Safety and tolerability of divalproex sodium in the treatment of signs and symptoms of mania in elderly patients with dementia: Results of a double-blind, placebo-controlled trial

Current Therapeutic Research - Clinical and Experimental

Volumn 62, Issue 1, 2001, Pages 51-67

  Tariot, Pierre N ^a,f   Schneider, Lon S ^b   Mintzer, Jacobo E ^c   Cutler, Andrew J ^d   Cunningham, Muriel R ^e   Thomas, James W ^e   Sommerville, Kenneth W ^e  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d Coordinated Research of Florida Inc ^*  (United States)

^e ABBOTT LABORATORIES   (United States)

^f Monroe Community Hospital   (United States)

Author keywords

Agitation; Dementia; Divalproex sodium; Elderly; Mania; Valproate

Indexed keywords

PLACEBO; VALPROATE SEMISODIUM;

AGED; AGITATION; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMENTIA; DISEASE SEVERITY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MANIA; MANIC DEPRESSIVE PSYCHOSIS; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SOMNOLENCE; SYMPTOMATOLOGY; THROMBOCYTOPENIA;

EID: 0035010076     PISSN: 0011393X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0011-393X(01)80042-4     Document Type: Article

References (47)

1. Behavioral and psychological signs and symptoms of dementia: Implications for research and treatment. Proceedings of an international consensus conference
2. The psychopathology of dementia
3. The prevalence of neuropsychiatric disorders in a nursing home population
4. Assessment of disruptive behavior/agitation in the elderly: Function, methods, and difficulties
5. Mental disorders in the nursing home: Another perspective
6. Agitated behaviors in the elderly. 1: A conceptual review
7. A description of agitation in a nursing home
8. Treatment of agitation in dementia
9. Anticonvulsant and other non-neuroleptic treatment of agitation in dementia
10. Efficacy and tolerability of carbamazepine for agitation and aggression in dementia
11. The diagnosis and treatment of mania in the elderly
12. Valproate in the treatment of acute mania: A placebo-controlled study
13. Efficacy of divalproex vs lithium and placebo in the treatment of mania
14. Secondary mania: Diagnosis and treatment
15. Valproate use in the older manic patient
16. Safety and efficacy of divalproex sodium in elderly bipolar patients
17. Sodium valproate in the treatment of behavioral disturbance in dementia
18. The effects of sodium valproate on disturbed behavior in dementia
19. Divalproex sodium in the treatment of aggressive behavior and dysphoria in patients with organic brain syndromes
20. Valproate in the treatment of behavioral agitation in elderly patients with dementia
21. Valproic acid for physically aggressive behavior in geriatric patients
22. Tolerability of divalproex sodium in elderly psychiatric patients with mixed diagnoses
23. An open trial of valproate for agitation in geriatric neuropsychiatric disorders
24. Divalproex: A possible alternative for demented, elderly aggressive patients
25. A pilot study on the use of divalproex sodium in the treatment of behavioral agitation in elderly patients with dementia: Assessment with BEHAVE-AD and CGI rating scales
26. Treatment of dementia with behavioral disturbance using divalproex or a combination of divalproex and a neuroleptic
27. Valproic acid treatment of agitation in dementia
28. The efficacy and tolerability of divalproex sodium in elderly demented patients with behavioral disturbances
29. Efficacy of valproate for agitation and aggression in dementia: Case reports
30. The use of adjunctive divalproex for neuroleptic unresponsive behavioral disturbances in nursing home residents with dementia
31. Case report of sodium valproate treatment of aggression associated with Alzheimer's disease
32. Divalproex sodium in the treatment of aggressive behavior
33. Valproate treatment of older psychotic patients with organic mental syndromes and behavioral dyscontrol
34. The use of valproate in an elderly population with affective symptoms
35. Clinical correlates of response to valproate in geriatric inpatients
36. The mania rating scale: Scale construction and inter-observer agreement
37. The Brief Psychiatric Rating Scale
38. A description of agitation in a nursing home
39. "Mini-mental state." A practical method for grading the cognitive state of patients for the clinician
40. Clinical Global Impressions
41. Pharmacokinetics of valproic acid in the elderly
42. Valproic acid clearance: Unbound fraction and diurnal variation in young and elderly adults
43. Antiepileptics in the elderly. Pharmacoepidemiology and pharmacokinetics