Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways

Toxicology in Vitro

Volumn 25, Issue 5, 2011, Pages 1027-1032

  Mou, Haibo ^a   Zheng, Yi ^a   Zhao, Peng ^a   Bao, Hanying ^a   Fang, Weijia ^a   Xu, Nong ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

A549; Apoptosis; Celastrol; Fas FasL; Lung cancer; Mitochondria

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CELASTROL; CYTOCHROME C; FAS ANTIGEN; FAS LIGAND; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER INHIBITION; CELL ACTIVATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SECRETION; UPREGULATION;

ANNEXIN A5; ANTIGENS, CD95; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, NON-SMALL-CELL LUNG; CASPASE 3; CASPASE 8; CASPASE 9; CELL LINE, TUMOR; CYTOCHROMES C; DNA FRAGMENTATION; DOWN-REGULATION; FAS LIGAND PROTEIN; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INHIBITORY CONCENTRATION 50; MEDICINE, CHINESE TRADITIONAL; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PROPIDIUM; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; TRITERPENES; UP-REGULATION;

TRIPTERYGIUM WILFORDII;

EID: 79957961355     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.03.023     Document Type: Article

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