The Roles of CYP3A and CYP2B Isoforms in Hepatic Bioactivation and Detoxification of the Pyrrolizidine Alkaloid Senecionine in Sheep and Hamsters

Toxicology and Applied Pharmacology

Volumn 151, Issue 2, 1998, Pages 229-235

  Huan, Jian Ya ^a,b   Miranda, Cristobal L ^a   Buhler, Donald R ^a   Cheeke, Peter R ^a  

^a OREGON STATE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRICETINAE; OVIS ARIES;

CYTOCHROME P450; CYTOCHROME P450 3A; ENZYME INHIBITOR; GESTODENE; ISOENZYME; N DEMETHYLASE; PREGNANE DERIVATIVE; PYRROLIZIDINE ALKALOID; SENECIONINE; TESTOSTERONE; TROLEANDOMYCIN; UNSPECIFIC MONOOXYGENASE;

ANIMAL; ARTICLE; BIOTRANSFORMATION; DRUG ANTAGONISM; DRUG DETOXIFICATION; ENZYMOLOGY; HAMSTER; IMMUNOCHEMISTRY; IMMUNOLOGY; IN VITRO STUDY; LIVER MICROSOME; MALE; METABOLISM; SHEEP;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; CRICETINAE; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; IMMUNOCHEMISTRY; ISOENZYMES; MALE; METABOLIC DETOXICATION, DRUG; MICROSOMES, LIVER; NORPREGNENES; OXIDOREDUCTASES, N-DEMETHYLATING; PYRROLIZIDINE ALKALOIDS; SHEEP; TESTOSTERONE; TROLEANDOMYCIN;

EID: 0032135643     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8482     Document Type: Article

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