Metabolic activation of pyrrolizidine alkaloids leading to phototoxicity and photogenotoxicity in human hacat keratinocytes

Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews

Volumn 32, Issue 4, 2014, Pages 362-384

  Wang, Chia Chi ^a,b   Xia, Qingsu ^a   Li, Meng ^c   Wang, Shuguang ^a   Zhao, Yuewei ^a   Tolleson, William H ^a   Yin, Jun Jie ^c   Fu, Peter P ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Dehydropyrrolizidine alkaloids; Human HaCaT keratinocytes; Lipid peroxidation; Photoirradiation; Reactive oxygen species; UVA light

Indexed keywords

DERMATOLOGY; DISEASES; DNA; FREE RADICAL REACTIONS; IRRADIATION; MAGNETIC MOMENTS; MAMMALS; METABOLISM; METABOLITES; REACTIVE OXYGEN SPECIES;

ELECTRON-TRANSFER REACTIONS; KERATINOCYTES; LACTATE DEHYDROGENASE; LIPID PEROXIDATION; METABOLIC ACTIVATION; PHOTO-IRRADIATION; PYRROLIZIDINE ALKALOID; UV-A LIGHT;

ALKALOIDS;

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; AGAROSE; DEHYDRORETRONECINE; DEHYDRORIDDELLIINE; FREE RADICAL; HYDROXYL RADICAL; LACTATE DEHYDROGENASE; MONOCROTALINE; MONOCROTALINE PYRROLE; PYRROLIZIDINE ALKALOID; REACTIVE OXYGEN METABOLITE; RIDDELLIINE; SINGLET OXYGEN; SUPEROXIDE; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA ADDUCT; DNA CLEAVAGE; DNA CROSS LINKING; DNA DAMAGE; ELECTRON SPIN RESONANCE; ELECTRON TRANSPORT; ENZYME ASSAY; ENZYME RELEASE; GENOTOXICITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; METABOLIC ACTIVATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MTS ASSAY; PHOTOCYTOTOXICITY; PHOTOGENOTOXICITY; PHOTOTOXICITY; RADIATION EXPOSURE; ULTRAVIOLET A RADIATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DERMATITIS, PHOTOTOXIC; DOSE RESPONSE; DRUG EFFECTS; LIPID PEROXIDATION; METABOLISM; RADIATION RESPONSE; TRANSFORMED CELL LINE; ULTRAVIOLET RADIATION;

ANIMALIA; MAMMALIA;

CELL LINE, TRANSFORMED; CELL SURVIVAL; DERMATITIS, PHOTOTOXIC; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTRON SPIN RESONANCE SPECTROSCOPY; HUMANS; KERATINOCYTES; LIPID PEROXIDATION; MEMBRANE POTENTIAL, MITOCHONDRIAL; MOLECULAR STRUCTURE; PYRROLIZIDINE ALKALOIDS; REACTIVE OXYGEN SPECIES; ULTRAVIOLET RAYS;

EID: 84918785492     PISSN: 10590501     EISSN: 15324095     Source Type: Journal    
DOI: 10.1080/10590501.2014.969980     Document Type: Article

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