Coupled methyl group epimerization and reduction by polyketide synthase ketoreductase domains. Ketoreductase-catalyzed equilibrium isotope exchange

Journal of the American Chemical Society

Volumn 135, Issue 44, 2013, Pages 16324-16327

  Garg, Ashish ^a   Khosla, Chaitan ^b   Cane, David E ^a  

^a BROWN UNIVERSITY   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC AMOUNTS; EPIMERIZATION; ISOTOPE EXCHANGE; KEY DETERMINANTS; MECHANISTIC ANALYSIS; METHYL GROUP; POLYKETIDE SYNTHASES; TIME-DEPENDENT LOSS;

FUNCTIONAL GROUPS; KETONES;

DEUTERIUM;

DEUTERIUM; EPIMERASE; ISOTOPE; KETOREDUCTASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; POLYKETIDE; POLYKETIDE SYNTHASE; POLYKETIDE SYNTHASE KETOREDUCTASE; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; EPIMERIZATION; EQUILIBRIUM CONSTANT; LIQUID CHROMATOGRAPHY; MULTIPLE SCLEROSIS; PROTEIN DOMAIN; REDUCTION KINETICS; SEQUENCE ALIGNMENT; STEREOCHEMISTRY;

ALCOHOL OXIDOREDUCTASES; BACTERIAL PROTEINS; BIOCATALYSIS; DEUTERIUM; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; TIME FACTORS;

EID: 84887776632     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja408944s     Document Type: Article

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