Maternal-fetal in vivo transfer of [13C]docosahexaenoic and other fatty acids across the human placenta 12 h after maternal oral intake

American Journal of Clinical Nutrition

Volumn 92, Issue 1, 2010, Pages 115-122

  Gil Sánchez, Alfonso ^a   Larqué, Elvira ^b   Demmelmair, Hans ^c   Acien, María I ^a   Faber, Fabienne L ^c   Parrilla, Juan J ^a   Koletzko, Berthold ^c  

^a HOSPITAL UNIVERSITARIO VIRGEN DE LA ARRIXACA   (Spain)

^b UNIVERSITY OF MURCIA   (Spain)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 13; DOCOSAHEXAENOIC ACID; FATTY ACID; LINOLEIC ACID; OLEIC ACID; PALMITIC ACID; PHOSPHOLIPID; TRIACYLGLYCEROL; CARBON;

ADULT; ARTICLE; BLOOD SAMPLING; CESAREAN SECTION; FEMALE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; LIPID BLOOD LEVEL; MATERNAL BLOOD; NORMAL HUMAN; PHOSPHOLIPID BLOOD LEVEL; PLACENTA; PLACENTAL TRANSFER; TRIACYLGLYCEROL BLOOD LEVEL; UMBILICAL CORD BLOOD; UMBILICAL VEIN; ADOLESCENT; AREA UNDER THE CURVE; BLOOD; FETOMATERNAL TRANSFUSION; METABOLISM; ORAL DRUG ADMINISTRATION; PATIENT SELECTION; PREGNANCY;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AREA UNDER CURVE; CARBON ISOTOPES; CESAREAN SECTION; DOCOSAHEXAENOIC ACIDS; FATTY ACIDS, NONESTERIFIED; FEMALE; HUMANS; MATERNAL-FETAL EXCHANGE; OLEIC ACID; PALMITIC ACID; PATIENT SELECTION; PLACENTA; PREGNANCY; YOUNG ADULT;

EID: 77954610451     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.2010.29589     Document Type: Article

References (39)

1. Innis SM. Dietary (n-3) fatty acids and brain development. J Nutr 2007;137:855-9.
2. Martínez M. Tissue levels of polyunsaturated fatty acids during early human development. J Pediatr 1992;120:S129-32.
3. Neuringer M, Anderson GJ, Connor WE. The essentiality of n-3 fatty acids for the development and function of the retina and brain. Annu Rev Nutr 1988;8:517-41. (Pubitemid 19136337)
4. Dutta-Roy AK. Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta. Am J Clin Nutr 2000;71:315S-22S.
5. Haggarty P. Placental regulation of fatty acid delivery and its effect on fetal growth-a review. Placenta 2002;23(suppl A):S28-S38.
6. Gauster M, Hiden U, Blaschitz A, et al. Dysregulation of placental endothelial lipase and lipoprotein lipase in intrauterine growth-restricted pregnancies. J Clin Endocrinol Metab 2007;92:2256-63.
7. Gauster M, Rechberger G, Sovic A, et al. Endothelial lipase releases saturated and unsaturated fatty acids of high density lipoprotein phosphatidylcholine. J Lipid Res 2005;46:1517-25.
8. McCoy MG, Sun GS, Marchadier D, Maugeais C, Glick JM, Rader DJ. Characterization of the lipolytic activity of endothelial lipase. J Lipid Res 2002;43:921-9.
9. Hanebutt FL, Demmelmair H, Schiessl B, Larque E, Koletzko B. Long-chain polyunsaturated fatty acid (LC-PUFA) transfer across the placenta. Clin Nutr 2008;27:685-93.
10. Berghaus TM, Demmelmair H, Koletzko B. Fatty acid composition of lipid classes in maternal and cord plasma at birth. Eur J Pediatr 1998;157:763-8.
11. Crawford MA, Hassam AG, Williams G. Essential fatty acids and fetal brain growth. Lancet 1976;1:452-3.
12. Koletzko B, Muller J. Cis- and trans-isomeric fatty acids in plasma lipids of newborn infants and their mothers. Biol Neonate 1990;57:172-8.
13. Hshie AT, Brenna JT. Dietary docosahexaenoic acid but not arachidonic acid influences central nervous system fatty acid status in baboon neonates. Prostaglandins Leukot Essent Fatty Acids 2009;81:105-10.
14. Chambaz J, Ravel D, Manier MC, Pepin D, Mulliez N, Bereziat G. Essential fatty acids interconversion in the human fetal liver. Biol Neonate 1985;47:136-40. (Pubitemid 15146916)
15. Szitanyi P, Koletzko B, Mydlilova A, Demmelmair H. Metabolism of 13C-labeled linoleic acid in newborn infants during the first week of life. Pediatr Res 1999;45:669-73.
16. Larqué E, Demmelmair H, Berger B, Hasbargen U, Koletzko B. In vivo investigation of the placental transfer of (13)C-labeled fatty acids in humans. J Lipid Res 2003;44:49-55.
17. Parra-Cordero M, Lees C, Missfelder-Lobos H, Seed P, Harris C. Fetal arterial and venous Doppler pulsatility index and time averaged velocity ranges. Prenat Diagn 2007;27:1251-7.
18. Folch J, Lees M, Stanley GA. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957;226:497-509.
19. Carnielli VP, Wattimena DJ, Luijendijk IH, Boerlage A, Degenhart HJ, Sauer PJ. The very low birth weight premature infant is capable of synthesizing arachidonic and docosahexaenoic acids from linoleic and linolenic acids. Pediatr Res 1996;40:169-74.
20. Demmelmair H, von Schenck U, Behrendt E, Sauerwald T, Koletzko B. Estimation of arachidonic acid synthesis in full term neonates using natural variation of 13C content. J Pediatr Gastroenterol Nutr 1995;21:31-6.
21. Brossard N, Pachiaudi C, Croset M, et al. Stable isotope tracer and gas-chromatography combustion isotope ratio mass spectrometry to study the in vivo compartmental metabolism of docosahexaenoic acid 1. Anal Biochem 1994;220:192-9.
22. Hodson L, Skeaff CM, Fielding BA. Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake 4. Prog Lipid Res 2008;47:348-80.
23. Herrera E, Amusquivar E, Lopez-Soldado I, Ortega H. Maternal lipid metabolism and placental lipid transfer. Horm Res 2006;65(suppl 3):59-64.
24. Macdonald JI, Sprecher H. Phospholipid fatty acid remodeling in mammalian cells. Biochim Biophys Acta 1991;1084:105-21.
25. Lagarde M, Bernoud N, Brossard N, et al. Lysophosphatidylcholine as a preferred carrier form of docosahexaenoic acid to the brain. J Mol Neurosci 2001;16:201-4.
26. Thies F, Delachambre MC, Bentejac M, Lagarde M, Lecerf J. Unsaturated fatty acids esterified in 2-acyl-l-lysophosphatidylcholine bound to albumin are more efficiently taken up by the young rat brain than the unesterified form. J Neurochem 1992;59:1110-6.
27. Brossard N, Croset M, Normand S, et al. Human plasma albumin transports [13C]docosahexaenoic acid in two lipid forms to blood cells. J Lipid Res 1997;38:1571-82. (Pubitemid 27427654)
28. Larque E, Krauss-Etschmann S, Campoy C, et al. Docosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteins. Am J Clin Nutr 2006;84:853-61.
29. Chen S, Subbaiah PV. Phospholipid and fatty acid specificity of endothelial lipase: potential role of the enzyme in the delivery of docosahexaenoic acid (DHA) to tissues. Biochim Biophys Acta 2007;1771:1319-28.
30. Magnusson-Olsson AL, Lager S, Jacobsson B, Jansson T, Powell TL. Effect of maternal triglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL de- ficiency 2. Am J Physiol Endocrinol Metab 2007;293:E24-30.
31. Ma K, Cilingiroglu M, Otvos JD, Ballantyne CM, Marian AJ, Chan L. Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Proc Natl Acad Sci USA 2003;100:2748-53.
32. Lindegaard ML, Olivecrona G, Christoffersen C, et al. Endothelial and lipoprotein lipases in human and mouse placenta. J Lipid Res 2005;46:2339-46.
33. Klingler M, Demmelmair H, Larque E, Koletzko B. Analysis of FA contents in individual lipid fractions from human placental tissue. Lipids 2003;38:561-6.
34. Viola G, Mietto L, Secchi FE, Ping L, Bruni A. Absorption and distribution of arachidonate in rats receiving lysophospholipids by oral route. J Lipid Res 1993;34:1843-52.
35. Szabo AJ, De LR, Grimaldi RD. Triglyceride synthesis by the human placenta. I. Incorporation of labeled palmitate into placental triglycerides. Am J Obstet Gynecol 1973;115:257-62.
36. Crabtree JT, Gordon MJ, Campbell FM, Dutta-Roy AK. Differential distribution and metabolism of arachidonic acid and docosahexaenoic acid by human placental choriocarcinoma (BeWo) cells. Mol Cell Biochem 1998;185:191-8.
37. Madsen EM, Lindegaard ML, Andersen CB, Damm P, Nielsen LB. Human placenta secretes apolipoprotein B-100-containing lipoproteins. J Biol Chem 2004;279:55271-6.
38. Crawford MA, Costeloe K, Ghebremeskel K, Phylactos A, Skirvin L, Stacey F. Are deficits of arachidonic and docosahexaenoic acids responsible for the neural and vascular complications of preterm babies? Am J Clin Nutr 1997;66:1032S-41S.
39. Campbell FM, Gordon MJ, Dutta-Roy AK. Preferential uptake of long chain polyunsaturated fatty acids by isolated human placental membranes. Mol Cell Biochem 1996;155:77-83.