Formation of DHP-derived DNA adducts in vivo from dietary supplements and Chinese herbal plant extracts containing carcinogenic pyrrolizidine alkaloids

Toxicology and Industrial Health

Volumn 22, Issue 8, 2006, Pages 321-327

  Chou, Ming W ^a   Fu, Peter P ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

dietary supplement; DNA adduct; pyrrolizidine alkaloid; riddelliine

Indexed keywords

DIHYDROPYRIDINE DERIVATIVE; HERBACEOUS AGENT; PLANT EXTRACT; PYRROLIZIDINE ALKALOID; 6,7 DIHYDRO 7 HYDROXY 1 HYDROXYMETHYL 5H PYRROLIZINE; BIOLOGICAL MARKER; CLIVORINE; COLTSFOOT ROOT EXTRACT; COMFREY EXTRACT; FLOS FARFARA; LASIOCARPINE; MONOCROTALINE; RETRONECINE; TUMOR MARKER; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BIOTRANSFORMATION; CHEMISTRY; DIET SUPPLEMENTATION; DNA ADDUCT; DRUG EFFECT; FEMALE; FISCHER 344 RAT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER; METABOLISM; PLANT ROOT; RAT; ANIMAL EXPERIMENT; ANIMAL TISSUE; CARCINOGENIC ACTIVITY; CONTROLLED STUDY; IN VIVO CULTURE; NONHUMAN; PLANT METABOLISM;

ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIETARY SUPPLEMENTS; DIHYDROPYRIDINES; DNA ADDUCTS; DRUGS, CHINESE HERBAL; FEMALE; LIVER; PLANT EXTRACTS; PLANT ROOTS; PYRROLIZIDINE ALKALOIDS; RATS; RATS, INBRED F344;

FLOS; RATTUS; SYMPHYTUM; TUSSILAGO FARFARA;

EID: 34248633358     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233706071765     Document Type: Article

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