Histone acetyltransferase p300 mediates histone acetylation of PS1 and BACE1 in a cellular model of Alzheimer's disease

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Lu, Xi ^a   Deng, Yushuang ^a   Yu, Daohai ^b   Cao, Huiming ^a   Wang, Li ^c   Liu, Li ^d   Yu, Caijia ^e   Zhang, Yuping ^a   Guo, Xiuming ^a   Yu, Gang ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Department of Bio therapy and Hemato oncology Chingqing Cancer Institute   (China)

^d CHONGQING TRADITIONAL CHINESE MEDICINE HOSPITAL   (China)

^e NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; CURCUMIN; E1A ASSOCIATED P300 PROTEIN; HISTONE ACETYLTRANSFERASE; PRESENILIN 1; ASPARTIC PROTEINASE; BACE1 PROTEIN, MOUSE; EP300 PROTEIN, MOUSE; HISTONE; SECRETASE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BACE1 GENE; CONTROLLED STUDY; GENE; GENE EXPRESSION; HISTONE ACETYLATION; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PS1 GENE; ACETYLATION; ANIMAL; CELL LINE; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; NERVE CELL; PATHOLOGY;

ACETYLATION; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CELL LINE; E1A-ASSOCIATED P300 PROTEIN; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; HISTONES; HUMANS; MICE; NEURONS; PRESENILIN-1; PROMOTER REGIONS, GENETIC; TRANSFECTION;

EID: 84904665084     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0103067     Document Type: Article

References (33)

1. Mattson MP (2004) Pathways towards and away from Alzheimer's disease. Nature 430:631-639.
2. Miller G (2010) Epigenetics. A role for epigenetics in cognition. Science 329:27.
3. Graff J, Rei D, Guan JS, Wang WY, Seo J, et al. (2012) An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature 483:222-226.
4. Peleg S, Sananbenesi F, Zovoilis A, Burkhardt S, Bahari-Javan S, et al. (2010) Altered histone acetylation is associated with age-dependent memory impairment in mice. Science 328:753-756.
5. Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, et al. (2009) HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459:55-60.
6. Kaelin WG Jr, McKnight SL (2013) Influence of metabolism on epigenetics and disease. Cell 153:56-69.
7. Marambaud P, Wen PH, Dutt A, Shioi J, Takashima A, et al. (2003) A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell 114:635-645. (Pubitemid 37159259)
8. Saura CA, Choi SY, Beglopoulos V, Malkani S, Zhang D, et al. (2004) Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron 42:23-36. (Pubitemid 38456965)
9. Marques SC, Lemos R, Ferreiro E, Martins M, de Mendonca A, et al. (2012) Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice. Neuroscience 220:256-266.
10. Graff J, Mansuy IM (2009) Epigenetic dysregulation in cognitive disorders. Eur J Neurosci 30:1-8.
11. Gu X, Sun J, Li S, Wu X, Li L (2013) Oxidative stress induces DNA demethylation and histone acetylation in SH-SY5Y cells: potential epigenetic mechanisms in gene transcription in Abeta production. Neurobiol Aging 34:1069-1079.
12. Guo X, Wu X, Ren L, Liu G, Li L (2011) Epigenetic mechanisms of amyloid-beta production in anisomycin-treated SH-SY5Y cells. Neuroscience 194:272-281.
13. Rouaux C, Jokic N, Mbebi C, Boutillier S, Loeffler JP, et al. (2003) Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration. EMBO J 22:6537-6549. (Pubitemid 38009601)
14. Oliveira AM, Wood MA, McDonough CB, Abel T (2007) Transgenic mice expressing an inhibitory truncated form of p300 exhibit long-term memory deficits. Learn Mem 14:564-572. (Pubitemid 47481689)
15. Thinakaran G, Teplow DB, Siman R, Greenberg B, Sisodia SS (1996) Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus. J Biol Chem 271:9390-9397.
16. Morimoto T, Sunagawa Y, Kawamura T, Takaya T, Wada H, et al. (2008) The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. J Clin Invest 118:868-878. (Pubitemid 351364595)
17. Xia X, Cai H, Qin S, Xu C (2012) Histone acetylase inhibitor curcumin impairs mouse spermiogenesis-an in vitro study. PLoS One 7:e48673.
18. Xu H, Gouras GK, Greenfield JP, Vincent B, Naslund J, et al. (1998) Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat Med 4:447-451. (Pubitemid 28212761)
19. Chen S, Feng B, George B, Chakrabarti R, Chen M, et al. (2010) Transcriptional coactivator p300 regulates glucose-induced gene expression in endothelial cells. Am J Physiol Endocrinol Metab 298:E127-137.
20. Wang Z, Yang D, Zhang X, Li T, Li J, et al. (2011) Hypoxia-induced down-regulation of neprilysin by histone modification in mouse primary cortical and hippocampal neurons. PLoS One 6:e19229.
21. Coulson DT, Beyer N, Quinn JG, Brockbank S, Hellemans J, et al. (2010) BACE1 mRNA expression in Alzheimer's disease postmortem brain tissue. J Alzheimers Dis 22:1111-1122.
22. Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, et al. (2007) Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science 316:750-754. (Pubitemid 46717684)
23. Theuns J, Van Broeckhoven C (2000) Transcriptional regulation of Alzheimer's disease genes: implications for susceptibility. Hum Mol Genet 9:2383-2394.
24. Bousiges O, Vasconcelos AP, Neidl R, Cosquer B, Herbeaux K, et al. (2010) Spatial memory consolidation is associated with induction of several lysine-acetyltransferase (histone acetyltransferase) expression levels and H2B/H4 acetylation-dependent transcriptional events in the rat hippocampus. Neuropsychopharmacology 35:2521-2537.
25. Chami L, Buggia-Prevot V, Duplan E, Delprete D, Chami M, et al. (2012) Nuclear factor-kappaB regulates betaAPP and beta- and gamma-secretases differently at physiological and supraphysiological Abeta concentrations. J Biol Chem 287:24573-24584.
26. Wu C, Miloslavskaya I, Demontis S, Maestro R, Galaktionov K (2004) Regulation of cellular response to oncogenic and oxidative stress by Seladin-1. Nature 432:640-645. (Pubitemid 39626272)
27. Liu R, Lei JX, Luo C, Lan X, Chi L, et al. (2012) Increased EID1 nuclear translocation impairs synaptic plasticity and memory function associated with pathogenesis of Alzheimer's disease. Neurobiol Dis 45:902-912.
28. Balasubramanyam K, Varier RA, Altaf M, Swaminathan V, Siddappa NB, et al. (2004) Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. J Biol Chem 279:51163-51171. (Pubitemid 40017859)
29. Sun H, Yang X, Zhu J, Lv T, Chen Y, et al. (2010) Inhibition of p300-HAT results in a reduced histone acetylation and down-regulation of gene expression in cardiac myocytes. Life Sci 87:707-714.
30. Belkacemi A, Doggui S, Dao L, Ramassamy C (2011) Challenges associated with curcumin therapy in Alzheimer disease. Expert Rev Mol Med 13:e34.
31. Wang HM, Zhao YX, Zhang S, Liu GD, Kang WY, et al. (2010) PPARgamma agonist curcumin reduces the amyloid-beta-stimulated inflammatory responses in primary astrocytes. J Alzheimers Dis 20:1189-1199.
32. Zhang C, Browne A, Child D, Tanzi RE (2010) Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein. J Biol Chem 285:28472-28480.
33. Goodman RH, Smolik S (2000) CBP/p300 in cell growth, transformation, and development. Genes Dev 14:1553-1577. (Pubitemid 30460905)