Design and evaluation of a novel evodiamine-phospholipid complex for improved oral bioavailability

AAPS PharmSciTech

Volumn 13, Issue 2, 2012, Pages 534-547

  Tan, Qunyou ^a   Liu, Shan ^b   Chen, Xueliang ^b   Wu, Mingjun ^b   Wang, Hong ^b   Yin, Huafeng ^b   He, Dan ^b   Xiong, Huarong ^b   Zhang, Jingqing ^b  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

bioavailability; evodiamine; phospholipid complex; process optimization

Indexed keywords

EVODIAMINE; PHOSPHOLIPID DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG DETERMINATION; DRUG FORMULATION; DRUG SCREENING; DRUG SOLUBILITY; FOURIER TRANSFORM INFRARED PHOTOACOUSTIC SPECTROSCOPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PARTICLE SIZE; PH; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; ULTRAVIOLET SPECTROSCOPY; ZETA POTENTIAL;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CARRIERS; DRUGS, CHINESE HERBAL; HYDROGEN-ION CONCENTRATION; INDOLE ALKALOIDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICROSCOPY, ELECTRON, SCANNING; MODELS, BIOLOGICAL; MODELS, CHEMICAL; PARTICLE SIZE; PHOSPHOLIPIDS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TECHNOLOGY, PHARMACEUTICAL;

EID: 84862877338     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-012-9772-9     Document Type: Article

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