4    Duman, R.S.5    Behar, K.L.6
  • 35
    • 82555205300 scopus 로고    scopus 로고
    • Cell atrophy and loss in depression: Reversal by antidepressant treatment
    • Banasr, M.; Dwyer, J.M.; Duman, R.S. Cell atrophy and loss in depression: Reversal by antidepressant treatment. Curr. Opin. Cell Biol. 2011, 23, 730-737.
    • (2011) Curr. Opin. Cell Biol. , vol.23 , pp. 730-737
    • Banasr, M.1    Dwyer, J.M.2    Duman, R.S.3
  • 36
    • 0142090726 scopus 로고    scopus 로고
    • Impairments of ERK signal transduction in the brain in a rat model of depression induced by neonatal exposure of clomipramine
    • Feng, P.; Guan, Z.; Yang, X.; Fang, J. Impairments of ERK signal transduction in the brain in a rat model of depression induced by neonatal exposure of clomipramine. Brain Res. 2003, 991, 195-205.
    • (2003) Brain Res. , vol.991 , pp. 195-205
    • Feng, P.1    Guan, Z.2    Yang, X.3    Fang, J.4
  • 37
    • 67349131573 scopus 로고    scopus 로고
    • Antiapoptotic and neurotrophic effects of antidepressants: A review of clinical and experimental studies
    • Drzyzga, L.R.; Marcinowska, A.; Obuchowicz, E. Antiapoptotic and neurotrophic effects of antidepressants: A review of clinical and experimental studies. Brain Res. Bull. 2009, 79, 248-257.
    • (2009) Brain Res. Bull. , vol.79 , pp. 248-257
    • Drzyzga, L.R.1    Marcinowska, A.2    Obuchowicz, E.3
  • 38
    • 77954953004 scopus 로고    scopus 로고
    • Dexamethasone enhances the norepinephrine-induced ERK/MAPK intracellular pathway possibly via dysregulation of the α2-adrenergic receptor: Implications for antidepressant drug mechanism of action
    • Yaniv, S.P.; Lucki, A.; Klein, E.; Ben-Shachar, D. Dexamethasone enhances the norepinephrine-induced ERK/MAPK intracellular pathway possibly via dysregulation of the α2-adrenergic receptor: Implications for antidepressant drug mechanism of action. Eur. J. Cell Biol. 2010, 89, 712-722.
    • (2010) Eur. J. Cell Biol. , vol.89 , pp. 712-722
    • Yaniv, S.P.1    Lucki, A.2    Klein, E.3    Ben-Shachar, D.4
  • 39
    • 79952964129 scopus 로고    scopus 로고
    • Leukocyte telomere length in major depression: Correlations with chronicity, inflammation and oxidative stress-Preliminary findings
    • Wolkowitz, O.M.; Mellon, S.H.; Epel, E.S.; Lin, J.; Dhabar, F.S.; Su, Y.; Blackburn, E.H. Leukocyte telomere length in major depression: Correlations with chronicity, inflammation and oxidative stress-Preliminary findings. PLoS One 2011, 6, e17837.
    • (2011) PLoS One , vol.6 , pp. e17837
    • Wolkowitz, O.M.1    Mellon, S.H.2    Epel, E.S.3    Lin, J.4    Dhabar, F.S.5    Su, Y.6    Blackburn, E.H.7
  • 40
    • 80051802478 scopus 로고    scopus 로고
    • Association between plasma paroxetine concentration and changes in plasma brain-derived neurotrophic factor levels in patients with major depressive disorder
    • Yasui-Furukori, N.; Tsuchimine, S.; Nakagami, T.; Fujii, A.; Sato, Y.; Tomita, T.; Yoshizawa, K.; Inoue, Y.; Kaneko, S. Association between plasma paroxetine concentration and changes in plasma brain-derived neurotrophic factor levels in patients with major depressive disorder. Hum. Psychopharmacol. 2011, 26, 194-200.
    • (2011) Hum. Psychopharmacol. , vol.26 , pp. 194-200
    • Yasui-Furukori, N.1    Tsuchimine, S.2    Nakagami, T.3    Fujii, A.4    Sato, Y.5    Tomita, T.6    Yoshizawa, K.7    Inoue, Y.8    Kaneko, S.9
  • 41
    • 54049133277 scopus 로고    scopus 로고
    • The molecular neurobiology of depression
    • Krishnan, V.; Nestler, E.J. The molecular neurobiology of depression. Nature 2008, 455, 894-902.
    • (2008) Nature , vol.455 , pp. 894-902
    • Krishnan, V.1    Nestler, E.J.2
  • 42
    • 80052271976 scopus 로고    scopus 로고
    • Reduced neurogenesis and pre-synaptic dysfunction in the olfactory bulb of a rat model of depression
    • Yang, D.; Li, Q.; Fang, L.; Cheng, K.; Zhang, R.; Zheng, P.; Zhan, Q.; Qi, Z.; Zhong, S.; Xie, P. Reduced neurogenesis and pre-synaptic dysfunction in the olfactory bulb of a rat model of depression. Neuroscience 2011, 192, 609-618.
    • (2011) Neuroscience , vol.192 , pp. 609-618
    • Yang, D.1    Li, Q.2    Fang, L.3    Cheng, K.4    Zhang, R.5    Zheng, P.6    Zhan, Q.7    Qi, Z.8    Zhong, S.9    Xie, P.10
  • 43
    • 0034671366 scopus 로고    scopus 로고
    • Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
    • Malberg, J.E.; Eisch, A.J.; Nestler, E.J.; Duman, R.S. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J. Neurosci. 2000, 20, 9104-9110.
    • (2000) J. Neurosci. , vol.20 , pp. 9104-9110
    • Malberg, J.E.1    Eisch, A.J.2    Nestler, E.J.3    Duman, R.S.4
  • 45
    • 0032937860 scopus 로고    scopus 로고
    • The role of microglia and macrophages in the pathophysiology of the CNS
    • Stoll, G.; Jander, S. The role of microglia and macrophages in the pathophysiology of the CNS. Prog. Neurobiol. 1999, 58, 233-247.
    • (1999) Prog. Neurobiol. , vol.58 , pp. 233-247
    • Stoll, G.1    Jander, S.2
  • 46
    • 26044443198 scopus 로고    scopus 로고
    • The pathogenesis of clinical depression: Stressor- and cytokine-induced alterations of neuroplasticity
    • Hayley, S.; Poulter, M.O.; Merali, Z.; Anisman, H. The pathogenesis of clinical depression: Stressor- and cytokine-induced alterations of neuroplasticity. Neuroscience 2005, 135, 659-678.
    • (2005) Neuroscience , vol.135 , pp. 659-678
    • Hayley, S.1    Poulter, M.O.2    Merali, Z.3    Anisman, H.4
  • 47
    • 67649221730 scopus 로고    scopus 로고
    • A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder
    • Khairova, R.A.; Machado-Vieira, R.; Du, J.; Manji, H.K. A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder. Int. J. Neuropsychopharmacol. 2009, 12, 561-578.
    • (2009) Int. J. Neuropsychopharmacol. , vol.12 , pp. 561-578
    • Khairova, R.A.1    Machado-Vieira, R.2    Du, J.3    Manji, H.K.4
  • 48
    • 34548809845 scopus 로고    scopus 로고
    • Inflammation, depression and dementia: Are they connected?
    • Leonard, B.E. Inflammation, depression and dementia: Are they connected? Neurochem. Res. 2007, 32, 1749-1756.
    • (2007) Neurochem. Res. , vol.32 , pp. 1749-1756
    • Leonard, B.E.1
  • 49
    • 57749179191 scopus 로고    scopus 로고
    • The inflammatory & neurodegenerative (I&ND) hypothesis of depression: Leads for future research and new drug developments in depression
    • Maes, M.; Yirmyia, R.; Noraberg, J.; Brene, S.; Hibbeln, J.; Perini, G.; Kubera, M.; Bob, P.; Lerer, B.; Maj, M. The inflammatory & neurodegenerative (I&ND) hypothesis of depression: Leads for future research and new drug developments in depression. Metab. Brain Dis. 2009, 24, 27-53.
    • (2009) Metab. Brain Dis. , vol.24 , pp. 27-53
    • Maes, M.1    Yirmyia, R.2    Noraberg, J.3    Brene, S.4    Hibbeln, J.5    Perini, G.6    Kubera, M.7    Bob, P.8    Lerer, B.9    Maj, M.10
  • 50
    • 67649717023 scopus 로고    scopus 로고
    • The psychoneuroimmunology of depression
    • Leonard, B.E.; Myint, A. The psychoneuroimmunology of depression. Hum. Psychopharmacol. 2009, 24, 165-175.
    • (2009) Hum. Psychopharmacol. , vol.24 , pp. 165-175
    • Leonard, B.E.1    Myint, A.2
  • 51
    • 69749086682 scopus 로고    scopus 로고
    • Noradrenaline reuptake inhibitors limit neuroinflammation in rat cortex following a systemic inflammatory challenge: Implications for depression and neurodegeneration
    • O'Sullivan, J.B.; Ryan, K.M.; Curtin, N.M.; Harkin, A.; Connor, T.J. Noradrenaline reuptake inhibitors limit neuroinflammation in rat cortex following a systemic inflammatory challenge: Implications for depression and neurodegeneration. Int. J. Neuropsychopharmacol. 2009, 12, 687-699.
    • (2009) Int. J. Neuropsychopharmacol. , vol.12 , pp. 687-699
    • O'Sullivan, J.B.1    Ryan, K.M.2    Curtin, N.M.3    Harkin, A.4    Connor, T.J.5
  • 52
    • 0042811001 scopus 로고    scopus 로고
    • Interferon-γ-induced conversion of tryptophan: Immunologic and neuropsychiatric aspects
    • Wirleitner, B.; Neurauter, G.; Schrocksnadel, K.; Frick, B.; Fuchs, D. Interferon-γ-induced conversion of tryptophan: Immunologic and neuropsychiatric aspects. Curr. Med. Chem. 2003, 10, 1581-1591.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1581-1591
    • Wirleitner, B.1    Neurauter, G.2    Schrocksnadel, K.3    Frick, B.4    Fuchs, D.5
  • 53
    • 0031471921 scopus 로고    scopus 로고
    • Role of pro- and anti-inflammatory cytokines during inflammation: Experimental and clinical findings
    • Dinarello, C.A. Role of pro- and anti-inflammatory cytokines during inflammation: Experimental and clinical findings. J. Biol. Regul. Homeost. Agents 1997, 11, 91-103.
    • (1997) J. Biol. Regul. Homeost. Agents , vol.11 , pp. 91-103
    • Dinarello, C.A.1
  • 54
    • 0031831906 scopus 로고    scopus 로고
    • Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist
    • Dinarello, C.A. Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist. Int. Rev. Immunol. 1998, 16, 457-499.
    • (1998) Int. Rev. Immunol. , vol.16 , pp. 457-499
    • Dinarello, C.A.1
  • 55
    • 64649095655 scopus 로고    scopus 로고
    • Depression and immunity: Inflammation and depressive symptoms in multiple sclerosis
    • Gold, S.M.; Irwin, M.R. Depression and immunity: Inflammation and depressive symptoms in multiple sclerosis. Immunol. Allergy Clin. North Am. 2009, 29, 309-320.
    • (2009) Immunol. Allergy Clin. North Am. , vol.29 , pp. 309-320
    • Gold, S.M.1    Irwin, M.R.2
  • 58
    • 84861078831 scopus 로고    scopus 로고
    • A review: Inflammatory process in Alzheimer's disease, role of cytokines
    • 2012
    • Rubio-Perez, J.M.; Morillas-Ruiz, J.M. A review: Inflammatory process in Alzheimer's disease, role of cytokines. Sci. World J. 2012, 2012, doi:10.1100/2012/756357.
    • (2012) Sci. World J
    • Rubio-Perez, J.M.1    Morillas-Ruiz, J.M.2
  • 59
    • 0031260283 scopus 로고    scopus 로고
    • IL-6: Insights into novel biological activities
    • Barton, BE. IL-6: Insights into novel biological activities. Clin. Immunol. Immunopathol. 1997, 85, 16-20.
    • (1997) Clin. Immunol. Immunopathol. , vol.85 , pp. 16-20
    • Barton, B.E.1
  • 60
    • 84874941047 scopus 로고    scopus 로고
    • Resveratrol Protects Cortical Neurons against Microglia-mediated Neuroinflammation
    • Zhang, F.; Wang, H.; Wu, Q.; Lu, Y.; Nie, J.; Xie, X.; Shi, J. Resveratrol Protects Cortical Neurons against Microglia-mediated Neuroinflammation. Phytother. Res. 2013, 27, 244-249.
    • (2013) Phytother. Res. , vol.27 , pp. 244-249
    • Zhang, F.1    Wang, H.2    Wu, Q.3    Lu, Y.4    Nie, J.5    Xie, X.6    Shi, J.7
  • 61
    • 0030044284 scopus 로고    scopus 로고
    • Interleukins 6 and 11 protect mice from mortality in a staphylococcal enterotoxin-induced toxic shock model
    • Barton, B.E.; Shortall, J.; Jackson, J.V. Interleukins 6 and 11 protect mice from mortality in a staphylococcal enterotoxin-induced toxic shock model. Infect. Immun. 1996, 64, 714-718.
    • (1996) Infect. Immun. , vol.64 , pp. 714-718
    • Barton, B.E.1    Shortall, J.2    Jackson, J.V.3
  • 63
    • 0028169379 scopus 로고
    • Response of interleukin-6-deficient mice to tumor necrosis factor-induced metabolic changes and lethality
    • Libert, C.; Takahashi, N.; Cauwels, A.; Brouckaert, P.; Bluethmann, H.; Fiers, W. Response of interleukin-6-deficient mice to tumor necrosis factor-induced metabolic changes and lethality. Eur. J. Immunol. 1994, 24, 2237-2242.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 2237-2242
    • Libert, C.1    Takahashi, N.2    Cauwels, A.3    Brouckaert, P.4    Bluethmann, H.5    Fiers, W.6
  • 64
    • 0032518415 scopus 로고    scopus 로고
    • IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses
    • Xing, Z.; Gauldie, J.; Cox, G.; Baumann, H.; Jordana, M.; Lei, X.F.; Achong, M.K. IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J. Clin. Investig. 1998, 101, 311-320.
    • (1998) J. Clin. Investig. , vol.101 , pp. 311-320
    • Xing, Z.1    Gauldie, J.2    Cox, G.3    Baumann, H.4    Jordana, M.5    Lei, X.F.6    Achong, M.K.7
  • 68
    • 65649152524 scopus 로고    scopus 로고
    • Associations of depression with C-reactive protein, IL-1, and IL-6: A meta-analysis
    • Howren, M.B.; Lamkin, D.M.; Suls, J. Associations of depression with C-reactive protein, IL-1, and IL-6: A meta-analysis. Psychosom. Med. 2009, 71, 171-186.
    • (2009) Psychosom. Med. , vol.71 , pp. 171-186
    • Howren, M.B.1    Lamkin, D.M.2    Suls, J.3
  • 69
    • 45549084470 scopus 로고    scopus 로고
    • Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression
    • Goshen, I.; Kreisel, T.; Ben-Menachem-Zidon, O.; Licht, T.; Weidenfeld, J.; Ben-Hur, T.; Yirmiya, R. Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol. Psychiatry 2008, 13, 717-728.
    • (2008) Mol. Psychiatry , vol.13 , pp. 717-728
    • Goshen, I.1    Kreisel, T.2    Ben-Menachem-Zidon, O.3    Licht, T.4    Weidenfeld, J.5    Ben-Hur, T.6    Yirmiya, R.7
  • 70
    • 38649092266 scopus 로고    scopus 로고
    • IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress
    • Koo, J.W.; Duman, R.S. IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc. Natl. Acad. Sci. USA 2008, 105, 751-756.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 751-756
    • Koo, J.W.1    Duman, R.S.2
  • 71
    • 31844437770 scopus 로고    scopus 로고
    • Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity
    • Patel, H.C.; Ross, F.M.; Heenan, L.E.; Davies, R.E.; Rothwell, N.J.; Allan, S.M. Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity. J. Neurosci. Res. 2006, 83, 385-391.
    • (2006) J. Neurosci. Res. , vol.83 , pp. 385-391
    • Patel, H.C.1    Ross, F.M.2    Heenan, L.E.3    Davies, R.E.4    Rothwell, N.J.5    Allan, S.M.6
  • 73
    • 13844270562 scopus 로고    scopus 로고
    • TNF α potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: Neuroprotection by NF kappa B inhibition
    • Zou, J.Y.; Crews, F.T. TNF α potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: Neuroprotection by NF kappa B inhibition. Brain Res. 2005, 1034, 11-24.
    • (2005) Brain Res. , vol.1034 , pp. 11-24
    • Zou, J.Y.1    Crews, F.T.2
  • 74
    • 84884907135 scopus 로고    scopus 로고
    • A guide to neurotoxic animal models of Parkinson's disease
    • spring Harb. Perspect. Med.
    • Tieu, K. A guide to neurotoxic animal models of Parkinson's disease. Cold Spring Harb. Perspect. Med. 2011, 1, doi:10.1101/cshperspect.a009316.
    • (2011) Cold , vol.1
    • Tieu, K.1
  • 75
    • 33747887455 scopus 로고    scopus 로고
    • Salsolinol, a derivate of dopamine, is a possible modulator of catecholaminergic transmission: A review of recent developments
    • Mravec, B. Salsolinol, a derivate of dopamine, is a possible modulator of catecholaminergic transmission: A review of recent developments. Physiol. Res. 2006, 55, 353-364.
    • (2006) Physiol. Res. , vol.55 , pp. 353-364
    • Mravec, B.1
  • 76
    • 0023690768 scopus 로고
    • Dopamine-derived alkaloids in alcoholism and in Parkinson's and Huntington's diseases
    • Dostert, P.; Strolin Benedetti, M.; Dordain, G. Dopamine-derived alkaloids in alcoholism and in Parkinson's and Huntington's diseases. J. Neural Transm. 1988, 74, 61-74.
    • (1988) J. Neural Transm. , vol.74 , pp. 61-74
    • Dostert, P.1    Strolin Benedetti, M.2    Dordain, G.3
  • 77
    • 0030840624 scopus 로고    scopus 로고
    • Isoquinoline neurotoxins in the brain and Parkinson's disease
    • Nagatsu, T. Isoquinoline neurotoxins in the brain and Parkinson's disease. Neurosci. Res. 1997, 29, 99-111.
    • (1997) Neurosci. Res. , vol.29 , pp. 99-111
    • Nagatsu, T.1
  • 78
    • 0030832958 scopus 로고    scopus 로고
    • A neutral N-methyltransferase activity in the striatum determines the level of an endogenous MPP+-like neurotoxin, 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion, in the substantia nigra of human brains
    • Naoi, M.; Maruyama, W.; Matsubara, K.; Hashizume, Y. A neutral N-methyltransferase activity in the striatum determines the level of an endogenous MPP+-like neurotoxin, 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion, in the substantia nigra of human brains. Neurosci. Lett. 1997, 235, 81-84.
    • (1997) Neurosci. Lett. , vol.235 , pp. 81-84
    • Naoi, M.1    Maruyama, W.2    Matsubara, K.3    Hashizume, Y.4
  • 79
    • 0036965466 scopus 로고    scopus 로고
    • Endogenous risk factors in Parkinson's disease: Dopamine and tetrahydroisoquinolines
    • Antkiewicz-Michaluk, L. Endogenous risk factors in Parkinson's disease: Dopamine and tetrahydroisoquinolines. Pol. J. Pharmacol. 2002, 54, 567-572.
    • (2002) Pol. J. Pharmacol. , vol.54 , pp. 567-572
    • Antkiewicz-Michaluk, L.1
  • 80
    • 0029019124 scopus 로고
    • N-methyl(R)salsolinol produces hydroxyl radicals: Involvement to neurotoxicity
    • Maruyama, W.; Dostert, P.; Matsubara, K.; Naoi, M. N-methyl(R)salsolinol produces hydroxyl radicals: Involvement to neurotoxicity. Free Radic. Biol. Med. 1995, 19, 67-75.
    • (1995) Free Radic. Biol. Med. , vol.19 , pp. 67-75
    • Maruyama, W.1    Dostert, P.2    Matsubara, K.3    Naoi, M.4
  • 81
    • 0029972510 scopus 로고    scopus 로고
    • Salsolinol, catecholamine metabolites, and visual hallucinations in L-dopa treated patients with Parkinson's disease
    • Moser, A.; Siebecker, F.; Vieregge, P.; Jaskowski, P.; Kompf, D. Salsolinol, catecholamine metabolites, and visual hallucinations in L-dopa treated patients with Parkinson's disease. J. Neural Transm. 1996, 103, 421-432.
    • (1996) J. Neural Transm. , vol.103 , pp. 421-432
    • Moser, A.1    Siebecker, F.2    Vieregge, P.3    Jaskowski, P.4    Kompf, D.5
  • 82
    • 84975751684 scopus 로고
    • Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: Relevance to Parkinson's disease
    • Hartley, A.; Stone, J.M.; Heron, C.; Cooper, J.M.; Schapira, A.H. Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: Relevance to Parkinson's disease. J. Neurochem. 1994, 63, 1987-1990.
    • (1994) J. Neurochem. , vol.63 , pp. 1987-1990
    • Hartley, A.1    Stone, J.M.2    Heron, C.3    Cooper, J.M.4    Schapira, A.H.5
  • 83
    • 0036470165 scopus 로고    scopus 로고
    • Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons
    • Gao, H.M.; Hong, J.S.; Zhang, W.; Liu, B. Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons. J. Neurosci. 2002, 22, 782-790.
    • (2002) J. Neurosci. , vol.22 , pp. 782-790
    • Gao, H.M.1    Hong, J.S.2    Zhang, W.3    Liu, B.4
  • 84
    • 70449713354 scopus 로고    scopus 로고
    • Acute action of rotenone on nigral dopaminergic neurons-involvement of reactive oxygen species and disruption of Ca2+ homeostasis
    • Freestone, P.S.; Chung, K.K.; Guatteo, E.; Mercuri, N.B.; Nicholson, L.F.; Lipski, J. Acute action of rotenone on nigral dopaminergic neurons-involvement of reactive oxygen species and disruption of Ca2+ homeostasis. Eur. J. Neurosci. 2009, 30, 1849-1859.
    • (2009) Eur. J. Neurosci. , vol.30 , pp. 1849-1859
    • Freestone, P.S.1    Chung, K.K.2    Guatteo, E.3    Mercuri, N.B.4    Nicholson, L.F.5    Lipski, J.6
  • 86
    • 0037443073 scopus 로고    scopus 로고
    • Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: Relevance to the etiology of Parkinson's disease
    • Gao, H.M.; Hong, J.S.; Zhang, W.; Liu, B. Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: Relevance to the etiology of Parkinson's disease. J. Neurosci. 2003, 23, 1228-1236.
    • (2003) J. Neurosci. , vol.23 , pp. 1228-1236
    • Gao, H.M.1    Hong, J.S.2    Zhang, W.3    Liu, B.4
  • 87
    • 84891857945 scopus 로고    scopus 로고
    • Protective effects of curcumin against rotenone and salsolinol-induced toxicity: Implications for Parkinson's disease
    • Qualls, Z.; Brown, D.; Ramlochansingh, C.; Hurley, L.L.; Tizabi, Y. Protective effects of curcumin against rotenone and salsolinol-induced toxicity: Implications for Parkinson's disease. Neurotox. Res. 2014, 25, 81-89.
    • (2014) Neurotox. Res. , vol.25 , pp. 81-89
    • Qualls, Z.1    Brown, D.2    Ramlochansingh, C.3    Hurley, L.L.4    Tizabi, Y.5
  • 88
    • 47749126515 scopus 로고    scopus 로고
    • Why neurodegenerative diseases are progressive: Uncontrolled inflammation drives disease progression
    • Gao, H.M.; Hong, J.S. Why neurodegenerative diseases are progressive: Uncontrolled inflammation drives disease progression. Trends Immunol. 2008, 29, 357-365.
    • (2008) Trends Immunol. , vol.29 , pp. 357-365
    • Gao, H.M.1    Hong, J.S.2
  • 89
    • 33847759064 scopus 로고    scopus 로고
    • Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
    • Qin, L.; Wu, X.; Block, M.L.; Liu, Y.; Breese, G.R.; Hong, J.S.; Knapp, D.J.; Crews, F.T. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 2007, 55, 453-462.
    • (2007) Glia , vol.55 , pp. 453-462
    • Qin, L.1    Wu, X.2    Block, M.L.3    Liu, Y.4    Breese, G.R.5    Hong, J.S.6    Knapp, D.J.7    Crews, F.T.8
  • 90
    • 84898757532 scopus 로고    scopus 로고
    • The role of innate and adaptive immunity in Parkinson's disease
    • Kannarkat, G.T.; Boss, J.M.; Tansey, M.G. The role of innate and adaptive immunity in Parkinson's disease. J. Parkinson's Dis. 2013, 4, 493-514.
    • (2013) J. Parkinson's Dis. , vol.4 , pp. 493-514
    • Kannarkat, G.T.1    Boss, J.M.2    Tansey, M.G.3
  • 91
    • 84899138668 scopus 로고    scopus 로고
    • LRRK2 and neuroinflammation: Partners in crime in Parkinson's disease?
    • Russo, I.; Bubacco, L.; Greggio, E. LRRK2 and neuroinflammation: Partners in crime in Parkinson's disease? J. Neuroinflam. 2014, 21, 11-52.
    • (2014) J. Neuroinflam. , vol.21 , pp. 11-52
    • Russo, I.1    Bubacco, L.2    Greggio, E.3
  • 94
    • 0027182417 scopus 로고
    • Interleukin-1β: A putative mediator of HPA axis hyperactivity in major depression?
    • Maes, M.; Bosmans, E.; Meltzer, H.Y.; Scharpe, S.; Suy, E. Interleukin-1β: A putative mediator of HPA axis hyperactivity in major depression? Am. J. Psychiatry 1993, 150, 1189-1193.
    • (1993) Am. J. Psychiatry , vol.150 , pp. 1189-1193
    • Maes, M.1    Bosmans, E.2    Meltzer, H.Y.3    Scharpe, S.4    Suy, E.5
  • 95
    • 0031033955 scopus 로고    scopus 로고
    • Intracerebral administration of Mycoplasma fermentans produces sickness behavior: Role of prostaglandins
    • Yirmiya, R.; Barak, O.; Avitsur, R.; Gallily, R.; Weidenfeld, J. Intracerebral administration of Mycoplasma fermentans produces sickness behavior: Role of prostaglandins. Brain Res. 1997, 749, 71-81.
    • (1997) Brain Res. , vol.749 , pp. 71-81
    • Yirmiya, R.1    Barak, O.2    Avitsur, R.3    Gallily, R.4    Weidenfeld, J.5
  • 96
    • 9644276925 scopus 로고    scopus 로고
    • Cytokines and psychopathology: Lessons from interferon-α
    • Capuron, L.; Miller, A.H. Cytokines and psychopathology: Lessons from interferon-α. Biol. Psychiatry 2004, 56, 819-824.
    • (2004) Biol. Psychiatry , vol.56 , pp. 819-824
    • Capuron, L.1    Miller, A.H.2
  • 97
    • 0036904039 scopus 로고    scopus 로고
    • Cytokine-induced changes in mood and behaviour: Implications for "depression due to a general medical condition", immunotherapy and antidepressive treatment
    • Pollak, Y.; Yirmiya, R. Cytokine-induced changes in mood and behaviour: Implications for "depression due to a general medical condition", immunotherapy and antidepressive treatment. Int. J. Neuropsychopharmacol. 2002, 5, 389-399.
    • (2002) Int. J. Neuropsychopharmacol. , vol.5 , pp. 389-399
    • Pollak, Y.1    Yirmiya, R.2
  • 98
    • 0032055840 scopus 로고    scopus 로고
    • The effects of psychological stress on humans: Increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety
    • Maes, M.; Song, C.; Lin, A.; de Jongh, R.; van Gastel, A.; Kenis, G.; Bosmans, E.; de Meester, I.; Benoy, I.; Neels, H.; et al. The effects of psychological stress on humans: Increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety. Cytokine 1998, 10, 313-318.
    • (1998) Cytokine , vol.10 , pp. 313-318
    • Maes, M.1    Song, C.2    Lin, A.3    De Jongh, R.4    Van Gastel, A.5    Kenis, G.6    Bosmans, E.7    De Meester, I.8    Benoy, I.9    Neels, H.10
  • 100
    • 34548049265 scopus 로고    scopus 로고
    • The effects of acute psychological stress on circulating inflammatory factors in humans: A review and meta-analysis
    • Steptoe, A.; Hamer, M.; Chida, Y. The effects of acute psychological stress on circulating inflammatory factors in humans: A review and meta-analysis. Brain Behav. Immun. 2007, 21, 901-912.
    • (2007) Brain Behav. Immun. , vol.21 , pp. 901-912
    • Steptoe, A.1    Hamer, M.2    Chida, Y.3
  • 101
    • 0035346411 scopus 로고    scopus 로고
    • Brain interleukin-1 is involved in blood interleukin-6 response to immobilization stress in rats
    • Ishikawa, I.; Kitamura, H.; Kimura, K.; Saito, M. Brain interleukin-1 is involved in blood interleukin-6 response to immobilization stress in rats. Jpn. J. Vet. Res. 2001, 49, 19-25.
    • (2001) Jpn. J. Vet. Res. , vol.49 , pp. 19-25
    • Ishikawa, I.1    Kitamura, H.2    Kimura, K.3    Saito, M.4
  • 105
    • 77954179493 scopus 로고    scopus 로고
    • The putative neurodegenerative links between depression and Alzheimer's disease
    • Wuwongse, S.; Chang, R.C.; Law, A.C. The putative neurodegenerative links between depression and Alzheimer's disease. Prog. Neurobiol. 2010, 91, 362-375.
    • (2010) Prog. Neurobiol. , vol.91 , pp. 362-375
    • Wuwongse, S.1    Chang, R.C.2    Law, A.C.3
  • 106
  • 107
    • 84881342288 scopus 로고    scopus 로고
    • Curcumin: An orally bioavailable blocker of TNF and other pro-inflammatory biomarkers
    • Aggarwal, B.; Gupta, S.C.; Sung, B. Curcumin: An orally bioavailable blocker of TNF and other pro-inflammatory biomarkers. Br. J. Pharmacol. 2013, 169, 1672-1692.
    • (2013) Br. J. Pharmacol. , vol.169 , pp. 1672-1692
    • Aggarwal, B.1    Gupta, S.C.2    Sung, B.3
  • 108
    • 84919716459 scopus 로고    scopus 로고
    • Synthesis, characterization and in vitro anticancer activity of C-5 curcumin analogues with potential to inhibit TNF-α-induced NF-κB activation
    • Anthwal, A.; Thakur, B.K.; Rawat, M.S.; Rawat, D.S.; Tyagi, A.K.; Aggarwal, B.B. Synthesis, characterization and in vitro anticancer activity of C-5 curcumin analogues with potential to inhibit TNF-α-induced NF-κB activation. Biomed. Res. Int. 2014, doi:10.1155/2014/524161.
    • (2014) Biomed. Res. Int
    • Anthwal, A.1    Thakur, B.K.2    Rawat, M.S.3    Rawat, D.S.4    Tyagi, A.K.5    Aggarwal, B.B.6
  • 110
    • 84894386559 scopus 로고    scopus 로고
    • Curcumin, an active constituent of the ancient medicinal herb Curcuma longa L.: Some uses and the establishment and biological basis of medical efficacy
    • Witkin, J.M.; Li, X. Curcumin, an active constituent of the ancient medicinal herb Curcuma longa L.: Some uses and the establishment and biological basis of medical efficacy. CNS Neurol. Disord. Drug Targets 2013, 12, 487-497.
    • (2013) CNS Neurol. Disord. Drug Targets , vol.12 , pp. 487-497
    • Witkin, J.M.1    Li, X.2
  • 111
    • 36549008159 scopus 로고    scopus 로고
    • The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors
    • Wang, R.; Xu, Y.; Wu, H.L.; Li, Y.B.; Li, Y.H.; Guo, J.B. The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors. Eur. J. Pharmacol. 2008, 578, 43-50.
    • (2008) Eur. J. Pharmacol. , vol.578 , pp. 43-50
    • Wang, R.1    Xu, Y.2    Wu, H.L.3    Li, Y.B.4    Li, Y.H.5    Guo, J.B.6
  • 112
  • 114
    • 84904876004 scopus 로고    scopus 로고
    • Curcumin for the treatment of major depression: A randomised, double-blind, placebo controlled study
    • Lopresti, A.L.; Maes, M.; Maker, G.L.; Hood, S.D.; Drummond, P.D. Curcumin for the treatment of major depression: A randomised, double-blind, placebo controlled study. J. Affect. Disord. 2014, 167, 368-375.
    • (2014) J. Affect. Disord. , vol.167 , pp. 368-375
    • Lopresti, A.L.1    Maes, M.2    Maker, G.L.3    Hood, S.D.4    Drummond, P.D.5
  • 116
    • 84921031937 scopus 로고    scopus 로고
    • Investigation of the Efficacy of Adjunctive Therapy with Bioavailability-Boosted Curcuminoids in Major Depressive Disorder
    • Panahi, Y.; Badeli, R.; Karami, G.R.; Sahebkar, A. Investigation of the Efficacy of Adjunctive Therapy with Bioavailability-Boosted Curcuminoids in Major Depressive Disorder. Phytother. Res. 2014, doi:10.1002/ptr.5211.
    • (2014) Phytother. Res.
    • Panahi, Y.1    Badeli, R.2    Karami, G.R.3    Sahebkar, A.4
  • 119
    • 84888041977 scopus 로고    scopus 로고
    • Amelioration of β-amyloid-induced cognitive dysfunction and hippocampal axon degeneration by curcumin is associated with suppression of CRMP-2 hyperphosphorylation
    • Wang, Y.; Yin, H.; Li, J.; Zhang, Y.; Han, B.; Zeng, Z.; Qiao, N.; Cui, X.; Lou, J.; Li, J. Amelioration of β-amyloid-induced cognitive dysfunction and hippocampal axon degeneration by curcumin is associated with suppression of CRMP-2 hyperphosphorylation. Neurosci. Lett. 2013, 557, 112-117.
    • (2013) Neurosci. Lett. , vol.557 , pp. 112-117
    • Wang, Y.1    Yin, H.2    Li, J.3    Zhang, Y.4    Han, B.5    Zeng, Z.6    Qiao, N.7    Cui, X.8    Lou, J.9    Li, J.10
  • 120
    • 84897428034 scopus 로고    scopus 로고
    • Safety and efficacy of an add-on therapy with curcumin phytosome and piperine and/or lipoic acid in subjects with a diagnosis of peripheral neuropathy treated with dexibuprofen
    • Di Pierro, F.; Settembre, R. Safety and efficacy of an add-on therapy with curcumin phytosome and piperine and/or lipoic acid in subjects with a diagnosis of peripheral neuropathy treated with dexibuprofen. J. Pain Res. 2013, 6, 497-503.
    • (2013) J. Pain Res. , vol.6 , pp. 497-503
    • Di Pierro, F.1    Settembre, R.2
  • 121
    • 84894260825 scopus 로고    scopus 로고
    • Curcumin nanoparticles attenuate neurochemical and neurobehavioral deficits in experimental model of Huntington's disease
    • Sandhir, R.; Yadav, A.; Mehrotra, A.; Sunkaria, A.; Singh, A.; Sharma, S. Curcumin nanoparticles attenuate neurochemical and neurobehavioral deficits in experimental model of Huntington's disease. Neuromolecular Med. 2014, 16, 106-118.
    • (2014) Neuromolecular Med. , vol.16 , pp. 106-118
    • Sandhir, R.1    Yadav, A.2    Mehrotra, A.3    Sunkaria, A.4    Singh, A.5    Sharma, S.6
  • 123
    • 84865393752 scopus 로고    scopus 로고
    • N-methyl N-nitrosourea induced functional and structural alterations in mice brain-role of curcumin
    • Singula, N.; Chawan, D.K. N-methyl N-nitrosourea induced functional and structural alterations in mice brain-role of curcumin. Neurotox. Res. 2012, 22, 115-126.
    • (2012) Neurotox. Res. , vol.22 , pp. 115-126
    • Singula, N.1    Chawan, D.K.2
  • 124
    • 77956402632 scopus 로고    scopus 로고
    • Review: Curcumin and Alzheimer's disease
    • Hamaguchi, T.; Ono, K.; Yamada, M. Review: Curcumin and Alzheimer's disease. CNS Neurosci. Ther. 2010, 16, 285-297.
    • (2010) CNS Neurosci. Ther. , vol.16 , pp. 285-297
    • Hamaguchi, T.1    Ono, K.2    Yamada, M.3
  • 126
  • 127
    • 84855858783 scopus 로고    scopus 로고
    • Curcumin: A potential neuroprotective agent in Parkinson's disease
    • Mythri, R.; Bharath, M.M. Curcumin: A potential neuroprotective agent in Parkinson's disease. Curr. Pharm. Des. 2012, 18, 91-99.
    • (2012) Curr. Pharm. Des. , vol.18 , pp. 91-99
    • Mythri, R.1    Bharath, M.M.2
  • 128
    • 84856583697 scopus 로고    scopus 로고
    • The promise of neuroprotective agents in Parkinson's disease
    • Seidl, S.E.; Potashkin, J.A. The promise of neuroprotective agents in Parkinson's disease. Front. Neurol. 2011, 2, doi:10.3389/fneur.2011.00068.
    • (2011) Front. Neurol. , vol.2
    • Seidl, S.E.1    Potashkin, J.A.2
  • 131
    • 84876804538 scopus 로고    scopus 로고
    • Neuroinflammation, neurodegeneration, and depression
    • Hurley, L.L.; Tizabi, Y. Neuroinflammation, neurodegeneration, and depression. Neurotox. Res. 2013, 23, 131-144.
    • (2013) Neurotox. Res. , vol.23 , pp. 131-144
    • Hurley, L.L.1    Tizabi, Y.2
  • 132
    • 84891684419 scopus 로고    scopus 로고
    • Antidepressant effects of AMPA and ketamine combination: Role of hippocampal BDNF, synapsin, and mTOR
    • Akinfiresoye, L.; Tizabi, Y. Antidepressant effects of AMPA and ketamine combination: Role of hippocampal BDNF, synapsin, and mTOR. Psychopharmacology 2013, 230, 291-298.
    • (2013) Psychopharmacology , vol.230 , pp. 291-298
    • Akinfiresoye, L.1    Tizabi, Y.2
  • 134
    • 84907841725 scopus 로고    scopus 로고
    • Curcumin and hesperidin improve cognition by suppressing mitochondrial dysfunction and apoptosis induced by D-galactose in rat brain
    • Banji, O.J.; Banji, D.; Ch, K. Curcumin and hesperidin improve cognition by suppressing mitochondrial dysfunction and apoptosis induced by D-galactose in rat brain. Food Chem. Toxicol. 2014, 74, 51-59.
    • (2014) Food Chem. Toxicol. , vol.74 , pp. 51-59
    • Banji, O.J.1    Banji, D.2    Ch, K.3
  • 135
    • 84896725752 scopus 로고    scopus 로고
    • Oxidative/nitrosative stress and immuno-inflammatory pathways in depression: Treatment implications
    • Anderson, G.; Maes, M. Oxidative/nitrosative stress and immuno-inflammatory pathways in depression: Treatment implications. Curr. Pharm. Des. 2014, 20, 3812-3847.
    • (2014) Curr. Pharm. Des. , vol.20 , pp. 3812-3847
    • Anderson, G.1    Maes, M.2
  • 136
    • 84911191807 scopus 로고    scopus 로고
    • Molecular chaperone dysfunction in neurodegenerative diseases and effects of curcumin
    • 2014
    • Maiti, P.; Manna, J.; Veleri, S.; Frautschy, S. Molecular Chaperone Dysfunction in Neurodegenerative Diseases and Effects of Curcumin. Biomed. Res. Int. 2014, 2014, doi:10.1155/2014/495091.
    • (2014) Biomed. Res. Int.
    • Maiti, P.1    Manna, J.2    Veleri, S.3    Frautschy, S.4
  • 137
    • 84906060881 scopus 로고    scopus 로고
    • Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice
    • Wang, C.; Zhang, X.; Teng, Z.; Zhang, T.; Li, Y. Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice. Eur. J. Pharmacol. 2014, 740, 312-320.
    • (2014) Eur. J. Pharmacol. , vol.740 , pp. 312-320
    • Wang, C.1    Zhang, X.2    Teng, Z.3    Zhang, T.4    Li, Y.5
  • 138
    • 84898011829 scopus 로고    scopus 로고
    • Curcumin I mediates neuroprotective effect through attenuation of quinoprotein formation, p-p38 MAPK expression, and caspase-3 activation in 6-hydroxydopamine treated SH-SY5Y cells
    • Meesarapee, B.; Thampithak, A.; Jaisin, Y.; Sanvarinda, P.; Suksamrarn, A.; Tuchinda, P.; Morales, N.P.; Sanvarinda, Y. Curcumin I mediates neuroprotective effect through attenuation of quinoprotein formation, p-p38 MAPK expression, and caspase-3 activation in 6-hydroxydopamine treated SH-SY5Y cells. Phytother. Res. 2014, 28, 611-616.
    • (2014) Phytother. Res. , vol.28 , pp. 611-616
    • Meesarapee, B.1    Thampithak, A.2    Jaisin, Y.3    Sanvarinda, P.4    Suksamrarn, A.5    Tuchinda, P.6    Morales, N.P.7    Sanvarinda, Y.8
  • 139
    • 78651299419 scopus 로고    scopus 로고
    • Curcumin dually inhibits both mammalian target of rapamycin and nuclear factor-κB pathways through a crossed phosphatidylinositol 3-kinase/Akt/IκB kinase complex signaling axis in adenoid cystic carcinoma
    • Sun, Z.J.; Chen, G.; Zhang, W.; Hu, X.; Liu, Y.; Zhou, Q.; Zhu, L.X.; Zhao, Y.F. Curcumin dually inhibits both mammalian target of rapamycin and nuclear factor-κB pathways through a crossed phosphatidylinositol 3-kinase/Akt/IκB kinase complex signaling axis in adenoid cystic carcinoma. Mol. Pharmacol. 2011, 79, 106-118.
    • (2011) Mol. Pharmacol. , vol.79 , pp. 106-118
    • Sun, Z.J.1    Chen, G.2    Zhang, W.3    Hu, X.4    Liu, Y.5    Zhou, Q.6    Zhu, L.X.7    Zhao, Y.F.8


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