Metabolic activation of the tumorigenic pyrrolizidine alkaloid, riddelliine, leading to DNA adduct formation in vivo

Chemical Research in Toxicology

Volumn 14, Issue 1, 2001, Pages 101-109

  Yang, Ya Chen ^a   Yan, Jian ^a   Doerge, Daniel R ^a   Chan, Po Cheun ^b   Fu, Peter P ^a   Chou, Hing W ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PYRROLIZIDINE ALKALOID; RIDDELLINE; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENICITY; CHEMICAL STRUCTURE; DNA ADDUCT; DOSE RESPONSE; FEMALE; GENOTOXICITY; LIVER CARCINOGENESIS; LIVER MICROSOME; LIVER TUMOR; NONHUMAN; RAT; XENOBIOTIC METABOLISM;

ANIMALS; BIOTRANSFORMATION; CARCINOGENS; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA; DNA ADDUCTS; FEMALE; ISOTOPE LABELING; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MICROSOMES, LIVER; MONOCROTALINE; PHOSPHORUS RADIOISOTOPES; PYRROLIZIDINE ALKALOIDS; RATS; RATS, INBRED F344;

EID: 0035148592     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx000150n     Document Type: Article

References (5)

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3. 1 Mice, NIH Publication 94-3350, U.S. Government Printing Office, Washington, DC.
4. Huxtable, R. J. (1980) Herbal teas and toxins: novel aspects of pyrrolizidine poisoning in the United States. Perspect. Biol. Med. 24, 1-14.
5. Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. (1988) Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals. Environ. Mol. Mutagen, 11 (Suppl. 12), 1-158.