Comparative actions of omega-3 fatty acids on in-vitro lipid droplet formation

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 89, Issue 5, 2013, Pages 359-366

  Barber, Elizabeth ^a   Sinclair, Andrew J ^b   Cameron Smith, David ^c  

^a MONASH UNIVERSITY   (Australia)

^b DEAKIN UNIVERSITY   (Australia)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Adipocyte; Docosahexaenoic acid (DHA); Docosapentaenoic acid (DPA); Eicosapentaenoic acid (EPA); Lipid droplets; Obesity; Stearic acid

Indexed keywords

ACYL COENZYME A DESATURASE; ADIPOSE TRIGLYCERIDE LIPASE; CAVEOLIN 1; CELL DEATH INDUCING DFF45 LIKE EFFECTOR A; DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; FAT DROPLET; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID; PERILIPIN; PERILIPIN A; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; STEARIC ACID; STEAROYL COENZYME A DESATURASE 1; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; IN VITRO STUDY; LIPOLYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADIPOCYTE; DOCOSAHEXAENOIC ACID (DHA); DOCOSAPENTAENOIC ACID (DPA); EICOSAPENTAENOIC ACID (EPA); LIPID DROPLETS; OBESITY; STEARIC ACID;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; APOPTOSIS REGULATORY PROTEINS; CARRIER PROTEINS; CAVEOLIN 1; CELL DIFFERENTIATION; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; FATTY ACIDS, UNSATURATED; GENE EXPRESSION; LIPID METABOLISM; MICE; PHOSPHOPROTEINS; STEARIC ACIDS; STEAROYL-COA DESATURASE;

EID: 84886852997     PISSN: 09523278     EISSN: 15322823     Source Type: Journal    
DOI: 10.1016/j.plefa.2013.07.006     Document Type: Article

References (54)

1. Meshkani R., Adeli K. Hepatic insulin resistance, metabolic syndrome and cardiovascular disease. Clin. Biochem. 2009, 42:1331-1346.
2. Wozniak S.E., Gee L.L., Wachtel M.S., Frezza E.E. Adipose tissue: the new endocrine organ? A review article. Dig. Dis. Sci. 2009, 54:1847-1856.
3. Hajer G.R., van Haeften T.W., Visseren F.L. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur. Heart J. 2008, 29:2959-2971.
4. Murphy S., Martin S., Parton R.G. Lipid droplet-organelle interactions; sharing the fats. Biochim. Biophys. Acta 1791, 2009:441-447.
5. Schoonjans K., Staels B., Auwerx J. The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation. Biochim. Biophys. Acta 1996, 1302:93-109.
6. Lafontan M., Langin D. Lipolysis and lipid mobilization in human adipose tissue. Prog. Lipid Res. 2009, 48:275-297.
7. Ahmadian M., Wang Y., Sul H.S. Lipolysis in adipocytes. Int. J. Biochem. Cell Biol. 2009, 42:555-559.
8. Zimmermann R., Strauss J.G., Haemmerle G., Schoiswohl G., Birner-Gruenberger R., Riederer M., Lass A., Neuberger G., Eisenhaber F., Hermetter A., Zechner R. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 2004, 306:1383-1386.
9. Brasaemle D.L., Dolios G., Shapiro L., Wang R. Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. J. Biol. Chem. 2004, 279:46835-46842.
10. Blouin C.M., Le Lay S., Lasnier F., Dugail I., Hajduch E. Regulated association of caveolins to lipid droplets during differentiation of 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun. 2008, 376:331-335.
11. Yang X., Heckmann B.L., Zhang X., Smas C.M., Liu J. Distinct mechanisms regulate ATGL-mediated adipocyte lipolysis by lipid droplet coat proteins. Mol. Endocrinol. 2013, 27:116-126.
12. Ost A., Ortegren U., Gustavsson J., Nystrom F.H., Stralfors P. Triacylglycerol is synthesized in a specific subclass of caveolae in primary adipocytes. J. Biol. Chem. 2005, 280:5-8.
13. Ding Y., Wu Y., Zeng R., Liao K. Proteomic profiling of lipid droplet-associated proteins in primary adipocytes of normal and obese mouse. Acta Biochim. Biophys. Sin. (Shanghai) 2012, 44:394-406.
14. Le Lay S., Blouin C.M., Hajduch E., Dugail I. Filling up adipocytes with lipids. Lessons from caveolin-1 deficiency. Biochim. Biophys. Acta 1791, 2009:514-518.
15. Cohen A.W., Razani B., Schubert W., Williams T.M., Wang X.B., Iyengar P., Brasaemle D.L., Scherer P.E., Lisanti M.P. Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation. Diabetes 2004, 53:1261-1270.
16. Brasaemle D.L., Rubin B., Harten I.A., Gruia-Gray J., Kimmel A.R., Londos C. Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis. J. Biol. Chem. 2000, 275:38486-38493.
17. Arimura N., Horiba T., Imagawa M., Shimizu M., Sato R. The peroxisome proliferator-activated receptor gamma regulates expression of the perilipin gene in adipocytes. J. Biol. Chem. 2004, 279:10070-10076.
18. Viswakarma N., Yu S., Naik S., Kashireddy P., Matsumoto K., Sarkar J., Surapureddi S., Jia Y., Rao M.S., Reddy J.K. Transcriptional regulation of Cidea, mitochondrial cell death-inducing DNA fragmentation factor alpha-like effector A, in mouse liver by peroxisome proliferator-activated receptor alpha and gamma. J. Biol. Chem. 2007, 282:18613-18624.
19. Lecchi C., Invernizzi G., Agazzi A., Modina S., Sartorelli P., Savoini G., Ceciliani F. Effects of EPA and DHA on lipid droplet accumulation and mRNA abundance of PAT proteins in caprine monocytes. Res. Vet. Sci. 2013, 94:246-251.
20. Puri V., Ranjit S., Konda S., Nicoloro S.M., Straubhaar J., Chawla A., Chouinard M., Lin C., Burkart A., Corvera S., Perugini R.A., Czech M.P. Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc. Natl. Acad. Sci. USA 2008, 105:7833-7838.
21. Raclot T., Oudart H. Selectivity of fatty acids on lipid metabolism and gene expression. Proc. Nutr. Soc. 1999, 58:633-646.
22. Rustan A.C., Hustvedt B.E., Drevon C.A. Dietary supplementation of very long-chain n-3 fatty acids decreases whole body lipid utilization in the rat. J. Lipid Res. 1993, 34:1299-1309.
23. Kopecky J., Rossmeisl M., Flachs P., Kuda O., Brauner P., Jilkova Z., Stankova B., Tvrzicka E., Bryhn M. n-3 PUFA: bioavailability and modulation of adipose tissue function. Proc. Nutr. Soc. 2009, 68:361-369.
24. Flachs P., Rossmeisl M., Bryhn M., Kopecky J. Cellular and molecular effects of n-3 polyunsaturated fatty acids on adipose tissue biology and metabolism. Clin. Sci. (London) 2009, 116:1-16.
25. Hsu J.M., Wang P.H., Liu B.H., Ding S.T. The effect of dietary docosahexaenoic acid on the expression of porcine lipid metabolism-related genes. J. Anim. Sci. 2004, 82:683-689.
26. Kim H.K., Della-Fera M., Lin J., Baile C.A. Docosahexaenoic acid inhibits adipocyte differentiation and induces apoptosis in 3T3-L1 preadipocytes. J. Nutr. 2006, 136:2965-2969.
27. Y.C. Wang, W.H. Kuo, C.Y. Chen, H.Y. Lin, H.T. Wu, B.H. Liu, C.H. Chen, H.J. Mersmann, K.J. Chang, S.T. Ding, Docosahexaenoic acid regulates serum amyloid A protein to promote lipolysis through down regulation of perilipin, J. Nutr. Biochem., vol. 21, (2010) pp. 317-324.
28. Manickam E., Sinclair A.J., Cameron-Smith D. Suppressive actions of eicosapentaenoic acid on lipid droplet formation in 3T3-L1 adipocytes. Lipids Health Dis. 2010, 9:57.
29. Kaur G., Begg D.P., Barr D., Garg M., Cameron-Smith D., Sinclair A.J. Short-term docosapentaenoic acid (22:5 n-3) supplementation increases tissue docosapentaenoic acid, DHA and EPA concentrations in rats. Br. J. Nutr. 2010, 103:32-37.
30. Howe P., Meyer B., Record S., Baghurst K. Dietary intake of long-chain omega-3 polyunsaturated fatty acids: contribution of meat sources. Nutrition 2006, 22:47-53.
31. Mann N.J., Johnson L.G., Warrick G.E., Sinclair A.J. The arachidonic acid content of the Australian diet is lower than previously estimated. J. Nutr. 1995, 125:2528-2535.
32. Koska J., Stefan N., Dubois S., Trinidad C., Considine R.V., Funahashi T., Bunt J.C., Ravussin E., Permana P.A. mRNA concentrations of MIF in subcutaneous abdominal adipose cells are associated with adipocyte size and insulin action. Int. J. Obes. (London) 2009, 33:842-850.
33. Imamura M., Inoguchi T., Ikuyama S., Taniguchi S., Kobayashi K., Nakashima N., Nawata H. ADRP stimulates lipid accumulation and lipid droplet formation in murine fibroblasts. Am. J. Physiol. Endocrinol. Metab. 2002, 283:E775-783.
34. Asgary S., Nazari B., Sarrafzadegan N., Parkhideh S., Saberi S., Esmaillzadeh A., Azadbakht L. Evaluation of fatty acid content of some Iranian fast foods with emphasis on trans fatty acids. Asia Pac. J. Clin. Nutr. 2009, 18:187-192.
35. Engstrom K., Saldeen A.S., Yang B., Mehta J.L., Saldeen T. Effect of fish oils containing different amounts of EPA, DHA, and antioxidants on plasma and brain fatty acids and brain nitric oxide synthase activity in rats. Upsala J. Med. Sci. 2009, 114:206-213.
36. Sessler A.M., Kaur N., Palta J.P., Ntambi J.M. Regulation of stearoyl-CoA desaturase 1 mRNA stability by polyunsaturated fatty acids in 3T3-L1 adipocytes. J. Biol. Chem. 1996, 271:29854-29858.
37. Sampath H., Ntambi J.M. The fate and intermediary metabolism of stearic acid. Lipids 2005, 40:1187-1191.
38. Hodson L., Fielding B.A. Stearoyl-CoA desaturase: rogue or innocent bystander?. Prog. Lipid Res. 2013, 52:15-42.
39. Cho S.Y., Shin E.S., Park P.J., Shin D.W., Chang H.K., Kim D., Lee H.H., Lee J.H., Kim S.H., Song M.J., Chang I.S., Lee O.S., Lee T.R. Identification of mouse Prp19p as a lipid droplet-associated protein and its possible involvement in the biogenesis of lipid droplets. J. Biol. Chem. 2007, 282:2456-2465.
40. Choi Y., Kim Y.C., Han Y.B., Park Y., Pariza M.W., Ntambi J.M. The trans-10,cis-12 isomer of conjugated linoleic acid downregulates stearoyl-CoA desaturase 1 gene expression in 3T3-L1 adipocytes. J. Nutr. 2000, 130:1920-1924.
41. Gong J., Sun Z., Li P. CIDE proteins and metabolic disorders. Curr. Opin. Lipidol. 2009, 20:121-126.
42. Zhou Z., Yon Toh S., Chen Z., Guo K., Ng C.P., Ponniah S., Lin S.C., Hong W., Li P. Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat. Genet. 2003, 35:49-56.
43. Gummesson A., Jernas M., Svensson P.A., Larsson I., Glad C.A., Schele E., Gripeteg L., Sjoholm K., Lystig T.C., Sjostrom L., Carlsson B., Fagerberg B., Carlsson L.M. Relations of adipose tissue CIDEA gene expression to basal metabolic rate, energy restriction, and obesity: population-based and dietary intervention studies. J. Clin. Endocrinol. Metab. 2007, 92:4759-4765.
44. Nordstrom E.A., Ryden M., Backlund E.C., Dahlman I., Kaaman M., Blomqvist L., Cannon B., Nedergaard J., Arner P. A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity. Diabetes 2005, 54:1726-1734.
45. Dahlman I., Kaaman M., Jiao H., Kere J., Laakso M., Arner P. The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects. Diabetes 2005, 54:3032-3034.
46. Granneman J.G., Moore H.P., Krishnamoorthy R., Rathod M. Perilipin controls lipolysis by regulating the interactions of AB-hydrolase containing 5 (Abhd5) and adipose triglyceride lipase (Atgl). J. Biol. Chem. 2009, 284:34538-34544.
47. Brasaemle D.L., Levin D.M., Adler-Wailes D.C., Londos C. The lipolytic stimulation of 3T3-L1 adipocytes promotes the translocation of hormone-sensitive lipase to the surfaces of lipid storage droplets. Biochim. Biophys. Acta 2000, 1483:251-262.
48. Granneman J.G., Moore H.P., Granneman R.L., Greenberg A.S., Obin M.S., Zhu Z. Analysis of lipolytic protein trafficking and interactions in adipocytes. J. Biol. Chem. 2007, 282:5726-5735.
49. Liu B.H., Kuo C.F., Wang Y.C., Ding S.T. Effect of docosahexaenoic acid and arachidonic acid on the expression of adipocyte determination and differentiation-dependent factor 1 in differentiating porcine adipocytes. J. Anim. Sci. 2005, 83:1516-1525.
50. Madsen L., Petersen R.K., Kristiansen K. Regulation of adipocyte differentiation and function by polyunsaturated fatty acids. Biochim. Biophys. Acta 1740, 2005:266-286.
51. Yu Y.H., Lin E.C., Wu S.C., Cheng W.T., Mersmann H.J., Wang P.H., Ding S.T. Docosahexaenoic acid regulates adipogenic genes in myoblasts via porcine peroxisome proliferator-activated receptor gamma. J. Anim. Sci. 2008, 86:3385-3392.
52. Wahle K.W., Milne L., McIntosh G. Regulation of polyunsaturated fatty acid metabolism in tissue phospholipids of obese (fa/fa) and lean (Fa/-) Zucker rats. 1. Effect of dietary lipids on cardiac tissue. Lipids 1991, 26:16-22.
53. Popeijus H.E., Saris W.H., Mensink R.P. Role of stearoyl-CoA desaturases in obesity and the metabolic syndrome. Int. J. Obes. (London) 2008, 32:1076-1082.
54. Rockett B.D., Teague H., Harris M., Melton M., Williams J., Wassall S.R., Shaikh S.R. Fish oil increases raft size and membrane order of B cells accompanied by differential effects on function. J. Lipid Res. 2012, 53:674-685.