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Volumn 9, Issue 2, 2014, Pages 85-100

Pharmacological approaches to targeting muscarinic acetylcholine receptors

Author keywords

Bitopic ligands; Multiple sclerosis; Muscarinic receptors; Neurological diseases; Nociception; Tumors

Indexed keywords

ACETYLCHOLINE; DARIFENACIN; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; NEUROTRANSMITTER; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; US5096890; US6106864;

EID: 84919771055     PISSN: 15748898     EISSN: 22123954     Source Type: Journal    
DOI: 10.2174/1574889809666141120131238     Document Type: Article
Times cited : (30)

References (152)
  • 2
    • 0027007991 scopus 로고
    • Characterization of the Ca2 + influx into embryonic cells after stimulation of the embryonic muscarinic receptors
    • Oettling G, Götz U, Drews U. Characterization of the Ca2 + influx into embryonic cells after stimulation of the embryonic muscarinic receptors. J Dev Physiol 1992; 17: 147-55.
    • (1992) J Dev Physiol , vol.17 , pp. 147-155
    • Oettling, G.1    Götz, U.2    Drews, U.3
  • 3
    • 0029860131 scopus 로고    scopus 로고
    • From oocytes to neuron: Do neurotransmitters function in the same way throughout development
    • Buzanikov GA, Shumukler YB, Lauder JM. From oocytes to neuron: do neurotransmitters function in the same way throughout development. Cell Mol Neurobiol 1996; 16: 533-59.
    • (1996) Cell Mol Neurobiol , vol.16 , pp. 533-559
    • Buzanikov, G.A.1    Shumukler, Y.B.2    Lauder, J.M.3
  • 4
    • 33744924761 scopus 로고    scopus 로고
    • Adrenergic and cholinergic control in the biology of epidermis: Physiological and clinical Significance
    • Grando SA, Pittelkow MR, Schellreunter KU. Adrenergic and cholinergic control in the biology of epidermis: physiological and clinical Significance. J Invest Dermatol 2006; 126: 1948-65.
    • (2006) J Invest Dermatol , vol.126 , pp. 1948-1965
    • Grando, S.A.1    Pittelkow, M.R.2    Schellreunter, K.U.3
  • 5
    • 23144441616 scopus 로고    scopus 로고
    • Expression of non neuronal acetylcholine in lymphocytes and its contributionof immune function
    • Kawashima K, Fuji T. Expression of non neuronal acetylcholine in lymphocytes and its contributionof immune function. Front Biosci 2004; 9 (suppl): 2063-85.
    • (2004) Front Biosci , vol.9 , pp. 2063-2085
    • Kawashima, K.1    Fuji, T.2
  • 6
    • 2042443069 scopus 로고    scopus 로고
    • Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells
    • Proskocil BJ, Harmanjatinder SS, Yibing J, Savchenk V, Blakely RD, Lindstrom J, et al. Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells. Endocrinol 2004; 145: 2498-506.
    • (2004) Endocrinol , vol.145 , pp. 2498-2506
    • Proskocil, B.J.1    Harmanjatinder, S.S.2    Yibing, J.3    Savchenk, V.4    Blakely, R.D.5    Lindstrom, J.6
  • 7
    • 0002687960 scopus 로고
    • Identification of acetylcholine and related esters of biological origin
    • Eichler O, Farah A, Koelle GB Eds. B, Heidelberg: New York Springer
    • Whittacher VP. Identification of acetylcholine and related esters of biological origin. In Eichler O, Farah A, Koelle GB Eds. Handbuch der Experimentellen Pharmakologie. B, Heidelberg: New York Springer 1963: 1-39.
    • (1963) Handbuch der Experimentellen Pharmakologie , pp. 1-39
    • Whittacher, V.P.1
  • 8
    • 0037470640 scopus 로고    scopus 로고
    • The non-neuronal cholinergic system in humans: Expression, function and pathophysiology
    • Wessler I, Kilbinger H, Bittinger F, Unger R, Kirkpatrick CJ. The non-neuronal cholinergic system in humans: Expression, function and pathophysiology. Life Sci 2003; 72: 2055-61.
    • (2003) Life Sci , vol.72 , pp. 2055-2061
    • Wessler, I.1    Kilbinger, H.2    Bittinger, F.3    Unger, R.4    Kirkpatrick, C.J.5
  • 9
    • 3342913105 scopus 로고    scopus 로고
    • Signalling cascades implicated in muscarinic regulation of proliferation of neural stem and progenitor cells
    • Ma W, Li BS, Zhang L, Pant H. Signalling cascades implicated in muscarinic regulation of proliferation of neural stem and progenitor cells. Drug News Perspect 2004; 17: 258-66.
    • (2004) Drug News Perspect , vol.17 , pp. 258-266
    • Ma, W.1    Li, B.S.2    Zhang, L.3    Pant, H.4
  • 10
    • 0842327743 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptors involved in the regulation of neural stem cell proliferation and differentiation in vitro
    • Zhou C, Wen ZX, Shi DM, Xie ZP. Muscarinic acetylcholine receptors involved in the regulation of neural stem cell proliferation and differentiation in vitro. Cell Biol Inter 2004; 28: 63-67.
    • (2004) Cell Biol Inter , vol.28 , pp. 63-67
    • Zhou, C.1    Wen, Z.X.2    Shi, D.M.3    Xie, Z.P.4
  • 11
    • 33845948153 scopus 로고    scopus 로고
    • Acetylcholine and regulation of gene expression in developing systems
    • Augusti-Tocco G, Biagioni S, Tata AM. Acetylcholine and regulation of gene expression in developing systems. J Mol Neurosci 2006; 30: 45-47.
    • (2006) J Mol Neurosci , vol.30 , pp. 45-47
    • Augusti-Tocco, G.1    Biagioni, S.2    Tata, A.M.3
  • 12
    • 70349787112 scopus 로고    scopus 로고
    • Novel pharmacological approaches to Schwann cells as neuroprotective agents for peripheral nerve regeneration
    • Magnaghi V, Procacci P, Tata AM. Novel pharmacological approaches to Schwann cells as neuroprotective agents for peripheral nerve regeneration. Int Rev Neurobiol 2009; 87: 295-315.
    • (2009) Int Rev Neurobiol , vol.87 , pp. 295-315
    • Magnaghi, V.1    Procacci, P.2    Tata, A.M.3
  • 13
    • 46749115525 scopus 로고    scopus 로고
    • Acetylcholine inhibits cell cycle progression in rat Schwann cells by activation of M2 receptor subtype
    • Loreti S, Ricordy R, De Stefano ME, Augusti-Tocco G, Tata AM. Acetylcholine inhibits cell cycle progression in rat Schwann cells by activation of M2 receptor subtype. Neuron Glia Biol 2007; 3: 269-79.
    • (2007) Neuron Glia Biol , vol.3 , pp. 269-279
    • Loreti, S.1    Ricordy, R.2    De Stefano, M.E.3    Augusti-Tocco, G.4    Tata, A.M.5
  • 14
    • 84859492260 scopus 로고    scopus 로고
    • Muscarinic receptor subtypes as potential targets to modulate oligodendrocyte progenitor survival, proliferation and differentiation
    • De Angelis F, Bernardo A, Magnaghi V, Minghetti L, Tata AM. Muscarinic receptor subtypes as potential targets to modulate oligodendrocyte progenitor survival, proliferation and differentiation. Dev Neurobiol 2012; 72: 713-28.
    • (2012) Dev Neurobiol , vol.72 , pp. 713-728
    • De Angelis, F.1    Bernardo, A.2    Magnaghi, V.3    Minghetti, L.4    Tata, A.M.5
  • 15
    • 70349816648 scopus 로고    scopus 로고
    • The neurology of the immune system: Neural reflexes regulate immunity
    • Rosas-Ballina M, Tracey KJ. The neurology of the immune system: neural reflexes regulate immunity. Neuron 2009; 64: 28-32.
    • (2009) Neuron , vol.64 , pp. 28-32
    • Rosas-Ballina, M.1    Tracey, K.J.2
  • 16
    • 0034104866 scopus 로고    scopus 로고
    • Extraneuronal cholinergic system in lymphocytes
    • Kawashima K, Fujii T. Extraneuronal cholinergic system in lymphocytes. Pharmacol Ther 2000; 86: 29-48.
    • (2000) Pharmacol Ther , vol.86 , pp. 29-48
    • Kawashima, K.1    Fujii, T.2
  • 17
    • 84867835356 scopus 로고    scopus 로고
    • Relation between pro-inflammatory cytokines and acetylcholine levels in relapsing-remitting multiple sclerosis patients
    • Reale M, De Angelis F, Di Nicola M, Capello E, di Ioia M, De Luca G, et al. Relation between pro-inflammatory cytokines and acetylcholine levels in relapsing-remitting multiple sclerosis patients. Int J Mol Sci 2012; 13: 12656-664.
    • (2012) Int J Mol Sci , vol.13 , pp. 12656-12664
    • Reale, M.1    De Angelis, F.2    Di Nicola, M.3    Capello, E.4    Di Ioia, M.5    De Luca, G.6
  • 18
    • 18144395496 scopus 로고    scopus 로고
    • Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures
    • De Simone R, Ajmone-Cat Ma, Carnevale D, Minghetti L. Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures. J Neuroinflamm 2005; 25: 1-10.
    • (2005) J Neuroinflamm , vol.25 , pp. 1-10
    • De Simone, R.1    Ajmone-Cat Ma Carnevale, D.2    Minghetti, L.3
  • 19
    • 0027465882 scopus 로고
    • Immunological localization of m1-m5 muscarinic receptor subtypes in peripheral tissues and brain
    • Levey AI. Immunological localization of m1-m5 muscarinic receptor subtypes in peripheral tissues and brain. Life Sci 1993; 52: 441-48.
    • (1993) Life Sci , vol.52 , pp. 441-448
    • Levey, A.I.1
  • 20
    • 0035016227 scopus 로고    scopus 로고
    • Pharmacological and functional characterization of muscarinic receptor subtypes in developing oligodendrocytes
    • Ragheb F, Molina-Holgado E, Cui QL, Khorchid A, Liu HN, Larocca JN, et al. Pharmacological and functional characterization of muscarinic receptor subtypes in developing oligodendrocytes. J Neurochem 2001; 77: 1396-406.
    • (2001) J Neurochem , vol.77 , pp. 1396-1406
    • Ragheb, F.1    Molina-Holgado, E.2    Cui, Q.L.3    Khorchid, A.4    Liu, H.N.5    Larocca, J.N.6
  • 22
    • 0031774720 scopus 로고    scopus 로고
    • International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors
    • Caufield MP, Birdsall NJM. International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev 1998; 50: 279-90.
    • (1998) Pharmacol Rev , vol.50 , pp. 279-290
    • Caufield, M.P.1    Birdsall, N.J.M.2
  • 23
    • 9044229994 scopus 로고
    • Subtypes of muscarinic receptors. Proceedings of the 4th international symposium on subtypes of muscarinic receptors
    • Levine RR, Birdsall NJM. Subtypes of muscarinic receptors. Proceedings of the 4th international symposium on subtypes of muscarinic receptors. Trends Pharmacol Sci 1989; 10(suppl): S1-s119.
    • (1989) Trends Pharmacol Sci , vol.10 , pp. S1-s119
    • Levine, R.R.1    Birdsall, N.J.M.2
  • 25
    • 0023661365 scopus 로고
    • Distint primary structures, ligand binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors
    • Peralta EG, Ashkenazi A, Winslow JW, Smith DH, Ramachandran J, Capon DJ. Distint primary structures, ligand binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. EMBO J 1987; 6: 3923-29.
    • (1987) EMBO J , vol.6 , pp. 3923-3929
    • Peralta, E.G.1    Ashkenazi, A.2    Winslow, J.W.3    Smith, D.H.4    Ramachandran, J.5    Capon, D.J.6
  • 26
    • 0027208248 scopus 로고
    • Muscarinic receptors: Characterization, coupling and function
    • Caufield MP. Muscarinic receptors: characterization, coupling and function. Pharmacol Ther 1993; 58: 319-79.
    • (1993) Pharmacol Ther , vol.58 , pp. 319-379
    • Caufield, M.P.1
  • 27
    • 0001130441 scopus 로고
    • Acetylcholine
    • Siegel GJ, Agranoff BW, Albers RW, Molinoff PB. Raven Press
    • Taylor P, Brown JH. Acetylcholine. In: Siegel GJ, Agranoff BW, Albers RW, Molinoff PB. Basic Neurochemistry. Raven Press 1994.
    • (1994) Basic Neurochemistry
    • Taylor, P.1    Brown, J.H.2
  • 28
    • 0028237231 scopus 로고
    • Muscarinic cholinergic agonists stimulate arachidonic acid release from mouse striatal neurons in primary culture
    • Tence M, Cordier J, Premont J, Glowinski J. Muscarinic cholinergic agonists stimulate arachidonic acid release from mouse striatal neurons in primary culture. J Pharmacol Exp Ther 1994; 269: 646-53.
    • (1994) J Pharmacol Exp Ther , vol.269 , pp. 646-653
    • Tence, M.1    Cordier, J.2    Premont, J.3    Glowinski, J.4
  • 29
    • 3042992785 scopus 로고
    • Stimulation of arachidonic acid release and inhibitionof mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells
    • Conklin BR, Brann MR, Buckley MJM, Bonner IT, Axelrod J. Stimulation of arachidonic acid release and inhibitionof mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells. Proc Natl Acad Sci USA 1988; 85: 8698-702.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 8698-8702
    • Conklin, B.R.1    Brann, M.R.2    Buckley, M.J.M.3    Bonner, I.T.4    Axelrod, J.5
  • 30
    • 0037406701 scopus 로고    scopus 로고
    • Regulation of muscarinic acetylcholine receptor signalling
    • Van Koppen CJ, Kaiser B. Regulation of muscarinic acetylcholine receptor signalling. Pharmacol Ther 2003; 98: 197-220.
    • (2003) Pharmacol Ther , vol.98 , pp. 197-220
    • Van Koppen, C.J.1    Kaiser, B.2
  • 31
    • 33644643568 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptors mediate survival through Src-like tyrosine kinase and PI3K/Akt pathways
    • Cui QL, Fogle E, Almazan G. Muscarinic acetylcholine receptors mediate survival through Src-like tyrosine kinase and PI3K/Akt pathways. Neurochem Int 2006; 48: 383-93.
    • (2006) Neurochem Int , vol.48 , pp. 383-393
    • Cui, Q.L.1    Fogle, E.2    Almazan, G.3
  • 33
    • 34548362105 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptors: Mutant mice provide new insights for drug development
    • Wess J, Eglen RM, Gautam D. Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nat Rev Drug Discov 2007; 6: 721-33.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 721-733
    • Wess, J.1    Eglen, R.M.2    Gautam, D.3
  • 34
    • 55649119507 scopus 로고
    • Modification of the binding properties of muscarinic receptors by gallamine
    • Stockton JM, Birdsall NJM, Burgen AS, Hulme EC. Modification of the binding properties of muscarinic receptors by gallamine. Mol Pharmacol 1983; 44: 102-10.
    • (1983) Mol Pharmacol , vol.44 , pp. 102-110
    • Stockton, J.M.1    Birdsall, N.J.M.2    Burgen, A.S.3    Hulme, E.C.4
  • 35
    • 55649124467 scopus 로고
    • Allosteric regulation of cloned m1-m5 muscarinic receptor subtypes
    • Ellis J, Seidenberg M, Brann MR. Allosteric regulation of cloned m1-m5 muscarinic receptor subtypes. Biochem Pharmacol 1993; 42: 199-205.
    • (1993) Biochem Pharmacol , vol.42 , pp. 199-205
    • Ellis, J.1    Seidenberg, M.2    Brann, M.R.3
  • 36
    • 0030902106 scopus 로고    scopus 로고
    • Selective allosteric enhancement of the binding and actions of acetylcholine at muscarinic receptor subtypes
    • Birdsall NJM, Farries T, Gharagozloo P, Kobayashi S, Kuonen D, Lazareno S, et al. Selective allosteric enhancement of the binding and actions of acetylcholine at muscarinic receptor subtypes. Life Sci 1997; 60: 1047-52.
    • (1997) Life Sci , vol.60 , pp. 1047-1052
    • Birdsall, N.J.M.1    Farries, T.2    Gharagozloo, P.3    Kobayashi, S.4    Kuonen, D.5    Lazareno, S.6
  • 37
    • 33845948922 scopus 로고    scopus 로고
    • Allosteric modulators and selective agonists of muscarinic receptors
    • Holzgrabe U, De Amici M, Mohr K. Allosteric modulators and selective agonists of muscarinic receptors. J Mol Neurosci 2006; 30(1-2): 165-68.
    • (2006) J Mol Neurosci , vol.30 , Issue.1-2 , pp. 165-168
    • Holzgrabe, U.1    De Amici, M.2    Mohr, K.3
  • 38
    • 0032497593 scopus 로고    scopus 로고
    • Universal template approach to drug design: Polyamines as selective muscarinic receptor antagonists
    • Bolognesi ML, Minarini A, Budriesi R, Cacciaguerra S, Chiarini A, Spampinato S, et al. Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists. J Med Chem 1998; 41: 4150-60.
    • (1998) J Med Chem , vol.41 , pp. 4150-4160
    • Bolognesi, M.L.1    Minarini, A.2    Budriesi, R.3    Cacciaguerra, S.4    Chiarini, A.5    Spampinato, S.6
  • 39
    • 0026805538 scopus 로고
    • Two polypeptides from Dendroaspis angusticeps venom selectivity inhibit the binding of central muscarinic cholinergic receptor ligands
    • Jerulinsky D, Cervenansky C, Pena C, Raskovsky S, Dajas F. Two polypeptides from Dendroaspis angusticeps venom selectivity inhibit the binding of central muscarinic cholinergic receptor ligands. Neurochem Int 1992; 20: 237-46.
    • (1992) Neurochem Int , vol.20 , pp. 237-246
    • Jerulinsky, D.1    Cervenansky, C.2    Pena, C.3    Raskovsky, S.4    Dajas, F.5
  • 40
    • 0027485462 scopus 로고
    • Purification and properties of m1-toxin, a specific antagonist of m1 muscarinic receptors
    • Max SI, Liang JS, Potter LT. Purification and properties of m1-toxin, a specific antagonist of m1 muscarinic receptors. J Neurosci 1993; 13: 4293-300.
    • (1993) J Neurosci , vol.13 , pp. 4293-4300
    • Max, S.I.1    Liang, J.S.2    Potter, L.T.3
  • 41
    • 8244240430 scopus 로고    scopus 로고
    • Pharmacology of butylthio [2. 2. 2] (LY297802/NNC11-1053): A novel analgesic with mixed muscarinic receptor agonist and antagonist activity
    • Shannon HE, Sheardown MJ, Bymaster FP, Calligaro DO, Delapp NW, Gidda J, et al. Pharmacology of butylthio [2. 2. 2] (LY297802/NNC11-1053): a novel analgesic with mixed muscarinic receptor agonist and antagonist activity. J Pharmacol Exp Ther 1997; 281: 884-94.
    • (1997) J Pharmacol Exp Ther , vol.281 , pp. 884-894
    • Shannon, H.E.1    Sheardown, M.J.2    Bymaster, F.P.3    Calligaro, D.O.4    Delapp, N.W.5    Gidda, J.6
  • 42
    • 84857375139 scopus 로고    scopus 로고
    • Allosteric modulation of seven transmembrane spanning receptors: Theory, practice, and opportunities for central nervous system drug discovery
    • Melancon BJ, Hopkins CR, Wood MR, Emmitte KA, Niswender CM, Christopoulos A, et al. Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery. J Med Chem 2012; 55: 1445-64.
    • (2012) J Med Chem , vol.55 , pp. 1445-1464
    • Melancon, B.J.1    Hopkins, C.R.2    Wood, M.R.3    Emmitte, K.A.4    Niswender, C.M.5    Christopoulos, A.6
  • 44
    • 0034676312 scopus 로고    scopus 로고
    • Therapeutic opportunities for muscarinic receptors in central nervous system
    • Felder CC, Bymaster FP, Ward J, Delapp N. Therapeutic opportunities for muscarinic receptors in central nervous system. J Med Chem 2000; 43: 4333-53.
    • (2000) J Med Chem , vol.43 , pp. 4333-4353
    • Felder, C.C.1    Bymaster, F.P.2    Ward, J.3    Delapp, N.4
  • 45
    • 2342444247 scopus 로고    scopus 로고
    • Anti-muscarinic for the treatment of overactive bladder: Current options and emerging therapies
    • Hedge SS, Mammen M, Jasper JR. Anti-muscarinic for the treatment of overactive bladder: current options and emerging therapies. Curr Opin Inv Drugs 2004; 5: 40-49.
    • (2004) Curr Opin Inv Drugs , vol.5 , pp. 40-49
    • Hedge, S.S.1    Mammen, M.2    Jasper, J.R.3
  • 46
    • 33745168973 scopus 로고    scopus 로고
    • Muscarinic receptor subtypes in neuronal and nonneuronal cholinergic function
    • Eglen RM. Muscarinic receptor subtypes in neuronal and nonneuronal cholinergic function. Autonomic Autocoid Pharmacol 2005; 26: 219-33.
    • (2005) Autonomic Autocoid Pharmacol , vol.26 , pp. 219-233
    • Eglen, R.M.1
  • 47
    • 0031918465 scopus 로고    scopus 로고
    • Tolterodine: A new muscarinic receptor antagonist, is metabolized by cytochrome P4502D6 and 3A4 in human liver microsomes
    • Postlind H, Danielson A, Lindgren A, Andersson SH. Tolterodine: a new muscarinic receptor antagonist, is metabolized by cytochrome P4502D6 and 3A4 in human liver microsomes. Drug Metab Dispos 1998; 26: 289-93.
    • (1998) Drug Metab Dispos , vol.26 , pp. 289-293
    • Postlind, H.1    Danielson, A.2    Lindgren, A.3    Andersson, S.H.4
  • 48
    • 48049117725 scopus 로고    scopus 로고
    • Fesoterodine: A novel muscarinic receptor antagonist for the treatment of overactive blabber syndrome
    • Michel MC. Fesoterodine: a novel muscarinic receptor antagonist for the treatment of overactive blabber syndrome. Expert Opin Pharmacother 2008; 9: 1787-96.
    • (2008) Expert Opin Pharmacother , vol.9 , pp. 1787-1796
    • Michel, M.C.1
  • 50
    • 29344471478 scopus 로고    scopus 로고
    • Characterization of muscarinic receptor binding and inhibition of salivation after oral administration of tolterodine in mice
    • Oki T, Maruyama S, Takagi Y, Yamamura HI, Yamada S. Characterization of muscarinic receptor binding and inhibition of salivation after oral administration of tolterodine in mice. Europ J Pharmacol 2006; 529: 157-63.
    • (2006) Europ J Pharmacol , vol.529 , pp. 157-163
    • Oki, T.1    Maruyama, S.2    Takagi, Y.3    Yamamura, H.I.4    Yamada, S.5
  • 52
    • 3042525451 scopus 로고    scopus 로고
    • The airway cholinergic system: Physiology and pharmacology
    • Racke K, Matthiesen S. The airway cholinergic system: physiology and pharmacology. Pulm Pharmacol Ther 2004; 17: 181-98.
    • (2004) Pulm Pharmacol Ther , vol.17 , pp. 181-198
    • Racke, K.1    Matthiesen, S.2
  • 53
    • 84897431084 scopus 로고    scopus 로고
    • The pharmacological rationale for combining muscarinic receptor antagonists and α-adrenoceptor agonists in the treatment of airway and bladder disease
    • Dale PR, Cernecka H, Schmidt M, Dowling MR, Charlton SJ, Pieper MO, et al. The pharmacological rationale for combining muscarinic receptor antagonists and α-adrenoceptor agonists in the treatment of airway and bladder disease. Curr Op Pharmacol 2014; 16: 31-42.
    • (2014) Curr Op Pharmacol , vol.16 , pp. 31-42
    • Dale, P.R.1    Cernecka, H.2    Schmidt, M.3    Dowling, M.R.4    Charlton, S.J.5    Pieper, M.O.6
  • 54
    • 4644353712 scopus 로고    scopus 로고
    • Tiotropium bromide: A review of its use as maintenance therapy in patients with COPD
    • Keam SJ, Keating GM. Tiotropium bromide: a review of its use as maintenance therapy in patients with COPD. Treat Resp Med 2004; 3: 247-68.
    • (2004) Treat Resp Med , vol.3 , pp. 247-268
    • Keam, S.J.1    Keating, G.M.2
  • 55
    • 0037315348 scopus 로고    scopus 로고
    • Sjogren's syndrome: Evolving therapies
    • Fox RI. Sjogren's syndrome: evolving therapies. Expert Opin Invest Drugs 2003; 12: 247-54.
    • (2003) Expert Opin Invest Drugs , vol.12 , pp. 247-254
    • Fox, R.I.1
  • 57
  • 80
    • 8244240430 scopus 로고    scopus 로고
    • Pharmacology of Butylthio [2. 2. 2](LY297802/NNC11-1053): A novel analgesic with mixed muscarinic receptor agonist and antagonist activity
    • Shannon HE, Sheardown JM, Bymaster FP, Calligaro DO, Delapp NW, Gidda J, et al. Pharmacology of Butylthio [2. 2. 2](LY297802/NNC11-1053): a novel analgesic with mixed muscarinic receptor agonist and antagonist activity. J Pharmacol Exp Ther 1997; 281: 884-94.
    • (1997) J Pharmacol Exp Ther , vol.281 , pp. 884-894
    • Shannon, H.E.1    Sheardown, J.M.2    Bymaster, F.P.3    Calligaro, D.O.4    Delapp, N.W.5    Gidda, J.6
  • 81
    • 84888040704 scopus 로고    scopus 로고
    • Development of allosteric modulators of GPCRs for treatment of CNS disorders
    • Nickols HH, Conn PJ. Development of allosteric modulators of GPCRs for treatment of CNS disorders. Neurobiol Dis 2014; 61: 55-71.
    • (2014) Neurobiol Dis , vol.61 , pp. 55-71
    • Nickols, H.H.1    Conn, P.J.2
  • 82
    • 84904500985 scopus 로고    scopus 로고
    • Scopolamine and depression: A role for muscarinic antagonism?
    • Hasselmann H. Scopolamine and depression: a role for muscarinic antagonism? CNS Neurol Disord Drug Targets 2014; 13: 673-83.
    • (2014) CNS Neurol Disord Drug Targets , vol.13 , pp. 673-683
    • Hasselmann, H.1
  • 83
    • 84878420520 scopus 로고    scopus 로고
    • Antidepressant effects of the muscarinic cholinergic receptor antagonist scopolamine: A review
    • Dreverts WC, Zarate CA, Furey ML. Antidepressant effects of the muscarinic cholinergic receptor antagonist scopolamine: a review. Biol Psich 2013; 73: 1156-63.
    • (2013) Biol Psich , vol.73 , pp. 1156-1163
    • Dreverts, W.C.1    Zarate, C.A.2    Furey, M.L.3
  • 85
    • 0030467247 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptor expression in memory circuits: Implications for treatment of Alzheimer's disease
    • Levey AI. Muscarinic acetylcholine receptor expression in memory circuits: implications for treatment of Alzheimer's disease. Proc Natl Acad Sci USA 1996; 93: 13541-46.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13541-13546
    • Levey, A.I.1
  • 86
    • 0030902127 scopus 로고    scopus 로고
    • Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioural symptoms in a Alzheimer disease
    • Bodick NC, Offen WW, Levey AI, Cutler NR, Gauthier SG, Satlin A, et al. Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioural symptoms in a Alzheimer disease. Arch Neurol 1997; 54: 465-73.
    • (1997) Arch Neurol , vol.54 , pp. 465-473
    • Bodick, N.C.1    Offen, W.W.2    Levey, A.I.3    Cutler, N.R.4    Gauthier, S.G.5    Satlin, A.6
  • 87
    • 84860466906 scopus 로고    scopus 로고
    • Continued optimization of the MLPCN probe ML071 into higly potent agonist of the M1 muscarinic acetylcholine receptor
    • Melancon BJ, Gogliotti RD, Tarr JC, Saleh SA, Chauder BA, Lebois EP, et al. Continued optimization of the MLPCN probe ML071 into higly potent agonist of the M1 muscarinic acetylcholine receptor. Bioorg Med Chem Lett 2012; 22: 3467-72.
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 3467-3472
    • Melancon, B.J.1    Gogliotti, R.D.2    Tarr, J.C.3    Saleh, S.A.4    Chauder, B.A.5    Lebois, E.P.6
  • 90
    • 13844257170 scopus 로고    scopus 로고
    • Selective targeting of Muscarinic receptors: Novel therapeutic approaches for psychotic disorders
    • Sur C, Kinney GG. Selective targeting of Muscarinic receptors: novel therapeutic approaches for psychotic disorders. Curr Neuropharmacol 2005; 3: 63-71.
    • (2005) Curr Neuropharmacol , vol.3 , pp. 63-71
    • Sur, C.1    Kinney, G.G.2
  • 92
    • 84867835356 scopus 로고    scopus 로고
    • Relation between pro-inflammatory cytokines and acetylcholine levels in relapsing-remitting multiple sclerosis patients
    • Reale M, De Angelis F, Di Nicola M, Capello E, Di Ioia M, De Luca G, et al. Relation between pro-inflammatory cytokines and acetylcholine levels in relapsing-remitting multiple sclerosis patients. Int J Mol Sci 2012, 13, 12656-64.
    • (2012) Int J Mol Sci , vol.13 , pp. 12656-12664
    • Reale, M.1    De Angelis, F.2    Di Nicola, M.3    Capello, E.4    Di Ioia, M.5    De Luca, G.6
  • 93
    • 0033985055 scopus 로고    scopus 로고
    • Induction of cellular contractions in the human melanoma cell line SK-mel 28 after muscarinic cholinergic stimulation
    • Sailer M, Oppitz M, Drews U. Induction of cellular contractions in the human melanoma cell line SK-mel 28 after muscarinic cholinergic stimulation. Anat Embryol 2000; 201: 27-37.
    • (2000) Anat Embryol , vol.201 , pp. 27-37
    • Sailer, M.1    Oppitz, M.2    Drews, U.3
  • 94
    • 0036223172 scopus 로고    scopus 로고
    • Muscarinic receptors in cell lines from ovarian carcinoma: Negative correlation with survival of patients
    • Oppitz M, Möbus V, Brock S, Drews U. Muscarinic receptors in cell lines from ovarian carcinoma: negative correlation with survival of patients. Gynecologic Oncol 2002; 85: 159-64.
    • (2002) Gynecologic Oncol , vol.85 , pp. 159-164
    • Oppitz, M.1    Möbus, V.2    Brock, S.3    Drews, U.4
  • 96
    • 0032884778 scopus 로고    scopus 로고
    • Human colon cancer cell proliferation mediated by the M3 muscarinic cholinergic receptor
    • Frucht H, Jensen RT, Dexter D, Yang Wl, Xiao Y. Human colon cancer cell proliferation mediated by the M3 muscarinic cholinergic receptor. Clinical Cancer Res 1999; 5: 2532-39.
    • (1999) Clinical Cancer Res , vol.5 , pp. 2532-2539
    • Frucht, H.1    Jensen, R.T.2    Dexter, D.3    Yang Wl Xiao, Y.4
  • 97
    • 34248597724 scopus 로고    scopus 로고
    • M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion
    • Song P, Sekhon HS, Lu A, Arredondo J, Sauer D, Gravett C, et al. M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion. Cancer Res 2007; 67: 3936-44.
    • (2007) Cancer Res , vol.67 , pp. 3936-3944
    • Song, P.1    Sekhon, H.S.2    Lu, A.3    Arredondo, J.4    Sauer, D.5    Gravett, C.6
  • 98
    • 0030064643 scopus 로고    scopus 로고
    • Acetylcholine as a mitogen: Muscarinic receptor-mediated proliferation of rat astrocytes and human astrocytoma cells
    • Guizzetti M, Costa P, Peters J, Costa LG. Acetylcholine as a mitogen: muscarinic receptor-mediated proliferation of rat astrocytes and human astrocytoma cells. Eur J Pharmacol 1996; 297: 265-73.
    • (1996) Eur J Pharmacol , vol.297 , pp. 265-273
    • Guizzetti, M.1    Costa, P.2    Peters, J.3    Costa, L.G.4
  • 99
    • 23044493073 scopus 로고    scopus 로고
    • Muscarinic cholinergic receptors in the human melanoma cell line SK-MEL28: Modulation of chemotaxis
    • Boss A, Oppitz M, Drews U. Muscarinic cholinergic receptors in the human melanoma cell line SK-MEL28: modulation of chemotaxis. Exp Dermatol 2005; 30: 557-64.
    • (2005) Exp Dermatol , vol.30 , pp. 557-564
    • Boss, A.1    Oppitz, M.2    Drews, U.3
  • 101
    • 21644452109 scopus 로고    scopus 로고
    • Activation of MAP kinase by muscarinic cholinergic receptors induces cell proliferation and protein synthesis in human breast cancer cells
    • Jimenez E, Montiel M. Activation of MAP kinase by muscarinic cholinergic receptors induces cell proliferation and protein synthesis in human breast cancer cells. J Cell Physiol 2005; 204: 678-86.
    • (2005) J Cell Physiol , vol.204 , pp. 678-686
    • Jimenez, E.1    Montiel, M.2
  • 102
    • 84872808405 scopus 로고    scopus 로고
    • M2 muscarinic receptor inhibits cell proliferation in human glioblastoma cell lines
    • Ferretti M, Fabbiano C, Di Bari M, Ponti D, Calogero A, Tata AM. M2 muscarinic receptor inhibits cell proliferation in human glioblastoma cell lines. Life Sci 2012; 91: 1134-37.
    • (2012) Life Sci , vol.91 , pp. 1134-1137
    • Ferretti, M.1    Fabbiano, C.2    Di Bari, M.3    Ponti, D.4    Calogero, A.5    Tata, A.M.6
  • 103
    • 84877019142 scopus 로고    scopus 로고
    • M2 receptor activation inhibits cell cycle progression and survival in human glioblastoma cells
    • Ferretti M, Fabbiano C, Ricordy R, Conte C, Castigli E, Sciaccaluga M, et al. M2 receptor activation inhibits cell cycle progression and survival in human glioblastoma cells. J Cell Mol Med 2013; 17(4): 552-66.
    • (2013) J Cell Mol Med , vol.17 , Issue.4 , pp. 552-566
    • Ferretti, M.1    Fabbiano, C.2    Ricordy, R.3    Conte, C.4    Castigli, E.5    Sciaccaluga, M.6
  • 104
    • 0037229715 scopus 로고    scopus 로고
    • Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma
    • Song P, Sekhon HS, Jia Y, Keller JA, Blusztajn JK, Mark GP, et al. Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma. Cancer Res 2003; 63: 214-21.
    • (2003) Cancer Res , vol.63 , pp. 214-221
    • Song, P.1    Sekhon, H.S.2    Jia, Y.3    Keller, J.A.4    Blusztajn, J.K.5    Mark, G.P.6
  • 105
    • 21644452109 scopus 로고    scopus 로고
    • Activation of MAP kinase by Muscarinic cholinergic receptors induces cell proliferation and protein synthesis in human breast cancer cells
    • Jimenez E, Montiel M. Activation of MAP kinase by Muscarinic cholinergic receptors induces cell proliferation and protein synthesis in human breast cancer cells. J Cell Physiol 2005; 204: 678-86.
    • (2005) J Cell Physiol , vol.204 , pp. 678-686
    • Jimenez, E.1    Montiel, M.2
  • 106
    • 0032561168 scopus 로고    scopus 로고
    • The role of protein kinase C+ and isozymes in DNA synthesis induced by muscarinic receptors in a glial cell line
    • Guizzetti M, Wei M, Costa LG. The role of protein kinase C+ and isozymes in DNA synthesis induced by muscarinic receptors in a glial cell line. Eur J Pharmacol 1998; 359: 223-33.
    • (1998) Eur J Pharmacol , vol.359 , pp. 223-233
    • Guizzetti, M.1    Wei, M.2    Costa, L.G.3
  • 107
    • 0034235510 scopus 로고    scopus 로고
    • Muscarinic activation of BK channels induces membrane oscillations in glioma cells and leads to inhibition of cell migration
    • Bordey A, Sontheimer H, Thouslard J. Muscarinic activation of BK channels induces membrane oscillations in glioma cells and leads to inhibition of cell migration. J Membrane Biol 2000; 176: 31-40.
    • (2000) J Membrane Biol , vol.176 , pp. 31-40
    • Bordey, A.1    Sontheimer, H.2    Thouslard, J.3
  • 108
    • 84918526849 scopus 로고    scopus 로고
    • M2 muscarinic receptors inhibit cell proliferation and migration in urothelial bladder cancer cells
    • Pacini L, De Falco E, Di Bari M, Coccia A, Siciliano C, Ponti D, et al. M2 muscarinic receptors inhibit cell proliferation and migration in urothelial bladder cancer cells. Cancer Biol Ther 2014; 15: doi: 10. 4161/15384047. 2014. 955740.
    • (2014) Cancer Biol Ther , vol.15
    • Pacini, L.1    De Falco, E.2    Di Bari, M.3    Coccia, A.4    Siciliano, C.5    Ponti, D.6
  • 111
    • 33645515459 scopus 로고    scopus 로고
    • The clinical pharmacokinetics of darifenacin
    • Skerjanec A. The clinical pharmacokinetics of darifenacin. Clin Pharmakinet 2006; 45: 325-50.
    • (2006) Clin Pharmakinet , vol.45 , pp. 325-350
    • Skerjanec, A.1
  • 112
    • 40549083717 scopus 로고    scopus 로고
    • Basic and clinic aspect of non neuronal acetylcholine: Expression of non neuronal acetylcholine in lung cancer provides a new target for cancer therapy
    • Song P, Spindel ER. Basic and clinic aspect of non neuronal acetylcholine: expression of non neuronal acetylcholine in lung cancer provides a new target for cancer therapy. J Pharmacol Sci 2008; 106: 180-85.
    • (2008) J Pharmacol Sci , vol.106 , pp. 180-185
    • Song, P.1    Spindel, E.R.2
  • 113
    • 33846113921 scopus 로고    scopus 로고
    • Migrastatin acts as a muscarinic acetylcholine receptor antagonist
    • Nakae K, Nishimura Y, Ohba S, Akamatsu Y. Migrastatin acts as a muscarinic acetylcholine receptor antagonist. J Antibiot 2006; 59: 685-92.
    • (2006) J Antibiot , vol.59 , pp. 685-692
    • Nakae, K.1    Nishimura, Y.2    Ohba, S.3    Akamatsu, Y.4
  • 114
    • 0033398486 scopus 로고    scopus 로고
    • Rat dorsal root ganglia express m1-m4 muscarinic receptor proteins
    • Bernardini N, Levey AI, Augusti TG. Rat dorsal root ganglia express m1-m4 muscarinic receptor proteins. J Pheripher Nervous Sys 1999; 4: 222-32.
    • (1999) J Pheripher Nervous Sys , vol.4 , pp. 222-232
    • Bernardini, N.1    Levey, A.I.2    Augusti, T.G.3
  • 115
    • 0034693250 scopus 로고    scopus 로고
    • Muscarinic receptor subtypes expression in rat and chick dorsal root ganglia
    • Tata AM, Vilaró MT, Mengod G. Muscarinic receptor subtypes expression in rat and chick dorsal root ganglia. Mol Brain Res 2000; 82: 1-10.
    • (2000) Mol Brain Res , vol.82 , pp. 1-10
    • Tata, A.M.1    Vilaró, M.T.2    Mengod, G.3
  • 116
    • 0027359663 scopus 로고
    • Characterization of the antinociception produced by intrathecally administered muscarinic agonistsin rats
    • Iwamoto ET, Marion L. Characterization of the antinociception produced by intrathecally administered muscarinic agonistsin rats. J Pharmacol Exp Ther 1993; 266: 329-38.
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 329-338
    • Iwamoto, E.T.1    Marion, L.2
  • 117
    • 0021847471 scopus 로고
    • Cholinergic agents: Antinociception without morphine type dependence in rats
    • Widman M, Tucker S, Brase DA, Dewey WL. Cholinergic agents: antinociception without morphine type dependence in rats. Life Sci 1985; 36: 2007-15.
    • (1985) Life Sci , vol.36 , pp. 2007-2015
    • Widman, M.1    Tucker, S.2    Brase, D.A.3    Dewey, W.L.4
  • 118
    • 0037470642 scopus 로고    scopus 로고
    • Muscarinic receptor subtypes mediating central and periph eral antinociception studied with muscarinic receptor knockout mice: A review
    • Wess J, Duttaroy A, Gomeza J, Zhang W, Yamada M, Felder CC, et al. Muscarinic receptor subtypes mediating central and periph eral antinociception studied with muscarinic receptor knockout mice: a review. Life Sci 2003; 72: 2047-54.
    • (2003) Life Sci , vol.72 , pp. 2047-2054
    • Wess, J.1    Duttaroy, A.2    Gomeza, J.3    Zhang, W.4    Yamada, M.5    Felder, C.C.6
  • 119
    • 0034677592 scopus 로고    scopus 로고
    • Involvement of M3 muscarinic receptors of the spinal cord in formalin-induced nociception in mice
    • Honda K, Harada A, Takano Y, Kamira H. Involvement of M3 muscarinic receptors of the spinal cord in formalin-induced nociception in mice. Brain Res 2000; 859: 38-44.
    • (2000) Brain Res , vol.859 , pp. 38-44
    • Honda, K.1    Harada, A.2    Takano, Y.3    Kamira, H.4
  • 120
    • 0035341506 scopus 로고    scopus 로고
    • Excitatory nicotinic and desensitizing muscarinic (M2) effects on C-nociceptors in isolated rat skin
    • Bernardini N, Sauer S, Haberberger R, Fisher MJM, Reeh PW. Excitatory nicotinic and desensitizing muscarinic (M2) effects on C-nociceptors in isolated rat skin. J Neurosci 2001; 21: 3295-302.
    • (2001) J Neurosci , vol.21 , pp. 3295-3302
    • Bernardini, N.1    Sauer, S.2    Haberberger, R.3    Fisher, M.J.M.4    Reeh, P.W.5
  • 121
    • 0037096241 scopus 로고    scopus 로고
    • Muscarinic M2 receptors on peripheral nerve endings: A molecular target of antinociception
    • Bernardini N, Roza C, Sauer S, Gomeza J, Wess J, Reeh W. Muscarinic M2 receptors on peripheral nerve endings: a molecular target of antinociception. J Neurosci 2002; 22: 1-5.
    • (2002) J Neurosci , vol.22 , pp. 1-5
    • Bernardini, N.1    Roza, C.2    Sauer, S.3    Gomeza, J.4    Wess, J.5    Reeh, W.6
  • 122
    • 0346724925 scopus 로고    scopus 로고
    • Cholinergic modulation of nociceptive responses in vivo and neuropeptide release in vitro at the level of the primary sensory neuron
    • Dussor GO, Helesic G, Hargreaves KM, Flores CM. Cholinergic modulation of nociceptive responses in vivo and neuropeptide release in vitro at the level of the primary sensory neuron. Pain 2004; 107: 22-32.
    • (2004) Pain , vol.107 , pp. 22-32
    • Dussor, G.O.1    Helesic, G.2    Hargreaves, K.M.3    Flores, C.M.4
  • 124
  • 126
    • 45749136445 scopus 로고    scopus 로고
    • Allosteric modulation of muscarinic acetylcholine receptors
    • Gregory KJ, Sexton PM, Christopoulos A. Allosteric modulation of muscarinic acetylcholine receptors. Curr Neuropharmacol 2007; 5(3): 157-67.
    • (2007) Curr Neuropharmacol , vol.5 , Issue.3 , pp. 157-167
    • Gregory, K.J.1    Sexton, P.M.2    Christopoulos, A.3
  • 127
    • 77951985712 scopus 로고    scopus 로고
    • Allosteric ligands for G protein-coupled receptors: A novel strategy with attractive therapeutic opportunities
    • De Amici M, Dallanoce C, Holzgrabe U, Tränkle C, Mohr K. Allosteric ligands for G protein-coupled receptors: a novel strategy with attractive therapeutic opportunities. Med Res Rev 2010; 30(3): 463-549.
    • (2010) Med Res Rev , vol.30 , Issue.3 , pp. 463-549
    • De Amici, M.1    Dallanoce, C.2    Holzgrabe, U.3    Tränkle, C.4    Mohr, K.5
  • 128
    • 84855879360 scopus 로고    scopus 로고
    • The best of both worlds? Bitopic orthosteric/allosteric ligands of G protein-coupled receptors
    • Valant C, Lane JR, Sexton PM, Christopoulos A. The best of both worlds? Bitopic orthosteric/allosteric ligands of G protein-coupled receptors. Annu Rev Pharmacol Toxicol 2012; 52: 153-78.
    • (2012) Annu Rev Pharmacol Toxicol , vol.52 , pp. 153-178
    • Valant, C.1    Lane, J.R.2    Sexton, P.M.3    Christopoulos, A.4
  • 129
    • 0038237079 scopus 로고    scopus 로고
    • Allosteric site on muscarinic acetylcholine receptors: Identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-occupied receptors
    • Voigtländer U, Jöhren K, Mohr M, Raasch A, Tränkle C, Buller S, et al. Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-occupied receptors. Mol Pharmacol 2003; 64(1): 21-31.
    • (2003) Mol Pharmacol , vol.64 , Issue.1 , pp. 21-31
    • Voigtländer, U.1    Jöhren, K.2    Mohr, M.3    Raasch, A.4    Tränkle, C.5    Buller, S.6
  • 130
    • 33745282128 scopus 로고    scopus 로고
    • Allosteric interactions with muscarinic acetylcholine receptors: Complex role of the conserved tryptophan M2 422Trp in a critical cluster of amino acids for baseline affinity, subtype selectivity, and cooperativity
    • Prilla S, Schrobang J, Ellis J, Höltje HD, Mohr K. Allosteric interactions with muscarinic acetylcholine receptors: complex role of the conserved tryptophan M2 422Trp in a critical cluster of amino acids for baseline affinity, subtype selectivity, and cooperativity. Mol Pharmacol 2006; 70(1): 181-93.
    • (2006) Mol Pharmacol , vol.70 , Issue.1 , pp. 181-193
    • Prilla, S.1    Schrobang, J.2    Ellis, J.3    Höltje, H.D.4    Mohr, K.5
  • 131
    • 19944401545 scopus 로고    scopus 로고
    • Allosterism at muscarinic receptors: Ligands and mechanisms
    • Birdsall NJ, Lazareno S. Allosterism at muscarinic receptors: ligands and mechanisms. Mini Rev Med Chem 2005; 5(6): 523-43.
    • (2005) Mini Rev Med Chem , vol.5 , Issue.6 , pp. 523-543
    • Birdsall, N.J.1    Lazareno, S.2
  • 133
    • 84892936679 scopus 로고    scopus 로고
    • Erk5 activation by Gq-coupled muscarinic receptors is independent of receptor internalization and α-arrestin recruitment
    • Sanchez-Fernandez G, Cabezudo S, Garcia-Hoz C, Tobin AB, Mayor F Jr, Ibas C. Erk5 activation by Gq-coupled muscarinic receptors is independent of receptor internalization and α-arrestin recruitment. Plos One 2013; 8: e84174.
    • (2013) Plos One , vol.8
    • Sanchez-Fernandez, G.1    Cabezudo, S.2    Garcia-Hoz, C.3    Tobin, A.B.4    Mayor, F.5    Ibas, C.6
  • 134
    • 76749144987 scopus 로고    scopus 로고
    • Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties
    • Leach K, Loiacono RE, Felder CC, McKinzie DL, Mogg A, Shaw DB, et al. Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties. Neuropsychopharmacol 2010; 35(4): 855-69.
    • (2010) Neuropsychopharmacol , vol.35 , Issue.4 , pp. 855-869
    • Leach, K.1    Loiacono, R.E.2    Felder, C.C.3    McKinzie, D.L.4    Mogg, A.5    Shaw, D.B.6
  • 135
    • 77954948432 scopus 로고    scopus 로고
    • Prediction of functionally selective allosteric interactions at an M3 muscarinic acetylcholine receptor mutant using Saccharomyces cerevisiae
    • Stewart GD, Sexton PM, Christopoulos A. Prediction of functionally selective allosteric interactions at an M3 muscarinic acetylcholine receptor mutant using Saccharomyces cerevisiae. Mol Pharmacol 2010; 78(2): 205-14.
    • (2010) Mol Pharmacol , vol.78 , Issue.2 , pp. 205-214
    • Stewart, G.D.1    Sexton, P.M.2    Christopoulos, A.3
  • 136
    • 0023889865 scopus 로고
    • Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity
    • Portoghese PS, Nagase H, Lipkowski AW, Larson DL, Takemori AE. Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity. J Med Chem 1988; 31(4): 836-41.
    • (1988) J Med Chem , vol.31 , Issue.4 , pp. 836-841
    • Portoghese, P.S.1    Nagase, H.2    Lipkowski, A.W.3    Larson, D.L.4    Takemori, A.E.5
  • 137
    • 0024405504 scopus 로고
    • Bivalent ligands and the message-address concept in the design of selective opioid receptor antagonists
    • Portoghese PS. Bivalent ligands and the message-address concept in the design of selective opioid receptor antagonists. Trends Pharmacol Sci 1989; 10(6): 230-5.
    • (1989) Trends Pharmacol Sci , vol.10 , Issue.6 , pp. 230-235
    • Portoghese, P.S.1
  • 138
    • 67650489125 scopus 로고    scopus 로고
    • Orthosteric/allosteric bitopic ligands: Going hybrid at GPCRs
    • Valant C, Sexton PM, Christopoulos A. Orthosteric/allosteric bitopic ligands: going hybrid at GPCRs. Mol Interv 2009; 9(3): 125-35.
    • (2009) Mol Interv , vol.9 , Issue.3 , pp. 125-135
    • Valant, C.1    Sexton, P.M.2    Christopoulos, A.3
  • 140
    • 84897874700 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptors X-ray structures: Potential implications for drug development
    • Kruse AC, Janxin H, Kobilka BK, Wess J. Muscarinic acetylcholine receptors X-ray structures: potential implications for drug development. Curr Op Pharmacol 2014; 16: 24-30.
    • (2014) Curr Op Pharmacol , vol.16 , pp. 24-30
    • Kruse, A.C.1    Janxin, H.2    Kobilka, B.K.3    Wess, J.4
  • 141
    • 30444436744 scopus 로고    scopus 로고
    • Design, synthesis, and action of oxotremorinerelated hybrid-type allosteric modulators of muscarinic acetylcholine receptors
    • Disingrini T, Muth M, Dallanoce C, Barocelli E, Bertoni S, Kellershohn K, et al. Design, synthesis, and action of oxotremorinerelated hybrid-type allosteric modulators of muscarinic acetylcholine receptors. J Med Chem 2006; 49(1): 366-72.
    • (2006) J Med Chem , vol.49 , Issue.1 , pp. 366-372
    • Disingrini, T.1    Muth, M.2    Dallanoce, C.3    Barocelli, E.4    Bertoni, S.5    Kellershohn, K.6
  • 142
    • 59649112659 scopus 로고    scopus 로고
    • Dualsteric GPCR targeting: A novel route to binding and signaling pathway selectivity
    • Antony J, Kellershohn K, Mohr-Andrä M, Kebig A, Prilla S, Muth M, et al. Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity. FASEB J 2009; 23(2): 442-50.
    • (2009) FASEB J , vol.23 , Issue.2 , pp. 442-450
    • Antony, J.1    Kellershohn, K.2    Mohr-Andrä, M.3    Kebig, A.4    Prilla, S.5    Muth, M.6
  • 143
    • 84867010308 scopus 로고    scopus 로고
    • The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling
    • Bock A, Merten N, Schrage R, Dallanoce C, Bätz J, Klöckner J, et al. The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling. Nat Commun 2012; 3: 1044.
    • (2012) Nat Commun , vol.3 , pp. 1044
    • Bock, A.1    Merten, N.2    Schrage, R.3    Dallanoce, C.4    Bätz, J.5    Klöckner, J.6
  • 144
    • 84894109151 scopus 로고    scopus 로고
    • Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: Synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity
    • Matera C, Flammini L, Quadri M, Vivo V, Ballabeni V, Holzgrabe U, et al. Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity. Eur J Med Chem 2014; 75C: 222-32.
    • (2014) Eur J Med Chem , vol.75 C , pp. 222-232
    • Matera, C.1    Flammini, L.2    Quadri, M.3    Vivo, V.4    Ballabeni, V.5    Holzgrabe, U.6
  • 146
    • 34547208823 scopus 로고    scopus 로고
    • A novel multivalent ligand that bridges the allosteric and orthosteric binding sites of the M2 muscarinic receptor
    • Steinfeld T, Mammen M, Smith JA, Wilson RD, Jasper JR. A novel multivalent ligand that bridges the allosteric and orthosteric binding sites of the M2 muscarinic receptor. Mol Pharmacol 2007; 72(2): 291-302.
    • (2007) Mol Pharmacol , vol.72 , Issue.2 , pp. 291-302
    • Steinfeld, T.1    Mammen, M.2    Smith, J.A.3    Wilson, R.D.4    Jasper, J.R.5
  • 147
    • 84880357897 scopus 로고    scopus 로고
    • Development of M1 mAChR allosteric and bitopic ligands: Prospective therapeutics for the treatment of cognitive deficits
    • Davie BJ, Christopoulos A, Scammells PJ. Development of M1 mAChR allosteric and bitopic ligands: prospective therapeutics for the treatment of cognitive deficits. ACS Chem Neurosci 2013; 4(7): 1026-48.
    • (2013) ACS Chem Neurosci , vol.4 , Issue.7 , pp. 1026-1048
    • Davie, B.J.1    Christopoulos, A.2    Scammells, P.J.3
  • 150
    • 81055140948 scopus 로고    scopus 로고
    • M5 muscarinic receptors mediate striatal dopamine activation by ventral tegmental morphine and pedunculopontine stimulation in mice
    • Steidl S, Miller AD, Blaha CD, Yeomans JS. M5 muscarinic receptors mediate striatal dopamine activation by ventral tegmental morphine and pedunculopontine stimulation in mice. PLoS One 2011; 6(11): e27538.
    • (2011) PLoS One , vol.6 , Issue.11
    • Steidl, S.1    Miller, A.D.2    Blaha, C.D.3    Yeomans, J.S.4


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