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Volumn 5, Issue OCT, 2014, Pages

Immunotherapeutic potential of extracellular vesicles

Author keywords

Adaptive immunity; Exosomes; Extracellular vesicles; Immunomodulation; Immunotherapy; Innate immunity

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 3; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; RETINOIC ACID INDUCIBLE PROTEIN I; TOLL LIKE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN;

EID: 84918816477     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00518     Document Type: Review
Times cited : (152)

References (169)
  • 1
    • 68849129712 scopus 로고    scopus 로고
    • Membrane vesicles as conveyors of immune responses
    • Thery C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol (2009) 9:581-93. doi: 10.1038/nri2567
    • (2009) Nat Rev Immunol , vol.9 , pp. 581-593
    • Thery, C.1    Ostrowski, M.2    Segura, E.3
  • 2
    • 79953243174 scopus 로고    scopus 로고
    • Exosomes as biomarker treasure chests for prostate cancer
    • Duijvesz D, Luider T, Bangma CH, Jenster G. Exosomes as biomarker treasure chests for prostate cancer. Eur Urol (2011) 59:823-31. doi:10.1016/j.eururo.2010.12.031
    • (2011) Eur Urol , vol.59 , pp. 823-831
    • Duijvesz, D.1    Luider, T.2    Bangma, C.H.3    Jenster, G.4
  • 3
    • 0032493658 scopus 로고    scopus 로고
    • Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes
    • Escola JM, Kleijmeer MJ, Stoorvogel W, Griffith JM, Yoshie O, Geuze HJ. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J Biol Chem (1998) 273:20121-7. doi:10.1074/jbc.273.32.20121
    • (1998) J Biol Chem , vol.273 , pp. 20121-20127
    • Escola, J.M.1    Kleijmeer, M.J.2    Stoorvogel, W.3    Griffith, J.M.4    Yoshie, O.5    Geuze, H.J.6
  • 4
    • 70350449455 scopus 로고    scopus 로고
    • ExoCarta: a compendium of exosomal proteins and RNA
    • Mathivanan S, Simpson RJ. ExoCarta: a compendium of exosomal proteins and RNA. Proteomics (2009) 9:4997-5000. doi:10.1002/pmic.200900351
    • (2009) Proteomics , vol.9 , pp. 4997-5000
    • Mathivanan, S.1    Simpson, R.J.2
  • 5
    • 55749112807 scopus 로고    scopus 로고
    • Proteomic profiling of exosomes: current perspectives
    • Simpson RJ, Jensen SS, Lim JW. Proteomic profiling of exosomes: current perspectives. Proteomics (2008) 8:4083-99. doi:10.1002/pmic.200800109
    • (2008) Proteomics , vol.8 , pp. 4083-4099
    • Simpson, R.J.1    Jensen, S.S.2    Lim, J.W.3
  • 7
    • 2642530235 scopus 로고    scopus 로고
    • Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization
    • Laulagnier K, Motta C, Hamdi S, Roy S, Fauvelle F, Pageaux JF, et al. Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization. Biochem J (2004) 380:161-71. doi:10.1042/BJ20031594
    • (2004) Biochem J , vol.380 , pp. 161-171
    • Laulagnier, K.1    Motta, C.2    Hamdi, S.3    Roy, S.4    Fauvelle, F.5    Pageaux, J.F.6
  • 8
    • 33846502114 scopus 로고    scopus 로고
    • Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies
    • Subra C, Laulagnier K, Perret B, Record M. Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies. Biochimie (2007) 89:205-12. doi:10.1016/j.biochi.2006.10.014
    • (2007) Biochimie , vol.89 , pp. 205-212
    • Subra, C.1    Laulagnier, K.2    Perret, B.3    Record, M.4
  • 9
    • 84904625179 scopus 로고    scopus 로고
    • Therapeutic MSC exosomes are derived from lipid raft microdomains in the plasma membrane.
    • Tan SS, Yin Y, Lee T, Lai RC, Yeo RW, Zhang B, et al. Therapeutic MSC exosomes are derived from lipid raft microdomains in the plasma membrane. J Extracell Vesicles (2013):2. doi:10.3402/jev.v2i0.22614
    • (2013) J Extracell Vesicles , vol.2
    • Tan, S.S.1    Yin, Y.2    Lee, T.3    Lai, R.C.4    Yeo, R.W.5    Zhang, B.6
  • 11
    • 24644466385 scopus 로고    scopus 로고
    • Human small intestinal epithelial cells constitutively express the key elements for antigen processing and the production of exosomes
    • Lin XP, Almqvist N, Telemo E. Human small intestinal epithelial cells constitutively express the key elements for antigen processing and the production of exosomes. Blood Cells Mol Dis (2005) 35:122-8. doi:10.1016/j.bcmd.2005.05.011
    • (2005) Blood Cells Mol Dis , vol.35 , pp. 122-128
    • Lin, X.P.1    Almqvist, N.2    Telemo, E.3
  • 12
    • 46249129583 scopus 로고    scopus 로고
    • Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes
    • Ji H, Erfani N, Tauro BJ, Kapp EA, Zhu HJ, Moritz RL, et al. Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes. Electrophoresis (2008) 29:2660-71. doi:10.1002/elps.200800015
    • (2008) Electrophoresis , vol.29 , pp. 2660-2671
    • Ji, H.1    Erfani, N.2    Tauro, B.J.3    Kapp, E.A.4    Zhu, H.J.5    Moritz, R.L.6
  • 13
    • 0024461106 scopus 로고
    • Reticulocyte maturation and exosome release: transferrin receptor containing exosomes shows multiple plasma membrane functions
    • Johnstone RM, Bianchini A, Teng K. Reticulocyte maturation and exosome release: transferrin receptor containing exosomes shows multiple plasma membrane functions. Blood (1989) 74:1844-51.
    • (1989) Blood , vol.74 , pp. 1844-1851
    • Johnstone, R.M.1    Bianchini, A.2    Teng, K.3
  • 14
    • 0036042235 scopus 로고    scopus 로고
    • Reticulocyte maturation: mitoptosis and exosome release
    • Geminard C, de Gassart A, Vidal M. Reticulocyte maturation: mitoptosis and exosome release. Biocell (2002) 26:205-15.
    • (2002) Biocell , vol.26 , pp. 205-215
    • Geminard, C.1    de Gassart, A.2    Vidal, M.3
  • 15
    • 0033485648 scopus 로고    scopus 로고
    • Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules
    • Heijnen HF, Schiel AE, Fijnheer R, Geuze HJ, Sixma JJ. Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules. Blood (1999) 94:3791-9.
    • (1999) Blood , vol.94 , pp. 3791-3799
    • Heijnen, H.F.1    Schiel, A.E.2    Fijnheer, R.3    Geuze, H.J.4    Sixma, J.J.5
  • 16
    • 0030687649 scopus 로고    scopus 로고
    • Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation
    • Raposo G, Tenza D, Mecheri S, Peronet R, Bonnerot C, Desaymard C. Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation. Mol Biol Cell (1997) 8:2631-45. doi:10.1091/mbc.8.12.2631
    • (1997) Mol Biol Cell , vol.8 , pp. 2631-2645
    • Raposo, G.1    Tenza, D.2    Mecheri, S.3    Peronet, R.4    Bonnerot, C.5    Desaymard, C.6
  • 17
    • 20244373139 scopus 로고    scopus 로고
    • Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming
    • Wolfers J, Lozier A, Raposo G, Regnault A, Thery C, Masurier C, et al. Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat Med (2001) 7:297-303. doi:10.1038/85438
    • (2001) Nat Med , vol.7 , pp. 297-303
    • Wolfers, J.1    Lozier, A.2    Raposo, G.3    Regnault, A.4    Thery, C.5    Masurier, C.6
  • 18
    • 84905052545 scopus 로고    scopus 로고
    • Tumour-derived exosomes as antigen delivery carriers in dendritic cell-based immunotherapy for malignant mesothelioma
    • Mahaweni NM, Kaijen-Lambers ME, Dekkers J, Aerts JG, Hegmans JP. Tumour-derived exosomes as antigen delivery carriers in dendritic cell-based immunotherapy for malignant mesothelioma. J Extracell Vesicles (2013):2. doi:10.3402/jev.v2i0.22492
    • (2013) J Extracell Vesicles , vol.2
    • Mahaweni, N.M.1    Kaijen-Lambers, M.E.2    Dekkers, J.3    Aerts, J.G.4    Hegmans, J.P.5
  • 19
    • 84901315268 scopus 로고    scopus 로고
    • Tumor-derived exosomes: a message delivery system for tumor progression
    • Atay S, Godwin AK. Tumor-derived exosomes: a message delivery system for tumor progression. Commun Integr Biol (2014) 7:e28231. doi:10.4161/cib.28231
    • (2014) Commun Integr Biol , vol.7
    • Atay, S.1    Godwin, A.K.2
  • 21
    • 84894211631 scopus 로고    scopus 로고
    • Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells
    • Lee JK, Park SR, Jung BK, Jeon YK, Lee YS, Kim MK, et al. Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells. PLoS One (2013) 8:e84256. doi:10.1371/journal.pone.0084256
    • (2013) PLoS One , vol.8
    • Lee, J.K.1    Park, S.R.2    Jung, B.K.3    Jeon, Y.K.4    Lee, Y.S.5    Kim, M.K.6
  • 23
    • 0031863853 scopus 로고    scopus 로고
    • Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes
    • Zitvogel L, Regnault A, Lozier A, Wolfers J, Flament C, Tenza D, et al. Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat Med (1998) 4:594-600. doi:10.1038/nm0598-594
    • (1998) Nat Med , vol.4 , pp. 594-600
    • Zitvogel, L.1    Regnault, A.2    Lozier, A.3    Wolfers, J.4    Flament, C.5    Tenza, D.6
  • 24
    • 84899100763 scopus 로고    scopus 로고
    • Dendritic-cell exosomes cross-present toll-like receptor-ligands and activate bystander dendritic cells
    • Sobo-Vujanovic A, Munich S, Vujanovic NL. Dendritic-cell exosomes cross-present toll-like receptor-ligands and activate bystander dendritic cells. Cell Immunol (2014) 289:119-27. doi:10.1016/j.cellimm.2014.03.016
    • (2014) Cell Immunol , vol.289 , pp. 119-127
    • Sobo-Vujanovic, A.1    Munich, S.2    Vujanovic, N.L.3
  • 25
    • 84884254033 scopus 로고    scopus 로고
    • Monocyte exosomes stimulate the osteogenic gene expression of mesenchymal stem cells
    • Ekstrom K, Omar O, Graneli C, Wang X, Vazirisani F, Thomsen P. Monocyte exosomes stimulate the osteogenic gene expression of mesenchymal stem cells. PLoS One (2013) 8:e75227. doi:10.1371/journal.pone.0075227
    • (2013) PLoS One , vol.8
    • Ekstrom, K.1    Omar, O.2    Graneli, C.3    Wang, X.4    Vazirisani, F.5    Thomsen, P.6
  • 26
    • 79551625424 scopus 로고    scopus 로고
    • Microvesicle-mediated RNA molecule delivery system using monocytes/macrophages
    • Akao Y, Iio A, Itoh T, Noguchi S, Itoh Y, Ohtsuki Y, et al. Microvesicle-mediated RNA molecule delivery system using monocytes/macrophages. Mol Ther (2011) 19:395-9. doi:10.1038/mt.2010.254
    • (2011) Mol Ther , vol.19 , pp. 395-399
    • Akao, Y.1    Iio, A.2    Itoh, T.3    Noguchi, S.4    Itoh, Y.5    Ohtsuki, Y.6
  • 27
    • 84904689513 scopus 로고    scopus 로고
    • Functional significance of macrophage-derived exosomes in inflammation and pain
    • McDonald MK, Tian Y, Qureshi RA, Gormley M, Ertel A, Gao R, et al. Functional significance of macrophage-derived exosomes in inflammation and pain. Pain (2014) 155:1527-39. doi:10.1016/j.pain.2014.04.029
    • (2014) Pain , vol.155 , pp. 1527-1539
    • McDonald, M.K.1    Tian, Y.2    Qureshi, R.A.3    Gormley, M.4    Ertel, A.5    Gao, R.6
  • 28
    • 84897980105 scopus 로고    scopus 로고
    • Exosomes derived from human macrophages suppress endothelial cell migration by controlling integrin trafficking
    • Lee HD, Kim YH, Kim DS. Exosomes derived from human macrophages suppress endothelial cell migration by controlling integrin trafficking. Eur J Immunol (2014) 44:1156-69. doi:10.1002/eji.201343660
    • (2014) Eur J Immunol , vol.44 , pp. 1156-1169
    • Lee, H.D.1    Kim, Y.H.2    Kim, D.S.3
  • 29
    • 84886945656 scopus 로고    scopus 로고
    • NK cell-released exosomes: natural nanobullets against tumors
    • Fais S. NK cell-released exosomes: natural nanobullets against tumors. Oncoimmunology (2013) 2:e22337. doi:10.4161/onci.22337
    • (2013) Oncoimmunology , vol.2
    • Fais, S.1
  • 30
    • 84866152581 scopus 로고    scopus 로고
    • Immune surveillance properties of human NK cell-derived exosomes
    • Lugini L, Cecchetti S, Huber V, Luciani F, Macchia G, Spadaro F, et al. Immune surveillance properties of human NK cell-derived exosomes. J Immunol (2012) 189:2833-42. doi:10.4049/jimmunol.1101988
    • (2012) J Immunol , vol.189 , pp. 2833-2842
    • Lugini, L.1    Cecchetti, S.2    Huber, V.3    Luciani, F.4    Macchia, G.5    Spadaro, F.6
  • 31
    • 78649325530 scopus 로고    scopus 로고
    • MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
    • Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol Cell Biol (2010) 88:851-6. doi:10.1038/icb.2010.64
    • (2010) Immunol Cell Biol , vol.88 , pp. 851-856
    • Buschow, S.I.1    van Balkom, B.W.2    Aalberts, M.3    Heck, A.J.4    Wauben, M.5    Stoorvogel, W.6
  • 32
    • 69849086481 scopus 로고    scopus 로고
    • Exosome release by primary B cells
    • McLellan AD. Exosome release by primary B cells. Crit Rev Immunol (2009) 29:203-17. doi:10.1615/CritRevImmunol.v29.i3.20
    • (2009) Crit Rev Immunol , vol.29 , pp. 203-217
    • McLellan, A.D.1
  • 33
    • 79952459878 scopus 로고    scopus 로고
    • CD4(+) T cell-released exosomes inhibit CD8(+) cytotoxic T-lymphocyte responses and antitumor immunity
    • Zhang H, Xie Y, Li W, Chibbar R, Xiong S, Xiang J. CD4(+) T cell-released exosomes inhibit CD8(+) cytotoxic T-lymphocyte responses and antitumor immunity. Cell Mol Immunol (2011) 8:23-30. doi:10.1038/cmi.2010.59
    • (2011) Cell Mol Immunol , vol.8 , pp. 23-30
    • Zhang, H.1    Xie, Y.2    Li, W.3    Chibbar, R.4    Xiong, S.5    Xiang, J.6
  • 34
    • 84884966795 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells-derived exosomes prolonged kidney allograft survival in a rat model
    • Yu X, Huang C, Song B, Xiao Y, Fang M, Feng J, et al. CD4+CD25+ regulatory T cells-derived exosomes prolonged kidney allograft survival in a rat model. Cell Immunol (2013) 285:62-8. doi:10.1016/j.cellimm.2013.06.010
    • (2013) Cell Immunol , vol.285 , pp. 62-68
    • Yu, X.1    Huang, C.2    Song, B.3    Xiao, Y.4    Fang, M.5    Feng, J.6
  • 35
    • 0020804037 scopus 로고
    • Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes
    • Harding C, Heuser J, Stahl P. Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes. J Cell Biol (1983) 97:329-39. doi:10.1083/jcb.97.2.329
    • (1983) J Cell Biol , vol.97 , pp. 329-339
    • Harding, C.1    Heuser, J.2    Stahl, P.3
  • 36
    • 0022201056 scopus 로고
    • Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes
    • Pan BT, Teng K, Wu C, Adam M, Johnstone RM. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J Cell Biol (1985) 101:942-8. doi:10.1083/jcb.101.3.942
    • (1985) J Cell Biol , vol.101 , pp. 942-948
    • Pan, B.T.1    Teng, K.2    Wu, C.3    Adam, M.4    Johnstone, R.M.5
  • 40
    • 0035863818 scopus 로고    scopus 로고
    • Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes
    • Skokos D, Le Panse S, Villa I, Rousselle JC, Peronet R, David B, et al. Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes. J Immunol (2001) 166:868-76. doi:10.4049/jimmunol.166.2.868
    • (2001) J Immunol , vol.166 , pp. 868-876
    • Skokos, D.1    Le Panse, S.2    Villa, I.3    Rousselle, J.C.4    Peronet, R.5    David, B.6
  • 41
    • 47249144117 scopus 로고    scopus 로고
    • Human tumor-derived exosomes down-modulate NKG2D expression
    • Clayton A, Mitchell JP, Court J, Linnane S, Mason MD, Tabi Z. Human tumor-derived exosomes down-modulate NKG2D expression. J Immunol (2008) 180:7249-58. doi:10.4049/jimmunol.180.11.7249
    • (2008) J Immunol , vol.180 , pp. 7249-7258
    • Clayton, A.1    Mitchell, J.P.2    Court, J.3    Linnane, S.4    Mason, M.D.5    Tabi, Z.6
  • 42
    • 84874988827 scopus 로고    scopus 로고
    • Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery
    • Yeo RW, Lai RC, Zhang B, Tan SS, Yin Y, Teh BJ, et al. Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery. Adv Drug Deliv Rev (2013) 65:336-41. doi:10.1016/j.addr.2012.07.001
    • (2013) Adv Drug Deliv Rev , vol.65 , pp. 336-341
    • Yeo, R.W.1    Lai, R.C.2    Zhang, B.3    Tan, S.S.4    Yin, Y.5    Teh, B.J.6
  • 43
    • 0033767690 scopus 로고    scopus 로고
    • Exosome: from internal vesicle of the multivesicular body to intercellular signaling device
    • Denzer K, Kleijmeer MJ, Heijnen HF, Stoorvogel W, Geuze HJ. Exosome: from internal vesicle of the multivesicular body to intercellular signaling device. J Cell Sci (2000) 113(Pt 19):3365-74.
    • (2000) J Cell Sci , vol.113 , pp. 3365-3374
    • Denzer, K.1    Kleijmeer, M.J.2    Heijnen, H.F.3    Stoorvogel, W.4    Geuze, H.J.5
  • 44
    • 0042174019 scopus 로고    scopus 로고
    • Protein sorting into multivesicular endosomes
    • Raiborg C, Rusten TE, Stenmark H. Protein sorting into multivesicular endosomes. Curr Opin Cell Biol (2003) 15:446-55. doi:10.1016/S0955-0674(03)00080-2
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 446-455
    • Raiborg, C.1    Rusten, T.E.2    Stenmark, H.3
  • 45
    • 43249109372 scopus 로고    scopus 로고
    • Isolation and characterization of exosomes from cell culture supernatants and biological fluids
    • Thery C, Amigorena S, Raposo G, Clayton A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol (2006) 3:22. doi:10.1002/0471143030.cb0322s30
    • (2006) Curr Protoc Cell Biol , vol.3 , pp. 22
    • Thery, C.1    Amigorena, S.2    Raposo, G.3    Clayton, A.4
  • 46
    • 0023038425 scopus 로고
    • Selective externalization of an ATP-binding protein structurally related to the clathrin-uncoating ATPase/heat shock protein in vesicles containing terminal transferrin receptors during reticulocyte maturation
    • Davis JQ, Dansereau D, Johnstone RM, Bennett V. Selective externalization of an ATP-binding protein structurally related to the clathrin-uncoating ATPase/heat shock protein in vesicles containing terminal transferrin receptors during reticulocyte maturation. J Biol Chem (1986) 261:15368-71.
    • (1986) J Biol Chem , vol.261 , pp. 15368-15371
    • Davis, J.Q.1    Dansereau, D.2    Johnstone, R.M.3    Bennett, V.4
  • 47
    • 12944329896 scopus 로고    scopus 로고
    • Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes
    • Kim JW, Wieckowski E, Taylor DD, Reichert TE, Watkins S, Whiteside TL. Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes. Clin Cancer Res (2005) 11:1010-20.
    • (2005) Clin Cancer Res , vol.11 , pp. 1010-1020
    • Kim, J.W.1    Wieckowski, E.2    Taylor, D.D.3    Reichert, T.E.4    Watkins, S.5    Whiteside, T.L.6
  • 48
    • 0242525678 scopus 로고    scopus 로고
    • T-cell apoptosis and suppression of T-cell receptor/CD3-zeta by Fas ligand-containing membrane vesicles shed from ovarian tumors
    • Taylor DD, Gercel-Taylor C, Lyons KS, Stanson J, Whiteside TL. T-cell apoptosis and suppression of T-cell receptor/CD3-zeta by Fas ligand-containing membrane vesicles shed from ovarian tumors. Clin Cancer Res (2003) 9:5113-9.
    • (2003) Clin Cancer Res , vol.9 , pp. 5113-5119
    • Taylor, D.D.1    Gercel-Taylor, C.2    Lyons, K.S.3    Stanson, J.4    Whiteside, T.L.5
  • 49
    • 77952293014 scopus 로고    scopus 로고
    • Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
    • Lai RC, Arslan F, Lee MM, Sze NS, Choo A, Chen TS, et al. Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res (2010) 4:214-22. doi:10.1016/j.scr.2009.12.003
    • (2010) Stem Cell Res , vol.4 , pp. 214-222
    • Lai, R.C.1    Arslan, F.2    Lee, M.M.3    Sze, N.S.4    Choo, A.5    Chen, T.S.6
  • 50
    • 0035166047 scopus 로고    scopus 로고
    • Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry
    • Clayton A, Court J, Navabi H, Adams M, Mason MD, Hobot JA, et al. Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry. J Immunol Methods (2001) 247:163-74. doi:10.1016/S0022-1759(00)00321-5
    • (2001) J Immunol Methods , vol.247 , pp. 163-174
    • Clayton, A.1    Court, J.2    Navabi, H.3    Adams, M.4    Mason, M.D.5    Hobot, J.A.6
  • 51
    • 45449093192 scopus 로고    scopus 로고
    • MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
    • Taylor DD, Gercel-Taylor C. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol Oncol (2008) 110:13-21. doi:10.1016/j.ygyno.2008.04.033
    • (2008) Gynecol Oncol , vol.110 , pp. 13-21
    • Taylor, D.D.1    Gercel-Taylor, C.2
  • 52
    • 75749091133 scopus 로고    scopus 로고
    • Microfluidic isolation and transcriptome analysis of serum microvesicles
    • Chen C, Skog J, Hsu CH, Lessard RT, Balaj L, Wurdinger T, et al. Microfluidic isolation and transcriptome analysis of serum microvesicles. Lab Chip (2010) 10:505-11. doi:10.1039/b916199f
    • (2010) Lab Chip , vol.10 , pp. 505-511
    • Chen, C.1    Skog, J.2    Hsu, C.H.3    Lessard, R.T.4    Balaj, L.5    Wurdinger, T.6
  • 53
    • 79953136097 scopus 로고    scopus 로고
    • Rab27a and Rab27b control different steps of the exosome secretion pathway
    • Ostrowski M, Carmo NB, Krumeich S, Fanget I, Raposo G, Savina A, et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol (2010) 12:19-30. doi:10.1038/ncb2000
    • (2010) Nat Cell Biol , vol.12 , pp. 19-30
    • Ostrowski, M.1    Carmo, N.B.2    Krumeich, S.3    Fanget, I.4    Raposo, G.5    Savina, A.6
  • 54
    • 24644445037 scopus 로고    scopus 로고
    • Preparation of human ovarian cancer ascites-derived exosomes for a clinical trial
    • Navabi H, Croston D, Hobot J, Clayton A, Zitvogel L, Jasani B, et al. Preparation of human ovarian cancer ascites-derived exosomes for a clinical trial. Blood Cells Mol Dis (2005) 35:149-52. doi:10.1016/j.bcmd.2005.06.008
    • (2005) Blood Cells Mol Dis , vol.35 , pp. 149-152
    • Navabi, H.1    Croston, D.2    Hobot, J.3    Clayton, A.4    Zitvogel, L.5    Jasani, B.6
  • 55
    • 0037114287 scopus 로고    scopus 로고
    • Production and characterization of clinical grade exosomes derived from dendritic cells
    • Lamparski HG, Metha-Damani A, Yao JY, Patel S, Hsu DH, Ruegg C, et al. Production and characterization of clinical grade exosomes derived from dendritic cells. J Immunol Methods (2002) 270:211-26. doi:10.1016/S0022-1759(02)00330-7
    • (2002) J Immunol Methods , vol.270 , pp. 211-226
    • Lamparski, H.G.1    Metha-Damani, A.2    Yao, J.Y.3    Patel, S.4    Hsu, D.H.5    Ruegg, C.6
  • 56
    • 84899703737 scopus 로고    scopus 로고
    • Evolutionary insights into the origin of innate and adaptive immune systems: different shades of grey
    • Sirisinha S. Evolutionary insights into the origin of innate and adaptive immune systems: different shades of grey. Asian Pac J Allergy Immunol (2014) 32:3-15.
    • (2014) Asian Pac J Allergy Immunol , vol.32 , pp. 3-15
    • Sirisinha, S.1
  • 57
    • 33845951211 scopus 로고    scopus 로고
    • DAMPs, PAMPs and alarmins: all we need to know about danger
    • Bianchi ME. DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol (2007) 81:1-5. doi:10.1189/jlb.0306164
    • (2007) J Leukoc Biol , vol.81 , pp. 1-5
    • Bianchi, M.E.1
  • 58
    • 66449088641 scopus 로고    scopus 로고
    • Pathogen recognition and inflammatory signaling in innate immune defenses
    • Mogensen TH. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev (2009) 22:240-73. doi:10.1128/CMR.00046-08
    • (2009) Clin Microbiol Rev , vol.22 , pp. 240-273
    • Mogensen, T.H.1
  • 59
    • 84856941699 scopus 로고    scopus 로고
    • Pattern recognition receptors: sentinels in innate immunity and targets of new vaccine adjuvants
    • Olive C. Pattern recognition receptors: sentinels in innate immunity and targets of new vaccine adjuvants. Expert Rev Vaccines (2012) 11:237-56. doi:10.1586/erv.11.189
    • (2012) Expert Rev Vaccines , vol.11 , pp. 237-256
    • Olive, C.1
  • 60
    • 78751560494 scopus 로고    scopus 로고
    • Pathogen recognition by the innate immune system
    • Kumar H, Kawai T, Akira S. Pathogen recognition by the innate immune system. Int Rev Immunol (2011) 30:16-34. doi:10.3109/08830185.2010.529976
    • (2011) Int Rev Immunol , vol.30 , pp. 16-34
    • Kumar, H.1    Kawai, T.2    Akira, S.3
  • 61
    • 12344335678 scopus 로고    scopus 로고
    • Innate and adaptive immunity: specificities and signaling hierarchies revisited
    • Vivier E, Malissen B. Innate and adaptive immunity: specificities and signaling hierarchies revisited. Nat Immunol (2005) 6:17-21. doi:10.1038/ni1153
    • (2005) Nat Immunol , vol.6 , pp. 17-21
    • Vivier, E.1    Malissen, B.2
  • 62
    • 79955746123 scopus 로고    scopus 로고
    • The control of adaptive immune responses by the innate immune system
    • Schenten D, Medzhitov R. The control of adaptive immune responses by the innate immune system. Adv Immunol (2011) 109:87-124. doi:10.1016/B978-0-12-387664-5.00003-0
    • (2011) Adv Immunol , vol.109 , pp. 87-124
    • Schenten, D.1    Medzhitov, R.2
  • 63
    • 0032191163 scopus 로고    scopus 로고
    • Innate immune recognition and control of adaptive immune responses
    • Medzhitov R, Janeway CA Jr. Innate immune recognition and control of adaptive immune responses. Semin Immunol (1998) 10:351-3. doi:10.1006/smim.1998.0136
    • (1998) Semin Immunol , vol.10 , pp. 351-353
    • Medzhitov, R.1    Janeway Jr., C.A.2
  • 64
    • 0021979942 scopus 로고
    • Antigen presenting cells and mechanisms of antigen presentation
    • Chesnut RW, Grey HM. Antigen presenting cells and mechanisms of antigen presentation. Crit Rev Immunol (1985) 5:263-316.
    • (1985) Crit Rev Immunol , vol.5 , pp. 263-316
    • Chesnut, R.W.1    Grey, H.M.2
  • 65
    • 0024217104 scopus 로고
    • Antigen presentation, antigen-presenting cells and antigen processing
    • Katz DR. Antigen presentation, antigen-presenting cells and antigen processing. Curr Opin Immunol (1988) 1:213-9. doi:10.1016/0952-7915(88)90004-0
    • (1988) Curr Opin Immunol , vol.1 , pp. 213-219
    • Katz, D.R.1
  • 66
    • 0035140119 scopus 로고    scopus 로고
    • The cell biology of antigen presentation in dendritic cells
    • Thery C, Amigorena S. The cell biology of antigen presentation in dendritic cells. Curr Opin Immunol (2001) 13:45-51. doi:10.1016/S0952-7915(00)00180-1
    • (2001) Curr Opin Immunol , vol.13 , pp. 45-51
    • Thery, C.1    Amigorena, S.2
  • 68
    • 0037183242 scopus 로고    scopus 로고
    • Malignant effusions and immunogenic tumour-derived exosomes
    • Andre F, Schartz NE, Movassagh M, Flament C, Pautier P, Morice P, et al. Malignant effusions and immunogenic tumour-derived exosomes. Lancet (2002) 360:295-305. doi:10.1016/S0140-6736(02)09552-1
    • (2002) Lancet , vol.360 , pp. 295-305
    • Andre, F.1    Schartz, N.E.2    Movassagh, M.3    Flament, C.4    Pautier, P.5    Morice, P.6
  • 69
    • 70350538868 scopus 로고    scopus 로고
    • Immunogenicity of allo-vesicle carrying ERBB2 tumor antigen for dendritic cell-based anti-tumor immunotherapy
    • Napoletano C, Rughetti A, Landi R, Pinto D, Bellati F, Rahimi H, et al. Immunogenicity of allo-vesicle carrying ERBB2 tumor antigen for dendritic cell-based anti-tumor immunotherapy. Int J Immunopathol Pharmacol (2009) 22:647-58.
    • (2009) Int J Immunopathol Pharmacol , vol.22 , pp. 647-658
    • Napoletano, C.1    Rughetti, A.2    Landi, R.3    Pinto, D.4    Bellati, F.5    Rahimi, H.6
  • 70
    • 0036906477 scopus 로고    scopus 로고
    • Indirect activation of naive CD4+ T cells by dendritic cell-derived exosomes
    • Thery C, Duban L, Segura E, Veron P, Lantz O, Amigorena S. Indirect activation of naive CD4+ T cells by dendritic cell-derived exosomes. Nat Immunol (2002) 3:1156-62. doi:10.1038/ni854
    • (2002) Nat Immunol , vol.3 , pp. 1156-1162
    • Thery, C.1    Duban, L.2    Segura, E.3    Veron, P.4    Lantz, O.5    Amigorena, S.6
  • 71
    • 8644286802 scopus 로고    scopus 로고
    • Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells
    • Morelli AE, Larregina AT, Shufesky WJ, Sullivan ML, Stolz DB, Papworth GD, et al. Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells. Blood (2004) 104:3257-66. doi:10.1182/blood-2004-03-0824
    • (2004) Blood , vol.104 , pp. 3257-3266
    • Morelli, A.E.1    Larregina, A.T.2    Shufesky, W.J.3    Sullivan, M.L.4    Stolz, D.B.5    Papworth, G.D.6
  • 72
    • 33746238574 scopus 로고    scopus 로고
    • Direct exosome stimulation of peripheral human T cells detected by ELISPOT
    • Admyre C, Johansson SM, Paulie S, Gabrielsson S. Direct exosome stimulation of peripheral human T cells detected by ELISPOT. Eur J Immunol (2006) 36:1772-81. doi:10.1002/eji.200535615
    • (2006) Eur J Immunol , vol.36 , pp. 1772-1781
    • Admyre, C.1    Johansson, S.M.2    Paulie, S.3    Gabrielsson, S.4
  • 73
    • 38449100732 scopus 로고    scopus 로고
    • Antigen presentation by exosomes released from peptide-pulsed dendritic cells is not suppressed by the presence of active CTL
    • Luketic L, Delanghe J, Sobol PT, Yang P, Frotten E, Mossman KL, et al. Antigen presentation by exosomes released from peptide-pulsed dendritic cells is not suppressed by the presence of active CTL. J Immunol (2007) 179:5024-32. doi:10.4049/jimmunol.179.8.5024
    • (2007) J Immunol , vol.179 , pp. 5024-5032
    • Luketic, L.1    Delanghe, J.2    Sobol, P.T.3    Yang, P.4    Frotten, E.5    Mossman, K.L.6
  • 74
    • 36848999329 scopus 로고    scopus 로고
    • B cell-derived exosomes can present allergen peptides and activate allergen-specific T cells to proliferate and produce TH2-like cytokines
    • Admyre C, Bohle B, Johansson SM, Focke-Tejkl M, Valenta R, Scheynius A, et al. B cell-derived exosomes can present allergen peptides and activate allergen-specific T cells to proliferate and produce TH2-like cytokines. J Allergy Clin Immunol (2007) 120:1418-24. doi:10.1016/j.jaci.2007.06.040
    • (2007) J Allergy Clin Immunol , vol.120 , pp. 1418-1424
    • Admyre, C.1    Bohle, B.2    Johansson, S.M.3    Focke-Tejkl, M.4    Valenta, R.5    Scheynius, A.6
  • 75
    • 0036319374 scopus 로고    scopus 로고
    • Exosomes bearing HLA-DR1 molecules need dendritic cells to efficiently stimulate specific T cells
    • Vincent-Schneider H, Stumptner-Cuvelette P, Lankar D, Pain S, Raposo G, Benaroch P, et al. Exosomes bearing HLA-DR1 molecules need dendritic cells to efficiently stimulate specific T cells. Int Immunol (2002) 14:713-22. doi:10.1093/intimm/dxf048
    • (2002) Int Immunol , vol.14 , pp. 713-722
    • Vincent-Schneider, H.1    Stumptner-Cuvelette, P.2    Lankar, D.3    Pain, S.4    Raposo, G.5    Benaroch, P.6
  • 76
    • 84855597096 scopus 로고    scopus 로고
    • Maturation and function of human dendritic cells are regulated by B lymphocytes
    • Morva A, Lemoine S, Achour A, Pers JO, Youinou P, Jamin C. Maturation and function of human dendritic cells are regulated by B lymphocytes. Blood (2012) 119:106-14. doi:10.1182/blood-2011-06-360768
    • (2012) Blood , vol.119 , pp. 106-114
    • Morva, A.1    Lemoine, S.2    Achour, A.3    Pers, J.O.4    Youinou, P.5    Jamin, C.6
  • 77
    • 84055170530 scopus 로고    scopus 로고
    • Role of dendritic cell maturity/costimulation for generation, homeostasis, and suppressive activity of regulatory T cells
    • Pletinckx K, Dohler A, Pavlovic V, Lutz MB. Role of dendritic cell maturity/costimulation for generation, homeostasis, and suppressive activity of regulatory T cells. Front Immunol (2011) 2:39. doi:10.3389/fimmu.2011.00039
    • (2011) Front Immunol , vol.2 , pp. 39
    • Pletinckx, K.1    Dohler, A.2    Pavlovic, V.3    Lutz, M.B.4
  • 78
    • 78751535378 scopus 로고    scopus 로고
    • The regulatory role of dendritic cells in the induction and maintenance of T-cell tolerance
    • Zanoni I, Granucci F. The regulatory role of dendritic cells in the induction and maintenance of T-cell tolerance. Autoimmunity (2011) 44:23-32. doi:10.3109/08916931003782148
    • (2011) Autoimmunity , vol.44 , pp. 23-32
    • Zanoni, I.1    Granucci, F.2
  • 80
    • 0141862085 scopus 로고    scopus 로고
    • MHC class I-mediated exogenous antigen presentation by exosomes secreted from immature and mature bone marrow derived dendritic cells
    • Utsugi-Kobukai S, Fujimaki H, Hotta C, Nakazawa M, Minami M. MHC class I-mediated exogenous antigen presentation by exosomes secreted from immature and mature bone marrow derived dendritic cells. Immunol Lett (2003) 89:125-31. doi:10.1016/S0165-2478(03)00128-7
    • (2003) Immunol Lett , vol.89 , pp. 125-131
    • Utsugi-Kobukai, S.1    Fujimaki, H.2    Hotta, C.3    Nakazawa, M.4    Minami, M.5
  • 81
    • 22044447897 scopus 로고    scopus 로고
    • ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming
    • Segura E, Nicco C, Lombard B, Veron P, Raposo G, Batteux F, et al. ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming. Blood (2005) 106:216-23. doi:10.1182/blood-2005-01-0220
    • (2005) Blood , vol.106 , pp. 216-223
    • Segura, E.1    Nicco, C.2    Lombard, B.3    Veron, P.4    Raposo, G.5    Batteux, F.6
  • 82
    • 24644485206 scopus 로고    scopus 로고
    • Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses
    • Segura E, Amigorena S, Thery C. Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses. Blood Cells Mol Dis (2005) 35:89-93. doi:10.1016/j.bcmd.2005.05.003
    • (2005) Blood Cells Mol Dis , vol.35 , pp. 89-93
    • Segura, E.1    Amigorena, S.2    Thery, C.3
  • 83
    • 49149111236 scopus 로고    scopus 로고
    • Exosomes as a short-range mechanism to spread alloantigen between dendritic cells during T cell allorecognition
    • Montecalvo A, Shufesky WJ, Stolz DB, Sullivan MG, Wang Z, Divito SJ, et al. Exosomes as a short-range mechanism to spread alloantigen between dendritic cells during T cell allorecognition. J Immunol (2008) 180:3081-90. doi:10.4049/jimmunol.180.5.3081
    • (2008) J Immunol , vol.180 , pp. 3081-3090
    • Montecalvo, A.1    Shufesky, W.J.2    Stolz, D.B.3    Sullivan, M.G.4    Wang, Z.5    Divito, S.J.6
  • 84
    • 34948874323 scopus 로고    scopus 로고
    • T cell-induced secretion of MHC class II-peptide complexes on B cell exosomes
    • Muntasell A, Berger AC, Roche PA. T cell-induced secretion of MHC class II-peptide complexes on B cell exosomes. EMBO J (2007) 26:4263-72. doi:10.1038/sj.emboj.7601842
    • (2007) EMBO J , vol.26 , pp. 4263-4272
    • Muntasell, A.1    Berger, A.C.2    Roche, P.A.3
  • 85
    • 3042643331 scopus 로고    scopus 로고
    • Toxoplasma gondii antigen-pulsed-dendritic cell-derived exosomes induce a protective immune response against T
    • Aline F, Bout D, Amigorena S, Roingeard P, Dimier-Poisson I. Toxoplasma gondii antigen-pulsed-dendritic cell-derived exosomes induce a protective immune response against T. gondii infection. Infect Immun (2004) 72:4127-37. doi:10.1128/IAI.72.7.4127-4137.2004
    • (2004) gondii infection. Infect Immun , vol.72 , pp. 4127-4137
    • Aline, F.1    Bout, D.2    Amigorena, S.3    Roingeard, P.4    Dimier-Poisson, I.5
  • 86
    • 79955085152 scopus 로고    scopus 로고
    • Induction of protective immunity against Eimeria tenella infection using antigen-loaded dendritic cells (DC) and DC-derived exosomes
    • Del Cacho E, Gallego M, Lee SH, Lillehoj HS, Quilez J, Lillehoj EP, et al. Induction of protective immunity against Eimeria tenella infection using antigen-loaded dendritic cells (DC) and DC-derived exosomes. Vaccine (2011) 29:3818-25. doi:10.1016/j.vaccine.2011.03.022
    • (2011) Vaccine , vol.29 , pp. 3818-3825
    • Del Cacho, E.1    Gallego, M.2    Lee, S.H.3    Lillehoj, H.S.4    Quilez, J.5    Lillehoj, E.P.6
  • 87
    • 0345015348 scopus 로고    scopus 로고
    • Presentation of donor major histocompatibility complex antigens by bone marrow dendritic cell-derived exosomes modulates allograft rejection
    • Peche H, Heslan M, Usal C, Amigorena S, Cuturi MC. Presentation of donor major histocompatibility complex antigens by bone marrow dendritic cell-derived exosomes modulates allograft rejection. Transplantation (2003) 76:1503-10. doi:10.1097/01.TP.0000092494.75313.38
    • (2003) Transplantation , vol.76 , pp. 1503-1510
    • Peche, H.1    Heslan, M.2    Usal, C.3    Amigorena, S.4    Cuturi, M.C.5
  • 88
    • 0037046580 scopus 로고    scopus 로고
    • Identification of a factor that links apoptotic cells to phagocytes
    • Hanayama R, Tanaka M, Miwa K, Shinohara A, Iwamatsu A, Nagata S. Identification of a factor that links apoptotic cells to phagocytes. Nature (2002) 417:182-7. doi:10.1038/417182a
    • (2002) Nature , vol.417 , pp. 182-187
    • Hanayama, R.1    Tanaka, M.2    Miwa, K.3    Shinohara, A.4    Iwamatsu, A.5    Nagata, S.6
  • 89
    • 81155151895 scopus 로고    scopus 로고
    • Exosomes derived from immature bone marrow dendritic cells induce tolerogenicity of intestinal transplantation in rats
    • Yang X, Meng S, Jiang H, Zhu C, Wu W. Exosomes derived from immature bone marrow dendritic cells induce tolerogenicity of intestinal transplantation in rats. J Surg Res (2011) 171:826-32. doi:10.1016/j.jss.2010.05.021
    • (2011) J Surg Res , vol.171 , pp. 826-832
    • Yang, X.1    Meng, S.2    Jiang, H.3    Zhu, C.4    Wu, W.5
  • 90
    • 84865580434 scopus 로고    scopus 로고
    • Tolerance induction by exosomes from immature dendritic cells and rapamycin in a mouse cardiac allograft model
    • Li X, Li JJ, Yang JY, Wang DS, Zhao W, Song WJ, et al. Tolerance induction by exosomes from immature dendritic cells and rapamycin in a mouse cardiac allograft model. PLoS One (2012) 7:e44045. doi:10.1371/journal.pone.0044045
    • (2012) PLoS One , vol.7
    • Li, X.1    Li, J.J.2    Yang, J.Y.3    Wang, D.S.4    Zhao, W.5    Song, W.J.6
  • 91
    • 59649083739 scopus 로고    scopus 로고
    • Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models
    • Bianco NR, Kim SH, Ruffner MA, Robbins PD. Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models. Arthritis Rheum (2009) 60:380-9. doi:10.1002/art.24229
    • (2009) Arthritis Rheum , vol.60 , pp. 380-389
    • Bianco, N.R.1    Kim, S.H.2    Ruffner, M.A.3    Robbins, P.D.4
  • 92
    • 30344460536 scopus 로고    scopus 로고
    • Exosomes derived from genetically modified DC expressing FasL are anti-inflammatory and immunosuppressive
    • Kim SH, Bianco N, Menon R, Lechman ER, Shufesky WJ, Morelli AE, et al. Exosomes derived from genetically modified DC expressing FasL are anti-inflammatory and immunosuppressive. Mol Ther (2006) 13:289-300. doi:10.1016/j.ymthe.2005.09.015
    • (2006) Mol Ther , vol.13 , pp. 289-300
    • Kim, S.H.1    Bianco, N.2    Menon, R.3    Lechman, E.R.4    Shufesky, W.J.5    Morelli, A.E.6
  • 93
    • 34848915428 scopus 로고    scopus 로고
    • Effective treatment of inflammatory disease models with exosomes derived from dendritic cells genetically modified to express IL-4
    • Kim SH, Bianco NR, Shufesky WJ, Morelli AE, Robbins PD. Effective treatment of inflammatory disease models with exosomes derived from dendritic cells genetically modified to express IL-4. J Immunol (2007) 179:2242-9. doi:10.4049/jimmunol.179.4.2242
    • (2007) J Immunol , vol.179 , pp. 2242-2249
    • Kim, S.H.1    Bianco, N.R.2    Shufesky, W.J.3    Morelli, A.E.4    Robbins, P.D.5
  • 94
    • 70449403221 scopus 로고    scopus 로고
    • B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function
    • Ruffner MA, Kim SH, Bianco NR, Francisco LM, Sharpe AH, Robbins PD. B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function. Eur J Immunol (2009) 39:3084-90. doi:10.1002/eji.200939407
    • (2009) Eur J Immunol , vol.39 , pp. 3084-3090
    • Ruffner, M.A.1    Kim, S.H.2    Bianco, N.R.3    Francisco, L.M.4    Sharpe, A.H.5    Robbins, P.D.6
  • 95
    • 20844458756 scopus 로고    scopus 로고
    • Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis
    • Kim SH, Lechman ER, Bianco N, Menon R, Keravala A, Nash J, et al. Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis. J Immunol (2005) 174:6440-8. doi:10.4049/jimmunol.174.10.6440
    • (2005) J Immunol , vol.174 , pp. 6440-6448
    • Kim, S.H.1    Lechman, E.R.2    Bianco, N.3    Menon, R.4    Keravala, A.5    Nash, J.6
  • 96
    • 84857793572 scopus 로고    scopus 로고
    • Immunosuppressive exosomes from TGF-beta1 gene-modified dendritic cells attenuate Th17-mediated inflammatory autoimmune disease by inducing regulatory T cells
    • Cai Z, Zhang W, Yang F, Yu L, Yu Z, Pan J, et al. Immunosuppressive exosomes from TGF-beta1 gene-modified dendritic cells attenuate Th17-mediated inflammatory autoimmune disease by inducing regulatory T cells. Cell Res (2012) 22:607-10. doi:10.1038/cr.2011.196
    • (2012) Cell Res , vol.22 , pp. 607-610
    • Cai, Z.1    Zhang, W.2    Yang, F.3    Yu, L.4    Yu, Z.5    Pan, J.6
  • 97
    • 27744482605 scopus 로고    scopus 로고
    • Maturation of function in dendritic cells for tolerance and immunity
    • Quah BJ, O'Neill HC. Maturation of function in dendritic cells for tolerance and immunity. J Cell Mol Med (2005) 9:643-54. doi:10.1111/j.1582-4934.2005.tb00494.x
    • (2005) J Cell Mol Med , vol.9 , pp. 643-654
    • Quah, B.J.1    O'Neill, H.C.2
  • 98
    • 60749137620 scopus 로고    scopus 로고
    • Exosomes are an effective vaccine against congenital toxoplasmosis in mice
    • Beauvillain C, Juste MO, Dion S, Pierre J, Dimier-Poisson I. Exosomes are an effective vaccine against congenital toxoplasmosis in mice. Vaccine (2009) 27:1750-7. doi:10.1016/j.vaccine.2009.01.022
    • (2009) Vaccine , vol.27 , pp. 1750-1757
    • Beauvillain, C.1    Juste, M.O.2    Dion, S.3    Pierre, J.4    Dimier-Poisson, I.5
  • 99
    • 33748480677 scopus 로고    scopus 로고
    • Exosomes from bone marrow dendritic cells pulsed with diphtheria toxoid preferentially induce type 1 antigen-specific IgG responses in naive recipients in the absence of free antigen
    • Colino J, Snapper CM. Exosomes from bone marrow dendritic cells pulsed with diphtheria toxoid preferentially induce type 1 antigen-specific IgG responses in naive recipients in the absence of free antigen. J Immunol (2006) 177:3757-62. doi:10.4049/jimmunol.177.6.3757
    • (2006) J Immunol , vol.177 , pp. 3757-3762
    • Colino, J.1    Snapper, C.M.2
  • 100
    • 63849165317 scopus 로고    scopus 로고
    • Antigen-loaded exosomes alone induce Th1-type memory through a B-cell-dependent mechanism
    • Qazi KR, Gehrmann U, Domange Jordo E, Karlsson MC, Gabrielsson S. Antigen-loaded exosomes alone induce Th1-type memory through a B-cell-dependent mechanism. Blood (2009) 113:2673-83. doi:10.1182/blood-2008-04-153536
    • (2009) Blood , vol.113 , pp. 2673-2683
    • Qazi, K.R.1    Gehrmann, U.2    Domange Jordo, E.3    Karlsson, M.C.4    Gabrielsson, S.5
  • 101
    • 36248943078 scopus 로고    scopus 로고
    • Mycoplasma contaminants present in exosome preparations induce polyclonal B cell responses
    • Quah BJ, O'Neill HC. Mycoplasma contaminants present in exosome preparations induce polyclonal B cell responses. J Leukoc Biol (2007) 82:1070-82. doi:10.1189/jlb.0507277
    • (2007) J Leukoc Biol , vol.82 , pp. 1070-1082
    • Quah, B.J.1    O'Neill, H.C.2
  • 102
    • 76749139918 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes for cancer immunotherapy: what's next?
    • Viaud S, Thery C, Ploix S, Tursz T, Lapierre V, Lantz O, et al. Dendritic cell-derived exosomes for cancer immunotherapy: what's next? Cancer Res (2010) 70:1281-5. doi:10.1158/0008-5472.CAN-09-3276
    • (2010) Cancer Res , vol.70 , pp. 1281-1285
    • Viaud, S.1    Thery, C.2    Ploix, S.3    Tursz, T.4    Lapierre, V.5    Lantz, O.6
  • 103
    • 85027933779 scopus 로고    scopus 로고
    • Exosomes: immune properties and potential clinical implementations
    • Chaput N, Thery C. Exosomes: immune properties and potential clinical implementations. Semin Immunopathol (2011) 33:419-40. doi:10.1007/s00281-010-0233-9
    • (2011) Semin Immunopathol , vol.33 , pp. 419-440
    • Chaput, N.1    Thery, C.2
  • 104
    • 24644524982 scopus 로고    scopus 로고
    • The immunogenicity of dendritic cell-derived exosomes
    • Quah BJ, O'Neill HC. The immunogenicity of dendritic cell-derived exosomes. Blood Cells Mol Dis (2005) 35:94-110. doi:10.1016/j.bcmd.2005.05.002
    • (2005) Blood Cells Mol Dis , vol.35 , pp. 94-110
    • Quah, B.J.1    O'Neill, H.C.2
  • 105
    • 34548512488 scopus 로고    scopus 로고
    • Exosomes released from infected macrophages contain Mycobacterium avium glycopeptidolipids and are proinflammatory
    • Bhatnagar S, Schorey JS. Exosomes released from infected macrophages contain Mycobacterium avium glycopeptidolipids and are proinflammatory. J Biol Chem (2007) 282:25779-89. doi:10.1074/jbc.M702277200
    • (2007) J Biol Chem , vol.282 , pp. 25779-25789
    • Bhatnagar, S.1    Schorey, J.S.2
  • 106
    • 36148959342 scopus 로고    scopus 로고
    • Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo
    • Bhatnagar S, Shinagawa K, Castellino FJ, Schorey JS. Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo. Blood (2007) 110:3234-44. doi:10.1182/blood-2007-03-079152
    • (2007) Blood , vol.110 , pp. 3234-3244
    • Bhatnagar, S.1    Shinagawa, K.2    Castellino, F.J.3    Schorey, J.S.4
  • 107
    • 77956314712 scopus 로고    scopus 로고
    • Exosomal Hsp70 induces a pro-inflammatory response to foreign particles including mycobacteria
    • Anand PK, Anand E, Bleck CK, Anes E, Griffiths G. Exosomal Hsp70 induces a pro-inflammatory response to foreign particles including mycobacteria. PLoS One (2010) 5:e10136. doi:10.1371/journal.pone.0010136
    • (2010) PLoS One , vol.5
    • Anand, P.K.1    Anand, E.2    Bleck, C.K.3    Anes, E.4    Griffiths, G.5
  • 108
    • 33744928376 scopus 로고    scopus 로고
    • A membrane form of TNF-alpha presented by exosomes delays T cell activation-induced cell death
    • Zhang HG, Liu C, Su K, Yu S, Zhang L, Zhang S, et al. A membrane form of TNF-alpha presented by exosomes delays T cell activation-induced cell death. J Immunol (2006) 176:7385-93. doi:10.4049/jimmunol.176.12.7385
    • (2006) J Immunol , vol.176 , pp. 7385-7393
    • Zhang, H.G.1    Liu, C.2    Su, K.3    Yu, S.4    Zhang, L.5    Zhang, S.6
  • 109
    • 78149360255 scopus 로고    scopus 로고
    • Proinflammatory exosomes in bronchoalveolar lavage fluid of patients with sarcoidosis
    • Qazi KR, Torregrosa Paredes P, Dahlberg B, Grunewald J, Eklund A, Gabrielsson S. Proinflammatory exosomes in bronchoalveolar lavage fluid of patients with sarcoidosis. Thorax (2010) 65:1016-24. doi:10.1136/thx.2009.132027
    • (2010) Thorax , vol.65 , pp. 1016-1024
    • Qazi, K.R.1    Torregrosa Paredes, P.2    Dahlberg, B.3    Grunewald, J.4    Eklund, A.5    Gabrielsson, S.6
  • 110
    • 20444431560 scopus 로고    scopus 로고
    • Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells
    • Gastpar R, Gehrmann M, Bausero MA, Asea A, Gross C, Schroeder JA, et al. Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells. Cancer Res (2005) 65:5238-47. doi:10.1158/0008-5472.CAN-04-3804
    • (2005) Cancer Res , vol.65 , pp. 5238-5247
    • Gastpar, R.1    Gehrmann, M.2    Bausero, M.A.3    Asea, A.4    Gross, C.5    Schroeder, J.A.6
  • 111
    • 44849084963 scopus 로고    scopus 로고
    • Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages
    • Vega VL, Rodriguez-Silva M, Frey T, Gehrmann M, Diaz JC, Steinem C, et al. Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages. J Immunol (2008) 180:4299-307. doi:10.4049/jimmunol.180.6.4299
    • (2008) J Immunol , vol.180 , pp. 4299-4307
    • Vega, V.L.1    Rodriguez-Silva, M.2    Frey, T.3    Gehrmann, M.4    Diaz, J.C.5    Steinem, C.6
  • 112
    • 27144529107 scopus 로고    scopus 로고
    • More efficient induction of HLA-A*0201-restricted and carcinoembryonic antigen (CEA)-specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumor cells
    • Dai S, Wan T, Wang B, Zhou X, Xiu F, Chen T, et al. More efficient induction of HLA-A*0201-restricted and carcinoembryonic antigen (CEA)-specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumor cells. Clin Cancer Res (2005) 11:7554-63. doi:10.1158/1078-0432.CCR-05-0810
    • (2005) Clin Cancer Res , vol.11 , pp. 7554-7563
    • Dai, S.1    Wan, T.2    Wang, B.3    Zhou, X.4    Xiu, F.5    Chen, T.6
  • 113
    • 33745362875 scopus 로고    scopus 로고
    • Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells
    • Chen W, Wang J, Shao C, Liu S, Yu Y, Wang Q, et al. Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells. Eur J Immunol (2006) 36:1598-607. doi:10.1002/eji.200535501
    • (2006) Eur J Immunol , vol.36 , pp. 1598-1607
    • Chen, W.1    Wang, J.2    Shao, C.3    Liu, S.4    Yu, Y.5    Wang, Q.6
  • 114
    • 84860849807 scopus 로고    scopus 로고
    • Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell antitumor responses in vitro
    • Lv LH, Wan YL, Lin Y, Zhang W, Yang M, Li GL, et al. Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell antitumor responses in vitro. J Biol Chem (2012) 287:15874-85. doi:10.1074/jbc.M112.340588
    • (2012) J Biol Chem , vol.287 , pp. 15874-15885
    • Lv, L.H.1    Wan, Y.L.2    Lin, Y.3    Zhang, W.4    Yang, M.5    Li, G.L.6
  • 115
    • 80051931141 scopus 로고    scopus 로고
    • Induction of a tumour-specific CTL response by exosomes isolated from heat-treated malignant ascites of gastric cancer patients
    • Zhong H, Yang Y, Ma S, Xiu F, Cai Z, Zhao H, et al. Induction of a tumour-specific CTL response by exosomes isolated from heat-treated malignant ascites of gastric cancer patients. Int J Hyperthermia (2011) 27:604-11. doi:10.3109/02656736.2011.564598
    • (2011) Int J Hyperthermia , vol.27 , pp. 604-611
    • Zhong, H.1    Yang, Y.2    Ma, S.3    Xiu, F.4    Cai, Z.5    Zhao, H.6
  • 116
    • 0037141153 scopus 로고    scopus 로고
    • Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles
    • Andreola G, Rivoltini L, Castelli C, Huber V, Perego P, Deho P, et al. Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles. J Exp Med (2002) 195:1303-16. doi:10.1084/jem.20011624
    • (2002) J Exp Med , vol.195 , pp. 1303-1316
    • Andreola, G.1    Rivoltini, L.2    Castelli, C.3    Huber, V.4    Perego, P.5    Deho, P.6
  • 117
  • 118
    • 20444453596 scopus 로고    scopus 로고
    • Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: role in immune escape
    • Huber V, Fais S, Iero M, Lugini L, Canese P, Squarcina P, et al. Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: role in immune escape. Gastroenterology (2005) 128:1796-804. doi:10.1053/j.gastro.2005.03.045
    • (2005) Gastroenterology , vol.128 , pp. 1796-1804
    • Huber, V.1    Fais, S.2    Iero, M.3    Lugini, L.4    Canese, P.5    Squarcina, P.6
  • 119
    • 61849139471 scopus 로고    scopus 로고
    • Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells
    • Klibi J, Niki T, Riedel A, Pioche-Durieu C, Souquere S, Rubinstein E, et al. Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells. Blood (2009) 113:1957-66. doi:10.1182/blood-2008-02-142596
    • (2009) Blood , vol.113 , pp. 1957-1966
    • Klibi, J.1    Niki, T.2    Riedel, A.3    Pioche-Durieu, C.4    Souquere, S.5    Rubinstein, E.6
  • 120
    • 33846864645 scopus 로고    scopus 로고
    • Exosomes released by EBV-infected nasopharyngeal carcinoma cells convey the viral latent membrane protein 1 and the immunomodulatory protein galectin 9
    • Keryer-Bibens C, Pioche-Durieu C, Villemant C, Souquere S, Nishi N, Hirashima M, et al. Exosomes released by EBV-infected nasopharyngeal carcinoma cells convey the viral latent membrane protein 1 and the immunomodulatory protein galectin 9. BMC Cancer (2006) 6:283. doi:10.1186/1471-2407-6-283
    • (2006) BMC Cancer , vol.6 , pp. 283
    • Keryer-Bibens, C.1    Pioche-Durieu, C.2    Villemant, C.3    Souquere, S.4    Nishi, N.5    Hirashima, M.6
  • 121
    • 34547686145 scopus 로고    scopus 로고
    • Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2
    • Clayton A, Mitchell JP, Court J, Mason MD, Tabi Z. Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2. Cancer Res (2007) 67:7458-66. doi:10.1158/0008-5472.CAN-06-3456
    • (2007) Cancer Res , vol.67 , pp. 7458-7466
    • Clayton, A.1    Mitchell, J.P.2    Court, J.3    Mason, M.D.4    Tabi, Z.5
  • 122
    • 77955406553 scopus 로고    scopus 로고
    • Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg)
    • Szajnik M, Czystowska M, Szczepanski MJ, Mandapathil M, Whiteside TL. Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg). PLoS One (2010) 5:e11469. doi:10.1371/journal.pone.0011469
    • (2010) PLoS One , vol.5
    • Szajnik, M.1    Czystowska, M.2    Szczepanski, M.J.3    Mandapathil, M.4    Whiteside, T.L.5
  • 123
    • 70349315105 scopus 로고    scopus 로고
    • Tumor-derived microvesicles promote regulatory T cell expansion and induce apoptosis in tumor-reactive activated CD8+ T lymphocytes
    • Wieckowski EU, Visus C, Szajnik M, Szczepanski MJ, Storkus WJ, Whiteside TL. Tumor-derived microvesicles promote regulatory T cell expansion and induce apoptosis in tumor-reactive activated CD8+ T lymphocytes. J Immunol (2009) 183:3720-30. doi:10.4049/jimmunol.0900970
    • (2009) J Immunol , vol.183 , pp. 3720-3730
    • Wieckowski, E.U.1    Visus, C.2    Szajnik, M.3    Szczepanski, M.J.4    Storkus, W.J.5    Whiteside, T.L.6
  • 124
    • 31144451576 scopus 로고    scopus 로고
    • Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function
    • Liu C, Yu S, Zinn K, Wang J, Zhang L, Jia Y, et al. Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function. J Immunol (2006) 176:1375-85. doi:10.4049/jimmunol.176.3.1375
    • (2006) J Immunol , vol.176 , pp. 1375-1385
    • Liu, C.1    Yu, S.2    Zinn, K.3    Wang, J.4    Zhang, L.5    Jia, Y.6
  • 125
    • 76549099879 scopus 로고    scopus 로고
    • Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes
    • Ashiru O, Boutet P, Fernandez-Messina L, Aguera-Gonzalez S, Skepper JN, Vales-Gomez M, et al. Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes. Cancer Res (2010) 70:481-9. doi:10.1158/0008-5472.CAN-09-1688
    • (2010) Cancer Res , vol.70 , pp. 481-489
    • Ashiru, O.1    Boutet, P.2    Fernandez-Messina, L.3    Aguera-Gonzalez, S.4    Skepper, J.N.5    Vales-Gomez, M.6
  • 126
    • 34249792918 scopus 로고    scopus 로고
    • Tumor exosomes inhibit differentiation of bone marrow dendritic cells
    • Yu S, Liu C, Su K, Wang J, Liu Y, Zhang L, et al. Tumor exosomes inhibit differentiation of bone marrow dendritic cells. J Immunol (2007) 178:6867-75. doi:10.4049/jimmunol.178.11.6867
    • (2007) J Immunol , vol.178 , pp. 6867-6875
    • Yu, S.1    Liu, C.2    Su, K.3    Wang, J.4    Liu, Y.5    Zhang, L.6
  • 127
    • 33749488765 scopus 로고    scopus 로고
    • Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-beta-mediated suppressive activity on T lymphocytes
    • Valenti R, Huber V, Filipazzi P, Pilla L, Sovena G, Villa A, et al. Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-beta-mediated suppressive activity on T lymphocytes. Cancer Res (2006) 66:9290-8. doi:10.1158/0008-5472.CAN-06-1819
    • (2006) Cancer Res , vol.66 , pp. 9290-9298
    • Valenti, R.1    Huber, V.2    Filipazzi, P.3    Pilla, L.4    Sovena, G.5    Villa, A.6
  • 128
    • 77952042113 scopus 로고    scopus 로고
    • Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells
    • Liu Y, Xiang X, Zhuang X, Zhang S, Liu C, Cheng Z, et al. Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells. Am J Pathol (2010) 176:2490-9. doi:10.2353/ajpath.2010.090777
    • (2010) Am J Pathol , vol.176 , pp. 2490-2499
    • Liu, Y.1    Xiang, X.2    Zhuang, X.3    Zhang, S.4    Liu, C.5    Cheng, Z.6
  • 129
    • 76649097628 scopus 로고    scopus 로고
    • Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells
    • Chalmin F, Ladoire S, Mignot G, Vincent J, Bruchard M, Remy-Martin JP, et al. Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J Clin Invest (2010) 120:457-71. doi:10.1172/JCI40483
    • (2010) J Clin Invest , vol.120 , pp. 457-471
    • Chalmin, F.1    Ladoire, S.2    Mignot, G.3    Vincent, J.4    Bruchard, M.5    Remy-Martin, J.P.6
  • 130
    • 77957364754 scopus 로고    scopus 로고
    • TLR2-mediated expansion of MDSCs is dependent on the source of tumor exosomes
    • Xiang X, Liu Y, Zhuang X, Zhang S, Michalek S, Taylor DD, et al. TLR2-mediated expansion of MDSCs is dependent on the source of tumor exosomes. Am J Pathol (2010) 177:1606-10. doi:10.2353/ajpath.2010.100245
    • (2010) Am J Pathol , vol.177 , pp. 1606-1610
    • Xiang, X.1    Liu, Y.2    Zhuang, X.3    Zhang, S.4    Michalek, S.5    Taylor, D.D.6
  • 131
    • 39449101177 scopus 로고    scopus 로고
    • Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses
    • Zeelenberg IS, Ostrowski M, Krumeich S, Bobrie A, Jancic C, Boissonnas A, et al. Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses. Cancer Res (2008) 68:1228-35. doi:10.1158/0008-5472.CAN-07-3163
    • (2008) Cancer Res , vol.68 , pp. 1228-1235
    • Zeelenberg, I.S.1    Ostrowski, M.2    Krumeich, S.3    Bobrie, A.4    Jancic, C.5    Boissonnas, A.6
  • 132
    • 49449105179 scopus 로고    scopus 로고
    • Exosomes as a tumor immune escape mechanism: possible therapeutic implications
    • Ichim TE, Zhong Z, Kaushal S, Zheng X, Ren X, Hao X, et al. Exosomes as a tumor immune escape mechanism: possible therapeutic implications. J Transl Med (2008) 6:37. doi:10.1186/1479-5876-6-37
    • (2008) J Transl Med , vol.6 , pp. 37
    • Ichim, T.E.1    Zhong, Z.2    Kaushal, S.3    Zheng, X.4    Ren, X.5    Hao, X.6
  • 133
    • 78650156338 scopus 로고    scopus 로고
    • Trophoblast-derived exosomes mediate monocyte recruitment and differentiation
    • Atay S, Gercel-Taylor C, Suttles J, Mor G, Taylor DD. Trophoblast-derived exosomes mediate monocyte recruitment and differentiation. Am J Reprod Immunol (2011) 65:65-77. doi:10.1111/j.1600-0897.2010.00880.x
    • (2011) Am J Reprod Immunol , vol.65 , pp. 65-77
    • Atay, S.1    Gercel-Taylor, C.2    Suttles, J.3    Mor, G.4    Taylor, D.D.5
  • 134
    • 80052577736 scopus 로고    scopus 로고
    • Human trophoblast-derived exosomal fibronectin induces pro-inflammatory IL-1beta production by macrophages
    • Atay S, Gercel-Taylor C, Taylor DD. Human trophoblast-derived exosomal fibronectin induces pro-inflammatory IL-1beta production by macrophages. Am J Reprod Immunol (2011) 66:259-69. doi:10.1111/j.1600-0897.2011.00995.x
    • (2011) Am J Reprod Immunol , vol.66 , pp. 259-269
    • Atay, S.1    Gercel-Taylor, C.2    Taylor, D.D.3
  • 136
    • 68949117871 scopus 로고    scopus 로고
    • Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: evidence for immunosuppressive function
    • Hedlund M, Stenqvist AC, Nagaeva O, Kjellberg L, Wulff M, Baranov V, et al. Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: evidence for immunosuppressive function. J Immunol (2009) 183:340-51. doi:10.4049/jimmunol.0803477
    • (2009) J Immunol , vol.183 , pp. 340-351
    • Hedlund, M.1    Stenqvist, A.C.2    Nagaeva, O.3    Kjellberg, L.4    Wulff, M.5    Baranov, V.6
  • 137
    • 31144445302 scopus 로고    scopus 로고
    • Pregnancy-associated exosomes and their modulation of T cell signaling
    • Taylor DD, Akyol S, Gercel-Taylor C. Pregnancy-associated exosomes and their modulation of T cell signaling. J Immunol (2006) 176:1534-42. doi:10.4049/jimmunol.176.3.1534
    • (2006) J Immunol , vol.176 , pp. 1534-1542
    • Taylor, D.D.1    Akyol, S.2    Gercel-Taylor, C.3
  • 138
    • 84886087073 scopus 로고    scopus 로고
    • Serum exosomes in pregnancy-associated immune modulation and neuroprotection during CNS autoimmunity
    • Williams JL, Gatson NN, Smith KM, Almad A, McTigue DM, Whitacre CC. Serum exosomes in pregnancy-associated immune modulation and neuroprotection during CNS autoimmunity. Clin Immunol (2013) 149:236-43. doi:10.1016/j.clim.2013.04.005
    • (2013) Clin Immunol , vol.149 , pp. 236-243
    • Williams, J.L.1    Gatson, N.N.2    Smith, K.M.3    Almad, A.4    McTigue, D.M.5    Whitacre, C.C.6
  • 139
    • 28244488762 scopus 로고    scopus 로고
    • Tolerosome-induced oral tolerance is MHC dependent
    • Ostman S, Taube M, Telemo E. Tolerosome-induced oral tolerance is MHC dependent. Immunology (2005) 116:464-76. doi:10.1111/j.1365-2567.2005.02245.x
    • (2005) Immunology , vol.116 , pp. 464-476
    • Ostman, S.1    Taube, M.2    Telemo, E.3
  • 140
    • 34548619487 scopus 로고    scopus 로고
    • Exosomes with immune modulatory features are present in human breast milk
    • Admyre C, Johansson SM, Qazi KR, Filen JJ, Lahesmaa R, Norman M, et al. Exosomes with immune modulatory features are present in human breast milk. J Immunol (2007) 179:1969-78. doi:10.4049/jimmunol.179.3.1969
    • (2007) J Immunol , vol.179 , pp. 1969-1978
    • Admyre, C.1    Johansson, S.M.2    Qazi, K.R.3    Filen, J.J.4    Lahesmaa, R.5    Norman, M.6
  • 141
    • 79958829029 scopus 로고    scopus 로고
    • Mesenchymal stem cells for the treatment of multiple sclerosis and other neurological diseases
    • Uccelli A, Laroni A, Freedman MS. Mesenchymal stem cells for the treatment of multiple sclerosis and other neurological diseases. Lancet Neurol (2011) 10:649-56. doi:10.1016/S1474-4422(11)70121-1
    • (2011) Lancet Neurol , vol.10 , pp. 649-656
    • Uccelli, A.1    Laroni, A.2    Freedman, M.S.3
  • 142
    • 84870586430 scopus 로고    scopus 로고
    • An update on stem cell transplantation in autoimmune rheumatologic disorders
    • Mascarenhas S, Avalos B, Ardoin SP. An update on stem cell transplantation in autoimmune rheumatologic disorders. Curr Allergy Asthma Rep (2012) 12:530-40. doi:10.1007/s11882-012-0298-8
    • (2012) Curr Allergy Asthma Rep , vol.12 , pp. 530-540
    • Mascarenhas, S.1    Avalos, B.2    Ardoin, S.P.3
  • 143
    • 85027926151 scopus 로고    scopus 로고
    • The immunomodulatory properties of mesenchymal stem cells
    • Marigo I, Dazzi F. The immunomodulatory properties of mesenchymal stem cells. Semin Immunopathol (2011) 33:593-602. doi:10.1007/s00281-011-0267-7
    • (2011) Semin Immunopathol , vol.33 , pp. 593-602
    • Marigo, I.1    Dazzi, F.2
  • 144
    • 0141886188 scopus 로고    scopus 로고
    • Veto-like activity of mesenchymal stem cells: functional discrimination between cellular responses to alloantigens and recall antigens
    • Potian JA, Aviv H, Ponzio NM, Harrison JS, Rameshwar P. Veto-like activity of mesenchymal stem cells: functional discrimination between cellular responses to alloantigens and recall antigens. J Immunol (2003) 171:3426-34. doi:10.4049/jimmunol.171.7.3426
    • (2003) J Immunol , vol.171 , pp. 3426-3434
    • Potian, J.A.1    Aviv, H.2    Ponzio, N.M.3    Harrison, J.S.4    Rameshwar, P.5
  • 145
    • 0037442264 scopus 로고    scopus 로고
    • Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation
    • Tse WT, Pendleton JD, Beyer WM, Egalka MC, Guinan EC. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation (2003) 75:389-97. doi:10.1097/01.TP.0000045055.63901.A9
    • (2003) Transplantation , vol.75 , pp. 389-397
    • Tse, W.T.1    Pendleton, J.D.2    Beyer, W.M.3    Egalka, M.C.4    Guinan, E.C.5
  • 146
    • 0036142769 scopus 로고    scopus 로고
    • Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo
    • Bartholomew A, Sturgeon C, Siatskas M, Ferrer K, McIntosh K, Patil S, et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol (2002) 30:42-8. doi:10.1016/S0301-472X(01)00769-X
    • (2002) Exp Hematol , vol.30 , pp. 42-48
    • Bartholomew, A.1    Sturgeon, C.2    Siatskas, M.3    Ferrer, K.4    McIntosh, K.5    Patil, S.6
  • 147
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • Di Nicola M, Carlo-Stella C, Magni M, Milanesi M, Longoni PD, Matteucci P, et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood (2002) 99:3838-43. doi:10.1182/blood.V99.10.3838
    • (2002) Blood , vol.99 , pp. 3838-3843
    • Di Nicola, M.1    Carlo-Stella, C.2    Magni, M.3    Milanesi, M.4    Longoni, P.D.5    Matteucci, P.6
  • 148
    • 0042740515 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex
    • Le Blanc K, Tammik L, Sundberg B, Haynesworth SE, Ringden O. Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scand J Immunol (2003) 57:11-20. doi:10.1046/j.1365-3083.2003.01176.x
    • (2003) Scand J Immunol , vol.57 , pp. 11-20
    • Le Blanc, K.1    Tammik, L.2    Sundberg, B.3    Haynesworth, S.E.4    Ringden, O.5
  • 149
    • 13544249606 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate allogeneic immune cell responses
    • Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood (2005) 105:1815-22. doi:10.1182/blood-2004-04-1559
    • (2005) Blood , vol.105 , pp. 1815-1822
    • Aggarwal, S.1    Pittenger, M.F.2
  • 152
    • 84896978090 scopus 로고    scopus 로고
    • Mesenchymal stem cell-based therapy for type 1 diabetes
    • Wu H, Mahato RI. Mesenchymal stem cell-based therapy for type 1 diabetes. Discov Med (2014) 17:139-43.
    • (2014) Discov Med , vol.17 , pp. 139-143
    • Wu, H.1    Mahato, R.I.2
  • 153
    • 43049103438 scopus 로고    scopus 로고
    • Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study
    • Le Blanc K, Frassoni F, Ball L, Locatelli F, Roelofs H, Lewis I, et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet (2008) 371:1579-86. doi:10.1016/S0140-6736(08)60690-X
    • (2008) Lancet , vol.371 , pp. 1579-1586
    • Le Blanc, K.1    Frassoni, F.2    Ball, L.3    Locatelli, F.4    Roelofs, H.5    Lewis, I.6
  • 154
    • 79952476648 scopus 로고    scopus 로고
    • Mesenchymal stromal cells for graft-versus-host disease: basic aspects and clinical outcomes
    • Sato K, Ozaki K, Mori M, Muroi K, Ozawa K. Mesenchymal stromal cells for graft-versus-host disease: basic aspects and clinical outcomes. J Clin Exp Hematop (2010) 50:79-89. doi:10.3960/jslrt.50.79
    • (2010) J Clin Exp Hematop , vol.50 , pp. 79-89
    • Sato, K.1    Ozaki, K.2    Mori, M.3    Muroi, K.4    Ozawa, K.5
  • 155
    • 84858080480 scopus 로고    scopus 로고
    • Long-term complications, immunologic effects, and role of passage for outcome in mesenchymal stromal cell therapy
    • von Bahr L, Sundberg B, Lonnies L, Sander B, Karbach H, Hagglund H, et al. Long-term complications, immunologic effects, and role of passage for outcome in mesenchymal stromal cell therapy. Biol Blood Marrow Transplant (2012) 18:557-64. doi:10.1016/j.bbmt.2011.07.023
    • (2012) Biol Blood Marrow Transplant , vol.18 , pp. 557-564
    • von Bahr, L.1    Sundberg, B.2    Lonnies, L.3    Sander, B.4    Karbach, H.5    Hagglund, H.6
  • 156
    • 84872168547 scopus 로고    scopus 로고
    • Mesenchymal stromal cells and regulatory T cells: the Yin and Yang of peripheral tolerance?
    • Burr SP, Dazzi F, Garden OA. Mesenchymal stromal cells and regulatory T cells: the Yin and Yang of peripheral tolerance? Immunol Cell Biol (2013) 91:12-8. doi:10.1038/icb.2012.60
    • (2013) Immunol Cell Biol , vol.91 , pp. 12-18
    • Burr, S.P.1    Dazzi, F.2    Garden, O.A.3
  • 157
    • 77958467862 scopus 로고    scopus 로고
    • Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications
    • Ghannam S, Bouffi C, Djouad F, Jorgensen C, Noel D. Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications. Stem Cell Res Ther (2010) 1:2. doi:10.1186/scrt2
    • (2010) Stem Cell Res Ther , vol.1 , pp. 2
    • Ghannam, S.1    Bouffi, C.2    Djouad, F.3    Jorgensen, C.4    Noel, D.5
  • 158
    • 34548833007 scopus 로고    scopus 로고
    • Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFN?R1 signaling and IDO expression
    • Gieseke F, Schütt B, Viebahn S, Koscielniak E, Friedrich W, Handgretinger R, et al. Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFN?R1 signaling and IDO expression. Blood (2007) 110:2197-200. doi:10.1182/blood-2007-04-083162
    • (2007) Blood , vol.110 , pp. 2197-2200
    • Gieseke, F.1    Schütt, B.2    Viebahn, S.3    Koscielniak, E.4    Friedrich, W.5    Handgretinger, R.6
  • 159
    • 15044348816 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms
    • Rasmusson I, Ringden O, Sundberg B, Le Blanc K. Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms. Exp Cell Res (2005) 305:33-41. doi:10.1016/j.yexcr.2004.12.013
    • (2005) Exp Cell Res , vol.305 , pp. 33-41
    • Rasmusson, I.1    Ringden, O.2    Sundberg, B.3    Le Blanc, K.4
  • 160
    • 20444458975 scopus 로고    scopus 로고
    • A paradoxical role for IFN-? in the immune properties of mesenchymal stem cells during viral challenge
    • Kang HS, Habib M, Chan J, Abavana C, Potian JA, Ponzio NM, et al. A paradoxical role for IFN-? in the immune properties of mesenchymal stem cells during viral challenge. Exp Hematol (2005) 33:796-803. doi:10.1016/j.exphem.2005.03.012
    • (2005) Exp Hematol , vol.33 , pp. 796-803
    • Kang, H.S.1    Habib, M.2    Chan, J.3    Abavana, C.4    Potian, J.A.5    Ponzio, N.M.6
  • 161
    • 33746889097 scopus 로고    scopus 로고
    • Role for interferon-? in the immunomodulatory activity of human bone marrow mesenchymal stem cells
    • Krampera M. Role for interferon-? in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells (2006) 24:386-98. doi:10.1634/stemcells.2005-0008
    • (2006) Stem Cells , vol.24 , pp. 386-398
    • Krampera, M.1
  • 162
    • 2942595706 scopus 로고    scopus 로고
    • Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation
    • Meisel R, Zibert A, Laryea M, Gobel U, Daubener W, Dilloo D. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood (2004) 103:4619-21. doi:10.1182/blood-2003-11-3909
    • (2004) Blood , vol.103 , pp. 4619-4621
    • Meisel, R.1    Zibert, A.2    Laryea, M.3    Gobel, U.4    Daubener, W.5    Dilloo, D.6
  • 163
    • 65649089130 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived microvesicles protect against acute tubular injury
    • Bruno S, Grange C, Deregibus MC, Calogero RA, Saviozzi S, Collino F, et al. Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol (2009) 20:1053-67. doi:10.1681/ASN.2008070798
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1053-1067
    • Bruno, S.1    Grange, C.2    Deregibus, M.C.3    Calogero, R.A.4    Saviozzi, S.5    Collino, F.6
  • 164
    • 84873919177 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury
    • Arslan F, Lai RC, Smeets MB, Akeroyd L, Choo A, Aguor EN, et al. Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. Stem Cell Res (2013) 10:301-12. doi:10.1016/j.scr.2013.01.002
    • (2013) Stem Cell Res , vol.10 , pp. 301-312
    • Arslan, F.1    Lai, R.C.2    Smeets, M.B.3    Akeroyd, L.4    Choo, A.5    Aguor, E.N.6
  • 165
    • 85029444629 scopus 로고    scopus 로고
    • Mesenchymal stem cell exosomes: the future msc-based therapy?
    • Chase LG, Vemuri MC, editors. Mesenchymal Stem Cell Therapy. New York: Humana Press
    • Lai RC, Yeo RW, Tan SS, Zhang B, Yin Y, Sze NS, et al. Mesenchymal stem cell exosomes: the future msc-based therapy? In: Chase LG, Vemuri MC, editors. Mesenchymal Stem Cell Therapy. New York: Humana Press (2012). pp. 39-61. doi:10.1007/978-1-62703-200-1_3
    • (2012) , pp. 39-61
    • Lai, R.C.1    Yeo, R.W.2    Tan, S.S.3    Zhang, B.4    Yin, Y.5    Sze, N.S.6
  • 166
    • 33947729230 scopus 로고    scopus 로고
    • Repeated direct endomyocardial transplantation of allogeneic mesenchymal stem cells: safety of a high dose, "off-the-shelf", cellular cardiomyoplasty strategy
    • Poh KK, Sperry E, Young RG, Freyman T, Barringhaus KG, Thompson CA. Repeated direct endomyocardial transplantation of allogeneic mesenchymal stem cells: safety of a high dose, "off-the-shelf", cellular cardiomyoplasty strategy. Int J Cardiol (2007) 117:360-4. doi:10.1016/j.ijcard.2006.04.092
    • (2007) Int J Cardiol , vol.117 , pp. 360-364
    • Poh, K.K.1    Sperry, E.2    Young, R.G.3    Freyman, T.4    Barringhaus, K.G.5    Thompson, C.A.6
  • 167
    • 64049083873 scopus 로고    scopus 로고
    • Is the intravascular administration of mesenchymal stem cells safe? Mesenchymal stem cells and intravital microscopy
    • Furlani D, Ugurlucan M, Ong L, Bieback K, Pittermann E, Westien I, et al. Is the intravascular administration of mesenchymal stem cells safe? Mesenchymal stem cells and intravital microscopy. Microvasc Res (2009) 77:370-6. doi:10.1016/j.mvr.2009.02.001
    • (2009) Microvasc Res , vol.77 , pp. 370-376
    • Furlani, D.1    Ugurlucan, M.2    Ong, L.3    Bieback, K.4    Pittermann, E.5    Westien, I.6
  • 168
    • 34548044258 scopus 로고    scopus 로고
    • Potential risks of bone marrow cell transplantation into infarcted hearts
    • Breitbach M, Bostani T, Roell W, Xia Y, Dewald O, Nygren JM, et al. Potential risks of bone marrow cell transplantation into infarcted hearts. Blood (2007) 110:1362-9. doi:10.1182/blood-2006-12-063412
    • (2007) Blood , vol.110 , pp. 1362-1369
    • Breitbach, M.1    Bostani, T.2    Roell, W.3    Xia, Y.4    Dewald, O.5    Nygren, J.M.6
  • 169
    • 84879409612 scopus 로고    scopus 로고
    • Exosomes for drug delivery - a novel application for the mesenchymal stem cell
    • Lai RC, Yeo RW, Tan KH, Lim SK. Exosomes for drug delivery - a novel application for the mesenchymal stem cell. Biotechnol Adv (2013) 31:543-51. doi:10.1016/j.biotechadv.2012.08.008
    • (2013) Biotechnol Adv , vol.31 , pp. 543-551
    • Lai, R.C.1    Yeo, R.W.2    Tan, K.H.3    Lim, S.K.4


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