Evodiamine induces G2/M arrest and apoptosis via mitochondrial and endoplasmic reticulum pathways in H446 and H1688 human small-cell lung cancer cells

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Fang, Chunshu ^a   Zhang, Jingqing ^b   Qi, Di ^a   Fan, Xiaoqing ^a   Luo, Jianchun ^b   Liu, Ling ^a   Tan, Qunyou ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CASPASE 12; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DEATH RECEPTOR; EVODIAMINE; FAS ANTIGEN; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; ANTINEOPLASTIC AGENT; QUINAZOLINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL GROWTH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG SELECTIVITY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC50; LUNG CANCER CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; SMALL CELL LUNG CANCER; UPREGULATION; CELL PROLIFERATION; DRUG EFFECTS; ENDOPLASMIC RETICULUM; LUNG NEOPLASMS; M PHASE CELL CYCLE CHECKPOINT; MITOCHONDRION; SMALL CELL LUNG CARCINOMA; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; ENDOPLASMIC RETICULUM; HUMANS; LUNG NEOPLASMS; M PHASE CELL CYCLE CHECKPOINTS; MITOCHONDRIA; QUINAZOLINES; SMALL CELL LUNG CARCINOMA;

EID: 84919400367     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0115204     Document Type: Article

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