Trichostatin A epigenetically increases calpastatin expression and inhibits calpain activity and calcium-induced SH-SY5Y neuronal cell toxicity

FEBS Journal

Volumn 280, Issue 24, 2013, Pages 6691-6701

  Seo, Jungwon ^a,b   Jo, Sangmee Ahn ^c   Hwang, Soojin ^a   Byun, Catherine Jeonghae ^a   Lee, Hyeon Ju ^c   Cho, Du Hyong ^d   Kim, Dueon ^b   Koh, Young Ho ^e   Jo, Inho ^a  

^a Ewha Womans University School of Medicine   (South Korea)

^b Wonkwang University   (South Korea)

^c Dankook University   (South Korea)

^d Konkuk University School of Medicine   (South Korea)

^e Korea National Institute of Health   (South Korea)

Author keywords

Alzheimer's disease; calpain; calpastatin; histone acetylation; neurotoxicity; trichostatin A

Indexed keywords

CALCIUM; CALPAIN; CALPAIN 1; CALPAIN 2; CALPASTATIN; CASPASE; IONOMYCIN; MESSENGER RNA; SMALL INTERFERING RNA; TRICHOSTATIN A;

ALZHEIMER DISEASE; ARTICLE; AUTOLYSIS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; EPIGENETICS; GENETIC REGULATION; HISTONE ACETYLATION; HISTONE MODIFICATION; HUMAN; HUMAN CELL; LEARNING; MEMORY; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION;

ALZHEIMER'S DISEASE; CALPAIN; CALPASTATIN; HISTONE ACETYLATION; NEUROTOXICITY; TRICHOSTATIN A;

ACETYLATION; APOPTOSIS; BLOTTING, WESTERN; CALCIUM; CALCIUM-BINDING PROTEINS; CALPAIN; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; EPIGENOMICS; HISTONE DEACETYLASE INHIBITORS; HISTONES; HUMANS; HYDROXAMIC ACIDS; IONOMYCIN; LUCIFERASES; NEUROBLASTOMA; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TUMOR CELLS, CULTURED;

EID: 84889651955     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12572     Document Type: Article

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