Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine

Cancer Letters

Volumn 231, Issue 1, 2006, Pages 138-145

  Xia, Qingsu ^a   Chou, Ming W ^a   Edgar, John A ^b   Doerge, Daniel R ^a   Fu, Peter P ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b CSIRO   (Australia)

Author keywords

Biomarker; DNA adduct; Lasiocarpine; Pyrrolizidine alkaloid

Indexed keywords

6,7 DIHYDRO 7 HYDROXY 1 HYDROXYMETHYL 5H PYRROLIZINE; BIOLOGICAL MARKER; DNA; LASIOCARPINE; PYRROLIZIDINE ALKALOID; PYRROLIZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CARCINOGENICITY; CONTROLLED STUDY; DNA ADDUCT; FEMALE; INCUBATION TIME; LIVER MICROSOME; MALE; METABOLIC ACTIVATION; METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT; THYMOCYTE;

ANIMALS; BIOLOGICAL MARKERS; CARCINOGENS; DNA ADDUCTS; MALE; MICROSOMES, LIVER; MONOCROTALINE; PYRROLIZIDINE ALKALOIDS; RATS; RATS, INBRED F344;

ANIMALIA;

EID: 28844480954     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2005.01.023     Document Type: Article

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