Polydatin, a natural precursor of resveratrol, induces β-defensin production and reduces inflammatory response

Inflammation

Volumn 36, Issue 1, 2013, Pages 26-34

  Ravagnan, Giampietro ^a   De Filippis, Anna ^b   Cartenì, Maria ^b   De Maria, Salvatore ^a   Cozza, Valentina ^c   Petrazzuolo, Marcella ^b   Tufano, Maria Antonietta ^b   Donnarumma, Giovanna ^b  

^a CA' FOSCARI UNIVERSITY OF VENICE   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

HaCat; polydatin; resveratrol

Indexed keywords

BETA DEFENSIN; GLYCOSIDE; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 70B; INTERLEUKIN 6; INTERLEUKIN 8; POLYDATIN; RESVERATROL; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL PROTECTION; CELL REGENERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HEAT STRESS; HUMAN; HUMAN CELL; INFLAMMATION; KERATINOCYTE; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE REPAIR; UPREGULATION; WESTERN BLOTTING;

BETA-DEFENSINS; CELL LINE; CYTOPROTECTION; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GLUCOSIDES; HEAT-SHOCK RESPONSE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INFLAMMATION; INTERLEUKIN-6; INTERLEUKIN-8; KERATINOCYTES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STILBENES; TUMOR NECROSIS FACTOR-ALPHA;

VITACEAE;

EID: 84872906695     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-012-9516-8     Document Type: Article

References (29)

1. Sugita, K., K. Kabashima, K. Atarashi, et al. 2007. Innate immunity mediated by epidermal keratinocytes promotes acquired immunity involving Langerhans cells and T cells in the skin. Clinical and Experimental Immunology 147: 176-183. (Pubitemid 44915569)
2. Medzhitov, R. 2001. Toll-like receptors and innate immunity. Nature Reviews Immunology 1: 135-145. (Pubitemid 33741967)
3. Barton, G.M., and R. Medzhitov. 2003. Toll-like receptor signalling pathways. Science 300: 1524-1525. (Pubitemid 36682871)
4. Kaisho, T., and S. Akira. 2006. Toll-like receptor function and signaling. The Journal of Allergy and Clinical Immunology 117: 979-987.
5. Zasloff, M. 2002. Antimicrobial peptides of multicellular organisms. Nature 415: 389-395. (Pubitemid 34100944)
6. Ghoreishi, M. 2000. Heat shock proteins in the pathogenesis of inflammatory skin diseases. Journal of Medical and Dental Sciences 47: 143-150.
7. Frankel, E.N., A.L. Waterhouse, and J.E. Kinsella. 1993. Inhibition of human LDL oxidation by resveratrol. Lancet 24: 1103-1104. (Pubitemid 23114451)
8. Dorozynski, A. 1997. Wine may prevent dementia. BMJ 314: 993.
9. Albani, D., L. Polito, A. Signorini, et al. 2010. Neuroprotective properties of resveratrol in different neurodegenerative disorders. Biofactors 36: 370-376.
10. Romero-Perez, A.I., M. Ibern-Gomez, R.M. Lamuela-Raventos, et al. 1999. Piceid, the major resveratrol derivative in grape juices. Journal of Agricultural and Food Chemistry 47: 1533-1536. (Pubitemid 29217152)
11. Falchetti, R., M.P. Fuggetta, G. Lanzilli, et al. 2001. Effects of resveratrol on human immune cell function. Life Science 70: 81-96. (Pubitemid 33124357)
12. Regev-Shoshani, G., O. Shoseyov, I. Bilkis, et al. 2003. Glycosylation of resveratrol protects it from enzymic oxidation. Biochemistry Journal 374: 157-163. (Pubitemid 37046939)
13. Sies, H. 2010. Polyphenols and health: update and perspectives. Archives of Biochemistry and Biophysics 501: 2-5.
14. Lanzilli, G., A. Cottarelli, G. Nicotera, et al. 2012. Anti-inflammatory effect of resveratrol and polidatin by in vitro IL-17 modulation. Inflammation 35: 240-248.
15. Ravagnan, G., R. Falchetti, and G. Lanzilli, et al. Solid phase extraction of trans-resveratrol from wines for HPLC analysis. Use of extracts from spermatophyte plants with immunomodulating activity. Pat EP 1292320.
16. Fabris, S., F. Momo, G. Ravagnan, et al. 2008. Antioxidant properties of resveratrol and piceid on lipid peroxidation in micelles and monolamellar liposomes. Biophysical Chemistry 135: 76-83.
17. Liu, L., A.A. Roberts, and T. Ganz. 2003. By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide. Journal of Immunology 170: 575-580. (Pubitemid 36026185)
18. Elsbach, P. 2003. What is the real role of antimicrobial polypeptides that can mediate several other inflammatory responses? The Journal of Clinical Investigation 111: 1643-1645. (Pubitemid 38057744)
19. Nagoaka, I., F. Niyonsaba, Y. Tsutsumi-Ishii, et al. 2008. Evaluation of the effect of human beta-defensins on neutrophil apoptosis. International Immunology 20: 543-553. (Pubitemid 351436191)
20. Mempel, M., B.N. Kalali, M. Ollert, et al. 2007. Toll-like receptors in dermatology. Dermatology Clinic 25: 531-540. Review. (Pubitemid 47446085)
21. Pivarcsi, A., L. Bodai, B. Rethi, et al. 2003. Expression and function of Toll like receptors 2 and 4 in human keratinocytes. International Immunology 15: 721-730. (Pubitemid 36675803)
22. Giannessi, D., C. Caselli, R.L. Vitale, et al. 2003. A possible cardioprotective effect of heat shock proteins during cardiac surgery inpediatric patients. Pharmacological Research 48: 519-529. (Pubitemid 37101212)
23. Morimoto, R.I., and M.G. Santoro. 1998. Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection. Nature Biotechnology 16: 833-838. (Pubitemid 28405852)
24. Manna, S.K., A. Mukhopadhyay, and B.B. Aggarwal. 2000. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. Journal of Immunology 164: 6509-6519. (Pubitemid 30408836)
25. Svobodova, A., A. Zdarilova, J. Maliskova, et al. 2007. Attenuation of UVA-induced damage to human keratinocytes by silymarin. Journal of Dermatological Science 46: 21-30. (Pubitemid 46366634)
26. Pinnel, S.R. 2003. Cutaneous photo-damage, oxidative stress and topical antioxidant protection. Journal of the American Academy of Dermatology 48: 1-22. (Pubitemid 36091527)
27. Chen, M., J. Li, W. Xiao, et al. 2006. Protective effect of resveratrol against oxidative damage of UVA irradiated HaCaT cells. Journal of Central South University 31: 635-639. (Pubitemid 44645932)
28. Roy, P., N. Kalra, N. Nigam, et al. 2009. Resveratrol enhances ultraviolet B-induced cell death through nuclear factor-kB pathway in human epidermoid carcinoma A431 cells. Biochemical and Biophysical Research Communications 384: 215-220.
29. Liu, Y., F. Chan, H. Sun, et al. 2011. Resveratrol protects human keratinocytes HaCat cells from UVA-induced oxidative stress damage downregulating Keap1 expression. European Journal of Pharmaceutics 650: 130-137.