메뉴 건너뛰기




Volumn 330, Issue 1, 2015, Pages 111-122

ATF6β regulates the Wfs1 gene and has a cell survival role in the ER stress response in pancreatic β-cells

Author keywords

ATF6; ER stress; Insulin; Pancreatic cells; Proinsulin

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ACTIVATING TRANSCRIPTION FACTOR 6ALPHA PROTEIN; ACTIVATING TRANSCRIPTION FACTOR 6BETA PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG; WFS1 PROTEIN; ATF6 PROTEIN, RAT; CALMODULIN BINDING PROTEIN; ISOPROTEIN; PROTEIN BINDING; WFS1 PROTEIN, RAT;

EID: 84917727835     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2014.10.007     Document Type: Article
Times cited : (26)

References (47)
  • 1
    • 35348827324 scopus 로고    scopus 로고
    • That which does not kill me makes me stronger: adapting to chronic ER stress
    • Rutkowski D.T., Kaufman R.J. That which does not kill me makes me stronger: adapting to chronic ER stress. Trends Biochem. Sci. 2007, 32:469-476.
    • (2007) Trends Biochem. Sci. , vol.32 , pp. 469-476
    • Rutkowski, D.T.1    Kaufman, R.J.2
  • 2
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • Ron D., Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 2007, 8:519-529.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 3
    • 34447527676 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress: signaling the unfolded protein response
    • Lai E., Teodoro T., Volchuk A. Endoplasmic reticulum stress: signaling the unfolded protein response. Physiology 2007, 22:193-201.
    • (2007) Physiology , vol.22 , pp. 193-201
    • Lai, E.1    Teodoro, T.2    Volchuk, A.3
  • 4
    • 43549105167 scopus 로고    scopus 로고
    • The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes
    • Scheuner D., Kaufman R.J. The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr. Rev. 2008, 29:317-333.
    • (2008) Endocr. Rev. , vol.29 , pp. 317-333
    • Scheuner, D.1    Kaufman, R.J.2
  • 5
    • 77957301909 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress response in the pancreatic beta-cell
    • Volchuk A., Ron D. The endoplasmic reticulum stress response in the pancreatic beta-cell. Diab., Obes. Metab. 2010, 12(2):S48-S57.
    • (2010) Diab., Obes. Metab. , vol.12 , Issue.2 , pp. S48-S57
    • Volchuk, A.1    Ron, D.2
  • 6
    • 84878777666 scopus 로고    scopus 로고
    • Signaling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation
    • Eizirik D.L., Miani M., Cardozo A.K. Signaling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation. Diabetologia 2013, 56:234-241.
    • (2013) Diabetologia , vol.56 , pp. 234-241
    • Eizirik, D.L.1    Miani, M.2    Cardozo, A.K.3
  • 7
    • 0024817131 scopus 로고
    • Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers
    • Hai T.W., Liu F., Coukos W.J., Green M.R. Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Genes Dev. 1989, 3:2083-2090.
    • (1989) Genes Dev. , vol.3 , pp. 2083-2090
    • Hai, T.W.1    Liu, F.2    Coukos, W.J.3    Green, M.R.4
  • 8
    • 0032693671 scopus 로고    scopus 로고
    • Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
    • Haze K., Yoshida H., Yanagi H., Yura T., Mori K. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol. Biol. Cell 1999, 10:3787-3799.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 3787-3799
    • Haze, K.1    Yoshida, H.2    Yanagi, H.3    Yura, T.4    Mori, K.5
  • 9
    • 0035310752 scopus 로고    scopus 로고
    • Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response
    • Haze K., Okada T., Yoshida H., Yanagi H., Yura T., Negishi M., Mori K. Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response. Biochem. J. 2001, 355:19-28.
    • (2001) Biochem. J. , vol.355 , pp. 19-28
    • Haze, K.1    Okada, T.2    Yoshida, H.3    Yanagi, H.4    Yura, T.5    Negishi, M.6    Mori, K.7
  • 10
    • 0029831269 scopus 로고    scopus 로고
    • The gene G13 in the class III region of the human MHC encodes a potential DNA-binding protein
    • Khanna A., Campbell R.D. The gene G13 in the class III region of the human MHC encodes a potential DNA-binding protein. Biochem. J. 1996, 319(Pt 1):81-89.
    • (1996) Biochem. J. , vol.319 , pp. 81-89
    • Khanna, A.1    Campbell, R.D.2
  • 12
    • 0037066741 scopus 로고    scopus 로고
    • The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi
    • Chen X., Shen J., Prywes R. The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi. J. Biol. Chem. 2002, 277:13045-13052.
    • (2002) J. Biol. Chem. , vol.277 , pp. 13045-13052
    • Chen, X.1    Shen, J.2    Prywes, R.3
  • 13
    • 0035141230 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response
    • Yoshida H., Okada T., Haze K., Yanagi H., Yura T., Negishi M., Mori K. Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response. Mol. Cell Biol. 2001, 21:1239-1248.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 1239-1248
    • Yoshida, H.1    Okada, T.2    Haze, K.3    Yanagi, H.4    Yura, T.5    Negishi, M.6    Mori, K.7
  • 14
    • 84859477044 scopus 로고    scopus 로고
    • Pancreatic beta-cells depend on basal expression of active ATF6alpha-p50 for cell survival even under nonstress conditions
    • Teodoro T., Odisho T., Sidorova E., Volchuk A. Pancreatic beta-cells depend on basal expression of active ATF6alpha-p50 for cell survival even under nonstress conditions. Am. J. Physiol. Cell Physiol. 2012, 302:C992-C1003.
    • (2012) Am. J. Physiol. Cell Physiol. , vol.302 , pp. C992-C1003
    • Teodoro, T.1    Odisho, T.2    Sidorova, E.3    Volchuk, A.4
  • 15
    • 0033815971 scopus 로고    scopus 로고
    • ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
    • Yoshida H., Okada T., Haze K., Yanagi H., Yura T., Negishi M., Mori K. ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol. Cell. Biol. 2000, 20:6755-6767.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 6755-6767
    • Yoshida, H.1    Okada, T.2    Haze, K.3    Yanagi, H.4    Yura, T.5    Negishi, M.6    Mori, K.7
  • 16
    • 0026550830 scopus 로고
    • Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines
    • Asfari M., Janjic D., Meda P., Li G., Halban P.A., Wollheim C.B. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 1992, 130:167-178.
    • (1992) Endocrinology , vol.130 , pp. 167-178
    • Asfari, M.1    Janjic, D.2    Meda, P.3    Li, G.4    Halban, P.A.5    Wollheim, C.B.6
  • 17
    • 0034006587 scopus 로고    scopus 로고
    • Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion
    • Hohmeier H.E., Mulder H., Chen G., Henkel-Rieger R., Prentki M., Newgard C.B. Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion. Diabetes 2000, 49:424-430.
    • (2000) Diabetes , vol.49 , pp. 424-430
    • Hohmeier, H.E.1    Mulder, H.2    Chen, G.3    Henkel-Rieger, R.4    Prentki, M.5    Newgard, C.B.6
  • 19
    • 38049004431 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor-1 signaling in pancreatic islet beta-cells is modulated by the extracellular matrix
    • Kilkenny D.M., Rocheleau J.V. Fibroblast growth factor receptor-1 signaling in pancreatic islet beta-cells is modulated by the extracellular matrix. Mol. Endocrinol. 2008, 22:196-205.
    • (2008) Mol. Endocrinol. , vol.22 , pp. 196-205
    • Kilkenny, D.M.1    Rocheleau, J.V.2
  • 21
    • 64149105766 scopus 로고    scopus 로고
    • GRP78, but not protein-disulfide isomerase, partially reverses hyperglycemia-induced inhibition of insulin synthesis and secretion in pancreatic {beta}-cells
    • Zhang L., Lai E., Teodoro T., Volchuk A. GRP78, but not protein-disulfide isomerase, partially reverses hyperglycemia-induced inhibition of insulin synthesis and secretion in pancreatic {beta}-cells. J. Biol. Chem. 2009, 284:5289-5298.
    • (2009) J. Biol. Chem. , vol.284 , pp. 5289-5298
    • Zhang, L.1    Lai, E.2    Teodoro, T.3    Volchuk, A.4
  • 23
    • 40449106191 scopus 로고    scopus 로고
    • Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells
    • Lai E., Bikopoulos G., Wheeler M.B., Rozakis-Adcock M., Volchuk A. Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells. Am. J. Physiol. Endocrinol. Metab. 2008, 294:E540-E550.
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.294 , pp. E540-E550
    • Lai, E.1    Bikopoulos, G.2    Wheeler, M.B.3    Rozakis-Adcock, M.4    Volchuk, A.5
  • 24
    • 33645280897 scopus 로고    scopus 로고
    • XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in the SH-SY5Y cells
    • Kakiuchi C., Ishiwata M., Hayashi A., Kato T. XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in the SH-SY5Y cells. J. Neurochem. 2006, 97:545-555.
    • (2006) J. Neurochem. , vol.97 , pp. 545-555
    • Kakiuchi, C.1    Ishiwata, M.2    Hayashi, A.3    Kato, T.4
  • 25
    • 33745116619 scopus 로고    scopus 로고
    • Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis
    • Karaskov E., Scott C., Zhang L., Teodoro T., Ravazzola M., Volchuk A. Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis. Endocrinology 2006, 147:3398-3407.
    • (2006) Endocrinology , vol.147 , pp. 3398-3407
    • Karaskov, E.1    Scott, C.2    Zhang, L.3    Teodoro, T.4    Ravazzola, M.5    Volchuk, A.6
  • 26
    • 77954872755 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress response in an INS-1 pancreatic beta-cell line with inducible expression of a folding-deficient proinsulin
    • Hartley T., Siva M., Lai E., Teodoro T., Zhang L., Volchuk A. Endoplasmic reticulum stress response in an INS-1 pancreatic beta-cell line with inducible expression of a folding-deficient proinsulin. BMC Cell Biol. 2010, (11):59.
    • (2010) BMC Cell Biol. , Issue.11 , pp. 59
    • Hartley, T.1    Siva, M.2    Lai, E.3    Teodoro, T.4    Zhang, L.5    Volchuk, A.6
  • 27
    • 70350463523 scopus 로고    scopus 로고
    • N-glycosylation of ATF6beta is essential for its proteolytic cleavage and transcriptional repressor function to ATF6alpha
    • Guan D., Wang H., Li V.E., Xu Y., Yang M., Shen Z. N-glycosylation of ATF6beta is essential for its proteolytic cleavage and transcriptional repressor function to ATF6alpha. J. Cell. Biochem. 2009, 108:825-831.
    • (2009) J. Cell. Biochem. , vol.108 , pp. 825-831
    • Guan, D.1    Wang, H.2    Li, V.E.3    Xu, Y.4    Yang, M.5    Shen, Z.6
  • 29
    • 44449101173 scopus 로고    scopus 로고
    • ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum
    • Adachi Y., Yamamoto K., Okada T., Yoshida H., Harada A., Mori K. ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum. Cell Struct. Funct. 2008, 33:75-89.
    • (2008) Cell Struct. Funct. , vol.33 , pp. 75-89
    • Adachi, Y.1    Yamamoto, K.2    Okada, T.3    Yoshida, H.4    Harada, A.5    Mori, K.6
  • 30
    • 34548172495 scopus 로고    scopus 로고
    • Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1
    • Yamamoto K., Sato T., Matsui T., Sato M., Okada T., Yoshida H., Harada A., Mori K. Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1. Dev. Cell 2007, 13:365-376.
    • (2007) Dev. Cell , vol.13 , pp. 365-376
    • Yamamoto, K.1    Sato, T.2    Matsui, T.3    Sato, M.4    Okada, T.5    Yoshida, H.6    Harada, A.7    Mori, K.8
  • 33
    • 47949127583 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner
    • Seo H.Y., Kim Y.D., Lee K.M., Min A.K., Kim M.K., Kim H.S., Won K.C., Park J.Y., Lee K.U., Choi H.S., Park K.G., Lee I.K. Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner. Endocrinology 2008, 149:3832-3841.
    • (2008) Endocrinology , vol.149 , pp. 3832-3841
    • Seo, H.Y.1    Kim, Y.D.2    Lee, K.M.3    Min, A.K.4    Kim, M.K.5    Kim, H.S.6    Won, K.C.7    Park, J.Y.8    Lee, K.U.9    Choi, H.S.10    Park, K.G.11    Lee, I.K.12
  • 34
    • 84856353556 scopus 로고    scopus 로고
    • Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression
    • Amyot J., Benterki I., Fontes G., Hagman D.K., Ferdaoussi M., Teodoro T., Volchuk A., Joly E., Poitout V. Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression. J. Mol. Endocrinol. 2011, 47:273-283.
    • (2011) J. Mol. Endocrinol. , vol.47 , pp. 273-283
    • Amyot, J.1    Benterki, I.2    Fontes, G.3    Hagman, D.K.4    Ferdaoussi, M.5    Teodoro, T.6    Volchuk, A.7    Joly, E.8    Poitout, V.9
  • 35
    • 84878624362 scopus 로고    scopus 로고
    • SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic beta-cells
    • Tiwari A., Schuiki I., Zhang L., Allister E.M., Wheeler M.B., Volchuk A. SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic beta-cells. J. Cell Sci. 2013, 126:1962-1968.
    • (2013) J. Cell Sci. , vol.126 , pp. 1962-1968
    • Tiwari, A.1    Schuiki, I.2    Zhang, L.3    Allister, E.M.4    Wheeler, M.B.5    Volchuk, A.6
  • 36
    • 28244435870 scopus 로고    scopus 로고
    • WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells
    • Fonseca S.G., Fukuma M., Lipson K.L., Nguyen L.X., Allen J.R., Oka Y., Urano F. WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells. J. Biol. Chem. 2005, 280:39609-39615.
    • (2005) J. Biol. Chem. , vol.280 , pp. 39609-39615
    • Fonseca, S.G.1    Fukuma, M.2    Lipson, K.L.3    Nguyen, L.X.4    Allen, J.R.5    Oka, Y.6    Urano, F.7
  • 37
    • 77957303908 scopus 로고    scopus 로고
    • A switch from life to death in endoplasmic reticulum stressed beta-cells
    • Oslowski C.M., Urano F. A switch from life to death in endoplasmic reticulum stressed beta-cells. Diab., Obesity Metab. 2010, 12(2):S58-S65. (Suppl).
    • (2010) Diab., Obesity Metab. , vol.12 , Issue.2 , pp. S58-S65
    • Oslowski, C.M.1    Urano, F.2
  • 38
    • 9244231766 scopus 로고    scopus 로고
    • Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress
    • Kharroubi I., Ladriere L., Cardozo A.K., Dogusan Z., Cnop M., Eizirik D.L. Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress. Endocrinology 2004, 145:5087-5096.
    • (2004) Endocrinology , vol.145 , pp. 5087-5096
    • Kharroubi, I.1    Ladriere, L.2    Cardozo, A.K.3    Dogusan, Z.4    Cnop, M.5    Eizirik, D.L.6
  • 39
    • 0034425698 scopus 로고    scopus 로고
    • EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome
    • Delepine M., Nicolino M., Barrett T., Golamaully M., Lathrop G.M., Julier C. EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome. Nat. Genet. 2000, 25:406-409.
    • (2000) Nat. Genet. , vol.25 , pp. 406-409
    • Delepine, M.1    Nicolino, M.2    Barrett, T.3    Golamaully, M.4    Lathrop, G.M.5    Julier, C.6
  • 40
    • 0034968330 scopus 로고    scopus 로고
    • Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival
    • Harding H.P., Zeng H., Zhang Y., Jungries R., Chung P., Plesken H., Sabatini D.D., Ron D. Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol. Cell 2001, 7:1153-1163.
    • (2001) Mol. Cell , vol.7 , pp. 1153-1163
    • Harding, H.P.1    Zeng, H.2    Zhang, Y.3    Jungries, R.4    Chung, P.5    Plesken, H.6    Sabatini, D.D.7    Ron, D.8
  • 41
    • 79957773163 scopus 로고    scopus 로고
    • Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion
    • Lee A.H., Heidtman K., Hotamisligil G.S., Glimcher L.H. Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion. Proc. Natl. Acad. Sci. USA 2011, 108:8885-8890.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 8885-8890
    • Lee, A.H.1    Heidtman, K.2    Hotamisligil, G.S.3    Glimcher, L.H.4
  • 43
    • 34547933706 scopus 로고    scopus 로고
    • Effects of the isoform-specific characteristics of ATF6 alpha and ATF6 beta on endoplasmic reticulum stress response gene expression and cell viability
    • Thuerauf D.J., Marcinko M., Belmont P.J., Glembotski C.C. Effects of the isoform-specific characteristics of ATF6 alpha and ATF6 beta on endoplasmic reticulum stress response gene expression and cell viability. J. Biol. Chem. 2007, 282:22865-22878.
    • (2007) J. Biol. Chem. , vol.282 , pp. 22865-22878
    • Thuerauf, D.J.1    Marcinko, M.2    Belmont, P.J.3    Glembotski, C.C.4
  • 44
    • 2442647920 scopus 로고    scopus 로고
    • Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction
    • Thuerauf D.J., Morrison L., Glembotski C.C. Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction. J. Biol. Chem. 2004, 279:21078-21084.
    • (2004) J. Biol. Chem. , vol.279 , pp. 21078-21084
    • Thuerauf, D.J.1    Morrison, L.2    Glembotski, C.C.3
  • 45
    • 78751513443 scopus 로고    scopus 로고
    • Peroxisome-generated hydrogen peroxide as important mediator of lipotoxicity in insulin-producing cells
    • Elsner M., Gehrmann W., Lenzen S. Peroxisome-generated hydrogen peroxide as important mediator of lipotoxicity in insulin-producing cells. Diabetes 2011, 60:200-208.
    • (2011) Diabetes , vol.60 , pp. 200-208
    • Elsner, M.1    Gehrmann, W.2    Lenzen, S.3
  • 46
    • 80053425920 scopus 로고    scopus 로고
    • Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1
    • Morishima N., Nakanishi K., Nakano A. Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1. J. Biol. Chem. 2011, 286:35227-35235.
    • (2011) J. Biol. Chem. , vol.286 , pp. 35227-35235
    • Morishima, N.1    Nakanishi, K.2    Nakano, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.