SDF2L1 interacts with the ER-associated degradation machinery and retards the degradationof mutant proinsulin in pancreatic β-cells

Journal of Cell Science

Volumn 126, Issue 9, 2013, Pages 1962-1968

  Tiwari Akansha, A ^a,b   Schuiki, Irmgard ^a   Zhang, Liling ^a   Allister, Emma M ^a,b   Wheeler, Michael B ^a,b   Volchuk, Allen ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

ER associated degradation; ER stress; ERAD; Insulin; Pancreatic cells.; Proinsulin; SDF2L1

Indexed keywords

GLUCOSE REGULATED PROTEIN 78; GREEN FLUORESCENT PROTEIN; MUTANT PROTEIN; PROINSULIN; PROTEIN; STROMAL CELL DERIVED FACTOR 2 LIKE 1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEGRADATION KINETICS; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; RAT; REGULATORY MECHANISM; TUMOR CELL LINE;

ER ASSOCIATED DEGRADATION; ER STRESS; ERAD; INSULIN; PANCREATIC Β-CELLS; PROINSULIN; SDF2L1;

ANIMALS; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; INSULIN-SECRETING CELLS; MEMBRANE PROTEINS; MUTATION; PROINSULIN; PROTEOLYSIS; RATS;

MUS;

EID: 84878624362     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.117374     Document Type: Article

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