Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid inhibits growth of human lung cancer A549 cells by arresting cell cycle and triggering apoptosis

Chinese Journal of Cancer Research

Volumn 24, Issue 2, 2012, Pages 109-115

  Li, Li ^a   Chen, George G ^b   Lu, Ying Nian ^a   Liu, Yi ^a   Wu, Ke Feng ^a   Gong, Xian Ling ^a   Gou, Zhan Ping ^a   Li, Ming Yue ^b   Liang, Nian Ci ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Apoptosis; G2 cell cycle arrest; Lung cancer; Pteris semipinnata L; Reactive oxygen species

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; APOPTOSIS INDUCING FACTOR; CASPASE 3; CISPLATIN; CYTOCHROME C; DNA FRAGMENT; ENT 11ALPHA HYDROXY 15 OXO KAUR 16 EN 19 OIC ACID; NATURAL PRODUCT; PROTEIN BAX; PROTEIN P21; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL STRUCTURE; CELL VIABILITY; CHINESE HERB; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EXPOSURE; DRUG MECHANISM; DRUG SENSITIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME RELEASE; HUMAN; HUMAN CELL; LUNG CANCER; MITOCHONDRION; NONHUMAN; PROTEIN EXPRESSION; PTERIS SEMIPINNATA; WESTERN BLOTTING;

EID: 84863670779     PISSN: 10009604     EISSN: 19930631     Source Type: Journal    
DOI: 10.1007/s11670-012-0109-8     Document Type: Article

References (42)

1. Yang P, Allen MS, Aubry MC, et al. Clinical features of 5,628 primary lung cancer patients: experience at Mayo Clinic from 1997 to 2003. Chest 2005; 128:452-62. (Pubitemid 40994510)
2. Govindan R, Page N, Morgensztern D, et al. Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database. J Clin Oncol 2006; 24:4539-44. (Pubitemid 46630948)
3. Erridge SC, Møller H, Price A, et al. International comparisons of survival from lung cancer: pitfalls and warnings. Nat Clin Pract Oncol 2007; 4:570-7. (Pubitemid 47534756)
4. Li J, Liang N, Mo L, et al. Comparison of the cytotoxicity of five constituents from Pteris semipinnata L. in vitro and the analysis of their structure-activity relationships. Acta Pharmaceutica Sinica 1998; 33:641-4. (Pubitemid 128465789)
5. Lu YN, Chen G, Wu KF, et al. Determination of 5F in Pteris semipinnata L injection by HPLC. Xin Yao Cai (in Chinese) 2008; 23:2048-58.
6. Gong XL, Chen ZH, Lu YN, et al. Purification of the antitumor compound 5F from Pteris semipinnata L. Zhong Cheng Yao (in Chinese) 2008; 30:1286-9.
7. Chen GG, Liang NC, Lee JF, et al. Over-expression of Bcl-2 against Pteris semipinnata L-induced apoptosis of human colon cancer cells via a NF-kappa B-related pathway. Apoptosis 2004; 9:619-27. (Pubitemid 39158638)
8. Liu Z, Ng EK, Liang NC, et al. Cell death induced by Pteris semipinnata L. is associated with p53 and oxidant stress in gastric cancer cells. FEBS Lett 2005; 579:1477-87. (Pubitemid 40289199)
9. Liu ZM, Chen GG, Vlantis AC, et al. Cell death induced by ent-11alpha-hydroxy-15-oxo-kaur-16-en-19-oic-acid in anaplastic thyroid carcinoma cells is via a mitochondrial-mediated pathway. Apoptosis 2005; 10:1345-56. (Pubitemid 43117680)
10. Li L, Liu Y, Lu YN, et al. Apoptosis effect and mechanism of 5F from Pteris semipinnata on HepG2 cells. Zhong Yao Cai (in Chinese) 2010; 33: 77-80.
11. Vlantis AC, Lo CS, Chen GG, et al. Induction of laryngeal cancer cell death by Ent-11-hydroxy-15-oxo-kaur-16-en-19-oic acid. Head Neck 2010; 32:1506-18.
12. Fuse E, Kuwabara T, Sparreboom A, et al. Review of UCN-01 development: a lesson in the importance of clinical pharmacology. J Clin Pharmacol 2005; 45:394-403. (Pubitemid 40490412)
13. Edelman MJ, Bauer KS Jr, Wu S, et al. Phase I and pharmacokinetic study of 7-hydroxystaurosporine and carboplatin in advanced solid tumors. Clin Cancer Res 2007; 13:2667-74. (Pubitemid 46788034)
14. Li MY, Leung J, Kong AW, et al. Anticancer efficacy of 5F in NNK-induced lung cancer development of A/J mice and human lung cancer cells. J Mol Med 2010; 88:1265-76.
15. Deng YF, Liang NC. Study on extraction and separation of diterpenoids from Pteris semipinnata. Zhong Guo Yao Li Xue Za Zhi (in Chinese) 2004; 39:42-4.
16. Tian Z, Shen J, Moseman AP, et al. Dulxanthone A induces cell cycle arrest and apoptosis via up-regulation of p53 through mitochondrial pathway in HepG2 cells. Int J Cancer 2008; 122:31-8. (Pubitemid 350209975)
17. Vaux DL, Korsmeyer SJ. Cell death in development. Cell 1999; 96: 245-54. (Pubitemid 29059354)
18. Jiang M, Wei Q, Pabla N, et al. Effects of hydroxyl radical scavenging on cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity. Biochem Pharmacol 2007; 73:1499-510. (Pubitemid 46452592)
19. Kim YH, Kim YW, Oh YJ, et al. Protective effect of the ethanol extract of the roots of Brassica rapa on cisplatin-induced nephrotoxicity in LLC-PK1 cells and rats. Biol Pharm Bull 2006; 29:2436-41.
20. Satoh M, Kashihara N, Fujimoto S, et al. A novel free radical scavenger, edarabone, protects against cisplatin-induced acute renal damage in vitro and in vivo. J Pharmacol Exp Ther 2003; 305:1183-90. (Pubitemid 36617997)
21. Nigg EA. Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle. Bioessays 1995; 17:471-80.
22. Gautier J, Solomon MJ, Booher RN, et al. cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell 1991; 67:197-211. (Pubitemid 121001436)
23. Sherr CJ. Cancer cell cycles. Science 1996; 274:1672-7.
24. Kroemer G. Mitochondrial control of apoptosis: an introduction. Biochem Biophys Res Commun 2003; 304:433-5. (Pubitemid 36511397)
25. Green DR, Reed JC. Mitochondria and apoptosis. Science 1998; 281:1309-12. (Pubitemid 28406816)
26. Senderowicz AM. Targeting cell cycle and apoptosis for the treatment of human malignancies. Curr Opin Cell Biol 2004; 16:670-8. (Pubitemid 39463118)
27. De Siervi A, Marinissen M, Diggs J, et al. Transcriptional activation of p21(waf1/cip1) by alkylphospholipids: role of the mitogen-activated protein kinase pathway in the transactivation of the human p21 (waf1/cip1) promoter by Sp1. Cancer Res 2004; 64:743-50. (Pubitemid 38120918)
28. Rigberg DA, Blinman TA, Kim FS, et al. Antisense blockade of p21/WAF1 decreases radiation-induced G2 arrest in esophageal squamous cell carcinoma. J Surg Res 1999; 81:6-10. (Pubitemid 29393768)
29. Ando T, Kawabe T, Ohara H, et al. Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage. J Biol Chem 2001; 276:42971-7.
30. Chu G. Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair. J Biol Chem 1994; 269:787-90.
31. Malugin A, Kopecková P, Kopecek J. HPMA copolymer-bound doxorubicin induces apoptosis in ovarian carcinoma cells by the disruption of mitochondrial function. Mol Pharm 2006; 3:351-61. (Pubitemid 44021441)
32. Yim EK, Lee KH, Bae JS, et al. Proteomic analysis of antiproliferative effects by treatment of 5-fluorouracil in cervical cancer cells. DNA Cell Biol 2004; 23:769-76.
33. Boulikas T, Vougiouka M. Cisplatin and platinum drugs at the molecular level. Oncol Rep 2003; 10:1663-82.
34. Sastre J, Pallardó FV, Viña J. Mitochondrial oxidative stress plays a key role in aging and apoptosis. IUBMB Life 2000; 49:427-35. (Pubitemid 30436178)
35. Carmody RJ, Cotter TG. Signalling apoptosis: a radical approach. Redox Rep 2001; 6:77-90. (Pubitemid 32519815)
36. Pelicano H, Feng L, Zhou Y, et al. Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism. J Biol Chem 2003; 278:37832-9. (Pubitemid 37175311)
37. Laurent A, Nicco C, Chéreau C, et al. Controlling tumor growth by modulating endogenous production of reactive oxygen species. Cancer Res 2005; 65:948-56. (Pubitemid 40216456)
38. Gupta A, Rosenberger SF, Bowden GT. Increased ROS levels contribute to elevated transcription factor and MAP kinase activities in malignantly progressed mouse keratinocyte cell lines. Carcinogenesis 1999; 20:2063-73. (Pubitemid 29535306)
39. Li L, Wu KF, Liu Y, et al. Ros is not involved in induction of cell death by induction of cancer cell death by Ent-11-hydroxy-15-oxo-kaur-16-en-19-oic acid in HepG2 cells. Zhong Guo Zhong Yao Za Zhi (in Chinese) 2010; 35:1287-91.
40. Chirino YI, Pedraza-Chaverri J. Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity. Exp Toxicol Pathol 2009; 61:223-42.
41. Rybak LP, Whitworth CA, Mukherjea D, et al. Mechanisms of cisplatin-induced ototoxicity and prevention. Hear Res 2007; 226: 157-67. (Pubitemid 46428033)
42. van den Berg JH, Beijnen JH, Balm AJ, et al. Future opportunities in preventing cisplatin induced ototoxicity. Cancer Treat Rev 2006; 32: 390-7. (Pubitemid 44063878)