Biomimetic synthesis and optimization of cyclic peptide antibiotics

Nature

Volumn 418, Issue 6898, 2002, Pages 658-661

  Kohli, Rahul M ^a   Walsh, Christopher T ^a   Burkart, Michael D ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CONFORMATIONS; OPTIMIZATION; PROTEINS;

EUKARYOTIC MEMBRANES;

ANTIBODIES;

CYCLOPEPTIDE; MACROCYCLIC COMPOUND; NATURAL PRODUCT; POLYKETIDE SYNTHASE; POLYPEPTIDE ANTIBIOTIC AGENT; THIOL ESTER HYDROLASE; TYROCIDINE;

ANTIBIOTICS; PEPTIDE;

ANTIMICROBIAL ACTIVITY; ARTICLE; BIOMIMETICS; COMBINATORIAL CHEMISTRY; CYCLIZATION; DRUG SPECIFICITY; DRUG SYNTHESIS; ENZYME IMMOBILIZATION; ENZYMOLOGY; MOLECULE; NONHUMAN; PRIORITY JOURNAL; SOLID;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIA; BIOLOGICAL PRODUCTS; CATALYSIS; CYCLIZATION; ERYTHROCYTES; HUMANS; HYDROLYSIS; MICROBIAL SENSITIVITY TESTS; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; PEPTIDES, CYCLIC; SUBSTRATE SPECIFICITY; THIOLESTER HYDROLASES; TYROCIDINE;

BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 0037043734     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature00907     Document Type: Article

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