Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine

Toxicology Letters

Volumn 178, Issue 2, 2008, Pages 77-82

  Xia, Qingsu ^a   Yan, Jian ^a   Chou, Ming W ^a   Fu, Peter P ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Dehydroheliotridine (DHH); DNA adducts; Heliotrine; Pyrrolizidine alkaloid

Indexed keywords

6,7 DIHYDRO 7 HYDROXY 1 HYDROXYMETHYL 5H PYRROLIZINE; DNA; HELIOTRINE; MONOCROTALINE; PYRROLIZIDINE ALKALOID; RETRONECINE; RETRORSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA ADDUCT; FISCHER 344 RAT; LIVER MICROSOME; METABOLIC ACTIVATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BIOLOGICAL MARKERS; BIOTRANSFORMATION; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; DNA; DNA ADDUCTS; ISOTOPE LABELING; MALE; MICROSOMES, LIVER; MONOCROTALINE; PYRROLIZIDINE ALKALOIDS; RATS; RATS, INBRED F344; STEREOISOMERISM; THYMUS GLAND;

RATTUS;

EID: 42649106804     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2008.02.008     Document Type: Article

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