The role of nutrition in children's neurocognitive development, from pregnancy through childhood

Frontiers in Human Neuroscience

Volumn , Issue MAR, 2013, Pages

  Nyaradi, Anett ^a,b   Li, Jianghong ^a,c,f   Hickling, Siobhan ^a,b   Foster, Jonathan ^a,b,d,e   Oddy, Wendy H ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c CURTIN UNIVERSITY   (Australia)

^d CURTIN UNIVERSITY   (Australia)

^e Neurosciences Unit   (Australia)

^f WZB BERLIN SOCIAL SCIENCE CENTER   (Germany)

Author keywords

Children; Cognitive development; Diet quality; Micronutrients; Nutrition

Indexed keywords

ARACHIDONIC ACID; CHOLINE; COD LIVER OIL; CYANOCOBALAMIN; DOCOSAHEXAENOIC ACID; ESSENTIAL FATTY ACID; FOLIC ACID; IODINE; IRON; LIPID; LONG CHAIN FATTY ACID; MULTIVITAMIN; OMEGA 3 FATTY ACID; POLYUNSATURATED FATTY ACID; TRACE ELEMENT; ZINC;

BRAIN DEVELOPMENT; BRAIN FUNCTION; BRAIN GROWTH; BRAIN MATURATION; BRAIN NERVE CELL; BRAIN REGION; BREAST FEEDING; CHILD NUTRITION; CHILDHOOD; CLINICAL FEATURE; COGNITION; COGNITIVE DEFECT; COGNITIVE DEVELOPMENT; DENDRITIC SPINE; DIET SUPPLEMENTATION; DIETARY INTAKE; DISEASE ASSOCIATION; DNA METHYLATION; ENERGY YIELD; ENVIRONMENTAL FACTOR; EXECUTIVE FUNCTION; FATTY ACID SYNTHESIS; FEEDING BEHAVIOR; FOLIC ACID BLOOD LEVEL; FOOD INTAKE; FOOD QUALITY; GENE EXPRESSION; GENE FUNCTION; GENETIC ASSOCIATION; GESTATION PERIOD; GRAY MATTER; HUMAN; INTELLIGENCE QUOTIENT; IODINE DEFICIENCY; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; LANGUAGE; LANGUAGE DEVELOPMENT; MACROBIOTIC DIET; MALNUTRITION; MATERNAL NUTRITION; MEAL; MEMORY; MENTAL FUNCTION; MENTAL PERFORMANCE; MYELINATION; NERVE TRACT; NEURAL TUBE; NEUROIMAGING; NEUROTRANSMISSION; NONHUMAN; NUTRITION; OBESITY; PERINATAL PERIOD; PREGNANCY; RANDOMIZED CONTROLLED TRIAL (TOPIC); READING; REVIEW; SIGNAL PROCESSING; SMALL FOR DATE INFANT; SOCIAL ADAPTATION; VITAMIN SUPPLEMENTATION; ZINC DEFICIENCY;

EID: 84933679118     PISSN: 16625161     EISSN: 16625161     Source Type: Journal    
DOI: 10.3389/fnhum.2013.00097     Document Type: Review

References (207)

1. Alamy, M., and Bengelloun, W.A. (2012). Malnutrition and brain development: An analysis of the effects of inadequate diet during different stages of life in rat. Neuroscience and Biobehavioral Reviews 36, 1463-1480.
2. Anderson, J.W., Johnstone, B.M., and Remley, D.T. (1999). Breast-feeding and cognitive development: a meta-analysis. The American Journal of Clinical Nutrition 70, 525-535.
3. Armstrong, B. (2002). Review: iron treatment does not improve psychomotor development and cognitive function at 30 days in children with iron deficiency anaemia. Evidence based mental health 5, 17.
4. Asato, M.R., Terwilliger, R., Woo, J., and Luna, B. (2010). White matter development in adolescence: A DTI study. Cerebral Cortex 20, 2122-2131.
5. Attig, L., Gabory, A., and Junien, C. (2010). Early nutrition and epigenetic programming: chasing shadows. Current Opinion in Clinical Nutrition and Metabolic Care 13, 284-293
6. Beard, J.L. (2008). Why iron deficiency is important in infant development. The Journal of Nutrition 138, 2534-2536.
7. Bellisle, F. (2004). Effects of diet on behaviour and cognition in children. British Journal of Nutrition 92, S227-S232.
8. Ben tez-Bribiesca, L., De La Rosa-Alvarez, I., and Mansilla-Olivares, A. (1999). Dendritic spine pathology in infants with severe protein-calorie malnutrition. Pediatrics 104, e21.
9. Benton, D. (2001). Micro-nutrient supplementation and the intelligence of children. Neuroscience and Biobehavioral Reviews 25, 297-309.
10. Benton, D. (2010a). The influence of dietary status on the cognitive performance of children. Molecular Nutrition and Food Research 54, 457-470.
11. Benton, D. (2010b). Neurodevelopment and neurodegeneration: are there critical stages for nutritional intervention? Nutrition Reviews 68, S6-S10.
12. Benton, D. (2012). Vitamins and neural and cognitive developmental outcomes in children. Proceedings of the Nutrition Society 71, 14-26.
13. Berbel, P., Mestre, J.L., Santamaria, A., Palazon, I., Franco, A., Graells, M., Gonzalez-Torga, A., and De Escobar, G.M. (2009). Delayed neurobehavioral development in children born to pregnant women with mild hypothyroxinemia during the first month of gestation: the importance of early iodine supplementation. Thyroid 19, 511-519.
14. Bhate, V. (2008). Vitamin B-12 status of pregnant Indian women and cognitive function in their 9-year-old children. Food and Nutrition Bulletin 29, 249-254.
15. Bhatnagar, S., and Taneja, S. (2001). Zinc and cognitive development. British Journal of Nutrition 85, S139-S145.
16. Bisset, S., Fournier, M., Janosz, M., and Pagani, L. (2012). Predicting academic and cognitive outcomes from weight status trajectories during childhood. International Journal of Obesity (Lond).
17. Black, M.M. (2003a). The Evidence Linking Zinc Deficiency with Children's Cognitive and Motor Functioning. The Journal of Nutrition 133, 1473S-1476S.
18. Black, M.M. (2003b). Micronutrient deficiencies and cognitive functioning. The Journal of Nutrition 133, 3927S-3931S.
19. Black, M.M., Baqui, A.H., Zaman, K., Ake Persson, L., El Arifeen, S., Le, K., Mcnary, S.W., Parveen, M., Hamadani, J.D., and Black, R.E. (2004). Iron and zinc supplementation promote motor development and exploratory behavior among Bangladeshi infants. The American Journal of Clinical Nutrition 80, 903-910.
20. Blakemore, S.-J., Burnett, S., and Dahl, R.E. (2010). The role of puberty in the developing adolescent brain. Human Brain Mapping 31, 926-933.
21. Bleichrodt, N., and Born, M. (1994). A metaanalysis of research on iodine and its relationship to cognitive development in The Damaged Brain of Iodine Deficiency, ed. Stanbury Jb. (New York: Cognizant Communication), 195-200.
22. Blencowe, H., Cousens, S., Modell, B., and Lawn, J. (2010). Folic acid to reduce neonatal mortality from neural tube disorders. International Journal of Epidemiology 39, i110-i121.
23. Boucher, O., Burden, M.J., Muckle, G., Saint-Amour, D., Ayotte, P., Dewailly, E., Nelson, C.A., Jacobson, S.W., and Jacobson, J.L. (2011). Neurophysiologic and neurobehavioral evidence of beneficial effects of prenatal omega-3 fatty acid intake on memory function at school age. The American Journal of Clinical Nutrition 93, 1025-1037.
24. Broadhurst, C.L., Cunnane, S.C., and Crawford, M.A. (1998). Rift Valley lake fish and shellfish provided brain-specific nutrition for early Homo. British Journal of Nutrition 79, 3-21.
25. Broadhurst, C.L., Wang, Y., Crawford, M.A., Cunnane, S.C., Parkington, J.E., and Schmidt, W.F. (2002). Brain-specific lipids from marine, lacustrine, or terrestrial food resources: potential impact on early African Homo sapiens. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 131, 653-673.
26. Brown, R.D., Langshaw, M.R., Uhr, E.J., Gibson, J.N., and Joshua, D.E. (2011). The impact of mandatory fortification of flour with folic acid on the blood folate levels of an Australian population. The Medical Journal of Australia 194, 65-67.
27. Bryan, J., Osendarp, S., Hughes, D., Calvaresi, E., Baghurst, K., and Van Klinken, J.-W. (2004). Nutrients for cognitive development in school-aged children. Nutrition Reviews 62, 295-306.
28. Burkhalter, T.M., and Hillman, C.H. (2011). A narrative review of physical activity, nutrition, and obesity to cognition and scholastic performance across the human lifespan. Advances in Nutrition: An International Review Journal 2, 201S-206S.
29. Campoy, C., Escolano-Margarit, M.V., Ramos, R., Parrilla-Roure, M., Csábi, G., Beyer, J., Ramirez-Tortosa, M.C., Molloy, A.M., Decsi, T., and Koletzko, B.V. (2011). Effects of prenatal fish-oil and 5-methyltetrahydrofolate supplementation on cognitive development of children at 6.5 y of age. The American Journal of Clinical Nutrition.
30. Caulfield, L.E., Putnick, D.L., Zavaleta, N., Lazarte, F., Albornoz, C., Chen, P., Dipietro, J.A., and Bornstein, M.H. (2010). Maternal gestational zinc supplementation does not influence multiple aspects of child development at 54 mo of age in Peru. The American Journal of Clinical Nutrition 92, 130-136.
31. Cetina, I. (2008). Long-chain omega-3 fatty acid supply in pregnancy and lactation. Current Opinion in Clinical Nutrition and Metabolic Care 11, 297-302.
32. Chugani, T. (1998). A Critical Period of Brain Development: studies of cerebral glucose utilization with PET. Preventive Medicine 27, 184-188.
33. Clark, C.a.C., Pritchard, V.E., and Woodward, L.J. (2010). Preschool executive functioning abilities predict early mathematics achievement. Developmental Psychology 46, 1176-1191.
34. Colombo, J., Kannass, K.N., Jill Shaddy, D., Kundurthi, S., Maikranz, J.M., Anderson, C.J., Blaga, O.M., and Carlson, S.E. (2004). Maternal DHA and the development of attention in infancy and toddlerhood. Child Development 75, 1254-1267.
35. Commonwealth of Australia (2006). Nutrient reference values for Australia and New Zealand
36. Coyle, P., Tran, N., Fung, J.N.T., Summers, B.L., and Rofe, A.M. (2009). Maternal dietary zinc supplementation prevents aberrant behaviour in an object recognition task in mice offspring exposed to LPS in early pregnancy. Behavioural Brain Research 197, 210-218.
37. Crawford, M., Bloom, M., Broadhurst, C., Schmidt, W., Cunnane, S., Galli, C., Gehbremeskel, K., Linseisen, F., Lloyd-Smith, J., and Parkington, J. (1999). Evidence for the unique function of docosahexaenoic acid during the evolution of the modern hominid brain. Lipids 34, S39-S47.
38. Daniels, J.L., Longnecker, M.P., Rowland, A.S., and Golding, J. (2004). Fish intake during pregnancy and early cognitive development of offspring. Epidemiology 15, 394-402.
39. De Benoist, B. (2008). Conclusions of a WHO Technical Consultation on folate and vitamin B12 deficiencies. Food and Nutrition Bulletin 29, S238-244.
40. De Onis, M. (2000). Is malnutrition declining? An analysis of changes in levels of child malnutrition since 1980. Bulletin of the World Health Organization 78, 1222.
41. De Onis, M., Blössner, M., and Borghi, E. (2010). Global prevalence and trends of overweight and obesity among preschool children. The American Journal of Clinical Nutrition 92, 1257-1264.
42. De Rooij, S.R., Wouters, H., Yonker, J.E., Painter, R.C., and Roseboom, T.J. (2010). Prenatal undernutrition and cognitive function in late adulthood. Proceedings of the National Academy of Sciences of the United States of America 107, 16881-16886.
43. De Souza, A.S., Fernandes, F.S., and Do Carmo, M.G. (2011). Effects of maternal malnutrition and postnatal nutritional rehabilitation on brain fatty acids, learning, and memory. Nutrition Reviews 69, 132-144.
44. Debassio, W.A., Kemper, T.L., Tonkiss, J., and Galler, J.R. (1996). Effect of prenatal protein deprivation on postnatal granule cell generation in the hippocampal dentate gyrus. Brain Research Bulletin 41, 379-383.
45. Delong, G.R., Stanbury, J.B., and Fierro-Benitez, R. (1985). Neurological signs in congenital iodine-deficiency disorder (endemic cretinism). Developmental Medicine and Child Neurology 27, 317-324.
46. Desouza, L.A., Ladiwala, U., Daniel, S.M., Agashe, S., Vaidya, R.A., and Vaidya, V.A. (2005). Thyroid hormone regulates hippocampal neurogenesis in the adult rat brain. Molecular and Cellular Neuroscience 29, 414-426.
47. Deungria, M. (2000). Perinatal iron deficiency decreases cytochrome c oxidase (CytOx) activity in selected regions of neonatal rat brain. Pediatric Research 48, 169-176.
48. Deutsch, G.K., Dougherty, R.F., Bammer, R., Siok, W.T., Gabrieli, J.D.E., and Wandell, B. (2005). Children's reading performance is correlated with white matter structure measured by diffusion tensor imaging. Cortex 41, 354-363.
49. Dewey, K.G., and Begum, K. (2011). Long-term consequences of stunting in early life. Maternal and Child Nutrition 7, 5-18.
50. Drane, D.L., and Logemann, J.A. (2000). A critical evaluation of the evidence on the association between type of infant feeding and cognitive development. Paediatric and Perinatal Epidemiology 14, 349-356.
51. Dror, D.K., and Allen, L.H. (2008). Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms. Nutrition Reviews 66, 250-255.
52. Dunstan, J.A., Simmer, K., Dixon, G., and Prescott, S.L. (2008). Cognitive assessment of children at age 21/2 years after maternal fish oil supplementation in pregnancy: a randomised controlled trial. Archives of Disease in Childhood Fetal and Neonatal Edition 93, F45-F50.
53. Eilander, A., Gera, T., Sachdev, H.S., Transler, C., Knaap, H.V.D., Kok, F.J., and Osendarp, S.J.M. (2010). Multiple micronutrient supplementation for improving cognitive performance in children: systematic review of randomized controlled trials. The American Journal of Clinical Nutrition 91, 115-130.
54. Eilander, A., Hundscheid, D.C., Osendarp, S.J., Transler, C., and Zock, P.L. (2007). Effects of n-3 long chain polyunsaturated fatty acid supplementation on visual and cognitive development throughout childhood: A review of human studies. Prostaglandins, Leukotrienes and Essential Fatty Acids 76, 189-203.
55. Engle, P.L. (2010). INCAP studies of malnutrition and cognitive behavior. Food and Nutrition Bulletin 31, 83-94.
56. Falkingham, M., Abdelhamid, A., Curtis, P., Fairweather-Tait, S., Dye, L., and Hooper, L. (2010). The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis. Nutrition Journal 9, 4.
57. Feldman, H.S., Jones, K.L., Lindsay, S., Slymen, D., Klonoff-Cohen, H., Kao, K., Rao, S., and Chambers, C. (2012). Prenatal alcohol exposure patterns and alcohol-related birth defects and growth deficiencies: a prospective study. Alcoholism, Clinical and Experimental Research 36, 670-676.
58. Florence, M.D., Asbridge, M., and Veugelers, P.J. (2008). Diet quality and academic performance. Journal of School Health 78, 209-215.
59. Forrest, D. (2004). The developing brain and maternal thyroid hormone: Finding the links. Endocrinology 145, 4034-4036.
60. Frick, J.E., Colombo, J., and Saxon, T.F. (1999). Individual and developmental differences in disengagement of fixation in early infancy. Child Development 70, 537-548.
61. Gale, C.R., Martyn, C.N., Marriott, L.D., Limond, J., Crozier, S., Inskip, H.M., Godfrey, K.M., Law, C.M., Cooper, C., Robinson, S.M., and The Southampton Women's Survey Study, G. (2009). Dietary patterns in infancy and cognitive and neuropsychological function in childhood. Journal of Child Psychology and Psychiatry 50, 816-823.
62. Gallego, G. (2010). Iodine deficiency in Australia: is iodine supplementation for pregnant and lactating women warranted? Medical Journal of Australia 192.
63. Georgieff, M.K. (2007). Nutrition and the developing brain: nutrient priorities and measurement. The American Journal of Clinical Nutrition 85, 614S-620S.
64. Ghosh, S.S., Kakunoori, S., Augustinack, J., Nieto-Castanon, A., Kovelman, I., Gaab, N., Christodoulou, J.A., Triantafyllou, C., Gabrieli, J.D.E., and Fischl, B. (2010). Evaluating the validity of volume-based and surface-based brain image registration for developmental cognitive neuroscience studies in children 4 to 11 years of age. NeuroImage 53, 85-93.
65. Gibson, R., and Heath, A.-L. (2011). Population groups at risk of zinc deficiency in Australia and New Zealand. Nutrition and Dietetics 68, 97-108.
66. Giedd, J., Stockman, M., Weddle, C., Liverpool, M., Alexander-Bloch, A., Wallace, G., Lee, N., Lalonde, F., and Lenroot, R. (2010). Anatomic magnetic resonance imaging of the developing child and adolescent brain and effects of genetic variation. Neuropsychology Review 20, 349-361.
67. Gökçay, G. (2010). Breastfeeding and child cognitive development. Child: Care, Health and Development 36, 591-591.
68. Gong, J., Dong, J., Wang, Y., Xu, H., Wei, W., Zhong, J., Liu, W., Xi, Q., and Chen, J. (2010). Developmental iodine deficiency and hypothyroidism impair neural development, up-regulate caveolin-1 and down-regulate synaptophysin in rat hippocampus. Journal of Neuroendocrinology 22, 129-139.
69. Gordon, R.C., and Gordon (2009). Iodine supplementation improves cognition in mildly iodine-deficient children. The American Journal of Clinical Nutrition 90, 1264-1271.
70. Granados-Ro as, L., Larriva-Sahd, Cintra L., Guti rrez-Ospina, G., Rondn, A., and D Az-Cintra, S.A. (2002). Prenatal protein malnutrition decreases mossy fibers-CA3 thorny excrescences asymmetrical synapses in adult rats. Brain Research 933, 164-171.
71. Grantham-McGregor, S. (1995). A review of studies of the effect of severe malnutrition on mental development. The Journal of Nutrition 125, 2233-2238.
72. Grantham-McGregor, S., and Ani, C. (2001). A review of studies on the effect of iron deficiency on cognitive development in children. The Journal of Nutrition 131, 649S-666S.
73. Grantham-McGregor, S., Cheung, Y.B., Cueto, S., Glewwe, P., Richter, L., and Strupp, B. (2007). Developmental potential in the first 5 years for children in developing countries. Lancet 369, 60-70.
74. Grantham McGregor, S. (2001). A review of studies on the effect of iron deficiency on cognitive development in children. The Journal of Nutrition 131, 649S-666S.
75. Grossman, A.W., Churchill, J.D., Mckinney, B.C., Kodish, I.M., Otte, S.L., and Greenough, W.T. (2003). Experience effects on brain development: possible contributions to psychopathology. Journal of Child Psychology and Psychiatry 44, 33-63.
76. Guesnet, P., and Alessandri, J.-M. (2011). Docosahexaenoic acid (DHA) and the developing central nervous system (CNS) Implications for dietary recommendations. Biochimie 93, 7-12.
77. Haddow, J.E., Palomaki, G.E., Allan, W.C., Williams, J.R., Knight, G.J., Gagnon, J., O'heir, C.E., Mitchell, M.L., Hermos, R.J., Waisbren, S.E., Faix, J.D., and Klein, R.Z. (1999). Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. New England Journal of Medicine 341, 549-555.
78. Hamadani, J.D., Fuchs, G.J., Osendarp, S.J.M., Huda, S.N., and Grantham-McGregor, S.M. (2002). Zinc supplementation during pregnancy and effects on mental development and behaviour of infants: a follow-up study. The Lancet 360, 290-294.
79. Heijmans, B.T., Tobi, E.W., Stein, A.D., Putter, H., Blauw, G.J., Susser, E.S., Slagboom, P.E., and Lumey, L.H. (2008). Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proceedings of the National Academy of Sciences 105, 17046-17049.
80. Helland, I.B., Saugstad, O.D., Smith, L., Saarem, K., Solvoll, K., Ganes, T., and Drevon, C.A. (2001). Similar effects on infants of n-3 and n-6 fatty acids supplementation to pregnant and lactating women. Pediatrics 108, e82.
81. Helland, I.B., Smith, L., Blomén, B., Saarem, K., Saugstad, O.D., and Drevon, C.A. (2008). Effect of supplementing pregnant and lactating mothers with n-3 very-long-chain fatty acids on children's IQ and body mass index at 7 years of age. Pediatrics 122, e472-e479.
82. Helland, I.B., Smith, L., Saarem, K., Saugstad, O.D., and Drevon, C.A. (2003). Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. Pediatrics 111, e39-e44.
83. Henriksen, T., and Clausen, T. (2002). The fetal origins hypothesis: placental insufficiency and inheritance versus maternal malnutrition in well-nourished populations. Acta Obstetricia et Gynecologica Scandinavica 81, 112-114.
84. Herba, C.M., Roza, S., Govaert, P., Hofman, A., Jaddoe, V., Verhulst, F.C., and Tiemeier, H. (2012). Breastfeeding and early brain development: the Generation R study. Maternal and Child Nutrition.
85. Herlenius, E., and Lagercrantz, H. (2004). Development of neurotransmitter systems during critical periods. Experimental Neurology 190, 8-21.
86. Hibbeln, J.R., Davis, J.M., Steer, C., Emmett, P., Rogers, I., Williams, C., and Golding, J. (2007). Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study. The Lancet 369, 578-585.
87. Hoffman, D.R., Boettcher, J.A., and Diersen-Schade, D.A. (2009). Toward optimizing vision and cognition in term infants by dietary docosahexaenoic and arachidonic acid supplementation: A review of randomized controlled trials. Prostaglandins, Leukotrienes and Essential Fatty Acids 81, 151-158.
88. Hoyland, A. (2009). A systematic review of the effect of breakfast on the cognitive performance of children and adolescents. Nutrition Research Reviews 22, 220-243.
89. Huttenlocher, P.R., and Dabholkar, A.S. (1997). Regional differences in synaptogenesis in human cerebral cortex. Journal of Comparative Neurology 387, 167-178.
90. Ingwersen, J., Defeyter, M.A., Kennedy, D.O., Wesnes, K.A., and Scholey, A.B. (2007). A low glycaemic index breakfast cereal preferentially prevents children's cognitive performance from declining throughout the morning. Appetite 49, 240-244.
91. Innis, S.M. (2007). Dietary (n-3) fatty acids and brain development. The Journal of Nutrition 137, 855-859.
92. Isaacs, E.B., Fischl, B.R., Quinn, B.T., Chong, W.K., Gadian, D.G., and Lucas, A. (2010). Impact of breast milk on intelligence quotient, brain size, and white matter development. Pediatric Research 67, 357-362.
93. Isaacs, E.B., Gadian, D.G., Sabatini, S., Chong, W.K., Quinn, B.T., Fischl, B.R., and Lucas, A. (2008). The Effect of early human diet on caudate volumes and IQ. Pediatric research 63, 308-314.
94. Isaacs, E.B., Morley, R., and Lucas, A. (2009). early diet and general cognitive outcome at adolescence in children born at or below 30 weeks gestation. The Journal of Pediatrics 155, 229-234.
95. Jacobson, J.L., Jacobson, S.W., Muckle, G., Kaplan-Estrin, M., Ayotte, P., and Dewailly, E. (2008). Beneficial effects of a polyunsaturated fatty acid on infant development: Evidence from the Inuit of Arctic Quebec. The Journal of Pediatrics 152, 356-364.e351.
96. Jain, A., Concato, J., and Leventhal, J.M. (2002). How good is the evidence linking breastfeeding and intelligence? Pediatrics 109, 1044-1053.
97. Jiménez-Chillarón, J.C., Díaz, R., Martínez, D., Pentinat, T., Ramón-Krauel, M., Ribó, S., and Plösch, T. (2012). The role of nutrition on epigenetic modifications and their implications on health. Biochimie 94, 2242-2263.
98. Joos, S.K., Pollitt, E., Mueller, W.H., and Albright, D.L. (1983). The Bacon Chow Study: Maternal nutritional supplementation and infant behavioral development. Child Development 54, 669-676.
99. Jorgenson, L.A., Wobken, J.D., and Georgieff, M.K. (2003). Perinatal iron deficiency alters apical dendritic growth in hippocampal CA1 pyramidal neurons. Developmental Neuroscience 25, 412-420.
100. Judge, M.P., Harel, O., and Lammi-Keefe, C.J. (2007). Maternal consumption of a docosahexaenoic acid-containing functional food during pregnancy: benefit for infant performance on problem-solving but not on recognition memory tasks at age 9 mo. The American Journal of Clinical Nutrition 85, 1572-1577.
101. Jurdak, N., Lichtenstein, A.H., and Kanarek, R.B. (2008). Diet-induced obesity and spatial cognition in young male rats. Nutritional Neuroscience 11, 48-54.
102. Kafouri, S., Kramer, M., Leonard, G., Perron, M., Pike, B., Richer, L., Toro, R., Veillette, S., Pausova, Z., and Paus, T. (2012). Breastfeeding and brain structure in adolescence. International Journal of Epidemiology.
103. Kasatkina, É., Samsonova, L., Ivakhnenko, V., Ibragimova, G., Ryabykh, A., Naumenko, L., and Evdokimova, Y. (2006). Gestational hypothyroxinemia and cognitive function in offspring. Neuroscience and Behavioral Physiology 36, 619-624.
104. Kirksey, A., Wachs, T.D., Yunis, F., Srinath, U., Rahmanifar, A., Mccabe, G.P., Galal, O.M., Harrison, G.G., and Jerome, N.W. (1994). Relation of maternal zinc nutriture to pregnancy outcome and infant development in an Egyptian village. The American Journal of Clinical Nutrition 60, 782-792.
105. Knudsen, E.I. (2004). Sensitive periods in the development of the brain and behavior. Journal of Cognitive Neuroscience 16, 1412-1425.
106. Kooistra, L., Crawford, S., Van Baar, A.L., Brouwers, E.P., and Pop, V.J. (2006). Neonatal effects of maternal hypothyroxinemia during early pregnancy. Pediatrics 117, 161-167.
107. Kostović, I., udaš, M., Radoš, M., and Hrabač, P. (2002). Laminar organization of the human fetal cerebrum revealed by histochemical markers and magnetic resonance imaging. Cerebral Cortex 12, 536-544.
108. Kramer Ms, Aboud F, Mironova E, and Et Al. (2008). Breastfeeding and child cognitive development: New evidence from a large randomized trial. Archives of General Psychiatry 65, 578-584.
109. Laus, M. (2011). Early postnatal protein-calorie malnutrition and cognition: a review of human and animal studies. International Journal of Environmental Research and Public Health 8, 590-612.
110. Lenroot, R.K., and Giedd, J.N. (2006). Brain development in children and adolescents: Insights from anatomical magnetic resonance imaging. Neuroscience and Biobehavioral Reviews 30, 718-729.
111. Leung, B., Wiens, K., and Kaplan, B. (2011). Does prenatal micronutrient supplementation improve children's mental development? A systematic review. BMC Pregnancy and Childbirth 11, 12.
112. Levenson, C.W. (2006). Regulation of the NMDA receptor: Implications for neuropsychological development. Nutrition Reviews 64, 428-432.
113. Levi, R.S., and Sanderson, I.R. (2004). Dietary regulation of gene expression. Current Opinion in Gastroenterology 20, 139-142.
114. Levitt, P. (2003). Structural and functional maturation of the developing primate brain. The Journal of Pediatrics 143, 35-45.
115. Li, Q., Yan, H., Zeng, L., Cheng, Y., Liang, W., Dang, S., Wang, Q., and Tsuji, I. (2009). Effects of maternal multimicronutrient supplementation on the mental development of infants in rural Western China: Follow-up evaluation of a double-blind, randomized, controlled trial. Pediatrics 123, e685-e692.
116. Li, Y., Dai, Q., Jackson, J.C., and Zhang, J. (2008). overweight is associated with decreased cognitive functioning among school-age children and adolescents. Obesity 16, 1809-1815.
117. Lillycrop, K.A., and Burdge, G.C. (2011). The Effect of nutrition during early life on the epigenetic regulation of transcription and implications for human diseases. Journal of Nutrigenetics and Nutrigenomics 4, 248-260.
118. Lillycrop, K.A., and Burdge, G.C. (2012). Epigenetic mechanisms linking early nutrition to long term health. Best Practice and Research Clinical Endocrinology and Metabolism 26, 667-676.
119. Lindqvist, A., Mohapel, P., Bouter, B., Frielingsdorf, H., Pizzo, D., Brundin, P., and Erlanson-Albertsson, C. (2006). High-fat diet impairs hippocampal neurogenesis in male rats. European Journal of Neurology 13, 1385-1388.
120. Logan, S., Martins, S., and Gilbert, R. (2001). Iron therapy for improving psychomotor development and cognitive function in children under the age of three with iron deficiency anaemia. Cochrane Database Systematic Reviews, CD001444.
121. Logi Kristjánsson, Á., Dóra Sigfúsdóttir, I., and Allegrante, J.P. (2010). Health behavior and academic achievement among adolescents: The relative contribution of dietary habits, physical activity, body mass index, and self-esteem. Health Education and Behavior 37, 51-64.
122. Louwman, M.W., Van Dusseldorp, M., Van De Vijver, F.J., Thomas, C.M., Schneede, J., Ueland, P.M., Refsum, H., and Van Staveren, W.A. (2000). Signs of impaired cognitive function in adolescents with marginal cobalamin status. The American Journal of Clinical Nutrition 72, 762-769.
123. Lozoff, B., and Georgieff, M.K. (2006). Iron deficiency and brain development. Seminars in Pediatric Neurology 13, 158-165.
124. Lucas, A., Morley, R., and Cole, T.J. (1998). Randomised trial of early diet in preterm babies and later intelligence quotient. British Medical Journal 317, 1481-1487.
125. Luna, B., and Sweeney, J.A. (2001). Studies of brain and cognitive maturation through childhood and adolescence: A strategy for testing neurodevelopmental hypotheses. Schizophrenia Bulletin 27, 443-455.
126. Makrides, M., Gibson, R.A., Mcphee, A.J., Yelland, L., Quinlivan, J., Ryan, P., and Team, D.I. (2010). Effect of DHA Supplementation during pregnancy on maternal depression and neurodevelopment of young children. Journal of the American Medical Association 304, 1675-1683.
127. Maret, W., and Sandstead, H.H. (2006). Zinc requirements and the risks and benefits of zinc supplementation. Journal of Trace Elements in Medicine and Biology 20, 3-18.
128. Mathangi, D.C., and Namasivayam, A. (2001). Effect of chronic protein restriction on motor co-ordination and brain neurotransmitters in albino rats. Food and Chemical Toxicology 39, 1039-1043.
129. Mccann, J.C., and Ames, B.N. (2005). Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. The American Journal of Clinical Nutrition 82, 281-295.
130. Mccann, J.C., Hudes, M., and Ames, B.N. (2006). An overview of evidence for a causal relationship between dietary availability of choline during development and cognitive function in offspring. Neuroscience and Biobehavioral Reviews 30, 696-712.
131. Mcgrath, N., Bellinger, D., Robins, J., Msamanga, G.I., Tronick, E., and Fawzi, W.W. (2006). Effect of maternal multivitamin supplementation on the mental and psychomotor development of children who are born to HIV-1-infected mothers in Tanzania. Pediatrics 117, e216-e225.
132. Meck, W.H., and Williams, C.L. (2003). Metabolic imprinting of choline by its availability during gestation: implications for memory and attentional processing across the lifespan. Neuroscience and Biobehavioral Reviews 27, 385-399.
133. Melse-Boonstra, A., and Jaiswal, N. (2010). Iodine deficiency in pregnancy, infancy and childhood and its consequences for brain development. Best Practice & Research Clinical Endocrinology and Metabolism 24, 29-38.
134. Micha, R., Rogers, P.J., and Nelson, M. (2011). Glycaemic index and glycaemic load of breakfast predict cognitive function and mood in school children: a randomized controlled trial. British Journal of Nutrition 106, 1552-1561.
135. Michaelsen, K.F., Lauritzen, L., and Mortensen, E.L. (2009). Effects of breast-feeding on cognitive function breast-feeding: early influences on later health, eds. G. Goldberg, A. Prentice, A. Prentice, S. Filteau & K. Simondon. Springer Netherlands), 199-215.
136. Molteni, R., Barnard, R.J., Ying, Z., Roberts, C.K., and Gómez-Pinilla, F. (2002). A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neuroscience 112, 803-814.
137. Murcia, M., Rebagliato, M., Iñiguez, C., Lopez-Espinosa, M.-J., Estarlich, M., Plaza, B., Barona-Vilar, C., Espada, M., Vioque, J., and Ballester, F. (2011). Effect of iodine supplementation during pregnancy on infant neurodevelopment at 1 year of age. American Journal of Epidemiology 173, 804-812.
138. Murgatroyd, C., and Spengler, D. (2011). Epigenetics of early child development. Frontiers in Psychiatry 2.
139. Mustafa, R., Ahmed, S., Gupta, A., and Venuto, R.C. (2012). A comprehensive review of hypertension in pregnancy. Journal of Pregnancy 2012, 105918.
140. Nagy, Z., Westerberg, H., and Klingberg, T. (2004). Maturation of white matter is associated with the development of cognitive functions during childhood. Journal of Cognitive Neuroscience 16, 1227-1233.
141. Niculescu, M.D., and Lupu, D.S. (2009). High fat diet-induced maternal obesity alters fetal hippocampal development. International Journal of Developmental Neuroscience 27, 627-633.
142. Northstone, K., Joinson, C., Emmett, P., Ness, A., and Paus, T. (2011). Are dietary patterns in childhood associated with IQ at 8 years of age? A population-based cohort study. Journal of Epidemiology and Community Health.
143. Oken, E., Braverman, L.E., Platek, D., Mitchell, M.L., Lee, S.L., and Pearce, E.N. (2009). Neonatal thyroxine, maternal thyroid function, and child cognition. Journal of Clinical Endocrinology and Metabolism 94, 497-503.
144. Oken, E., Radesky, J.S., Wright, R.O., Bellinger, D.C., Amarasiriwardena, C.J., Kleinman, K.P., Hu, H., and Gillman, M.W. (2008a). Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort. American Journal of Epidemiology 167, 1171-1181.
145. Oken, E., Usterdal, M.L., Gillman, M.W., Knudsen, V.K., Halldorsson, T.I., Strøm, M., Bellinger, D.C., Hadders-Algra, M., Michaelsen, K.F., and Olsen, S.F. (2008b). Associations of maternal fish intake during pregnancy and breastfeeding duration with attainment of developmental milestones in early childhood: a study from the Danish National Birth Cohort. The American Journal of Clinical Nutrition 88, 789-796.
146. Palermo, T.M., and Dowd, J.B. (2012). Childhood obesity and human capital accumulation. Social Science and Medicine 75, 1989-1998.
147. Pallotto, E.K., and Kilbride, H.W. (2006). Perinatal outcome and later implications of intrauterine growth restriction. Clinical Obstetrics and Gynecology 49, 257-269.
148. Penhune, V.B. (2011). Sensitive periods in human development: Evidence from musical training. Cortex 47, 1126-1137.
149. Peper, J.S., Brouwer, R.M., Schnack, H.G., Van Baal, G.C., Van Leeuwen, M., Van Den Berg, S.M., Delemarre-Van De Waal, H.A., Boomsma, D.I., Kahn, R.S., and Hulshoff Pol, H.E. (2009). Sex steroids and brain structure in pubertal boys and girls. Psychoneuroendocrinology 34, 332-342.
150. Pepper, M.R., and Black, M.M. (2011). B12 in fetal development. Seminars in Cell and Developmental Biology 22, 619-623.
151. Pop, V.J. (2001). Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clinical Endocrinology 50, 149.
152. Pop, V.J., Brouwers, E.P., Vader, H.L., Vulsma, T., Van Baar, A.L., and De Vijlder, J.J. (2003). Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3-year follow-up study. Clinical Endocrinology 59, 282-288.
153. Prado, E.L., Alcock, K.J., Muadz, H., Ullman, M.T., and Shankar, A.H. (2012). Maternal multiple micronutrient supplements and child cognition: A randomized trial in Indonesia. Pediatrics 130, e536-e546.
154. Qian, M. (2005). The effects of iodine on intelligence in children: a meta-analysis of studies conducted in China. Asia Pacific Journal of Clinical Nutrition 14, 32.
155. Ramakrishnan, U., Imhoff-Kunsch, B., and Digirolamo, A.M. (2009). Role of docosahexaenoic acid in maternal and child mental health. The American Journal of Clinical Nutrition 89, 958S-962S.
156. Rey, J. (2003). Breastfeeding and cognitive development. Acta Pædiatrica 92, 11-18.
157. Riano Galan, I., Sanchez Martinez, P., Pilar Mosteiro Diaz, M., and Rivas Crespo, M.F. (2005). Psycho-intellectual development of 3 year-old children with early gestational iodine deficiency. Journal of Pediatric Endocrinology and Metabolism 18 Suppl 1, 1265-1272.
158. Rioux, F.M. (2011). Relationship between maternal DHA and iron status and infants' cognitive performance. Canadian Journal of Dietetic Practice and Research 72, 76-76.
159. Rosales, F., Reznick, J.S., and Zeisel, S. (2009). Understanding the role of nutrition in the brain and behavioral development of toddlers and preschool children: identifying and addressing methodological barriers. Nutritional Neuroscience 12, 190-202.
160. Roseboom, T., De Rooij, S., and Painter, R. (2006). The Dutch famine and its long-term consequences for adult health. Early Human Development 82, 485-491.
161. Ross, C.E., and Mirowsky, J. (1999). Refining the association between education and health: The effects of quantity, credential, and selectivity. Demography 36, 445-460.
162. Ryan, A.S., Astwood, J.D., Gautier, S., Kuratko, C.N., Nelson, E.B., and Salem Jr, N. Effects of long-chain polyunsaturated fatty acid supplementation on neurodevelopment in childhood: A review of human studies. Prostaglandins, Leukotrienes and Essential Fatty Acids 82, 305-314.
163. Sachdev, H., Gera, T., and Nestel, P. (2005). Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials. Public Health Nutrition 8, 117-132.
164. Schmidt, M.K., Muslimatun, S., West, C.E., Schultink, W., and Hautvast, J.G.a.J. (2004). Mental and psychomotor development in Indonesian infants of mothers supplemented with vitamin A in addition to iron during pregnancy. British Journal of Nutrition 91, 279-285.
165. Schuchardt, J., Huss, M., Stauss-Grabo, M., and Hahn, A. (2010). Significance of long-chain polyunsaturated fatty acids (PUFAs) for the development and behaviour of children. European Journal of Pediatrics 169, 149-164.
166. Schulzke, S.M. (2011). Longchain polyunsaturated fatty acid supplementation in preterm infants. Cochrane Database of Systematic Reviews.
167. Shah, D., and Sachdev, H.P.S. (2006). Zinc deficiency in pregnancy and fetal outcome. Nutrition Reviews 64, 15-30.
168. Shaw, G.M., Carmichael, S.L., Yang, W., Selvin, S., and Schaffer, D.M. (2004). Periconceptional dietary intake of choline and betaine and neural tube defects in offspring. American Journal of Epidemiology 160, 102-109.
169. Signore, C., Ueland, P.M., Troendle, J., and Mills, J.L. (2008). Choline concentrations in human maternal and cord blood and intelligence at 5 y of age. The American Journal of Clinical Nutrition 87, 896-902.
170. Simmer, K., Patole, S., and Rao, S. (2008). Longchain polyunsaturated fatty acid supplementation in infants born at term. Cochrane Database of Systematic Reviews, CD000376.
171. Simopoulos, A.P. (1999). Evolutionary aspects of omega-3 fatty acids in the food supply. Prostaglandins, Leukotrienes and Essential Fatty Acids 60, 421-429.
172. Simopoulos, A.P. (2008). The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Experimental Biology and Medicine 233, 674-688.
173. Sisk, C. (2004). The neural basis of puberty and adolescence. Nature Neuroscience 7,
174. Smithers, L.G., Golley, R.K., Mittinty, M.N., Brazionis, L., Northstone, K., Emmett, P., and Lynch, J.W. (2012). Dietary patterns at 6, 15 and 24 months of age are associated with IQ at 8 years of age. European Journal of Epidemiology 27, 525-535.
175. Stevenson, J. (2006). Dietary influences on cognitive development and behaviour in children. Proceedings of the Nutrition Society 65, 361-365.
176. Summers, B.L., Henry, C.M.A., Rofe, A.M., and Coyle, P. (2008). Dietary zinc supplementation during pregnancy prevents spatial and object recognition memory impairments caused by early prenatal ethanol exposure. Behavioural Brain Research 186, 230-238.
177. Taki, Y., Hashizume, H., Sassa, Y., Takeuchi, H., Asano, M., Asano, K., and Kawashima, R. (2010). Breakfast staple types affect brain gray matter volume and cognitive function in healthy children. PLoS ONE 5, e15213.
178. Tamura, T., Goldenberg, R.L., Chapman, V.R., Johnston, K.E., Ramey, S.L., and Nelson, K.G. (2005). Folate status of mothers during pregnancy and mental and psychomotor development of their children at five years of age. Pediatrics 116, 703-708.
179. Tamura, T., Goldenberg, R.L., Hou, J., Johnston, K.E., Cliver, S.P., Ramey, S.L., and Nelson, K.G. (2002). Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age. Obstetrical and Gynecological Survey 57, 493-494.
180. Tamura, T., Goldenberg, R.L., Ramey, S.L., Nelson, K.G., and Chapman, V.R. (2003). Effect of zinc supplementation of pregnant women on the mental and psychomotor development of their children at 5 y of age. The American Journal of Clinical Nutrition 77, 1512-1516.
181. Taneja, S., Bhandari, N., Bahl, R., and Bhan, M.K. (2005). Impact of zinc supplementation on mental and psychomotor scores of children aged 12 to 18 months: A randomized, double-blind trial. The Journal of Pediatrics 146, 506-511.
182. Tangney, C.C., and Scarmeas, N. (2011). The good, bad, and ugly?: How blood nutrient concentrations may reflect cognitive performance. Neurology.
183. Tanumihardjo, S.A., Anderson, C., Kaufer-Horwitz, M., Bode, L., Emenaker, N.J., Haqq, A.M., Satia, J.A., Silver, H.J., and Stadler, D.D. (2007). Poverty, obesity, and malnutrition: an international perspective recognizing the paradox. Journal of the American Dietetic Association 107, 1966-1972.
184. Thatcher, R.W. (1991). Maturation of the human frontal lobes: Physiological evidence for staging. Developmental Neuropsychology 7, 397-419.
185. Theodore, R.F., Thompson, J.M.D., Waldie, K.E., Wall, C., Becroft, D.M.O., Robinson, E., Wild, C.J., Clark, P.M., and Mitchell, E.A. (2009). Dietary patterns and intelligence in early and middle childhood. Intelligence 37, 506-513.
186. Tofail, F. (2006). Supplementation of fish-oil and soy-oil during pregnancy and psychomotor development of infants. Journal of Health, Population and Nutrition 24, 48-56.
187. Tofail, F., Persson, L.Å., El Arifeen, S., Hamadani, J.D., Mehrin, F., Ridout, D., Ekström, E.-C., Huda, S.N., and Grantham-McGregor, S.M. (2008). Effects of prenatal food and micronutrient supplementation on infant development: a randomized trial from the Maternal and Infant Nutrition Interventions, Matlab (MINIMat) study. The American Journal of Clinical Nutrition 87, 704-711.
188. Toga, A.W., Thompson, P.M., and Sowell, E.R. (2006). Mapping brain maturation. Trends in Neurosciences 29, 148-159.
189. Tramontana, M.G., Hooper, S.R., and Selzer, S.C. (1988). Research on the preschool prediction of later academic achievement: A review. Developmental Review 8, 89-146.
190. Uddin, L.Q., Supekar, K., and Menon, V. (2010). Typical and atypical development of functional human brain networks: insights from resting-state fMRI. Frontiers in Systems Neuroscience 4.
191. United Nations Children's Fund, and World Health Organization (2004). Low Birthweight: Country, regional and global estimates. (UNICEF, New York).
192. Van Petten, C. (2004). Relationship between hippocampal volume and memory ability in healthy individuals across the lifespan: review and meta-analysis. Neuropsychologia 42, 1394-1413.
193. Veena, S.R., Krishnaveni, G.V., Srinivasan, K., Wills, A.K., Muthayya, S., Kurpad, A.V., Yajnik, C.S., and Fall, C.H.D. (2010). Higher maternal plasma folate but not vitamin b-12 concentrations during pregnancy are associated with better cognitive function scores in 9-to 10-year-old children in South India. The Journal of Nutrition 140, 1014-1022.
194. Velasco, I., Carreira, M., Santiago, P., Muela, J.A., García-Fuentes, E., Sánchez-Muñoz, B., Garriga, M.J., González-Fernández, M.C., Rodríguez, Á., Caballero, F.F., Machado, A., González-Romero, S., Anarte, M.T., and Soriguer, F. (2009). Effect of iodine prophylaxis during pregnancy on neurocognitive development of children during the first two years of life. Journal of Clinical Endocrinology and Metabolism 94, 3234-3241.
195. Vermiglio, F., Lo Presti, V.P., Moleti, M., Sidoti, M., Tortorella, G., Scaffidi, G., Castagna, M.G., Mattina, F., Violi, M.A., Crisà, A., Artemisia, A., and Trimarchi, F. (2004). Attention deficit and hyperactivity disorders in the offspring of mothers exposed to mild-moderate iodine deficiency: A possible novel iodine deficiency disorder in developed countries. Journal of Clinical Endocrinology and Metabolism 89, 6054-6060.
196. World Health Organization (2004). Iodine status worldwide, WHO global database on iodine deficiency.
197. World Health Organization (2008). Worldwide prevalence of anaemia 1993-2005: WHO Global Database on Anaemia.
198. Wurtman, R.J. (2008). Synapse formation and cognitive brain development: effect of docosahexaenoic acid and other dietary constituents. Metabolism 57, S6-S10.
199. Zeisel, S. (2006a). The fetal origins of memory: The role of dietary choline in optimal brain development. The Journal of Pediatrics 149, S131-S136.
200. Zeisel, S.H. (2006b). Choline: Critical role during fetal development and dietary requirements in adults. Annual Review of Nutrition 26, 229-250.
201. Zeisel, S.H. (2009). Importance of methyl donors during reproduction. The American Journal of Clinical Nutrition 89, 673S-677S.
202. Zhang, X.-M., Huang, G.-W., Tian, Z.-H., Ren, D.-L., and Wilson, J. (2009). Folate stimulates ERK1/2 phosphorylation and cell proliferation in fetal neural stem cells. Nutritional Neuroscience 12, 226-232.
203. Zhou, S.J., Gibson, R.A., Crowther, C.A., Baghurst, P., and Makrides, M. (2006). Effect of iron supplementation during pregnancy on the intelligence quotient and behavior of children at 4 y of age: long-term follow-up of a randomized controlled trial. The American Journal of Clinical Nutrition 83, 1112-1117.
204. Zimmermann, M. (2006). Iodine supplementation improves cognition in iodine-deficient schoolchildren in Albania: a randomized, controlled, double-blind study. The American Journal of Clinical Nutrition 83, 108-114.
205. Zimmermann, M.B. (2007). The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: A review. Thyroid 17, 829-835.
206. Zimmermann, M.B. (2009). Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: a review. The American Journal of Clinical Nutrition 89, 668S-672S.
207. Zimmermann, M.B. (2011). The role of iodine in human growth and development. Seminars in Cell and Developmental Biology 22, 645-652.