GRP78, but not protein-disulfide isomerase, partially reverses hyperglycemia-induced inhibition of insulin synthesis and secretion in pancreatic β-cells

Journal of Biological Chemistry

Volumn 284, Issue 8, 2009, Pages 5289-5298

  Zhang, Liling ^a   Lai, Elida ^a,b   Teodoro, Tracy ^a,b   Volchuk, Allen ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DYSFUNCTION; CELL FUNCTIONS; ENDOPLASMIC RETICULUM STRESS; ER STRESS; GLUCOSE CONCENTRATION; GLUCOSE-STIMULATED INSULIN SECRETIONS; INSULIN PROMOTERS; MRNA LEVEL; OVER-EXPRESSION; OXIDOREDUCTASE; PROINSULIN; PROTEIN DISULFIDE ISOMERASE; PROTEIN LEVEL; TRANSLATION RATES; TYPE-2 DIABETES; UNFOLDED PROTEIN RESPONSE;

BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BIOSYNTHESIS; CELL MEMBRANES; GENE EXPRESSION; GLUCOSE;

INSULIN;

ACTIVATING TRANSCRIPTION FACTOR 6; DISULFIDE ISOMERASE; GLUCOSE; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; INSULIN; ISOMERASE; MESSENGER RNA; OXIDOREDUCTASE; PROINSULIN; PROTEIN; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; ATF6 PROTEIN, HUMAN; ATF6 PROTEIN, RAT; CHAPERONE; DDIT3 PROTEIN, HUMAN; DNA BINDING PROTEIN; HEAT SHOCK PROTEIN; HSPA5 PROTEIN, RAT; INITIATION FACTOR 2; MOLECULAR CHAPERONE GRP78; PROTEIN DISULFIDE ISOMERASE; REGULATORY FACTOR X TRANSCRIPTION FACTORS; SWEETENING AGENT; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL LEVEL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE OVEREXPRESSION; HUMAN; HYPERGLYCEMIA; INSULIN RELEASE; INSULIN SYNTHESIS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; STRESS; ANIMAL; BIOSYNTHESIS; CELL LINE; GENETICS; METABOLISM; MORTALITY; SECRETION;

ACTIVATING TRANSCRIPTION FACTOR 6; ANIMALS; CELL LINE; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; EUKARYOTIC INITIATION FACTOR-2; GLUCOSE; HEAT-SHOCK PROTEINS; HUMANS; HYPERGLYCEMIA; INSULIN-SECRETING CELLS; MOLECULAR CHAPERONES; PROINSULIN; PROTEIN DISULFIDE-ISOMERASES; RATS; RNA, MESSENGER; SWEETENING AGENTS; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS;

EID: 64149105766     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M805477200     Document Type: Article

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