Structural studies of an A2-type modular polyketide synthase ketoreductase reveal features controlling α-substituent stereochemistry

ACS Chemical Biology

Volumn 8, Issue 9, 2013, Pages 1964-1971

  Zheng, Jianting ^a   Piasecki, Shawn K ^a   Keatinge Clay, Adrian T ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A2 TYPE MODULAR POLYKETIDE SYNTHASE KETOREDUCTASE; ALKYL GROUP; AMPHOTERICIN POLYKETIDE SYNTHASE; HYDROXYL GROUP; LACTONE DERIVATIVE; METHYL GROUP; MUTANT PROTEIN; POLYKETIDE; POLYKETIDE SYNTHASE; TRIKETIDE LACTODE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVITY; ENZYME ENGINEERING; ENZYME MECHANISM; ENZYME STRUCTURE; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; STEREOCHEMISTRY;

ALCOHOL OXIDOREDUCTASES; BACTERIAL PROTEINS; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; LACTONES; MODELS, MOLECULAR; MUTAGENESIS; PROTEIN CONFORMATION; STEREOISOMERISM; STREPTOMYCES;

EID: 84884653644     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400161g     Document Type: Article

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