Thioester bonds of thiocoraline can be replaced with N Me-Amide bridges without affecting its DNA-binding properties

ACS Medicinal Chemistry Letters

Volumn 5, Issue 1, 2014, Pages 45-50

  Zamudio Vázquez, Rubí ^a,b   Albericio, Fernando ^a,b,c   Tulla Puche, Judit ^a,b   Fox, Keith R ^d  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c UNIVERSITY OF KWAZULU NATAL   (South Africa)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

antitumor; bisintercalator; DNA binding; DNase I footprinting; fluorescence melting; Thiocoraline

Indexed keywords

AMIDE; ANTINEOPLASTIC ANTIBIOTIC; DEOXYRIBONUCLEASE I; DEPSIPEPTIDE; DNA FRAGMENT; DOUBLE STRANDED DNA; ECHINOMYCIN; LIGAND; NATURAL PRODUCT; THIOCORALINE; THIOESTER;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; DNA SEQUENCE; DRUG DNA BINDING; HYDROGEN BOND; ISOTOPE LABELING; LIGAND BINDING; MELTING POINT; PRIORITY JOURNAL; TEMPERATURE;

EID: 84892606540     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml400323x     Document Type: Article

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