Importance of fatty acids in the perinatal period

World Review of Nutrition and Dietetics

Volumn 112, Issue , 2015, Pages 31-47

  Demmelmair, Hans ^a   Koletzko, Berthold ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; UNSATURATED FATTY ACID;

ASTHMA; BREAST MILK; CHEMISTRY; DIET; DRUG EFFECTS; FEMALE; FETUS BLOOD; HUMAN; INFANT; PERINATAL CARE; POSTNATAL CARE; PREGNANCY; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK FACTOR; VISION;

ARACHIDONIC ACID; ASTHMA; DIET; DOCOSAHEXAENOIC ACIDS; FATTY ACIDS, UNSATURATED; FEMALE; FETAL BLOOD; HUMANS; INFANT; MILK, HUMAN; PERINATAL CARE; POSTNATAL CARE; PREGNANCY; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK FACTORS; VISION, OCULAR;

EID: 84918786722     PISSN: 00842230     EISSN: 16623975     Source Type: Book Series    
DOI: 10.1159/000365427     Document Type: Article

References (79)

1. Willett WC: Dietary fats and coronary heart disease. J Intern Med 2012;272:13-24.
2. Bateson P, Barker D, Clutton-Brock T, et al: Developmental plasticity and human health. Nature 2004;430:419-421.
3. Koletzko B, Symonds ME, Olsen SF, Early Nutrition Programming Project, Early Nutrition Academy: Programming research: where are we and where do we go from here? Am J Clin Nutr 2011;94:2036S-2043S.
4. Schmitz G, Ecker J: The opposing effects of n-3 and n-6 fatty acids. Prog Lipid Res 2008;47:147-155.
5. Plourde M, Cunnane SC: Extremely limited synthesis of long chain polyunsaturates in adults: Implications for their dietary essentiality and use as supplements. Appl Physiol Nutr Metab 2007;32:619-634.
6. Schaeffer L, Gohlke H, Müller M, et al: Common genetic variants of the fads1 fads2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum Mol Genet 2006;15:1745-1756.
7. Ganesan B, Brothersen C, McMahon DJ: Fortification of foods with omega-3 polyunsaturated fatty acids. Crit Rev Food Sci Nutr 2014;54:98-114.
8. Simopoulos AP: The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med (Maywood) 2008;233:674-688.
9. Berghaus TM, Demmelmair H, Koletzko B: Fatty acid composition of lipid classes in maternal and cord plasma at birth. Eur J Pediatr 1998;157:763-768.
10. Gil-Sánchez A, Koletzko B, Larqué E: Current understanding of placental fatty acid transport. Curr Opin Clin Nutr Metab Care 2012;15:265-272.
11. Al MD, Van Houwelingen AC, Kester AD, et al: Maternal essential fatty acid patterns during normal pregnancy and their relationship to the neonatal essential fatty acid status. Br J Nutr 1995;74:55-68.
12. Gil-Sánchez A, Larqué E, Demmelmair H, et al: Maternal-fetal in vivo transfer of [13c]docosahexaenoic and other fatty acids across the human placenta 12 h after maternal oral intake. Am J Clin Nutr 2010;92:115-122.
13. Larqué E, Demmelmair H, Berger B, et al: In vivo investigation of the placental transfer of (13) c-labeled fatty acids in humans. J Lipid Res 2003;44:49-55.
14. Gauster M, Hiden U, Blaschitz A, et al: Dysregulation of placental endothelial lipase and lipoprotein lipase in intrauterine growth-restricted pregnancies. J Clin Endocrinol Metab 2007;92:2256-2263.
15. Campbell FM, Clohessy AM, Gordon MJ, et al: Uptake of long chain fatty acids by human placental choriocarcinoma (bewo) cells: Role of plasma membrane fatty acid-binding protein. J Lipid Res 1997;38:2558-2568.
16. Larqué E, Demmelmair H, Gil-Sánchez A, et al: Placental transfer of fatty acids and fetal implications. Am J Clin Nutr 2011;94:1908S-1913S.
17. Scifres CM, Chen B, Nelson DM, et al: Fatty acid binding protein 4 regulates intracellular lipid accumulation in human trophoblasts. J Clin Endocrinol Metab 2011;96:E1083-E1091.
18. Szitanyi P, Koletzko B, Mydlilova A, et al: Metabolism of 13C-labelled linoleic acid in newborn infants during the first week of life. Pediatr Res 1999;45:669-673.
19. Brenna JT, Varamini B, Jensen RG, et al: Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr 2007;85:1457-1464.
20. Fleddermann M, Demmelmair H, Grote V, et al: Infant formula composition affects energetic efficiency for growth: The BeMIM study, a randomized controlled trial. Clin Nutr 2013;33:588-595.
21. Sauerwald UC, Fink MM, Demmelmair H, et al: Effect of different levels of docosahexaenoic acid supply on fatty acid status and linoleic and alpha-linolenic acid conversion in preterm infants. J Pediatr Gastroenterol Nutr 2012;54:353-363.
22. Poston L: Gestational weight gain: Influences on the long-term health of the child. Curr Opin Clin Nutr Metab Care 2012;15:252-257.
23. Négrel R, Gaillard D, Ailhaud G: Prostacyclin as a potent effector of adipose-cell differentiation. Biochem J 1989;257:399-405.
24. Ailhaud G, Massiera F, Weill P, et al: Temporal changes in dietary fats: Role of n-6 polyunsaturated fatty acids in excessive adipose tissue development and relationship to obesity. Prog Lipid Res 2006;45:203-236.
25. Barber E, Sinclair AJ, Cameron-Smith D: Comparative actions of omega-3 fatty acids on in-vitro lipid droplet formation. Prostaglandins Leukot Essent Fatty Acids 2013;89:359-366.
26. Hihi AK, Michalik L, Wahli W: PPARs: Transcriptional effectors of fatty acids and their derivatives. Cell Mol Life Sci 2002;59:790-798.
27. Massiera F, Saint-Marc P, Seydoux J, et al: Arachidonic acid and prostacyclin signaling promote adipose tissue development: A human health concern? J Lipid Res 2003;44:271-279.
28. Madsen L, Pedersen LM, Liaset B, et al: cAMP-dependent signaling regulates the adipogenic effect of n-6 polyunsaturated fatty acids. J Biol Chem 2008;283:7196-7205.
29. Aprikian O, Reynaud D, Pace-Asciak C, et al: Neonatal dietary supplementation of arachidonic acid increases prostaglandin levels in adipose tissue but does not promote fat mass development in guinea pigs. Am J Physiol Regul Integr Comp Physiol 2007;293:R2006-R2012.
30. Hussain A, Nookaew I, Khoomrung S, et al: A maternal diet of fatty fish reduces body fat of offspring compared with a maternal diet of beef and a postweaning diet of fish improves insulin sensitivity and lipid profile in adult C57BL/6 male mice. Acta Physiol (Oxf) 2013;209:220-234.
31. Oosting A, Kegler D, Boehm G, et al: N-3 long-chain polyunsaturated fatty acids prevent excessive fat deposition in adulthood in a mouse model of postnatal nutritional programming. Pediatr Res 2010;68:494-499.
32. ∗3Leiden mice. Mol Nutr Food Res 2012;56:1081-1089.
33. Rodríguez G, Iglesia I, Bel-Serrat S, et al: Effect of n-3 long chain polyunsaturated fatty acids during the perinatal period on later body composition. Br J Nutr 2012;107(Suppl 2):S117-S128.
34. Lucia Bergmann R, Bergmann KE, Haschke-Becher E, et al: Does maternal docosahexaenoic acid supplementation during pregnancy and lactation lower bmi in late infancy? J Perinat Med 2007;35:295-300.
35. Hauner H, Much D, Vollhardt C, et al: Effect of reducing the n-6:n-3 long-chain PUFA ratio during pregnancy and lactation on infant adipose tissue growth within the first year of life: An open-label randomized controlled trial. Am J Clin Nutr 2012;95:383-394.
36. Much D, Brunner S, Vollhardt C, et al: Effect of dietary intervention to reduce the n-6/n-3 fatty acid ratio on maternal and fetal fatty acid profile and its relation to offspring growth and body composition at 1 year of age. Eur J Clin Nutr 2013;67:282-288.
37. Hauner H, Brunner S, Amann-Gassner U: The role of dietary fatty acids for early human adipose tissue growth. Am J Clin Nutr 2013;98:549S-555S.
38. Rosenfeld E, Beyerlein A, Hadders-Algra M, et al: IPD meta-analysis shows no effect of LC-PUFA supplementation on infant growth at 18 months. Acta Paediatr 2009;98:91-97.
39. De Jong C, Boehm G, Kikkert HK, et al: The Groningen LCPUFA study: No effect of short-term postnatal long-chain polyunsaturated fatty acids in healthy term infants on cardiovascular and anthropometric development at 9 years. Pediatr Res 2011;70:411-416.
40. Donahue SM, Rifas-Shiman SL, Olsen SF, et al: Associations of maternal prenatal dietary intake of n-3 and n-6 fatty acids with maternal and umbilical cord blood levels. Prostaglandins Leukot Essent Fatty Acids 2009;80:289-296.
41. Moon RJ, Harvey NC, Robinson SM, et al: Maternal plasma polyunsaturated fatty acid status in late pregnancy is associated with offspring body composition in childhood. J Clin Endocrinol Metab 2013;98:299-307.
42. Standl M, Thiering E, Demmelmair H, et al: Agedependent effects of cord blood long-chain PUFA composition on BMI during the first 10 years of life. Br J Nutr 2014 Feb. 13:1-8. [Epub ahead of print] PubMed PMID: 24521544.
43. Lauritzen L, Hansen HS, Jørgensen MH, et al: The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. Prog Lipid Res 2001;40:1-94.
44. Luchtman DW, Song C: Cognitive enhancement by omega-3 fatty acids from child-hood to old age: Findings from animal and clinical studies. Neuropharmacology 2013;64:550-565.
45. Chalon S: Omega-3 fatty acids and monoamine neurotransmission. Prostaglandins Leukot Essent Fatty Acids 2006;75:259-269.
46. Cao D, Kevala K, Kim J, et al: Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function. J Neurochem 2009;111:510-521.
47. Calderon F, Kim HY: Docosahexaenoic acid promotes neurite growth in hippocampal neurons. J Neurochem 2004;90:979-988.
48. Brenna JT: Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal life. Matern Child Nutr 2011;7(Suppl 2):59-79.
49. Nyaradi A, Li J, Hickling S, et al: The role of nutrition in children's neurocognitive development, from pregnancy through childhood. Front Hum Neurosci 2013;7:97.
50. Gould JF, Smithers LG, Makrides M: The effect of maternal omega-3 (n-3) LCPUFA supplementation during pregnancy on early childhood cognitive and visual development: A systematic review and metaanalysis of randomized controlled trials. Am J Clin Nutr 2013;97:531-544.
51. Makrides M: DHA supplementation during the perinatal period and neurodevelopment: Do some babies benefit more than others? Prostaglandins Leukot Essent Fatty Acids 2013;88:87-90.
52. Koletzko B, Lien E, Agostoni C, et al: The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: Review of current knowledge and consensus recommendations. J Perinat Med 2008;36:5-14.
53. Qawasmi A, Landeros-Weisenberger A, Bloch MH: Meta-analysis of LCPUFA supplementation of infant formula and visual acuity. Pediatrics 2013;131:e262-e272.
54. Schulzke SM, Patole SK, Simmer K: Long-chain polyunsaturated fatty acid supplementation in preterm infants. Cochrane Database Syst Rev 2011: DOI: 10.1002/14651858. CD000375.pub4.
55. Simmer K, Patole SK, Rao SC: Long-chain polyunsaturated fatty acid supplementation in infants born at term. Cochrane Database Syst Rev 2011, DOI: 10.1002/14651858. CD000376.pub3.
56. Qawasmi A, Landeros-Weisenberger A, Leckman JF, et al: Meta-analysis of long-chain polyunsaturated fatty acid supplementation of formula and infant cognition. Pediatrics 2012;129:1141-1149.
57. Makrides M, Collins CT, Gibson RA: Impact of fatty acid status on growth and neurobehavioural development in humans. Matern Child Nutr 2011;7(Suppl 2):80-88.
58. Carlson SE: Early determinants of development: A lipid perspective. Am J Clin Nutr 2009;89:1523S-1529S.
59. Drover J, Hoffman DR, Castañeda YS, et al: Three randomized controlled trials of early long-chain polyunsaturated fatty acid supplementation on means-end problem solving in 9-month-olds. Child Dev 2009;80:1376-1384.
60. Krauss-Etschmann S, Shadid R, Campoy C, et al: Effects of fish-oil and folate supplementation of pregnant women on maternal and fetal plasma concentrations of docosahexaenoic acid and eicosapentaenoic acid: A European randomized multicenter trial. Am J Clin Nutr 2007;85:1392-1400.
61. Gibson RA, Neumann MA, Makrides M: Effect of increasing breast milk docosahexaenoic acid on plasma and erythrocyte phospholipid fatty acids and neural indices of exclusively breast fed infants. Eur J Clin Nutr 1997;51:578-584.
62. Hibbeln JR, Davis JM, Steer C, et al: Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): An observational cohort study. Lancet 2007;369:578-585.
63. Bath SC, Steer CD, Golding J, et al: Effect of inadequate iodine status in UK pregnant women on cognitive outcomes in their children: Results from the Avon longitudinal study of parents and children (ALSPAC). Lancet 2013;382:331-337.
64. Steer CD, Lattka E, Koletzko B, et al: Maternal fatty acids in pregnancy, FADS polymorphisms, and child intelligence quotient at 8 y of age. Am J Clin Nutr 2013;98:1575-1582.
65. Steer CD, Davey Smith GD, Emmett PM, et al: FADS2 polymorphisms modify the effect of breastfeeding on child IQ. PLoS ONE 2010;5:e11570.
66. Lehmann I, Herberth G: Cord blood immune status: Predicting health or allergy? Allergy 2012;67:445-448.
67. Prescott SL, Dunstan JA: Prenatal fatty acid status and immune development: The pathways and the evidence. Lipids 2007;42:801-810.
68. Calder PC: N-3 fatty acids, inflammation and immunity: New mechanisms to explain old actions. Proc Nutr Soc 2013;72:326-336.
69. Serhan CN, Chiang N, Van Dyke TE: Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol 2008;8:349-361.
70. Oh DY, Talukdar S, Bae EJ, et al: GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 2010;142:687-698.
71. Kremmyda LS, Vlachava M, Noakes PS, et al: Atopy risk in infants and children in relation to early exposure to fish, oily fish, or long-chain omega-3 fatty acids: A systematic review. Clin Rev Allergy Immunol 2011;41:36-66.
72. Klemens CM, Berman DR, Mozurkewich EL: The effect of perinatal omega-3 fatty acid supplementation on inflammatory markers and allergic diseases: A systematic review. BJOG 2011;118:916-925.
73. Krauss-Etschmann S, Hartl D, Rzehak P, et al: Decreased cord blood IL-4, IL-13, and CCR4 and increased TGF-beta levels after fish oil supplementation of pregnant women. J Allergy Clin Immunol 2008;121:464-470.
74. Olsen SF, Østerdal ML, Salvig JD, et al: Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial. Am J Clin Nutr 2008;88:167-175.
75. Lauritzen L, Kjaer TM, Fruekilde MB, et al: Fish oil supplementation of lactating mothers affects cytokine production in 2 1/2-year-old children. Lipids 2005;40:669-676.
76. Dunstan JA, Mori TA, Barden A, et al: Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: A randomized, controlled trial. J Allergy Clin Immunol 2003;112:1178-1184.
77. Furuhjelm C, Warstedt K, Larsson J, et al: Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy. Acta Paediatr 2009;98:1461-1467.
78. Imhoff-Kunsch B, Briggs V, Goldenberg T, et al: Effect of n-3 long-chain polyunsaturated fatty acid intake during pregnancy on maternal, infant, and child health outcomes: A systematic review. Paediatr Perinat Epidemiol 2012;26(Suppl 1):91-107.
79. Kohlboeck G, Glaser C, Tiesler C, et al: Effect of fatty acid status in cord blood serum on children's behavioral difficulties at 10 y of age: Results from the lisaplus study. Am J Clin Nutr 2011;94:1592-1599.