Mimulone-induced autophagy through p53-mediated AMPK/mTOR pathway increases caspase-mediated apoptotic cell death in A549 human lung cancer cells

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  An, Hyun Kyu ^a   Kim, Kyoung Sook ^a   Lee, Ji Won ^a   Park, Mi Hyun ^a   Moon, Hyung In ^a   Park, Shin Ji ^a   Baik, Ji Sue ^a   Kim, Cheorl Ho ^b   Lee, Young Choon ^a  

^a Dong A University   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN 1; CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; FLAVONOID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3 I; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3 II; MIMULONE; PROTEIN P53; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BENZOTHIAZOLE DERIVATIVE; FLAVANONE DERIVATIVE; MTOR PROTEIN, HUMAN; PIFITHRIN; TARGET OF RAPAMYCIN KINASE; TOLUENE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; BIOACCUMULATION; BREAST CANCER CELL LINE; CELL PROLIFERATION; CELL VACUOLE; CELL VIABILITY; COLORECTAL CANCER CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; HUMAN; HUMAN CELL; LUNG CANCER CELL LINE; NON SMALL CELL LUNG CANCER; OSTEOSARCOMA CELL LINE; PROTEIN EXPRESSION; TRANSACTIVATION; ADENOCARCINOMA; ANALOGS AND DERIVATIVES; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; GENE SILENCING; GENETICS; HCT 116 CELL LINE; LAMIALES; LUNG TUMOR; MCF-7 CELL LINE; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

PAULOWNIA TOMENTOSA;

ADENOCARCINOMA; AMP-ACTIVATED PROTEIN KINASES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; AUTOPHAGY; BENZOTHIAZOLES; CELL LINE, TUMOR; CELL SURVIVAL; FLAVANONES; GENE KNOCKDOWN TECHNIQUES; HCT116 CELLS; HUMANS; LAMIALES; LUNG NEOPLASMS; MCF-7 CELLS; TOLUENE; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84916926095     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0114607     Document Type: Article

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