Polyketide intermediate mimics as probes for revealing cryptic stereochemistry of ketoreductase domains

ACS Chemical Biology

Volumn 9, Issue 12, 2014, Pages 2914-2922

  Li, Yang ^a   Fiers, William D ^a   Bernard, Steffen M ^b,d   Smith, Janet L ^c,d   Aldrich, Courtney C ^a   Fecik, Robert A ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Chemical Biology Program   (United States)

^c Department of Biological Chemistry ^*  (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; KETOREDUCTASE; MALONYL COENZYME A; OXIDOREDUCTASE; PIKROMYCIN MODULE 2; POLYKETIDE SYNTHASE; THIOESTER; UNCLASSIFIED DRUG; WEINREB AMIDE; BIOMIMETIC MATERIAL; MOLECULAR PROBE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; POLYKETIDE; RECOMBINANT PROTEIN;

ALDOL REACTION; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; AMINOLYSIS; ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BIOINFORMATICS; DIASTEREOISOMER; DRUG DESIGN; ELECTROSPRAY MASS SPECTROMETRY; EPOXIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN BOND; KINETICS; LIQUID CHROMATOGRAPHY; MICHAEL ADDITION; MOLECULAR RECOGNITION; OXIDATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN PROTEIN INTERACTION; STEADY STATE; STEREOCHEMISTRY; STUDY; TANDEM MASS SPECTROMETRY; TAUTOMER; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; ESCHERICHIA COLI; GENE EXPRESSION; GENETICS; METABOLISM; MOLECULAR GENETICS; MOLECULAR PROBE; PROTEIN TERTIARY STRUCTURE; STEREOISOMERISM; STREPTOMYCES; SYNTHESIS;

AMINO ACID SEQUENCE; BIOMIMETIC MATERIALS; ESCHERICHIA COLI; GENE EXPRESSION; KINETICS; MODELS, MOLECULAR; MOLECULAR PROBES; MOLECULAR SEQUENCE DATA; NADP; POLYKETIDE SYNTHASES; POLYKETIDES; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; STEREOISOMERISM; STREPTOMYCES; SUBSTRATE SPECIFICITY;

EID: 84919617653     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb5006883     Document Type: Article

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