-
1
-
-
0035146929
-
Life-or-death decision by the Bcl-2 protein family
-
Adams JM and Cory S (2001) Life-or-death decision by the Bcl-2 protein family. Trends Biochem Sci 26:61-66.
-
(2001)
Trends Biochem Sci
, vol.26
, pp. 61-66
-
-
Adams, J.M.1
Cory, S.2
-
2
-
-
21844464054
-
Bax form multispanning monomers that oligomerize to permeabilize membranes during apoptosis
-
Annis MG, Soucie EL, Dlugosz PJ, Cruz-Aguado JA, Penn LZ, Leber B, and Andrews DW (2005) Bax form multispanning monomers that oligomerize to permeabilize membranes during apoptosis. EMBO J 24:2096-2103.
-
(2005)
EMBO J
, vol.24
, pp. 2096-2103
-
-
Annis, M.G.1
Soucie, E.L.2
Dlugosz, P.J.3
Cruz-Aguado, J.A.4
Penn, L.Z.5
Leber, B.6
Andrews, D.W.7
-
3
-
-
33750619845
-
How do Bax and Bak lead to permeabilization of the out mitochnodrial membrane?
-
Antignani A and Youle RJ (2006) How do Bax and Bak lead to permeabilization of the out mitochnodrial membrane? Curr Opin Cell Biol 18:685-689.
-
(2006)
Curr Opin Cell Biol
, vol.18
, pp. 685-689
-
-
Antignani, A.1
Youle, R.J.2
-
4
-
-
35648949422
-
BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancer with oncogenic EGFR mutations
-
Costa DB, Halmos B, Kumar A, Schumer ST, Huberman MS, Boggon TJ, Tenen DG, and Kobayashi S (2007) BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancer with oncogenic EGFR mutations. PLoS Med 4:e315.
-
(2007)
PLoS Med
, vol.4
-
-
Costa, D.B.1
Halmos, B.2
Kumar, A.3
Schumer, S.T.4
Huberman, M.S.5
Boggon, T.J.6
Tenen, D.G.7
Kobayashi, S.8
-
5
-
-
35648953299
-
Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics
-
Cragg MS, Kuroda J, Puthalakath H, Huang DCS, and Strasser A (2007) Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics. PLoS Med 4:e316.
-
(2007)
PLoS Med
, vol.4
-
-
Cragg, M.S.1
Kuroda, J.2
Puthalakath, H.3
Huang, D.C.S.4
Strasser, A.5
-
6
-
-
14644435131
-
Enhanced sensitivity to the HER1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib hydrochloride in chemotherapy-resistant tumor cell lines
-
Dai Q, Ling YH, Lia M, Zou YY, Kroog G, Iwata KK, and Perez-Soler R (2005) Enhanced sensitivity to the HER1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib hydrochloride in chemotherapy-resistant tumor cell lines. Clin Cancer Res 11:1572-1578.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 1572-1578
-
-
Dai, Q.1
Ling, Y.H.2
Lia, M.3
Zou, Y.Y.4
Kroog, G.5
Iwata, K.K.6
Perez-Soler, R.7
-
7
-
-
37549001026
-
Proapoptotic BH3-only bcl-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion
-
Deng J, Shimamura T, Perera S, Carlson NE, Cai D, Shapiro GI, Wong KK, and Letai A (2007) Proapoptotic BH3-only bcl-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion. Cancer Res 67:11867-11875.
-
(2007)
Cancer Res
, vol.67
, pp. 11867-11875
-
-
Deng, J.1
Shimamura, T.2
Perera, S.3
Carlson, N.E.4
Cai, D.5
Shapiro, G.I.6
Wong, K.K.7
Letai, A.8
-
8
-
-
0034284637
-
Mitochondria as the central control point of apoptosis
-
Desagher S and Martinou JC (2000) Mitochondria as the central control point of apoptosis. Trends Cell Biol 10:369-3777.
-
(2000)
Trends Cell Biol
, vol.10
, pp. 369-3777
-
-
Desagher, S.1
Martinou, J.C.2
-
9
-
-
35648965243
-
Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas
-
Gong Y, Somwar R, Politi K, Balak M, Chmielecki J, Jiang X, and Pao W (2007) Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS Med 4:e294.
-
(2007)
PLoS Med
, vol.4
-
-
Gong, Y.1
Somwar, R.2
Politi, K.3
Balak, M.4
Chmielecki, J.5
Jiang, X.6
Pao, W.7
-
10
-
-
0034616946
-
Apoptotic pathways: Paper wraps stone blunts scissors
-
Green DR (2000) Apoptotic pathways: paper wraps stone blunts scissors. Cell 102:1-4.
-
(2000)
Cell
, vol.102
, pp. 1-4
-
-
Green, D.R.1
-
11
-
-
0032528118
-
Enforced dimerization on Bax results in its translocation, mitochondrial dysfunction and apoptosis
-
Gross A, Jockel J, Wei MC, and Korsmeyer SJ (1998) Enforced dimerization on Bax results in its translocation, mitochondrial dysfunction and apoptosis. EMBO J 17:3878-3885.
-
(1998)
EMBO J
, vol.17
, pp. 3878-3885
-
-
Gross, A.1
Jockel, J.2
Wei, M.C.3
Korsmeyer, S.J.4
-
12
-
-
0024520982
-
Epidermal growth factor binding, stimulation of phosphorylation, and gluconeogenesis in rat proximal tubule
-
Harris RC and Daniel TO (1989) Epidermal growth factor binding, stimulation of phosphorylation, and gluconeogenesis in rat proximal tubule. J Cell Physiol 139:383-391.
-
(1989)
J Cell Physiol
, vol.139
, pp. 383-391
-
-
Harris, R.C.1
Daniel, T.O.2
-
13
-
-
0033635733
-
BH3-only proteins-essential initiators of apoptotic cell death
-
Huang DC and Strasser A (2000) BH3-only proteins-essential initiators of apoptotic cell death. Cell 103:839-842.
-
(2000)
Cell
, vol.103
, pp. 839-842
-
-
Huang, D.C.1
Strasser, A.2
-
14
-
-
33749846225
-
Role of Bax and Bak in mitochondrial morphogenesis
-
Karbowski M, Norris KL, Cleland MM, Jeong SY, and Youle RJ (2006) Role of Bax and Bak in mitochondrial morphogenesis. Nature 443:658-662.
-
(2006)
Nature
, vol.443
, pp. 658-662
-
-
Karbowski, M.1
Norris, K.L.2
Cleland, M.M.3
Jeong, S.Y.4
Youle, R.J.5
-
15
-
-
0034630167
-
Induction of apoptosis by cancer chemotherapy
-
Kaufmann SH and Earnshaw WC (2000) Induction of apoptosis by cancer chemotherapy. Exp Cell Res 256:42-49.
-
(2000)
Exp Cell Res
, vol.256
, pp. 42-49
-
-
Kaufmann, S.H.1
Earnshaw, W.C.2
-
16
-
-
0028847003
-
The biochemistry of programmed cell death
-
Kroemer G, Petit P, Zamzami N, Vayssière JL, and Mignotte B (1995) The biochemistry of programmed cell death. FASEB J 9:1277-1287.
-
(1995)
FASEB J
, vol.9
, pp. 1277-1287
-
-
Kroemer, G.1
Petit, P.2
Zamzami, N.3
Vayssière, J.L.4
Mignotte, B.5
-
17
-
-
33749510073
-
Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukic cells, and resistance due to their loss id overcome by a BH3 mimetic
-
Kuroda J, Puthalakath H, Cragg MS, Kelly PN, Bouillet P, Huang DC, Kimura S, Ottmann OG, Druker BJ, Villunger A, et al. (2006) Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukic cells, and resistance due to their loss id overcome by a BH3 mimetic. Proc Natl Acad Sci U S A 103:14907-14912.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 14907-14912
-
-
Kuroda, J.1
Puthalakath, H.2
Cragg, M.S.3
Kelly, P.N.4
Bouillet, P.5
Huang, D.C.6
Kimura, S.7
Ottmann, O.G.8
Druker, B.J.9
Villunger, A.10
-
18
-
-
0040971260
-
Cleavage of BID by caspase 8 mediated the mitochondrial damage in the Fas pathway of apoptosis
-
Li H, Zhu H, Xu CJ, and Yuan J (1998) Cleavage of BID by caspase 8 mediated the mitochondrial damage in the Fas pathway of apoptosis. Cell 98:481-490.
-
(1998)
Cell
, vol.98
, pp. 481-490
-
-
Li, H.1
Zhu, H.2
Xu, C.J.3
Yuan, J.4
-
19
-
-
0141706672
-
Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells
-
Ling YH, Liebes L, Zou Y, and Perez-Soler R (2003) Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. J Biol Chem 278:33714-33723.
-
(2003)
J Biol Chem
, vol.278
, pp. 33714-33723
-
-
Ling, Y.H.1
Liebes, L.2
Zou, Y.3
Perez-Soler, R.4
-
21
-
-
0018371450
-
Inhibitors of the ATP synthetase systems
-
Linnett PE and Beechey RB (1979) Inhibitors of the ATP synthetase systems. Methods Enzymol 55:472-518.
-
(1979)
Methods Enzymol
, vol.55
, pp. 472-518
-
-
Linnett, P.E.1
Beechey, R.B.2
-
22
-
-
0035927546
-
The monoclonal antibody 225 activates caspase-8 and induces apoptosis through a tumor necrosis factor receptor family-independent pathway
-
Liu B and Fan Z (2001) The monoclonal antibody 225 activates caspase-8 and induces apoptosis through a tumor necrosis factor receptor family-independent pathway. Oncogene 20:3726-3734.
-
(2001)
Oncogene
, vol.20
, pp. 3726-3734
-
-
Liu, B.1
Fan, Z.2
-
23
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, et al. (2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350:2129-2139.
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
Harris, P.L.7
Haserlat, S.M.8
Supko, J.G.9
Haluska, F.G.10
-
24
-
-
0347986675
-
Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases
-
Majewski N, Nogueira V, Robey RB, and Hay N (2004) Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases. Mol Cell Biol 24:730-740.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 730-740
-
-
Majewski, N.1
Nogueira, V.2
Robey, R.B.3
Hay, N.4
-
25
-
-
0030774045
-
Induction of apoptosis and cell cycle arrest by OSI-774, an inhibitor of epidermal growth factor tyrosine kinase
-
Moyer JD, Barbacci EG, Iwata KK, Arnold L, Boman B, Cunningham A, DiOrio C, Doty J, Morin MJ, Moyer MP, et al. (1997) Induction of apoptosis and cell cycle arrest by OSI-774, an inhibitor of epidermal growth factor tyrosine kinase. Cancer Res 57:4838-4848.
-
(1997)
Cancer Res
, vol.57
, pp. 4838-4848
-
-
Moyer, J.D.1
Barbacci, E.G.2
Iwata, K.K.3
Arnold, L.4
Boman, B.5
Cunningham, A.6
DiOrio, C.7
Doty, J.8
Morin, M.J.9
Moyer, M.P.10
-
26
-
-
0034104525
-
Tyrosine kinase inhibitions targeted to the epidermal growth factor receptor subfamily: Role as anticancer agents
-
Noonberg SB and Benz CC (2000) Tyrosine kinase inhibitions targeted to the epidermal growth factor receptor subfamily: role as anticancer agents. Drugs 59:753-767.
-
(2000)
Drugs
, vol.59
, pp. 753-767
-
-
Noonberg, S.B.1
Benz, C.C.2
-
27
-
-
0344820721
-
Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase
-
Okun JG, Lümmen P, and Brandt U (1999) Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase. J Biol Chem 274:2625-2630.
-
(1999)
J Biol Chem
, vol.274
, pp. 2625-2630
-
-
Okun, J.G.1
Lümmen, P.2
Brandt, U.3
-
28
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Jänne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, et al. (2004) EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304:1497-1500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Jänne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
Herman, P.7
Kaye, F.J.8
Lindeman, N.9
Boggon, T.J.10
-
29
-
-
0037113881
-
Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin
-
Panaretakis T, Pokrovskaja K, Shoshan MC, and Grandér D (2002) Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin. J Biol Chem 277:44317-44326.
-
(2002)
J Biol Chem
, vol.277
, pp. 44317-44326
-
-
Panaretakis, T.1
Pokrovskaja, K.2
Shoshan, M.C.3
Grandér, D.4
-
30
-
-
0032695910
-
Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinoma with OSI-774: Dynamics of receptor inhibition in situ and antitumor effects in athymic mice
-
Pollack VA, Savage DM, Baker DA, Tsaparikos KE, Sloan DE, Moyer JD, Barbacci EG, Pustilnik LR, Smolarek TA, Davis JA, et al. (1999) Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinoma with OSI-774: dynamics of receptor inhibition in situ and antitumor effects in athymic mice. J Pharmacol Exp Ther 291:739-748.
-
(1999)
J Pharmacol Exp Ther
, vol.291
, pp. 739-748
-
-
Pollack, V.A.1
Savage, D.M.2
Baker, D.A.3
Tsaparikos, K.E.4
Sloan, D.E.5
Moyer, J.D.6
Barbacci, E.G.7
Pustilnik, L.R.8
Smolarek, T.A.9
Davis, J.A.10
-
31
-
-
0036463649
-
Apoptosis-based therapies
-
Reed JC (2002) Apoptosis-based therapies. Nat Rev Drug Discov 1:111-121.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 111-121
-
-
Reed, J.C.1
-
32
-
-
0028955388
-
Epidermal growth factor-related peptides and their receptor in human malignancies
-
Salomon DS, Brandt R, Ciardiello F, and Normanno N (1995) Epidermal growth factor-related peptides and their receptor in human malignancies. Crit Rev Oncol Hematol 19:183-232.
-
(1995)
Crit Rev Oncol Hematol
, vol.19
, pp. 183-232
-
-
Salomon, D.S.1
Brandt, R.2
Ciardiello, F.3
Normanno, N.4
-
33
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
Shepherd FA, Rodrigues Pereira J, Ciuleanu T, Tan EH, Hirsh V, Thongprasert S, Campos D, Maoleekoonpiroj S, Smylie M, Martins R, et al. (2005) Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 353:123-132.
-
(2005)
N Engl J Med
, vol.353
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues Pereira, J.2
Ciuleanu, T.3
Tan, E.H.4
Hirsh, V.5
Thongprasert, S.6
Campos, D.7
Maoleekoonpiroj, S.8
Smylie, M.9
Martins, R.10
-
34
-
-
33244474580
-
Tumor necrosis factor-α induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K
-
Stankiewicz AR, Lachapelle G, Foo CP, Radicioni SM, and Mosser DD (2005) Tumor necrosis factor-α induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K. J Biol Chem 280:38729-38739.
-
(2005)
J Biol Chem
, vol.280
, pp. 38729-38739
-
-
Stankiewicz, A.R.1
Lachapelle, G.2
Foo, C.P.3
Radicioni, S.M.4
Mosser, D.D.5
-
35
-
-
0035976902
-
Tumor necrosis factor-α induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K
-
Sundararajan R, Cuconati A, Nelson D, and White E (2001) Tumor necrosis factor-α induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K. J Biol Chem 276:45120-45127.
-
(2001)
J Biol Chem
, vol.276
, pp. 45120-45127
-
-
Sundararajan, R.1
Cuconati, A.2
Nelson, D.3
White, E.4
-
36
-
-
0033713002
-
Structure of Bax: Coregulation of dimmer formation and intracellular localization
-
Suzuki M, Youle RJ, and Tjandra N (2000) Structure of Bax: coregulation of dimmer formation and intracellular localization. Cell 103:645-654.
-
(2000)
Cell
, vol.103
, pp. 645-654
-
-
Suzuki, M.1
Youle, R.J.2
Tjandra, N.3
-
37
-
-
33750220063
-
Critical role for mitochondrial oxidative phosphorylation in the activation of tumor suppression Bax and Bak
-
Tomiyama A, Serizawa S, Tachibana K, Sakurada K, Samejima H, Kuchino Y, and Kitanaka C (2006) Critical role for mitochondrial oxidative phosphorylation in the activation of tumor suppression Bax and Bak. J Natl Cancer Inst 98:1462-1473.
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 1462-1473
-
-
Tomiyama, A.1
Serizawa, S.2
Tachibana, K.3
Sakurada, K.4
Samejima, H.5
Kuchino, Y.6
Kitanaka, C.7
-
39
-
-
0034630161
-
The CD95 (APO-1/Fas) and TRAIL (APO-2L) apoptosis system
-
Walczak H and Krammer PH (2000) The CD95 (APO-1/Fas) and TRAIL (APO-2L) apoptosis system. Exp Cell Res 256:58-66.
-
(2000)
Exp Cell Res
, vol.256
, pp. 58-66
-
-
Walczak, H.1
Krammer, P.H.2
-
40
-
-
0036830438
-
Bcl-XL protects Bim-induced Bax conformational change and cytochrome c release independent of interacting with Bax or BinEL
-
Yamaguchi H and Wang HG (2002) Bcl-XL protects Bim-induced Bax conformational change and cytochrome c release independent of interacting with Bax or BinEL. J Biol Chem 277:41604-41612.
-
(2002)
J Biol Chem
, vol.277
, pp. 41604-41612
-
-
Yamaguchi, H.1
Wang, H.G.2
-
41
-
-
0023942517
-
-
Yarden Y and Ullrich A (1988) Growth factor receptor tyrosine kinases. Annu Re. Biochem 57:443-478.
-
Yarden Y and Ullrich A (1988) Growth factor receptor tyrosine kinases. Annu Re. Biochem 57:443-478.
-
-
-
|