Pyrrolizidine alkaloid-derived DNA adducts as a common biological biomarker of pyrrolizidine alkaloid-induced tumorigenicity

Chemical Research in Toxicology

Volumn 26, Issue 9, 2013, Pages 1384-1396

  Xia, Qingsu ^a   Zhao, Yuewei ^a   Von Tungeln, Linda S ^a   Doerge, Daniel R ^a   Lin, Ge ^b   Cai, Lining ^c   Fu, Peter P ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b Prince of Wales Hospital   (Hong Kong)

^c Biotranex LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; BIOLOGICAL MARKER; CLIVORINE; HELIOTRINE; LASIOCARPINE; LYCOPSAMINE; MONOCROTALINE; PLATYPHYLLIINE; PYRROLIZIDINE ALKALOID; PYRROLIZINE DERIVATIVE; RETRONECINE; RETRORSINE; RIDDELLIINE N OXIDE; RIDDELLINE; SENKIRKINE; UNCLASSIFIED DRUG; CARCINOGEN; DNA ADDUCT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENICITY; CONTROLLED STUDY; DNA ADDUCT; FEMALE; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIVER; LIVER TUMOR; MASS SPECTROMETRY; METABOLISM; NONHUMAN; RAT; SYNTHESIS; ADMINISTRATION AND DOSAGE; ANIMAL; CARCINOGEN TESTING; CHEMICAL STRUCTURE; CHEMICALLY INDUCED; CHEMISTRY; EXPERIMENTAL LIVER NEOPLASM; FISCHER 344 RAT; LIVER MICROSOME;

ANIMALIA; RATTUS;

ANIMALS; BIOLOGICAL MARKERS; CARCINOGENICITY TESTS; CARCINOGENS; DNA ADDUCTS; FEMALE; LIVER NEOPLASMS, EXPERIMENTAL; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PYRROLIZIDINE ALKALOIDS; RATS; RATS, INBRED F344;

EID: 84884224379     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx400241c     Document Type: Article

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