A Synthetic Podophyllotoxin Derivative Exerts Anti-Cancer Effects by Inducing Mitotic Arrest and Pro-Apoptotic ER Stress in Lung Cancer Preclinical Models

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Chen, Jia Yang ^a   Tang, Yen An ^a   Li, Wen Shan ^b   Chiou, Yu Ching ^b,c   Shieh, Jiunn Min ^d,e   Wang, Yi Ching ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b INSTITUTE OF CHEMISTRY   (Taiwan)

^c NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

^d CHI MEI MEDICAL CENTER   (Taiwan)

^e CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA B KINASE; CHING 001; PACLITAXEL; PODOPHYLLOTOXIN DERIVATIVE; SURVIVIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; PODOPHYLLOTOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DRUG STRUCTURE; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; LUNG CANCER; MICROTUBULE; MITOSIS INHIBITION; MOUSE; NONHUMAN; POLYMERIZATION; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; BIOLOGICAL MODEL; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; DISEASE MODEL; DRUG EFFECTS; DRUG SCREENING; GENETICS; LUNG NEOPLASMS; M PHASE CELL CYCLE CHECKPOINT; METABOLISM; MITOSIS; PROTEIN MULTIMERIZATION; TOXICITY; TUMOR CELL LINE; TUMOR VOLUME;

ANIMALIA;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DNA DAMAGE; DRUG EVALUATION, PRECLINICAL; ENDOPLASMIC RETICULUM STRESS; HUMANS; LUNG NEOPLASMS; M PHASE CELL CYCLE CHECKPOINTS; MICE; MICROTUBULES; MITOSIS; MODELS, BIOLOGICAL; PODOPHYLLOTOXIN; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84876975648     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062082     Document Type: Article

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