CD4+CD25+ regulatory T cells-derived exosomes prolonged kidney allograft survival in a rat model

Cellular Immunology

Volumn 285, Issue 1-2, 2013, Pages 62-68

  Yu, Xuesong ^a,b   Huang, Chibing ^a   Song, Bo ^a   Xiao, Ya ^a   Fang, Mingqi ^a   Feng, Jiayu ^a   Wang, Pingxian ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b Department of Nephrology   (China)

Author keywords

Exosome; Kidney transplantation; Rat; Tolerance; Tregs

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL ISOLATION; CELL SELECTION; CONTROLLED STUDY; EXOSOME; FLOW CYTOMETRY; GRAFT RECIPIENT; GRAFT SURVIVAL; HISTOPATHOLOGY; IMMUNOMAGNETIC SEPARATION; IN VITRO STUDY; IN VIVO STUDY; ISOLATION AND PURIFICATION; KIDNEY ALLOGRAFT; KIDNEY ALLOGRAFT REJECTION; KIDNEY PARENCHYMA; LIVING DONOR; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MALE; MESENTERY LYMPH NODE; MIXED LYMPHOCYTE REACTION; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RAT; REGULATORY T LYMPHOCYTE; SURVIVAL TIME; T CELL CULTURE; TRANSPLANTATION TOLERANCE;

EXOSOME; KIDNEY TRANSPLANTATION; RAT; TOLERANCE; TREGS;

ANIMALS; ANTIGENS, CD4; CELL PROLIFERATION; EXOSOMES; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; KIDNEY; KIDNEY TRANSPLANTATION; MALE; RATS; RATS, INBRED LEW; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HOMOLOGOUS;

EID: 84884966795     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2013.06.010     Document Type: Article

References (23)

1. Hammerman Marc R. Transplantation of renal precursor cells: a new therapeutic approach. Pediatr. Nephrol. 2000, 14:513-517.
2. Edemir Bayram, Kurian Sunil M., Eisenacher Martin, et al. Activation of counter-regulatory mechanisms in a rat renal acute rejection model. BMC Genomics 2008, 9:71-79.
3. + regulatory T cells in solid-organ transplantation. Int. Immunopharmacol. 2009, 9:564-569.
4. high regulatory T cells in kidney transplantation. Transpl. Immunol. 2008, 19:69-73.
5. Calvo-Turrubiartes, Romano-Moreno, García-Hernández M., et al. Quantitative analysis of regulatory T cells in kidney graft recipients: a relationship with calcineurin inhibitor level. Transpl. Immunol. 2009, 21:43-49.
6. high regulatory T cell from transplant recipients permits functional analysis of small blood samples. J. Immunol. Methods 2006, 314:103-113.
7. Cho Jung-ah, Lee Yeong-Shin, Kim Soo-Hyun, et al. MHC independent anti-tumor immune responses induced by Hsp70-enriched exosomes generate tumor regression in murine models. Cancer Lett. 2009, 275:256-265.
8. H2-like cytokines. J. Allergy Clin. Immunol. 2007, 120:1418-1424.
9. Chaput Nathalie, Taieb Julien, Noel E.C., et al. Exosome-based immunotherapy. Cancer Immunol. Immunother. 2004, 53:234-239.
10. Chaput Nathalie, Schartz Nöel E.C., André Fabrice, et al. Exosomes as potent cell-free peptide-based vaccine. II. Exosomes in CpG adjuvants efficiently prime naive Tc1 lymphocytes leading to tumor rejection. J. Immunol. 2004, 172:2137-2146.
11. Peche H., Heslan M., Usal C., Amigorena S., Cuturi M.C. Presentation of donor major histocompatibility complex antigens by bone marrow dendritic cell-derived exosomes modulates allograft rejection. Transplantation 2003, 76:1503-1510.
12. Zhang X., Izikson L., Liu L., et al. Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration. J. Immunol. 2001, 167:4245-4253.
13. Grone Hermann-Josef, Weber Christian, Weber Kim S.C., et al. Met-RANTES reduces vascular and tubular damage during acute renal transplant rejection: blocking monocyte arrest and recruitment. FASEB J. 1999, 13:1371-1383.
14. Escudier Bernard, Dorval Thierry, Chaput Nathalie, et al. Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial. J. Transl. Med. 2005, 3:10-17.
15. Almqvist Nin, Lonnqvist Anna, Hultkrantz Susanne, et al. Serum-derived exosomes from antigen-fed mice prevent allergic sensitization in a model of allergic asthma. Immunology 2008, 125:21-27.
16. Zhang Huang-Ge, Liu Cunren, Su Kaihun A membrane form of TNF-presented by exosomes delays T cell activation-induced cell death. J. Immunol. 2006, 176:7385-7393.
17. Huang Yuchuan, Shan Juan, Zhang Chuntao, et al. Research article peripheral blood T regulatory cell counts may not predict transplant rejection. BMC Immunol. 2010, 11:40-46.
18. + T regulatory cell-mediated suppression. Immunity 2009, 30:636-645.
19. Johnstone Rose M. Exosomes biological significance: a concise review. Blood Cells Mol. Dis. 2006, 36:315-321.
20. Zhang Haifeng, Xie Yufeng, Li Wei, et al. CD41 T cell-released exosomes inhibit CD81 cytotoxic T-lymphocyte responses and antitumor immunity. Cell. Mol. Immunol. 2011, 8:23-30.
21. Golshayan Dela, Wyss Jean-Christophe, Abulker Caroline Wyss, et al. Transplantation tolerance induced by regulatory T cells: In vivo mechanisms and sites of action. Int. Immunopharmacol. 2009, 9:683-688.
22. + regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J. Exp. Med. 2002, 8:389-399.
23. Weiner Howard L. Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells. Microbes Infect. 2001, 3:947-954.