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Volumn 17, Issue 10, 2013, Pages 1360-1368

Ameliorating effects of curcumin on 6-OHDA-induced dopaminergic denervation, glial response, and SOD1 reduction in the striatum of hemiparkinsonian mice

Author keywords

6 OHDA; Astrocyte; Curcumin; Microglia; Nigrostriatal dopaminergic axon; SOD1

Indexed keywords

CALCIUM BINDING PROTEIN; CALCIUM BINDING PROTEIN IBA1; COPPER ZINC SUPEROXIDE DISMUTASE; CURCUMIN; GLIAL FIBRILLARY ACIDIC PROTEIN; OXIDOPAMINE; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

EID: 84878621998     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (59)

References (50)
  • 2
    • 0023740773 scopus 로고
    • Rate of cell death in parkinsonism indicates active neuropathological process
    • MCGEER PL, ITAGAKI S, AKIYAMA H, MCGEER EG. Rate of cell death in parkinsonism indicates active neuropathological process. Ann Neurol 1988; 24: 574-576.
    • (1988) Ann Neurol , vol.24 , pp. 574-576
    • McGeer, P.L.1    Itagaki, S.2    Akiyama, H.3    McGeer, E.G.4
  • 3
    • 0036522967 scopus 로고    scopus 로고
    • Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
    • WU DC, JACKSON-LEWIS V, VILA M, TIEU K, TEISMANN P, VADSETH C, CHOI DK, ISCHIROPOULOS H, PRZEDBORSKI S. Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci 2002; 22: 1763-1771.
    • (2002) J Neurosci , vol.22 , pp. 1763-1771
    • Dc, W.U.1    Jackson-Lewis, V.2    Vila, M.3    Tieu, K.4    Teismann, P.5    Vadseth, C.6    Choi, D.K.7    Ischiropoulos, H.8    Przedborski, S.9
  • 4
    • 0034520395 scopus 로고    scopus 로고
    • Inflammatory regulators in Parkinson's disease: INOS, lipocortin-1, and cyclooxygenases-1 and -2
    • KNOTT C, STERN G, WILKIN GP. Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and -2. Mol Cell Neurosci 2000; 16: 724-739.
    • (2000) Mol Cell Neurosci , vol.16 , pp. 724-739
    • Knott, C.1    Stern, G.2    Wilkin, G.P.3
  • 5
    • 0002606082 scopus 로고    scopus 로고
    • Reactive astrocytosis
    • Michael Aschner and Harold K. Kimelberg, editors. Boca Raton (FL): CRC Press
    • NORENBERG MD. Reactive astrocytosis. In: Michael Aschner and Harold K. Kimelberg, editors. The role of glia in neurotoxicity. Boca Raton (FL): CRC Press 1996; pp. 93-107.
    • (1996) The Role of Glia in Neurotoxicity , pp. 93-107
    • Norenberg, M.D.1
  • 6
    • 0036263210 scopus 로고    scopus 로고
    • Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats. Part II: Suppression of astrocytic activation by a novel agent (R)-(-)-2-propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early improvement of neurologic deficits
    • TATEISHI N, MORI T, KAGAMIISHI Y, SATOH S, KATSUBE N, MORIKAWA E, MORIMOTO T, MATSUI T, ASANO T. Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats. Part II: suppression of astrocytic activation by a novel agent (R)-(-)-2-propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early improvement of neurologic deficits. J Cereb Blood Flow Metab 2002; 22: 723-734.
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 723-734
    • Tateishi, N.1    Mori, T.2    Kagamiishi, Y.3    Satoh, S.4    Katsube, N.5    Morikawa, E.6    Morimoto, T.7    Matsui, T.8    Asano, T.9
  • 7
    • 0016652087 scopus 로고
    • Brain peroxidase and catalase in Parkinson disease
    • AMBANI LM, VAN WOERT MH, MURPHY S. Brain peroxidase and catalase in Parkinson disease. Arch Neurol 1975; 32: 114-118.
    • (1975) Arch Neurol , vol.32 , pp. 114-118
    • Ambani, L.M.1    Van Woert, M.H.2    Murphy, S.3
  • 9
    • 0026746512 scopus 로고
    • Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: A LAMMA study
    • GOOD PF, OLANOW CW, PERL DP. Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study. Brain Res 1992; 593: 343-346.
    • (1992) Brain Res , vol.593 , pp. 343-346
    • Good, P.F.1    Olanow, C.W.2    Perl, D.P.3
  • 10
    • 0020308323 scopus 로고
    • Parkinson's disease: A disorder due to nigral glutathione deficiency?
    • PERRY TL, GODIN DV, HANSEN S. Parkinson's disease: a disorder due to nigral glutathione deficiency? Neurosci Lett 1982; 33: 305-310.
    • (1982) Neurosci Lett , vol.33 , pp. 305-310
    • Perry, T.L.1    Godin, D.V.2    Hansen, S.3
  • 11
    • 4644360633 scopus 로고    scopus 로고
    • Oxidants, antioxidants and the ischemic brain
    • WARNER DS, SHENG H, BATINIC-HABERLE I. Oxidants, antioxidants and the ischemic brain. J Exp Biol 2004; 207: 3221-3231.
    • (2004) J Exp Biol , vol.207 , pp. 3221-3231
    • Warner, D.S.1    Sheng, H.2    Batinic-Haberle, I.3
  • 13
    • 0035914342 scopus 로고    scopus 로고
    • Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu,Zn-SOD in mitochondria
    • OKADO-MATSUMOTO A, FRIDOVICH I. Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu,Zn-SOD in mitochondria. J Biol Chem 2001; 276: 38388-38393.
    • (2001) J Biol Chem , vol.276 , pp. 38388-38393
    • Okado-Matsumoto, A.1    Fridovich, I.2
  • 14
    • 0031946038 scopus 로고    scopus 로고
    • Attenuation of 6- hydroxydopamine-induced dopaminergic nigrostriatal lesions in superoxide dismutase transgenic mice
    • ASANUMA M, HIRATA H, CADET JL. Attenuation of 6- hydroxydopamine-induced dopaminergic nigrostriatal lesions in superoxide dismutase transgenic mice. Neuroscience 1998; 85: 907-917.
    • (1998) Neuroscience , vol.85 , pp. 907-917
    • Asanuma, M.1    Hirata, H.2    Cadet, J.L.3
  • 15
    • 0026583465 scopus 로고
    • E, EPSTEIN CJ, CADET JL. Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced neurotoxicity
    • CARLSON
    • PRZEDBORSKI S, KOSTIC V, JACKSON-LEWIS V, NAINI AB, SIMONETTI S, FAHN S, CARLSON E, EPSTEIN CJ, CADET JL. Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced neurotoxicity. J Neurosci 1992; 12: 1658-1667.
    • (1992) J Neurosci , vol.12 , pp. 1658-1667
    • Przedborski, S.1    Kostic, V.2    Jackson-Lewis, V.3    Naini, A.B.4    Simonetti, S.5    Fahn, S.6
  • 16
    • 0033969953 scopus 로고    scopus 로고
    • Enhanced N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in mice deficient in CuZn-superoxide dismutase or glutathione peroxidase
    • ZHANG J, GRAHAM DG, MONTINE TJ, HO YS. Enhanced N-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine toxicity in mice deficient in CuZn-superoxide dismutase or glutathione peroxidase. J Neuropathol Exp Neurol 2000; 59: 53-61.
    • (2000) J Neuropathol Exp Neurol , vol.59 , pp. 53-61
    • Zhang, J.1    Graham, D.G.2    Montine, T.J.3    Ho, Y.S.4
  • 17
    • 0035686083 scopus 로고    scopus 로고
    • Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology
    • FRAUTSCHY SA, HU W, KIM P, MILLER SA, CHU T, HARRISWHITE ME, COLE GM. Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol Aging 2001; 22: 993-1005.
    • (2001) Neurobiol Aging , vol.22 , pp. 993-1005
    • Frautschy, S.A.1    Hu, W.2    Kim, P.3    Miller, S.A.4    Chu, T.5    Harriswhite, M.E.6    Cole, G.M.7
  • 18
    • 0346850976 scopus 로고    scopus 로고
    • Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats
    • THIYAGARAJAN M, SHARMA SS. Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats. Life Sci 2004; 74: 969-985.
    • (2004) Life Sci , vol.74 , pp. 969-985
    • Thiyagarajan, M.1    Sharma, S.S.2
  • 19
    • 30444450708 scopus 로고    scopus 로고
    • Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition
    • WU A, YING Z, GOMEZ-PINILLA F. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition. Exp Neurol 2006; 197: 309-317.
    • (2006) Exp Neurol , vol.197 , pp. 309-317
    • Wu, A.1    Ying, Z.2    Gomez-Pinilla, F.3
  • 20
    • 84859395842 scopus 로고    scopus 로고
    • Curcumin protects nigrostriatal dopaminergic neurons and reduces glial activation in 6-hydroxydopamine hemiparkinsonian mice model
    • TRIPANICHKUL W, JAROENSUPPAPERCH EO. Curcumin protects nigrostriatal dopaminergic neurons and reduces glial activation in 6-hydroxydopamine hemiparkinsonian mice model. Int J Neurosci 2012; 122: 263-270.
    • (2012) Int J Neurosci , vol.122 , pp. 263-270
    • Tripanichkul, W.1    Jaroensuppaperch, E.O.2
  • 22
    • 25444508963 scopus 로고    scopus 로고
    • Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease
    • ZBARSKY V, DATLA KP, PARKAR S, RAI DK, ARUOMA OI, DEXTER DT. Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease. Free Radic Res 2005; 39: 1119-1125.
    • (2005) Free Radic Res , vol.39 , pp. 1119-1125
    • Zbarsky, V.1    Datla, K.P.2    Parkar, S.3    Rai, D.K.4    Aruoma, O.I.5    Dexter, D.T.6
  • 24
    • 65649105139 scopus 로고    scopus 로고
    • Curcumin attenuates 6-hydroxydopamine-induced cytotoxicity by anti-oxidation and nuclear factor-kappa B modulation in MES23.5 cells
    • WANG J, DU XX, JIANG H, XIE JX. Curcumin attenuates 6-hydroxydopamine- induced cytotoxicity by anti-oxidation and nuclear factor-kappa B modulation in MES23.5 cells. Biochem Pharmacol 2009; 78: 178-183.
    • (2009) Biochem Pharmacol , vol.78 , pp. 178-183
    • Wang, J.1    Du, X.X.2    Jiang, H.3    Xie, J.X.4
  • 25
    • 77949532182 scopus 로고    scopus 로고
    • Curcumin prevents dopaminergic neuronal death through inhibition of the c-Jun N-terminal kinase pathway
    • YU S, ZHENG W, XIN N, CHI ZH, WANG NQ, NIE YX, FENG WY, WANG ZY. Curcumin prevents dopaminergic neuronal death through inhibition of the c-Jun N-terminal kinase pathway. Rejuvenation Res 2010; 13: 55-64.
    • (2010) Rejuvenation Res , vol.13 , pp. 55-64
    • Yu, S.1    Zheng, W.2    Xin, N.3    Chi, Z.H.4    Wang, N.Q.5    Nie, Y.X.6    Feng, W.Y.7    Wang, Z.Y.8
  • 26
    • 33745056543 scopus 로고    scopus 로고
    • Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway
    • CHEN J, TANG XQ, ZHI JL, CUI Y, YU HM, TANG EH, SUN SN, FENG JQ, CHEN PX. Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway. Apoptosis 2006; 11: 943-953.
    • (2006) Apoptosis , vol.11 , pp. 943-953
    • Chen, J.1    Tang, X.Q.2    Zhi, J.L.3    Cui, Y.4    Yu, H.M.5    Tang, E.H.6    Sun, S.N.7    Feng, J.Q.8    Chen, P.X.9
  • 27
    • 0026054746 scopus 로고
    • Lesion of the rat entorhinal cortex leads to a rapid microglial reaction in the dentate gyrus. A light and electron microscopical study
    • GEHRMANN J, SCHOEN SW, KREUTZBERG GW. Lesion of the rat entorhinal cortex leads to a rapid microglial reaction in the dentate gyrus. A light and electron microscopical study. Acta Neuropathol 1991; 82: 442-455.
    • (1991) Acta Neuropathol , vol.82 , pp. 442-455
    • Gehrmann, J.1    Schoen, S.W.2    Kreutzberg, G.W.3
  • 28
    • 0028323342 scopus 로고
    • Microglial and astroglial reactions to anterograde axonal degeneration: A histochemical and immunocytochemical study of the adult rat fascia dentata after entorhinal perforant path lesions
    • JENSEN MB, GONZALEZ B, CASTELLANO B, ZIMMER J. Microglial and astroglial reactions to anterograde axonal degeneration: a histochemical and immunocytochemical study of the adult rat fascia dentata after entorhinal perforant path lesions. Exp Brain Res 1994; 98: 245-260.
    • (1994) Exp Brain Res , vol.98 , pp. 245-260
    • Jensen, M.B.1    Gonzalez, B.2    Castellano, B.3    Zimmer, J.4
  • 29
    • 0027500819 scopus 로고
    • Alterations in striatal glial fibrillary acidic protein expression in response to 6-hydroxydopamine-induced denervation
    • SHENG JG, SHIRABE S, NISHIYAMA N, SCHWARTZ JP. Alterations in striatal glial fibrillary acidic protein expression in response to 6-hydroxydopamine- induced denervation. Exp Brain Res 1993; 95: 450-456.
    • (1993) Exp Brain Res , vol.95 , pp. 450-456
    • Sheng, J.G.1    Shirabe, S.2    Nishiyama, N.3    Schwartz, J.P.4
  • 30
    • 0024281211 scopus 로고
    • Response of endogenous glial cells to motor neuron degeneration induced by toxic ricin
    • STREIT WJ, KREUTZBERG GW. Response of endogenous glial cells to motor neuron degeneration induced by toxic ricin. J Comp Neurol 1988; 268: 248-263.
    • (1988) J Comp Neurol , vol.268 , pp. 248-263
    • Streit, W.J.1    Kreutzberg, G.W.2
  • 31
    • 0035800589 scopus 로고    scopus 로고
    • Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum
    • HE Y, APPEL S, LE W. Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum. Brain Res 2001; 909: 187-193.
    • (2001) Brain Res , vol.909 , pp. 187-193
    • He, Y.1    Appel, S.2    Le, W.3
  • 33
    • 0031470830 scopus 로고    scopus 로고
    • Expression of TNF and TNF receptors (p55 and p75) in the rat brain after focal cerebral ischemia
    • BOTCHKINA GI, MEISTRELL ME, 3RD, BOTCHKINA IL, TRACEY KJ. Expression of TNF and TNF receptors (p55 and p75) in the rat brain after focal cerebral ischemia. Mol Med 1997; 3: 765-781.
    • (1997) Mol Med , vol.3 , pp. 765-781
    • Botchkina, G.I.1    Meistrell III, M.E.2    Botchkina, I.L.3    Tracey, K.J.4
  • 34
    • 0035083678 scopus 로고    scopus 로고
    • Astrocytes produce and release interleukin-1, interleukin-6, tumor necrosis factor alpha and interferon-gamma following traumatic and metabolic injury
    • LAU LT, YU AC. Astrocytes produce and release interleukin-1, interleukin-6, tumor necrosis factor alpha and interferon-gamma following traumatic and metabolic injury. J Neurotrauma 2001; 18: 351-359.
    • (2001) J Neurotrauma , vol.18 , pp. 351-359
    • Lau, L.T.1    Yu, A.C.2
  • 35
    • 0344141389 scopus 로고    scopus 로고
    • Prolonged and concomitant induction of astroglial immunoreactivity of interleukin-1beta and interleukin-6 in the rat hippocampus after transient global ischemia
    • ORZYLOWSKA O, ODERFELD-NOWAK B, ZAREMBA M, JANUSZEWSKI S, MOSSAKOWSKI M. Prolonged and concomitant induction of astroglial immunoreactivity of interleukin-1beta and interleukin-6 in the rat hippocampus after transient global ischemia. Neurosci Lett 1999; 263: 72-76.
    • (1999) Neurosci Lett , vol.263 , pp. 72-76
    • Orzylowska, O.1    Oderfeld-Nowak, B.2    Zaremba, M.3    Januszewski, S.4    Mossakowski, M.5
  • 37
    • 79952485690 scopus 로고    scopus 로고
    • Curcumin provides neuroprotection after spinal cord injury
    • LIN MS, LEE YH, CHIU WT, HUNG KS. Curcumin Provides Neuroprotection After Spinal Cord Injury. J Surg Res 2009; 166: 280-289.
    • (2009) J Surg Res , vol.166 , pp. 280-289
    • Lin, M.S.1    Lee, Y.H.2    Chiu, W.T.3    Hung, K.S.4
  • 38
    • 51749116969 scopus 로고    scopus 로고
    • Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture
    • YANG S, ZHANG D, YANG Z, HU X, QIAN S, LIU J, WILSON B, BLOCK M, HONG JS. Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture. Neurochem Res 2008; 33: 2044-2053.
    • (2008) Neurochem Res , vol.33 , pp. 2044-2053
    • Yang, S.1    Zhang, D.2    Yang, Z.3    Hu, X.4    Qian, S.5    Liu, J.6    Wilson, B.7    Block, M.8    Hong, J.S.9
  • 39
    • 54249119100 scopus 로고    scopus 로고
    • Comparison of inhibitory potency of three different curcuminoid pigments on nitric oxide and tumor necrosis factor production of rat primary microglia induced by lipopolysaccharide
    • ZHANG LJ, WU CF, MENG XL, YUAN D, CAI XD, WANG QL, YANG JY. Comparison of inhibitory potency of three different curcuminoid pigments on nitric oxide and tumor necrosis factor production of rat primary microglia induced by lipopolysaccharide. Neurosci Lett 2008; 447: 48-53.
    • (2008) Neurosci Lett , vol.447 , pp. 48-53
    • Zhang, L.J.1    Wu, C.F.2    Meng, X.L.3    Yuan, D.4    Cai, X.D.5    Wang, Q.L.6    Yang, J.Y.7
  • 40
    • 33746519193 scopus 로고    scopus 로고
    • Protective effects of ethanolic extract of Delphinium denudatum in a rat model of Parkinson's disease
    • AHMAD M, YOUSUF S, KHAN MB, AHMAD AS, SALEEM S, HODA MN, ISLAM F. Protective effects of ethanolic extract of Delphinium denudatum in a rat model of Parkinson's disease. Hum Exp Toxicol 2006; 25: 361-368.
    • (2006) Hum Exp Toxicol , vol.25 , pp. 361-368
    • Ahmad, M.1    Yousuf, S.2    Khan, M.B.3    Ahmad, A.S.4    Saleem, S.5    Hoda, M.N.6    Islam, F.7
  • 42
    • 0028916715 scopus 로고
    • Free radical-generated neurotoxicity of 6-hydroxydopamine
    • KUMAR R, AGARWAL AK, SETH PK. Free radical-generated neurotoxicity of 6-hydroxydopamine. J Neurochem 1995; 64: 1703-1707.
    • (1995) J Neurochem , vol.64 , pp. 1703-1707
    • Kumar, R.1    Agarwal, A.K.2    Seth, P.K.3
  • 43
    • 0035856862 scopus 로고    scopus 로고
    • 6-Hydroxydopaminelesioning of the nigrostriatal pathway in rats alters basal ganglia mRNA for copper, zinc- and manganese-superoxide dismutase, but not glutathione peroxidase
    • KUNIKOWSKA G, JENNER P. 6-Hydroxydopaminelesioning of the nigrostriatal pathway in rats alters basal ganglia mRNA for copper, zinc- and manganese-superoxide dismutase, but not glutathione peroxidase. Brain Res 2001; 922: 51-64.
    • (2001) Brain Res , vol.922 , pp. 51-64
    • Kunikowska, G.1    Jenner, P.2
  • 44
    • 0026446062 scopus 로고
    • Vitamin e attenuates the toxic effects of 6-hydroxydopamine on free radical scavenging systems in rat brain
    • PERUMAL AS, GOPAL VB, TORDZRO WK, COOPER TB, CADET JL. Vitamin E attenuates the toxic effects of 6-hydroxydopamine on free radical scavenging systems in rat brain. Brain Res Bull 1992; 29: 699-701.
    • (1992) Brain Res Bull , vol.29 , pp. 699-701
    • Perumal, A.S.1    Gopal, V.B.2    Tordzro, W.K.3    Cooper, T.B.4    Cadet, J.L.5
  • 45
    • 5544229693 scopus 로고    scopus 로고
    • Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP
    • SCHOBER A. Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP. Cell Tissue Res 2004; 318: 215-224.
    • (2004) Cell Tissue Res , vol.318 , pp. 215-224
    • Schober, A.1
  • 46
    • 20444471551 scopus 로고    scopus 로고
    • Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype
    • THIRUCHELVAM M, PROKOPENKO O, CORY-SLECHTA DA, BUCKLEY B, MIROCHNITCHENKO O. Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype. J Biol Chem 2005; 280: 22530-22539.
    • (2005) J Biol Chem , vol.280 , pp. 22530-22539
    • Thiruchelvam, M.1    Prokopenko, O.2    Cory-Slechta, D.A.3    Buckley, B.4    Mirochnitchenko, O.5
  • 47
    • 0035503597 scopus 로고    scopus 로고
    • The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    • LIM GP, CHU T, YANG F, BEECH W, FRAUTSCHY SA, COLE GM. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 2001; 21: 8370-8377.
    • (2001) J Neurosci , vol.21 , pp. 8370-8377
    • Lim, G.P.1    Chu, T.2    Yang, F.3    Beech, W.4    Frautschy, S.A.5    Cole, G.M.6
  • 50
    • 33745067467 scopus 로고    scopus 로고
    • Immediate and delayed treatments with curcumin prevents forebrain ischemia-induced neuronal damage and oxidative insult in the rat hippocampus
    • AL-OMAR FA, NAGI MN, ABDULGADIR MM, AL JONI KS, AL-MAJED AA. Immediate and delayed treatments with curcumin prevents forebrain ischemia-induced neuronal damage and oxidative insult in the rat hippocampus. Neurochem Res 2006; 31: 611-618.
    • (2006) Neurochem Res , vol.31 , pp. 611-618
    • Al-Omar, F.A.1    Nagi, M.N.2    Abdulgadir, M.M.3    Al Joni, K.S.4    Al-Majed, A.A.5


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