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Volumn 4, Issue 12, 2013, Pages

Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells, and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway

Author keywords

lung cancer; novel antitumor agent; Ras Raf ERK p53 p21 pathway; Wentilactone A

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CISPLATIN; CYCLIN B1; CYCLOPHOSPHAMIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROCASPASE 3; PROTEIN P21; PROTEIN P53; RAF PROTEIN; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; WENTILACTONE A;

EID: 84891805362     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.484     Document Type: Article
Times cited : (67)

References (49)
  • 1
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • Siegel R, Ward E, Brawley O, Jemal A. Cancer Statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011; 61: 212-236
    • (2011) CA Cancer J Clin , vol.61 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3    Jemal, A.4
  • 2
    • 84874171209 scopus 로고    scopus 로고
    • Palliative endobronchial brachytherapy for non-small cell lung cancer
    • doi:10.1002/14651858. CD004284.pub32012
    • Reveiz L, Rueda JR, Cardona AF. Palliative endobronchial brachytherapy for non-small cell lung cancer. Cochrane Database Syst Rev 2012; doi:10.1002/14651858. CD004284.pub32012
    • (2012) Cochrane Database Syst Rev
    • Reveiz, L.1    Rueda, J.R.2    Cardona, A.F.3
  • 3
    • 77955634444 scopus 로고    scopus 로고
    • Array comparative genomic hybridization-based characterization of genetic alterations in pulmonary neuroendocrine tumors
    • Voortman J, Lee JH, Killian JK, Suuriniemi M, Wang Y, Lucchi M et al. Array comparative genomic hybridization-based characterization of genetic alterations in pulmonary neuroendocrine tumors. Pro Natl Acad Sci USA 2010; 107: 13040-13045
    • (2010) Pro Natl Acad Sci USA , vol.107 , pp. 13040-13045
    • Voortman, J.1    Lee, J.H.2    Killian, J.K.3    Suuriniemi, M.4    Wang, Y.5    Lucchi, M.6
  • 4
    • 44249086425 scopus 로고    scopus 로고
    • Non-small cell lung cancer: Epidemiology, risk factors, treatment and survivorship
    • Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA. Non-small cell lung cancer: Epidemiology, risk factors, treatment and survivorship. Mayo Clin Proc 2008; 83: 584-594
    • (2008) Mayo Clin Proc , vol.83 , pp. 584-594
    • Molina, J.R.1    Yang, P.2    Cassivi, S.D.3    Schild, S.E.4    Adjei, A.A.5
  • 5
    • 84868300169 scopus 로고    scopus 로고
    • The synergistic effect of EGFR tyrosine kinase inhibitor gefitinib in combination with aromatase inhibitor anastrozole in non-small cell lung cancer cell lines
    • Shen L, Li Z, Shen S, Niu X, Yu Y, Li Z et al. The synergistic effect of EGFR tyrosine kinase inhibitor gefitinib in combination with aromatase inhibitor anastrozole in non-small cell lung cancer cell lines. Lung Cancer 2012; 78: 193-200
    • (2012) Lung Cancer , vol.78 , pp. 193-200
    • Shen, L.1    Li, Z.2    Shen, S.3    Niu, X.4    Yu, Y.5    Li, Z.6
  • 6
    • 84879113773 scopus 로고    scopus 로고
    • Novel therapeutic targets in non-small cell lung cancer
    • Alamgeer M, Ganju V, Watkins DN. Novel therapeutic targets in non-small cell lung cancer. Curr Opin Pharmacol 2013; 13: 394-401
    • (2013) Curr Opin Pharmacol , vol.13 , pp. 394-401
    • Alamgeer, M.1    Ganju, V.2    Watkins, D.N.3
  • 7
    • 84867627577 scopus 로고    scopus 로고
    • A framework for identification of actionable cancer genome dependencies in small cell lung cancer
    • Sos ML, Dietlein F, Peifer M, Schö ttle J, Balke-Want H, Mü ller C et al. A framework for identification of actionable cancer genome dependencies in small cell lung cancer. Proc Natl Acad Sci USA 2012; 109: 17034-17039
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 17034-17039
    • Sos, M.L.1    Dietlein, F.2    Peifer, M.3    Schöttle, J.4    Balke-Want, H.5    Müller, C.6
  • 8
    • 0037264633 scopus 로고    scopus 로고
    • Targeting ras signalling pathways in cancer therapy
    • Downward J. Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 2003; 3: 11-22
    • (2003) Nat Rev Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 9
    • 1642553461 scopus 로고    scopus 로고
    • The dark side of Ras: Regulation of apoptosis
    • Cox AD, Der CJ. The dark side of Ras: Regulation of apoptosis. Oncogene 2003; 22: 8999-9006
    • (2003) Oncogene , vol.22 , pp. 8999-9006
    • Cox, A.D.1    Der, C.J.2
  • 10
    • 0036452342 scopus 로고    scopus 로고
    • Ras-mediated activation of erk by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines
    • WoessmannW, Chen X, Borkhardt A. Ras-mediated activation of ERK by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines. Cancer Chemother Pharmacol 2002; 50: 397-404
    • (2002) Cancer Chemother Pharmacol , vol.50 , pp. 397-404
    • WoessmannW Chen, X.1    Borkhardt, A.2
  • 11
    • 0035843123 scopus 로고    scopus 로고
    • Taxol-induced apoptosis depends on map kinase pathways (erk and p38) and is independent of p53
    • Bacus SS, Gudkov AV, Lowe M, Lyass L, Yung Y, Komarov AP et al. Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. Oncogene 2001; 20: 147-155
    • (2001) Oncogene , vol.20 , pp. 147-155
    • Bacus, S.S.1    Gudkov, A.V.2    Lowe, M.3    Lyass, L.4    Yung, Y.5    Komarov, A.P.6
  • 12
    • 0037066686 scopus 로고    scopus 로고
    • Erk activation mediates cell cycle arrest and apoptosis after dna damage independently of p53
    • Tang D, Wu D, Hirao A, Lahti JM, Liu L, Mazza B et al. ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J Biol Chem 2002; 277: 12710-12717
    • (2002) J Biol Chem , vol.277 , pp. 12710-12717
    • Tang, D.1    Wu, D.2    Hirao, A.3    Lahti, J.M.4    Liu, L.5    Mazza, B.6
  • 13
    • 84863259548 scopus 로고    scopus 로고
    • Asperolides a-c, tetranorlabdane diterpenoids from the marine alga-derived endophytic fungus aspergillus wentii en-48
    • Sun HF, Li XM, Meng L, Cui CM, Gao SS, Li CS et al. Asperolides A-C, tetranorlabdane diterpenoids from the marine alga-derived endophytic fungus Aspergillus wentii EN-48. J Nat Prod 2012; 75: 148-152
    • (2012) J Nat Prod , vol.75 , pp. 148-152
    • Sun, H.F.1    Li, X.M.2    Meng, L.3    Cui, C.M.4    Gao, S.S.5    Li, C.S.6
  • 14
    • 84875776625 scopus 로고    scopus 로고
    • Asperolide a, a marine-derived tetranorditerpenoid, induces g2/m arrest in human nci-h460 lung carcinoma cells, is mediated by p53-p21 stabilization and modulated by ras/raf/mek/erk signaling pathway
    • Lv C, Sun W, Sun H, Wei S, Chen R, Wang B et al. Asperolide A, a marine-derived tetranorditerpenoid, induces g2/m arrest in human nci-h460 lung carcinoma cells, is mediated by p53-p21 stabilization and modulated by ras/raf/mek/erk signaling pathway. Mar Drugs 2012; 11: 316-331
    • (2012) Mar Drugs , vol.11 , pp. 316-331
    • Lv, C.1    Sun, W.2    Sun, H.3    Wei, S.4    Chen, R.5    Wang, B.6
  • 15
    • 84879623318 scopus 로고    scopus 로고
    • Wentilactone b induces g2/m phase arrest and apoptosis via the ras/raf/mapk signaling pathway in human hepatoma smmc-7721 cells
    • Zhang Z, Miao L, Lv C, Sun H, Wei S, Wang B et al. Wentilactone B induces G2/M phase arrest and apoptosis via the Ras/Raf/MAPK signaling pathway in human hepatoma SMMC-7721 cells. Cell Death Dis 2013; 4: E657
    • (2013) Cell Death Dis , vol.4
    • Zhang, Z.1    Miao, L.2    Lv, C.3    Sun, H.4    Wei, S.5    Wang, B.6
  • 16
    • 0347997608 scopus 로고    scopus 로고
    • Mapk signal pathways in the regulation of cell proliferation in mammalian cells
    • Zhang W, Liu HT. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res 2002; 12: 9-18
    • (2002) Cell Res , vol.12 , pp. 9-18
    • Zhang, W.1    Liu, H.T.2
  • 19
    • 4444240191 scopus 로고    scopus 로고
    • The functional interactions between the p53 and mapk signaling pathways
    • Wu GS. The functional interactions between the p53 and MAPK signaling pathways. Cancer Biol Ther 2004; 3: 156-161
    • (2004) Cancer Biol Ther , vol.3 , pp. 156-161
    • Wu, G.S.1
  • 20
    • 0031594705 scopus 로고    scopus 로고
    • Nuclear accumulation of p21cip1 at the onset of mitosis: A role at the g2/m-phase transition
    • Dulić V, Stein GH, Far DF, Reed SI. Nuclear accumulation of p21Cip1 at the onset of mitosis: A role at the G2/M-phase transition. Mol Cell Biol 1998; 18: 546-557
    • (1998) Mol Cell Biol , vol.18 , pp. 546-557
    • Dulić, V.1    Stein, G.H.2    Far, D.F.3    Reed, S.I.4
  • 21
    • 0035984912 scopus 로고    scopus 로고
    • Ros stress-Activated kinases and stress signaling in cancer
    • Benhar M, Engelberg D, Levitzki A. ROS stress-Activated kinases and stress signaling in cancer. EMBO Rep 2002; 3: 420-425
    • (2002) EMBO Rep , vol.3 , pp. 420-425
    • Benhar, M.1    Engelberg, D.2    Levitzki, A.3
  • 22
    • 21244461140 scopus 로고    scopus 로고
    • Sulforaphaneinduced cell death in human prostate cancer cells is initiated by reactive oxygen species
    • Singh SV, Srivastava SK, Choi S, Lew KL, Antosiewicz J, Xiao D et al. Sulforaphaneinduced cell death in human prostate cancer cells is initiated by reactive oxygen species. J Biol Chem 2005; 280: 19911-19924
    • (2005) J Biol Chem , vol.280 , pp. 19911-19924
    • Singh, S.V.1    Srivastava, S.K.2    Choi, S.3    Lew, K.L.4    Antosiewicz, J.5    Xiao, D.6
  • 23
    • 56349151331 scopus 로고    scopus 로고
    • In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway
    • Zhang R, Humphreys I, Sahu RP, Shi Y, Srivastava SK. In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway. Apoptosis 2008; 13: 1465-1478
    • (2008) Apoptosis , vol.13 , pp. 1465-1478
    • Zhang, R.1    Humphreys, I.2    Sahu, R.P.3    Shi, Y.4    Srivastava, S.K.5
  • 24
    • 39649102145 scopus 로고    scopus 로고
    • Aminoflavone induces oxidative dna damage and reactive oxidative species-mediated apoptosis in breast cancer cells
    • McLean L, Soto U, Agama K, Francis J, Jimenez R, Pommier Y et al. Aminoflavone induces oxidative DNA damage and reactive oxidative species-mediated apoptosis in breast cancer cells. Int. J. Cancer 2008; 22: 1665-1674
    • (2008) Int. J. Cancer , vol.22 , pp. 1665-1674
    • McLean, L.1    Soto, U.2    Agama, K.3    Francis, J.4    Jimenez, R.5    Pommier, Y.6
  • 25
    • 0036478970 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species in cell death signalling
    • Fleury C, Mignotte B, Vayssière JL. Mitochondrial reactive oxygen species in cell death signalling. Biochimie 2002; 84: 131-141
    • (2002) Biochimie , vol.84 , pp. 131-141
    • Fleury, C.1    Mignotte, B.2    Vayssière, J.L.3
  • 26
    • 0032889677 scopus 로고    scopus 로고
    • Redox regulation of cellular signalling
    • Kamata H, Hirata H. Redox Regulation of Cellular Signalling. Cell Signal 1999; 11: 1-14
    • (1999) Cell Signal , vol.11 , pp. 1-14
    • Kamata, H.1    Hirata, H.2
  • 27
    • 0031055415 scopus 로고    scopus 로고
    • Minimal ras-binding domain of raf1 can be used as an activationspecific probe for ras
    • de Rooij J, Bos JL. Minimal Ras-binding domain of Raf1 can be used as an activationspecific probe for Ras. Oncogene 1997; 14: 623-625
    • (1997) Oncogene , vol.14 , pp. 623-625
    • De Rooij, J.1    Bos, J.L.2
  • 28
    • 44049093161 scopus 로고    scopus 로고
    • Kö tting C, Kallenbach A, Suveyzdis Y, Wittinghofer A, Gerwert K.
    • Kö tting C, Kallenbach A, Suveyzdis Y, Wittinghofer A, Gerwert K. The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy. Proc Natl Acad Sci USA 2008; 105: 6260-6265
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 6260-6265
  • 29
    • 0033579412 scopus 로고    scopus 로고
    • Regulation of the p53 tumor suppressor protein
    • Oren M. Regulation of the p53 tumor suppressor protein. J BiolChem1999; 274: 36031-36034
    • (1999) J BiolChem , vol.274 , pp. 36031-36034
    • Oren, M.1
  • 30
    • 0035370483 scopus 로고    scopus 로고
    • Regulation and function of the p53 tumor suppressor protein
    • Ryan KM, Phillips AC, Vousden KH. Regulation and function of the p53 tumor suppressor protein. Curr Opin Cell Biol 2001; 13: 332-337
    • (2001) Curr Opin Cell Biol , vol.13 , pp. 332-337
    • Ryan, K.M.1    Phillips, A.C.2    Vousden, K.H.3
  • 31
    • 0032508504 scopus 로고    scopus 로고
    • Enhanced phosphorylation of p53 by atm in response to dna damage
    • Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L et al. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 1998; 281: 1674-1677
    • (1998) Science , vol.281 , pp. 1674-1677
    • Banin, S.1    Moyal, L.2    Shieh, S.3    Taya, Y.4    Anderson, C.W.5    Chessa, L.6
  • 32
    • 0034617077 scopus 로고    scopus 로고
    • Erks and p38 kinase phosphorylate p53 protein at serine 15 in response to uv radiation
    • She QB, Chen N, Dong Z. ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation. J Biol Chem 2000; 275: 20444-20449
    • (2000) J Biol Chem , vol.275 , pp. 20444-20449
    • She, Q.B.1    Chen, N.2    Dong, Z.3
  • 34
    • 0028292480 scopus 로고
    • Identification of a p53-dependent negative response element in the bcl-2 gene
    • Miyashita T, Harigai M, Hanada M, Reed JC. Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res 1994; 54: 3131-3135
    • (1994) Cancer Res , vol.54 , pp. 3131-3135
    • Miyashita, T.1    Harigai, M.2    Hanada, M.3    Reed, J.C.4
  • 35
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995; 80: 293-299
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 37
    • 0842278331 scopus 로고    scopus 로고
    • Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
    • Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 2004; 303: 1010-1014
    • (2004) Science , vol.303 , pp. 1010-1014
    • Chipuk, J.E.1    Kuwana, T.2    Bouchier-Hayes, L.3    Droin, N.M.4    Newmeyer, D.D.5    Schuler, M.6
  • 38
    • 34247325105 scopus 로고    scopus 로고
    • P53 and Bad: Remote strangers become close friends
    • Jiang P, Du W, Wu M. p53 and Bad: Remote strangers become close friends. Cell Res 2007; 17: 283-285
    • (2007) Cell Res , vol.17 , pp. 283-285
    • Jiang, P.1    Du, W.2    Wu, M.3
  • 39
    • 0348014686 scopus 로고    scopus 로고
    • Dna damage response and mcl-1 destruction initiate apoptosis in adenovirus-infected cells
    • Cuconati A, Mukherjee C, Perez D, White E. DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells. Genes Dev 2003; 17: 2922-2932
    • (2003) Genes Dev , vol.17 , pp. 2922-2932
    • Cuconati, A.1    Mukherjee, C.2    Perez, D.3    White, E.4
  • 40
  • 41
    • 67549142261 scopus 로고    scopus 로고
    • Life and death partners: Apoptosis, autophagy and the cross-Talk between them
    • Eisenberg-Lerner A, Bialik S, Simon HU, Kimchi A. Life and death partners: Apoptosis, autophagy and the cross-Talk between them. Cell Death Differ 2009; 16: 966-975
    • (2009) Cell Death Differ , vol.16 , pp. 966-975
    • Eisenberg-Lerner, A.1    Bialik, S.2    Simon, H.U.3    Kimchi, A.4
  • 43
    • 79955026310 scopus 로고    scopus 로고
    • Death pathways triggered by activated Ras in cancer cells
    • Overmeyer JH, Maltese WA. Death pathways triggered by activated Ras in cancer cells. Front Biosci 2011; 16: 1693-1713
    • (2011) Front Biosci , vol.16 , pp. 1693-1713
    • Overmeyer, J.H.1    Maltese, W.A.2
  • 44
    • 79959956903 scopus 로고    scopus 로고
    • Regulation of Ras proteins by reactive nitrogen species
    • Davis MF, Vigil D, Campbell SL. Regulation of Ras proteins by reactive nitrogen species. Free Radic Biol Med 2011; 51: 565-575
    • (2011) Free Radic Biol Med , vol.51 , pp. 565-575
    • Davis, M.F.1    Vigil, D.2    Campbell, S.L.3
  • 45
    • 84874433733 scopus 로고    scopus 로고
    • Regulation of small gtpases by gefs gaps, and gdis
    • Cherfils J, Zeghouf M. Regulation of small GTPases by GEFs, GAPs, and GDIs. Physiol Rev 2013; 93: 269-309
    • (2013) Physiol Rev , vol.93 , pp. 269-309
    • Cherfils, J.1    Zeghouf, M.2
  • 46
    • 17744388107 scopus 로고    scopus 로고
    • A permissive function of phosphoinositide 3-kinase in ras activation mediated by inhibition of GTPase-Activating proteins
    • Rubio II, Wetzker R. A permissive function of phosphoinositide 3-kinase in ras activation mediated by inhibition of GTPase-Activating proteins. Curr Biol 2000; 10: R883
    • (2000) Curr Biol , vol.10
    • Rubio, I.I.1    Wetzker, R.2
  • 47
    • 0032474731 scopus 로고    scopus 로고
    • Ras-independent activation of ral by a ca(2+)-dependent pathway
    • Hofer F, Berdeaux R, Martin GS. Ras-independent activation of Ral by a Ca(2+)-dependent pathway. Curr Biol 1998; 8: 839-842
    • (1998) Curr Biol , vol.8 , pp. 839-842
    • Hofer, F.1    Berdeaux, R.2    Martin, G.S.3
  • 48
    • 0034117603 scopus 로고    scopus 로고
    • Clinical perspectives on platinum resistance
    • Giaccone G. Clinical perspectives on platinum resistance. Drugs 2000; 59: 37-38
    • (2000) Drugs , vol.59 , pp. 37-38
    • Giaccone, G.1
  • 49
    • 35649024810 scopus 로고    scopus 로고
    • Understanding cisplatin resistance using cellular models
    • Stordal B, Davey M. Understanding cisplatin resistance using cellular models. IUBMB Life 2007; 59: 696-699
    • (2007) IUBMB Life , vol.59 , pp. 696-699
    • Stordal, B.1    Davey, M.2


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