Neonatal exposure to benzo[a]pyrene decreases the levels of serum testosterone and histone H3K14 acetylation of the StAR promoter in the testes of SD rats

Toxicology

Volumn 302, Issue 2-3, 2012, Pages 285-291

  Liang, Jiren ^a,b   Zhu, Hongyan ^a,b   Li, Cuizhen ^a,b   Ding, Yicheng ^c   Zhou, Zhijun ^a,b   Wu, Qing ^a,b  

^a FUDAN UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c SHANGHAI UNIVERSITY   (China)

Author keywords

Benzo a pyrene; H3K14 acetylation; Neonatal exposure; Serum testosterone; StAR; Testis

Indexed keywords

3BETA HYDROXY DELTA5 STEROID DEHYDROGENASE; BENZO[A]PYRENE; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CORN OIL; CYTOCHROME P450 1A1; HISTONE H3; STEROID 17ALPHA MONOOXYGENASE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE; HISTONE; MESSENGER RNA; PHOSPHOPROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; EPIDIDYMIS; FEMALE; GENE EXPRESSION; HISTONE ACETYLATION; LIVER; MALE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROMOTER REGION; RAT; SPERMATOGENESIS; SPERMATOZOON COUNT; TESTIS; TESTIS WEIGHT; TESTOSTERONE BLOOD LEVEL; ACETYLATION; ANIMAL; BLOOD; DRUG EFFECT; GENETIC EPIGENESIS; GENETICS; METABOLISM; ORGAN SIZE; PHYSIOLOGY; SPERMATOZOON; SPRAGUE DAWLEY RAT;

RATTUS; ZEA MAYS;

ACETYLATION; ANIMALS; ANIMALS, NEWBORN; BENZO(A)PYRENE; BODY WEIGHT; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; CYTOCHROME P-450 CYP1A1; EPIGENESIS, GENETIC; FEMALE; HISTONES; LIVER; MALE; ORGAN SIZE; PHOSPHOPROTEINS; PROMOTER REGIONS, GENETIC; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SPERMATOZOA; STEROID 17-ALPHA-HYDROXYLASE; TESTIS; TESTOSTERONE;

EID: 84897120109     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.08.010     Document Type: Article

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