-
1
-
-
38649124003
-
Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders
-
Abel T., Zukin R.S. Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders. Curr. Opin. Pharmacol. 2008, 8:57-64.
-
(2008)
Curr. Opin. Pharmacol.
, vol.8
, pp. 57-64
-
-
Abel, T.1
Zukin, R.S.2
-
2
-
-
0035947372
-
Impairment of the ubiquitin-proteasome system by protein aggregation
-
Bence N.F., et al. Impairment of the ubiquitin-proteasome system by protein aggregation. Science 2001, 292:1552-1555.
-
(2001)
Science
, vol.292
, pp. 1552-1555
-
-
Bence, N.F.1
-
3
-
-
84893751693
-
Epigenetic suppression of neuroligin 1 underlies amyloid-induced memory deficiency
-
Bie B., et al. Epigenetic suppression of neuroligin 1 underlies amyloid-induced memory deficiency. Nat. Neurosci. 2014, 17:223-231.
-
(2014)
Nat. Neurosci.
, vol.17
, pp. 223-231
-
-
Bie, B.1
-
4
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
Braak H., Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991, 82:239-259.
-
(1991)
Acta Neuropathol.
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
5
-
-
0029013727
-
Staging of Alzheimer's disease-related neurofibrillary changes
-
Braak H., Braak E. Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol. Aging 1995, 16:271-278.
-
(1995)
Neurobiol. Aging
, vol.16
, pp. 271-278
-
-
Braak, H.1
Braak, E.2
-
6
-
-
0031302684
-
Staging of Alzheimer-related cortical destruction
-
Braak H., Braak E. Staging of Alzheimer-related cortical destruction. Int. Psychogeriatr. / IPA. 1997, 9:257-261.
-
(1997)
Int. Psychogeriatr. / IPA.
, vol.9
, pp. 257-261
-
-
Braak, H.1
Braak, E.2
-
7
-
-
84898459011
-
Pharmacological targeting of the I 2-amyloid precursor protein intracellular domain
-
Branca C., et al. Pharmacological targeting of the I 2-amyloid precursor protein intracellular domain. Sci. Rep. 2014, 4.
-
(2014)
Sci. Rep.
, vol.4
-
-
Branca, C.1
-
8
-
-
0037183481
-
CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects
-
Buerger K., et al. CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects. Neurology 2002, 59:627-629.
-
(2002)
Neurology
, vol.59
, pp. 627-629
-
-
Buerger, K.1
-
9
-
-
0026046950
-
Tau protein binds to microtubules through a flexible array of distributed weak sites
-
Butner K.A., Kirschner M.W. Tau protein binds to microtubules through a flexible array of distributed weak sites. J. Cell Biol. 1991, 115:717-730.
-
(1991)
J. Cell Biol.
, vol.115
, pp. 717-730
-
-
Butner, K.A.1
Kirschner, M.W.2
-
10
-
-
0035816661
-
A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60
-
Cao X., Sudhof T.C. A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 2001, 293:115-120.
-
(2001)
Science
, vol.293
, pp. 115-120
-
-
Cao, X.1
Sudhof, T.C.2
-
11
-
-
28644439093
-
Transcriptional regulation of cyclooxygenase-2 in response to proteasome inhibitors involves reactive oxygen species-mediated signaling pathway and recruitment of CCAAT/enhancer-binding protein δ and CREB-binding protein
-
Chen J.J., et al. Transcriptional regulation of cyclooxygenase-2 in response to proteasome inhibitors involves reactive oxygen species-mediated signaling pathway and recruitment of CCAAT/enhancer-binding protein δ and CREB-binding protein. Mol. Biol. Cell 2005, 16:5579-5591.
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 5579-5591
-
-
Chen, J.J.1
-
12
-
-
0141987860
-
The ubiquitin proteasome system in neurodegenerative diseases: Sometimes the chicken, sometimes the egg
-
Ciechanover A., Brundin P. The ubiquitin proteasome system in neurodegenerative diseases: Sometimes the chicken, sometimes the egg. Neuron 2003, 40:427-446.
-
(2003)
Neuron
, vol.40
, pp. 427-446
-
-
Ciechanover, A.1
Brundin, P.2
-
13
-
-
84903362440
-
Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain
-
Coppieters N., et al. Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain. Neurobiol. Aging 2014, 35:1334-1344.
-
(2014)
Neurobiol. Aging
, vol.35
, pp. 1334-1344
-
-
Coppieters, N.1
-
14
-
-
84898046903
-
Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise
-
Cosín-Tomás M., et al. Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise. Front. Aging Neurosci. 2014, 6.
-
(2014)
Front. Aging Neurosci.
, vol.6
-
-
Cosín-Tomás, M.1
-
15
-
-
0031093625
-
Reduction of histone cytotoxicity by the Alzheimer [beta]-amyloid peptide precursor
-
Currie J.R., et al. Reduction of histone cytotoxicity by the Alzheimer [beta]-amyloid peptide precursor. Biochim. Biophys. Acta Mol. Cell Res. 1997, 1355:248-258.
-
(1997)
Biochim. Biophys. Acta Mol. Cell Res.
, vol.1355
, pp. 248-258
-
-
Currie, J.R.1
-
16
-
-
0019308904
-
Senile dementia and Alzheimer's disease: A current view
-
De Boni U., Crapper McLachlan D.R. Senile dementia and Alzheimer's disease: A current view. Life Sci. 1980, 27:1-14.
-
(1980)
Life Sci.
, vol.27
, pp. 1-14
-
-
De Boni, U.1
Crapper McLachlan, D.R.2
-
17
-
-
77952996319
-
Genome-wide kinetics of nucleosome turnover determined by metabolic labeling of histones
-
Deal R.B., et al. Genome-wide kinetics of nucleosome turnover determined by metabolic labeling of histones. Science 2010, 328:1161-1164.
-
(2010)
Science
, vol.328
, pp. 1161-1164
-
-
Deal, R.B.1
-
18
-
-
0027354484
-
Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease
-
Dickson D.W., et al. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia 1993, 7:75-83.
-
(1993)
Glia
, vol.7
, pp. 75-83
-
-
Dickson, D.W.1
-
19
-
-
84858018481
-
Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces beta-secretase (BACE1) levels and Abeta generation
-
Ding Y., et al. Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces beta-secretase (BACE1) levels and Abeta generation. J. Biol. Chem. 2012, 287:8424-8433.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 8424-8433
-
-
Ding, Y.1
-
20
-
-
0027058857
-
Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau
-
Drechsel D.N., et al. Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau. Mol. Biol. Cell 1992, 3:1141-1154.
-
(1992)
Mol. Biol. Cell
, vol.3
, pp. 1141-1154
-
-
Drechsel, D.N.1
-
21
-
-
34248523169
-
Recovery of learning and memory is associated with chromatin remodelling
-
Fischer A., et al. Recovery of learning and memory is associated with chromatin remodelling. Nature 2007, 447:178-182.
-
(2007)
Nature
, vol.447
, pp. 178-182
-
-
Fischer, A.1
-
22
-
-
35948976890
-
Report on an open-label prospective study of divalproex sodium for the behavioral and psychological symptoms of dementia as monotherapy and in combination with second-generation antipsychotic medication
-
Forester B., et al. Report on an open-label prospective study of divalproex sodium for the behavioral and psychological symptoms of dementia as monotherapy and in combination with second-generation antipsychotic medication. Am. J. Geriatr. Pharmacother. 2007, 5:209-217.
-
(2007)
Am. J. Geriatr. Pharmacother.
, vol.5
, pp. 209-217
-
-
Forester, B.1
-
23
-
-
84896719812
-
Tau promotes neurodegeneration through global chromatin relaxation
-
Frost B., et al. Tau promotes neurodegeneration through global chromatin relaxation. Nat. Neurosci. 2014, 17:357-366.
-
(2014)
Nat. Neurosci.
, vol.17
, pp. 357-366
-
-
Frost, B.1
-
24
-
-
0038708285
-
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease
-
Giannakopoulos P., et al. Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease. Neurology 2003, 60:1495-1500.
-
(2003)
Neurology
, vol.60
, pp. 1495-1500
-
-
Giannakopoulos, P.1
-
25
-
-
0002792366
-
Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau
-
Goedert M., et al. Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau. Proc. Natl. Acad. Sci. U. S. A. 1988, 85:4051-4055.
-
(1988)
Proc. Natl. Acad. Sci. U. S. A.
, vol.85
, pp. 4051-4055
-
-
Goedert, M.1
-
26
-
-
0027217679
-
The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development
-
Goedert M., et al. The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development. Proc. Natl. Acad. Sci. U. S. A. 1993, 90:5066-5070.
-
(1993)
Proc. Natl. Acad. Sci. U. S. A.
, vol.90
, pp. 5066-5070
-
-
Goedert, M.1
-
27
-
-
80051984937
-
Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression
-
Govindarajan N., et al. Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression. J. Alzheimers Dis. 2012, 26:187-197.
-
(2012)
J. Alzheimers Dis.
, vol.26
, pp. 187-197
-
-
Govindarajan, N.1
-
28
-
-
44649134044
-
Epigenetic codes in cognition and behaviour
-
Graff J., Mansuy I.M. Epigenetic codes in cognition and behaviour. Behav. Brain Res. 2008, 192:70-87.
-
(2008)
Behav. Brain Res.
, vol.192
, pp. 70-87
-
-
Graff, J.1
Mansuy, I.M.2
-
29
-
-
84862777943
-
An epigenetic blockade of cognitive functions in the neurodegenerating brain
-
Graff J., et al. An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature 2012, 483:222-226.
-
(2012)
Nature
, vol.483
, pp. 222-226
-
-
Graff, J.1
-
30
-
-
0028979993
-
Amyloid beta-protein inhibits ubiquitin-dependent protein degradation in vitro
-
Gregori L., et al. Amyloid beta-protein inhibits ubiquitin-dependent protein degradation in vitro. J. Biol. Chem. 1995, 270:19702-19708.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 19702-19708
-
-
Gregori, L.1
-
31
-
-
0033394155
-
Memory and mental status correlates of modified Braak staging
-
Grober E., et al. Memory and mental status correlates of modified Braak staging. Neurobiol. Aging 1999, 20:573-579.
-
(1999)
Neurobiol. Aging
, vol.20
, pp. 573-579
-
-
Grober, E.1
-
32
-
-
0023009658
-
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments
-
Grundke-Iqbal I., et al. Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J. Biol. Chem. 1986, 261:6084-6089.
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 6084-6089
-
-
Grundke-Iqbal, I.1
-
33
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
-
Grundke-Iqbal I., et al. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc. Natl. Acad. Sci. U. S. A. 1986, 83:4913-4917.
-
(1986)
Proc. Natl. Acad. Sci. U. S. A.
, vol.83
, pp. 4913-4917
-
-
Grundke-Iqbal, I.1
-
34
-
-
84872305918
-
Oxidative stress induces DNA demethylation and histone acetylation in SH-SY5Y cells: potential epigenetic mechanisms in gene transcription in Abeta production
-
Gu X., et al. Oxidative stress induces DNA demethylation and histone acetylation in SH-SY5Y cells: potential epigenetic mechanisms in gene transcription in Abeta production. Neurobiol. Aging 2013, 34:1069-1079.
-
(2013)
Neurobiol. Aging
, vol.34
, pp. 1069-1079
-
-
Gu, X.1
-
35
-
-
65549123471
-
HDAC2 negatively regulates memory formation and synaptic plasticity
-
Guan J.S., et al. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 2009, 459:55-60.
-
(2009)
Nature
, vol.459
, pp. 55-60
-
-
Guan, J.S.1
-
36
-
-
3142743789
-
Value of CSF B-amyloid1-42 and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment
-
Hampel H., et al. Value of CSF B-amyloid1-42 and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment. Mol. Psychiatry 2004, 9:705-710.
-
(2004)
Mol. Psychiatry
, vol.9
, pp. 705-710
-
-
Hampel, H.1
-
37
-
-
84903386121
-
Epigenetic regulations of immediate early genes expression involved in memory formation by the amyloid precursor protein of alzheimer disease
-
Hendrickx A., et al. Epigenetic regulations of immediate early genes expression involved in memory formation by the amyloid precursor protein of alzheimer disease. PLoS One 2014, 9.
-
(2014)
PLoS One
, vol.9
-
-
Hendrickx, A.1
-
38
-
-
37249012276
-
Nucleosome destabilization in the epigenetic regulation of gene expression
-
Henikoff S. Nucleosome destabilization in the epigenetic regulation of gene expression. Nat. Rev. Genet. 2008, 9:15-26.
-
(2008)
Nat. Rev. Genet.
, vol.9
, pp. 15-26
-
-
Henikoff, S.1
-
39
-
-
0031916507
-
Valproic acid treatment of agitation in dementia
-
Herrmann N. Valproic acid treatment of agitation in dementia. Can. J. Psychiatry 1998, 43:69-72.
-
(1998)
Can. J. Psychiatry
, vol.43
, pp. 69-72
-
-
Herrmann, N.1
-
40
-
-
33846218161
-
A placebo-controlled trial of valproate for agitation and aggression in Alzheimer's disease
-
Herrmann N., et al. A placebo-controlled trial of valproate for agitation and aggression in Alzheimer's disease. Dement. Geriatr. Cogn. Disord. 2007, 23:116-119.
-
(2007)
Dement. Geriatr. Cogn. Disord.
, vol.23
, pp. 116-119
-
-
Herrmann, N.1
-
42
-
-
84893118788
-
Curcumin attenuates amyloid-beta-induced tau hyperphosphorylation in human neuroblastoma SH-SY5Y cells involving PTEN/Akt/GSK-3beta signaling pathway
-
Huang H.C., et al. Curcumin attenuates amyloid-beta-induced tau hyperphosphorylation in human neuroblastoma SH-SY5Y cells involving PTEN/Akt/GSK-3beta signaling pathway. J. Recept. Signal Transduct. Res. 2014, 34:26-37.
-
(2014)
J. Recept. Signal Transduct. Res.
, vol.34
, pp. 26-37
-
-
Huang, H.C.1
-
43
-
-
0034682736
-
Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis
-
Ikura T., et al. Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell 2000, 102:463-473.
-
(2000)
Cell
, vol.102
, pp. 463-473
-
-
Ikura, T.1
-
44
-
-
84857620173
-
Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies
-
Irwin D.J., et al. Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies. Brain 2012, 135:807-818.
-
(2012)
Brain
, vol.135
, pp. 807-818
-
-
Irwin, D.J.1
-
45
-
-
0031445786
-
A pilot study on the use of divalproex sodium in the treatment of behavioral agitation in elderly patients with dementia: Assessment with the BEHAVE-AD and CGI rating scales
-
Kasckow J.W., et al. A pilot study on the use of divalproex sodium in the treatment of behavioral agitation in elderly patients with dementia: Assessment with the BEHAVE-AD and CGI rating scales. Curr. Ther. Res. Clin. Exp. 1997, 58:981-989.
-
(1997)
Curr. Ther. Res. Clin. Exp.
, vol.58
, pp. 981-989
-
-
Kasckow, J.W.1
-
46
-
-
84870552401
-
Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules
-
Kelly T.K., et al. Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules. Genome Res. 2012, 22:2497-2506.
-
(2012)
Genome Res.
, vol.22
, pp. 2497-2506
-
-
Kelly, T.K.1
-
47
-
-
76749091005
-
Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease
-
Kilgore M., et al. Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 2010, 35:870-880.
-
(2010)
Neuropsychopharmacology
, vol.35
, pp. 870-880
-
-
Kilgore, M.1
-
48
-
-
9144234107
-
Inhibition of histone deacetylation enhances the neurotoxicity induced by the C-terminal fragments of amyloid precursor protein
-
Kim H.S., et al. Inhibition of histone deacetylation enhances the neurotoxicity induced by the C-terminal fragments of amyloid precursor protein. J. Neurosci. Res. 2004, 75:117-124.
-
(2004)
J. Neurosci. Res.
, vol.75
, pp. 117-124
-
-
Kim, H.S.1
-
49
-
-
0031974036
-
The efficacy and tolerability of divalproex sodium in elderly demented patients with behavioral disturbances
-
Kunik M.E., et al. The efficacy and tolerability of divalproex sodium in elderly demented patients with behavioral disturbances. Int. J. Geriatr. Psychiatry 1998, 13:29-34.
-
(1998)
Int. J. Geriatr. Psychiatry
, vol.13
, pp. 29-34
-
-
Kunik, M.E.1
-
50
-
-
20844438031
-
Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents
-
Langley B., et al. Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents. Curr. Drug Targets CNS Neurol. Disord. 2005, 4:41-50.
-
(2005)
Curr. Drug Targets CNS Neurol. Disord.
, vol.4
, pp. 41-50
-
-
Langley, B.1
-
51
-
-
13244276460
-
Epigenetic mechanisms in memory formation
-
Levenson J.M., Sweatt J.D. Epigenetic mechanisms in memory formation. Nat. Rev. Neurosci. 2005, 6:108-118.
-
(2005)
Nat. Rev. Neurosci.
, vol.6
, pp. 108-118
-
-
Levenson, J.M.1
Sweatt, J.D.2
-
52
-
-
4644261125
-
Regulation of histone acetylation during memory formation in the hippocampus
-
Levenson J.M., et al. Regulation of histone acetylation during memory formation in the hippocampus. J. Biol. Chem. 2004, 279:40545-40559.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 40545-40559
-
-
Levenson, J.M.1
-
53
-
-
0019841867
-
Changes in chromatin structure associated with Alzheimer's disease
-
Lewis P.N., et al. Changes in chromatin structure associated with Alzheimer's disease. J. Neurochem. 1981, 37:1193-1202.
-
(1981)
J. Neurochem.
, vol.37
, pp. 1193-1202
-
-
Lewis, P.N.1
-
54
-
-
84897120109
-
Neonatal exposure to benzo[a]pyrene decreases the levels of serum testosterone and histone H3K14 acetylation of the StAR promoter in the testes of SD rats
-
Liang J., et al. Neonatal exposure to benzo[a]pyrene decreases the levels of serum testosterone and histone H3K14 acetylation of the StAR promoter in the testes of SD rats. Toxicology 2012, 302:285-291.
-
(2012)
Toxicology
, vol.302
, pp. 285-291
-
-
Liang, J.1
-
55
-
-
84878927731
-
Disruption of neocortical histone H3 homeostasis by soluble Abeta: implications for Alzheimer's disease
-
Lithner C.U., et al. Disruption of neocortical histone H3 homeostasis by soluble Abeta: implications for Alzheimer's disease. Neurobiol. Aging 2013, 34:2081-2090.
-
(2013)
Neurobiol. Aging
, vol.34
, pp. 2081-2090
-
-
Lithner, C.U.1
-
56
-
-
0029145509
-
Valproate in the treatment of behavioral agitation in elderly patients with dementia
-
Lott A.D., et al. Valproate in the treatment of behavioral agitation in elderly patients with dementia. J. Neuropsychiatry Clin. Neurosci. 1995, 7:314-319.
-
(1995)
J. Neuropsychiatry Clin. Neurosci.
, vol.7
, pp. 314-319
-
-
Lott, A.D.1
-
57
-
-
0036931742
-
Neuroprotective properties of valproate: potential benefit for AD and tauopathies
-
Loy R., Tariot P.N. Neuroprotective properties of valproate: potential benefit for AD and tauopathies. J. Mol. Neurosci. 2002, 19:303-307.
-
(2002)
J. Mol. Neurosci.
, vol.19
, pp. 303-307
-
-
Loy, R.1
Tariot, P.N.2
-
58
-
-
84904665084
-
Histone acetyltransferase p300 mediates histone acetylation of PS1 and BACE1 in a cellular model of Alzheimer's disease
-
Lu X., et al. Histone acetyltransferase p300 mediates histone acetylation of PS1 and BACE1 in a cellular model of Alzheimer's disease. PLoS One 2014, 9.
-
(2014)
PLoS One
, vol.9
-
-
Lu, X.1
-
59
-
-
0025117535
-
Chromatin structure and gene expression in Alzheimer's disease
-
Lukiw W.J., Crapper McLachlan D.R. Chromatin structure and gene expression in Alzheimer's disease. Mol. Brain Res. 1990, 7:227-233.
-
(1990)
Mol. Brain Res.
, vol.7
, pp. 227-233
-
-
Lukiw, W.J.1
Crapper McLachlan, D.R.2
-
60
-
-
0041302197
-
Histone deacetylases
-
Marks P.A., et al. Histone deacetylases. Curr. Opin. Pharmacol. 2003, 3:344-351.
-
(2003)
Curr. Opin. Pharmacol.
, vol.3
, pp. 344-351
-
-
Marks, P.A.1
-
61
-
-
84864770859
-
Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice
-
Marques S.C., et al. Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice. Neuroscience 2012, 220:256-266.
-
(2012)
Neuroscience
, vol.220
, pp. 256-266
-
-
Marques, S.C.1
-
62
-
-
84864409298
-
Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease
-
McFarland K.N., et al. Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease. PLoS One 2012, 7.
-
(2012)
PLoS One
, vol.7
-
-
McFarland, K.N.1
-
63
-
-
0023035288
-
Chromatin structure in scrapie and Alzheimer's disease
-
McLachlan D.R.C., et al. Chromatin structure in scrapie and Alzheimer's disease. Can. J. Neurol. Sci. 1986, 13:427-431.
-
(1986)
Can. J. Neurol. Sci.
, vol.13
, pp. 427-431
-
-
McLachlan, D.R.C.1
-
64
-
-
34249724360
-
Noncoding RNAs and RNA editing in brain development, functional diversification, and neurological disease
-
Mehler M.F., Mattick J.S. Noncoding RNAs and RNA editing in brain development, functional diversification, and neurological disease. Physiol. Rev. 2007, 87:799-823.
-
(2007)
Physiol. Rev.
, vol.87
, pp. 799-823
-
-
Mehler, M.F.1
Mattick, J.S.2
-
65
-
-
77954855825
-
SIRT1 is essential for normal cognitive function and synaptic plasticity
-
Michan S., et al. SIRT1 is essential for normal cognitive function and synaptic plasticity. J. Neurosci. 2010, 30:9695-9707.
-
(2010)
J. Neurosci.
, vol.30
, pp. 9695-9707
-
-
Michan, S.1
-
66
-
-
66149121016
-
Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: A mechanism for synergy in leukemia cells
-
Miller C.P., et al. Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: A mechanism for synergy in leukemia cells. Blood 2009, 113:4289-4299.
-
(2009)
Blood
, vol.113
, pp. 4289-4299
-
-
Miller, C.P.1
-
67
-
-
0025908356
-
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
-
Mirra S.S., et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991, 41:479-486.
-
(1991)
Neurology
, vol.41
, pp. 479-486
-
-
Mirra, S.S.1
-
68
-
-
0023140474
-
Ubiquitin is a component of paired helical filaments in Alzheimer's disease
-
Mori H., et al. Ubiquitin is a component of paired helical filaments in Alzheimer's disease. Science 1987, 235:1641-1644.
-
(1987)
Science
, vol.235
, pp. 1641-1644
-
-
Mori, H.1
-
69
-
-
0024453856
-
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease
-
Morris J.C., et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology 1989, 39:1159-1165.
-
(1989)
Neurology
, vol.39
, pp. 1159-1165
-
-
Morris, J.C.1
-
70
-
-
77955980364
-
Histone deacetylases govern cellular mechanisms underlying behavioral and synaptic plasticity in the developing and adult brain
-
Morris M.J., et al. Histone deacetylases govern cellular mechanisms underlying behavioral and synaptic plasticity in the developing and adult brain. Behav. Pharmacol. 2010, 21:409-419.
-
(2010)
Behav. Pharmacol.
, vol.21
, pp. 409-419
-
-
Morris, M.J.1
-
71
-
-
77957663117
-
High content analysis of histone acetylation in human cells and tissues
-
Narayan P.J., Dragunow M. High content analysis of histone acetylation in human cells and tissues. J. Neurosci. Methods 2010, 193:54-61.
-
(2010)
J. Neurosci. Methods
, vol.193
, pp. 54-61
-
-
Narayan, P.J.1
Dragunow, M.2
-
72
-
-
0030853759
-
Treatment of dementia with behavioral disturbance using divalproex or a combination of divalproex and a neuroleptic
-
Narayan M., Nelson J.C. Treatment of dementia with behavioral disturbance using divalproex or a combination of divalproex and a neuroleptic. J. Clin. Psychiatry 1997, 58:351-354.
-
(1997)
J. Clin. Psychiatry
, vol.58
, pp. 351-354
-
-
Narayan, M.1
Nelson, J.C.2
-
74
-
-
0027249667
-
A new fluorometric assay for cytotoxicity measurements in-vitro
-
Page B., et al. A new fluorometric assay for cytotoxicity measurements in-vitro. Int. J. Oncol. 1993, 3:473-476.
-
(1993)
Int. J. Oncol.
, vol.3
, pp. 473-476
-
-
Page, B.1
-
75
-
-
77950666255
-
Proteomic identification of interactions between histones and plasma proteins: Implications for cytoprotection
-
Pemberton A.D., et al. Proteomic identification of interactions between histones and plasma proteins: Implications for cytoprotection. Proteomics 2010, 10:1484-1493.
-
(2010)
Proteomics
, vol.10
, pp. 1484-1493
-
-
Pemberton, A.D.1
-
76
-
-
33751237039
-
Divalproex sodium for the treatment of behavioural problems associated with dementia in the elderly
-
Porsteinsson A.P. Divalproex sodium for the treatment of behavioural problems associated with dementia in the elderly. Drugs Aging 2006, 23:877-886.
-
(2006)
Drugs Aging
, vol.23
, pp. 877-886
-
-
Porsteinsson, A.P.1
-
77
-
-
0035172216
-
Placebo-controlled study of divalproex sodium for agitation in dementia
-
Porsteinsson A.P., et al. Placebo-controlled study of divalproex sodium for agitation in dementia. Am. J. Geriatr. Psychiatry 2001, 9:58-66.
-
(2001)
Am. J. Geriatr. Psychiatry
, vol.9
, pp. 58-66
-
-
Porsteinsson, A.P.1
-
78
-
-
0038679746
-
Valproate therapy for agitation in dementia: open-label extension of a double-blind trial
-
Porsteinsson A.P., et al. Valproate therapy for agitation in dementia: open-label extension of a double-blind trial. Am. J. Geriatr. Psychiatry 2003, 11:434-440.
-
(2003)
Am. J. Geriatr. Psychiatry
, vol.11
, pp. 434-440
-
-
Porsteinsson, A.P.1
-
79
-
-
0027234919
-
Interaction between the beta-amyloid peptide precursor and histones
-
Potempska A., et al. Interaction between the beta-amyloid peptide precursor and histones. Arch. Biochem. Biophys. 1993, 304:448-453.
-
(1993)
Arch. Biochem. Biophys.
, vol.304
, pp. 448-453
-
-
Potempska, A.1
-
80
-
-
84863757162
-
Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients
-
Rao J.S., et al. Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients. Transl. Psychiatry 2012, 2.
-
(2012)
Transl. Psychiatry
, vol.2
-
-
Rao, J.S.1
-
81
-
-
67349220155
-
Phenylbutyrate ameliorates cognitive deficit and reduces Tau pathology in an Alzheimer's disease mouse model
-
Ricobaraza A., et al. Phenylbutyrate ameliorates cognitive deficit and reduces Tau pathology in an Alzheimer's disease mouse model. Neuropsychopharmacology 2009, 34:1721-1732.
-
(2009)
Neuropsychopharmacology
, vol.34
, pp. 1721-1732
-
-
Ricobaraza, A.1
-
82
-
-
0034912742
-
Histone acetyltransferases
-
Roth S.Y., et al. Histone acetyltransferases. Annu. Rev. Biochem. 2001, 70:81-120.
-
(2001)
Annu. Rev. Biochem.
, vol.70
, pp. 81-120
-
-
Roth, S.Y.1
-
83
-
-
4143141116
-
Targeting CREB-binding protein (CBP) loss of function as a therapeutic strategy in neurological disorders
-
Rouaux C., et al. Targeting CREB-binding protein (CBP) loss of function as a therapeutic strategy in neurological disorders. Biochem. Pharmacol. 2004, 68:1157-1164.
-
(2004)
Biochem. Pharmacol.
, vol.68
, pp. 1157-1164
-
-
Rouaux, C.1
-
84
-
-
33750363298
-
The roles of intracellular protein-degradation pathways in neurodegeneration
-
Rubinsztein D.C. The roles of intracellular protein-degradation pathways in neurodegeneration. Nature 2006, 443:780-786.
-
(2006)
Nature
, vol.443
, pp. 780-786
-
-
Rubinsztein, D.C.1
-
85
-
-
42749089622
-
High throughput quantification of mutant huntingtin aggregates
-
Scotter E.L., et al. High throughput quantification of mutant huntingtin aggregates. J. Neurosci. Methods 2008, 171:174-179.
-
(2008)
J. Neurosci. Methods
, vol.171
, pp. 174-179
-
-
Scotter, E.L.1
-
86
-
-
84889651955
-
Trichostatin A epigenetically increases calpastatin expression and inhibits calpain activity and calcium-induced SH-SY5Y neuronal cell toxicity
-
Seo J., et al. Trichostatin A epigenetically increases calpastatin expression and inhibits calpain activity and calcium-induced SH-SY5Y neuronal cell toxicity. FEBS J. 2013, 280:6691-6701.
-
(2013)
FEBS J.
, vol.280
, pp. 6691-6701
-
-
Seo, J.1
-
87
-
-
84878243515
-
A phenotypic change but not proliferation underlies glial responses in Alzheimer disease
-
Serrano-Pozo A., et al. A phenotypic change but not proliferation underlies glial responses in Alzheimer disease. Am. J. Pathol. 2013, 182:2332-2344.
-
(2013)
Am. J. Pathol.
, vol.182
, pp. 2332-2344
-
-
Serrano-Pozo, A.1
-
88
-
-
41149090082
-
DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons
-
Siegmund K.D., et al. DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS One 2007, 2.
-
(2007)
PLoS One
, vol.2
-
-
Siegmund, K.D.1
-
89
-
-
0036085791
-
Sodium valproate in the treatment of aggressive behavior in patients with dementia-a randomized placebo controlled clinical trial
-
Sival R.C., et al. Sodium valproate in the treatment of aggressive behavior in patients with dementia-a randomized placebo controlled clinical trial. Int. J. Geriatr. Psychiatry 2002, 17:579-585.
-
(2002)
Int. J. Geriatr. Psychiatry
, vol.17
, pp. 579-585
-
-
Sival, R.C.1
-
90
-
-
0034610814
-
The language of covalent histone modifications
-
Strahl B.D., Allis C.D. The language of covalent histone modifications. Nature 2000, 403:41-45.
-
(2000)
Nature
, vol.403
, pp. 41-45
-
-
Strahl, B.D.1
Allis, C.D.2
-
91
-
-
0028577208
-
Immunohistochemical evidence for apoptosis in Alzheimer's disease
-
Su J.H., et al. Immunohistochemical evidence for apoptosis in Alzheimer's disease. Neuroreport 1994, 5:2529-2533.
-
(1994)
Neuroreport
, vol.5
, pp. 2529-2533
-
-
Su, J.H.1
-
92
-
-
0031009367
-
Topographic associations between DNA fragmentation and Alzheimer's disease neuropathology in the hippocampus
-
Sugaya K., et al. Topographic associations between DNA fragmentation and Alzheimer's disease neuropathology in the hippocampus. Neurochem. Int. 1997, 31:275-281.
-
(1997)
Neurochem. Int.
, vol.31
, pp. 275-281
-
-
Sugaya, K.1
-
93
-
-
29644441522
-
Role of 14-3-3gamma in FE65-dependent gene transactivation mediated by the amyloid beta-protein precursor cytoplasmic fragment
-
Sumioka A., et al. Role of 14-3-3gamma in FE65-dependent gene transactivation mediated by the amyloid beta-protein precursor cytoplasmic fragment. J. Biol. Chem. 2005, 280:42364-42374.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 42364-42374
-
-
Sumioka, A.1
-
94
-
-
84907196865
-
Reconfiguration of nucleosome-depleted regions at distal regulatory elements accompanies DNA methylation of enhancers and insulators in cancer
-
Taberlay P.C., et al. Reconfiguration of nucleosome-depleted regions at distal regulatory elements accompanies DNA methylation of enhancers and insulators in cancer. Genome Res. 2014, 10.1101/gr.163485.113.
-
(2014)
Genome Res.
-
-
Taberlay, P.C.1
-
95
-
-
0035010076
-
Safety and tolerability of divalproex sodium in the treatment of signs and symptoms of mania in elderly patients with dementia: Results of a double-blind, placebo-controlled trial
-
Tariot P.N., et al. Safety and tolerability of divalproex sodium in the treatment of signs and symptoms of mania in elderly patients with dementia: Results of a double-blind, placebo-controlled trial. Curr. Ther. Res. Clin. Exp. 2001, 62:51-67.
-
(2001)
Curr. Ther. Res. Clin. Exp.
, vol.62
, pp. 51-67
-
-
Tariot, P.N.1
-
96
-
-
33644877231
-
Divalproex sodium in nursing home residents with possible or probable Alzheimer disease complicated by agitation: A randomized, controlled trial
-
Tariot P.N., et al. Divalproex sodium in nursing home residents with possible or probable Alzheimer disease complicated by agitation: A randomized, controlled trial. Am. J. Geriatr. Psychiatr. 2005, 13:942-949.
-
(2005)
Am. J. Geriatr. Psychiatr.
, vol.13
, pp. 942-949
-
-
Tariot, P.N.1
-
97
-
-
0036850325
-
Cellular memory and the histone code
-
Turner B.M. Cellular memory and the histone code. Cell 2002, 111:285-291.
-
(2002)
Cell
, vol.111
, pp. 285-291
-
-
Turner, B.M.1
-
98
-
-
34250026412
-
Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation
-
Vecsey C.G., et al. Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. J. Neurosci. 2007, 27:6128-6140.
-
(2007)
J. Neurosci.
, vol.27
, pp. 6128-6140
-
-
Vecsey, C.G.1
-
99
-
-
34249295729
-
Immunohistochemical staining of post-mortem adult human brain sections
-
Waldvogel H.J., et al. Immunohistochemical staining of post-mortem adult human brain sections. Nat. Protoc. 2006, 1:2719-2732.
-
(2006)
Nat. Protoc.
, vol.1
, pp. 2719-2732
-
-
Waldvogel, H.J.1
-
100
-
-
48449098512
-
The collection and processing of human brain tissue for research
-
Waldvogel H.J., et al. The collection and processing of human brain tissue for research. Cell Tissue Bank. 2008, 9:169-179.
-
(2008)
Cell Tissue Bank.
, vol.9
, pp. 169-179
-
-
Waldvogel, H.J.1
-
101
-
-
79953797454
-
An effect of DNA sequence on nucleosome occupancy and removal
-
Wang X., et al. An effect of DNA sequence on nucleosome occupancy and removal. Nat. Struct. Mol. Biol. 2011, 18:507-509.
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 507-509
-
-
Wang, X.1
-
102
-
-
84893087435
-
Epigenetic mechanisms linking diabetes and synaptic impairments
-
Wang J., et al. Epigenetic mechanisms linking diabetes and synaptic impairments. Diabetes 2014, 63:645-654.
-
(2014)
Diabetes
, vol.63
, pp. 645-654
-
-
Wang, J.1
-
103
-
-
84894227393
-
Valproic acid reduces neuritic plaque formation and improves learning deficits in APPSwe/PS1A246E transgenic mice via preventing the prenatal hypoxia-induced down-regulation of neprilysin
-
Wang Z., et al. Valproic acid reduces neuritic plaque formation and improves learning deficits in APPSwe/PS1A246E transgenic mice via preventing the prenatal hypoxia-induced down-regulation of neprilysin. CNS Neurosci. Ther. 2014, 20:209-217.
-
(2014)
CNS Neurosci. Ther.
, vol.20
, pp. 209-217
-
-
Wang, Z.1
-
104
-
-
36349036676
-
Fe65 stimulates proteolytic liberation of the beta-amyloid precursor protein intracellular domain
-
Wiley J.C., et al. Fe65 stimulates proteolytic liberation of the beta-amyloid precursor protein intracellular domain. J. Biol. Chem. 2007, 282:33313-33325.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 33313-33325
-
-
Wiley, J.C.1
-
105
-
-
33749345201
-
A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes
-
Wood M.A., et al. A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes. Learn. Mem. 2006, 13:609-617.
-
(2006)
Learn. Mem.
, vol.13
, pp. 609-617
-
-
Wood, M.A.1
-
106
-
-
84884150739
-
Suppression of central chemokine fractalkine receptor signaling alleviates amyloid-induced memory deficiency
-
Wu J., et al. Suppression of central chemokine fractalkine receptor signaling alleviates amyloid-induced memory deficiency. Neurobiol. Aging 2013, 34:2843-2852.
-
(2013)
Neurobiol. Aging
, vol.34
, pp. 2843-2852
-
-
Wu, J.1
-
107
-
-
77956649731
-
Joining the dots: From chromatin remodeling to neuronal plasticity
-
Zocchi L., Sassone-Corsi P. Joining the dots: From chromatin remodeling to neuronal plasticity. Curr. Opin. Neurobiol. 2010, 20:432-440.
-
(2010)
Curr. Opin. Neurobiol.
, vol.20
, pp. 432-440
-
-
Zocchi, L.1
Sassone-Corsi, P.2
|