Abnormal regulation of hepatic glucose output in maturity-onset diabetes of the young caused by a specific mutation of the glucokinase gene

Diabetes

Volumn 46, Issue 2, 1997, Pages 204-208

  Tappy, Luc ^a,d   Dussoix, Philippe ^b   Iynedjian, Patrick ^c   Henry, Sylvie ^a   Schneiter, Philippe ^a   Zahnd, Gaston ^b   Jéquier, Eric ^a   Philippe, Jacques ^b  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; DEUTERIUM; GLUCAGON; GLUCOKINASE; GLUCOSE; GLUCOSE 6 PHOSPHATE; HEMOGLOBIN A1C; INSULIN; SOMATOSTATIN;

ADULT; ARTICLE; CASE REPORT; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE MUTATION; GLUCONEOGENESIS; GLUCOSE ABSORPTION; GLUCOSE BLOOD LEVEL; GLUCOSE OXIDATION; HUMAN; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; LIPID OXIDATION; LIVER METABOLISM; MALE; MATURITY ONSET DIABETES MELLITUS; PRIORITY JOURNAL;

EID: 0030903085     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.2.204     Document Type: Article

References (23)

1. Fajans SS: Scope and heterogeneous nature of MODY. Diabetes Care 13:49-64, 1990
2. Froguel P, Hager J, Vionnet N: The genetics of type II diabetes. Curr Opin Endocr Metab 2:285-289, 1995
3. Froguel P, Zouali H, Vionnet N, Velho G, Vaxillaire M, Sun F, Lesage S, Stoffel M, Takeda J, Passa P, Permutt A, Beckmann JS, Bell GI, Cohen D: Familial hyperglycemia due to mutations in glucokinase: definition of a subtype of diabetes mellitus. N Engl J Med 328:697-702, 1993
4. Iynedjian PB: Mammalian glucokinase and its gene. Biochem J 293:1-13, 1993
5. Matschinsky FM: A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm. Diabetes 45:223-241, 1996
6. Velho G, Froguel P, Clement K, Pueyo ME, Rakotoambinina B, Zouali H, Passa P, Cohen D, Robert JJ: Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young. Lancet 340:444-448, 1992
7. Byrne MM, Stuns J, Clément K, Vionnet N, Pueyo ME, Stoffel M, Takeda J, Passa P, Cohen D, Bell GI, Velho G, Froguel P, Polonsky KS: Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations. J Clin Invest 93:1120-1130, 1994
8. Cahill GFJ, Ashmore J, Renold AE, Hastings AB: Blood glucose and the liver. Am J Med 26:264-282, 1959
9. Velho G, Hwang J-H, Petersen K, Persegkin G, Pueyo ME, Rothman DL, Froguel P, Shulman GI: Altered hepatic glycogen synthesis in glucokinase-deficient subjects (Abstract). Diabetes (Suppl. 1):A131, 1994
10. Gidh-Jain M, Takeda J, Xu LZ: Glucokinase mutations associated with non-insulin-dependent (type II) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships. Proc Natl Acad Sci USA 90:1932-1936, 1993
11. Efendic S, Karlander S, Vranic M: Mild type II diabetes markedly increases glucose cycling in the postabsorptive state and during glucose infusion irrespective of obesity. J Clin Invest 81:1953-1961, 1988
12. Jéquier E, Felber J: Indirect calorimetry. Baillieres Clin Endocrinol Metab 1:911-935, 1987
13. Finegood DT, Bergman RN, Vranic M: Estimation of endogenous glucose production during hyperinsulinemic euglycemic glucose clamps: comparison of labelled and unlabelled glucose infusates. Diabetes 36:914-924, 1987
14. Gay LJ, Schneiter P, Schutz Y, Di Vetta V, Jéquier E, Tappy L: A noninvasive assessment of hepatic glycogen kinetics and post-absorptive gluconeogenesis in man. Diabetologia 37:517-523, 1994
15. 14C-glucose. Recent Prog Horm Res 19:445-488, 1963
16. Chiasson JL, Liljenquist JE, Lacy WW, Jennings AS, Cherrington AD: Gluconeogenesis: methodological approaches in vivo. Federatio Proceedings 36:229-235, 1977
17. Livesey G, Elia M: Estimation of energy expenditure, net carbohydrate utilization, and net fat oxidation and synthesis by indirect calorimetry evaluation of errors with special reference to the detailed composition of foods. Am J Clin Nutr 47:608-628, 1988
18. Liang Y, Kesavan P, Wang LQ, Niswender K, Tanizawa Y, Permutt MA, Magnuson MA, Matschinsky FN: Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme. Biochem J 309:167-173, 1995
19. Barzilai N, Rossetti L: Role of glucokinase and glucose 6-phosphatase in the acute and chronic regulation of hepatic glucose fluxes by insulin. J Biol Chem 268:25019-25025, 1993
20. Rossetti L, Giaccari A, Barzilai N, Howard K, Sebel G, Hu M: Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. J Clin Invest 92:1126-1134, 1993
21. Yki-Järvinen H: Glucose toxicity. Endocr Rev 13:415-431, 1992
22. Clement K, Pueyo ME, Vaxillaire M, Rakotoambinina B, Thuillier F, Passa P, Froguel P, Robert JJ, Velho G: Assessment of insulin sensitivity in glucokinase-deficient subjects. Diabetologia 39:82-90, 1996
23. Bali D, Svetlanov A, Lee HW, Fusco DeMane D, Leiser M, Li B, Barzilai N, Surana M, Hou H, Fleischer N: Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. J Biol Chem 270:21464-21467, 1995